Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_186_библиотеки_им_акад_М_И_Перельмана
.pdf
Electrophysiologictestingwillnotdetectsmallfiberneuropathy;EMGandNCSwillbenormal.The
lackofEMG/NCSabnormalitiesandanormal,ornearnormal,neurologicexaminationinapatientwith
symptomaticneuropathyarewhatshouldleadyoutosuspectasmallfiberneuropathy.Skinbiopsy,which
willshowabsentordiminishednerveendings,isthediagnostictestofchoice.Thereisnospecific
treatment;variousanticonvulsantsandantidepressantscanbeusedforpaincontrol.
Examplesofnervefibersonskinpunchbiopsiesandmicroscopy,fromahealthycontrolandapatientwith
smallfiberneuropathy.Notethelowerdensityofnervefibersinthepatientwithsmallfiberneuropathy.
(ModifiedfromHaüserW,PerrotS.FibromyalgiaSyndromeandWidespreadPain.WoltersKluwer;
2018.)
MononeuritisMultiplex
Mononeuritismultiplexisunlikethepolyneuropathieswehavejustdiscussed.Thepolyneuropathies
evolvesymmetrically,progressively,andcontinuously,whereasmononeuritismultiplexproceedsina
kindofscattershotaccumulationofisolated,noncontiguousmononeuropathies.Bydefinition,itmust
involve2ormorenoncontiguousnerveseithersimultaneouslyorsequentially.Mononeuritismultiplexis
https://t.me/med1917

farlesscommonthanpolyneuropathy.
https://t.me/med1917

https://t.me/med1917

Multiplex.Ifyoulookquickly,theinvolvedareasmayresemblethestockingglovedistributionofa
polyneuropathy.Butacloserevaluationwillrevealthatthelesionsarenotsymmetricandinvolveseveral
distinctperipheralnerves.Acarefulexaminationwillrevealthedifference.
Vasculitisisacommoncause,mostoftenthedisordersassociatedwithantineutrophilcytoplasmic
autoantibodies (ANCA; such as granulomatosis with polyangiitis and microscopic polyangiitis),
polyarteritis nodosa, cryoglobulinemia, and vasculitis associated with connective tissue diseases
suchasSjogrensyndrome.
Othercausesinclude:
ischemicnervedamage(e.g.,duetodiabetesorsicklecellanemia)
variousinfections(mostlyviraldiseasessuchashepatitisB,hepatitisC,HIV,andWestNilevirus)
neoplasticprocesses(fromtumorinfiltrationofnervesorasaresultofaparaneoplasticsyndrome).
Nervesofthelowerextremitiesaretypicallyaffectedfirst;footdropduetoperonealnervedamageis
themostcommonmotorcomplaint.Overtime,however,virtuallyanyperipheralnervecanbeaffected,
includingthosesupplyingstrengthandsensationtotheupperextremities,thecranialnervesandautonomic
nerves.
Nervebiopsyisoftenhelpfultodiagnosetheunderlyingetiology;itcanconfirmavasculitisandallow
treatmenttobeinitiatedwithcorticosteroids,aswellasruleoutinfiltrativedisorderslikelymphoma.
Managementotherwiseinvolvesrecognizingandtreatingtheunderlyingcondition,aswellaspain
controlwiththesamemedicationsusedforthemorecommonpolyneuropathies.
Plexopathies
Theplexopathiesinvolvemultiplenervesbutarecausedbysinglelesionsthatinvolveasubstantialpart
oforanentireplexus,eitherthebrachialplexusorthelumbosacralplexus.Thesesyndromesarerareand
aremostoftencausedbytrauma,ischemia,inflammation,malignancy,diabetes,andradiationtherapy.
BrachialPlexopathies
Thebrachialplexusisoneofthemosttestedanatomicalstructuresinthebody.ThemnemonicReal
TexansDrinkColdBeerisoftenreliedupontohelpremembertheanatomy:
Roots(C5T1)
Trunks(superior/upper:C56,middle:C7,inferior/lower:C8T1)
Divisions(eachtrunksplitsintoanteriorandposteriordivisions)
Cords(lateral,posterior,andmedial)
Branches(thenervesgivenoffbyeachcord)
Lateralcord→musculocutaneousnerve(C57),lateralrootofthemediannerve(C5T1)
Posteriorcord→axillarynerve(C56),radialnerve(C5T1)
Medialcord→ulnarnerve(C8T1),medialrootofthemediannerve(C5T1)
https://t.me/med1917

Thebrachialplexus.
Brachialplexopathiesaretypicallyclassifiedintothosethataretraumatic(usuallyaresultofsports
injuriesormotorvehicleaccidents)andthosethatarenot.Afewspecificsyndromesinvolvingthe
brachialplexusinclude:
Erbpalsyiscausedbyatearofthesuperiororuppertrunkofthebrachialplexus(involvingC5and
C6).Thismostoftenoccursininfantsduringdelivery,aresultoflateraltractionontheneckofthe
baby due to shoulder dystocia. It presents with impaired shoulder abduction (due to deltoid and
supraspinatus involvement; the arm hangs limply by the side), lateral rotation (infraspinatus
involvement; the arm is medially rotated) and arm flexion and supination (biceps brachii
involvement; the arm is extended and pronated). The majority of cases resolve with time and
physicaltherapy.Surgicalrepairissecondlinetreatmentifneeded.
https://t.me/med1917

AsummaryofthecommonneurologiccomplicationsseenininfantswithErbpalsy.
Klumpkepalsyiscausedbyatearoftheinferiororlowertrunkofthebrachialplexus(involving
C8T1).ItisalsotypicallycausedbytraumaduringdeliverybutislesscommonthanErbpalsy.This
palsy presents with weakness in the intrinsic hand muscles innervated by the ulnar and median
nerves(resultingin“clawhand,”characterizedbyanextendedwrist,extendedmetacarpophalangeal
joints,andflexeddistal interphalangealjoints),C8T1dermatomalnumbnessand,not uncommonly,
Hornersyndrome,duetothecloseapproximationoftheT1nerveroottothesympatheticchain.
https://t.me/med1917

The“clawhand”ofKlumpkepalsy.
ParsonageTurner syndrome (also known as neuralgic amyotrophy) is an acute inflammatory
brachialplexitisthatcaninvolveanyportionofthebrachialplexus.Mostoftenitisidiopathic,but
https://t.me/med1917

approximately 50% of patients report some sort of antecedent event, such as surgery or a viral
illness.Itclassicallypresentswiththeacuteonsetofseverearmandshoulderpainfollowedwithin
days to weeks by patchy upper extremity weakness. Most cases are unilateral, but bilateral
involvement can occur. Recovery is gradual, often over months to years. There is no specific
treatment.
Box11.7ThoracicOutletSyndrome
Thoracicoutletsyndromereferstoagroupofdisorderscausedbycompressionofthe
nerves,arteries,andveinswithinthethoracicoutlet(thespacebetweentheclavicleandfirst
rib).Themostcommoncauseisthepresenceofanomalousribsoraninjury.Theclinical
pictureisusuallydominatedbycompressionofthebloodvessels,causingupperextremity
edema.However,whenthenervesofthebrachialplexusarealsoinvolved(thisis
exceedinglyrare!),thepatientwillcomplainofpain,numbness,anddysesthesiasofthe
upperextremityprovokedbyelevatingthearmorturningtheneck.Iftheconditionis
untreated,muscularatrophycandevelop.
LumbosacralPlexopathies
Theseareuncommon,sowewon’tspendtoomuchtimehere(and,happily,unlikewiththebrachial
plexus,thereisnoneedtolearnthepreciseanatomy).Thereareastrikinglywiderangeofpotential
etiologies,including:
Diabetes. Diabetic amyotrophy (also known as diabetic radiculoplexus neuropathy) typically
presents acutely withasymmetric focal legpain followed by proximal legweakness. Associated
autonomicsymptomsarecommon.Partialrecoveryoverweekstomonthsisstandard.
Idiopathic. Idiopathic lumbosacral plexopathy presents similarly to diabetic amyotrophy, but in
patientswithoutdiabetes.
Neoplasm.Neoplasticinvasionofthelumbosacralplexusismostoftenduetodirectextensionofa
tumor(nearlyanyformofcarcinoma,melanoma,orlymphomacanbeimplicated),butitcanalsobe
caused by leptomeningeal involvement or hematogenous or lymphatic spread. Neoplastic
lumbosacralplexopathyis nearlyalwayspainful, characterizedbyshocklikepainsinthe involved
lowerextremity.
Radiation.Radiationlumbosacralplexopathytendstooccurmonthstoyearsafterpelvicradiation.
Itis oftenbilateralandrarelypainful,presentinginsteadwithweaknessand,occasionally,sensory
loss.
Retroperitoneal hematoma. These typically develop within the psoas muscle and can occur
spontaneously or following femoral arterial or venous catheterizations (most often in patients on
anticoagulation).Severebackandlegpainandfemoralneuropathyarecommon.
Mononeuropathies
Mononeuropathy,theinvolvementofasinglenerve,canresultfromalmostanydiseaseprocess.Any
nervecanbeaffected,andwecouldlistasmanymononeuropathiesastherearenervesinthebody,buta
fewsyndromesarecommonanddeservetobesingledout:
https://t.me/med1917

Medianneuropathyatthewrist(carpaltunnelsyndrome)
Ulnarneuropathyattheelbow
Peronealandtibialneuropathies
Bellpalsy
Meralgiaparesthetica
CarpalTunnelSyndrome
Carpaltunnelsyndrome(CTS)isaformofmedianneuropathyduetoentrapmentofthemediannerve
(whichisderivedfromspinalnervesC5T1)withinthenarrowcarpaltunnelinthewrist.Thisisusually
causedbyrepetitivetraumafromoccupationsthatrequirefrequentflexionandextensionofthewrist
(although,surprisingly,spendingthedayhammeringawayatacomputerkeyboardhasnotbeen
convincinglyfoundtocauseCTS!).Otherimportantriskfactorstokeepinmindincludehypothyroidism
(duetoaccumulationofmucinousmaterialwithinthecarpaltunnel),pregnancy(duetofluidaccumulation
andedema),andamyloidosis(due,nosurprise,toamyloiddeposition).
Patientswillcomplainofnumbnessandparesthesiasinthehand,oftendescribedastinglingandoften
worseatnight.Examinationwillrevealthatthesensorysymptomsarelimitedtothefirstthreedigitsof
thehandandthemedialsideoftheringfinger.Accompanyingpain,however,neednotbelimitedtothe
mediannervedistributionandcanradiatethroughouttheentirehandandevenupthearm.Bilateral
symptomsaresurprisinglycommon,affectingmorethanhalfofpatientswithCTS.
Compressionofthemediannervewithinthecarpaltunnelleadstosensorycomplaintsinthefirstthree
digitsandthemedialsideoftheringfinger.
Variousdiagnosticmaneuversmayhelpyoumakethediagnosis.ThePhalentestinvolveshaving
https://t.me/med1917

patientsflextheirwristfor1minuteandseeingifthatelicitsorexacerbatestheirsymptoms.TheTinel
testinvolvestappingoverthecarpaltunnelandseeingifthatproducessymptomsinthefingers.If
positive,bothtestsaresuggestiveofthediagnosis,buttheirsensitivityandspecificityarelimited(cited
asaround50%to80%).Wristxraysmaybeindicatedtoexcludeotherdiagnoses,andelectrophysiologic
testingcanbehelpfulwhenthediagnosisremainsunclear.
Phalentestforcarpaltunnelsyndrome.
Conservativetreatmentinvolvesavoidanceoftheactivitythatiscausingtheproblem(unfortunatelynot
alwayspossible)andtheuseofawristsplintatnight.Physicaltherapyandtargetedexercisesdon’t
appeartoaddmuch.Somepatientsmaybenefitfromlocalinjectionofacorticosteroid.Forpatientswith
persistentsymptoms,surgicalreleaseofthecarpaltunnelisarelativelysimpleprocedurethatcanleadto
completeresolutionofsymptoms.
UlnarNeuropathy
Ulnarneuropathyislesscommonthanmedianneuropathy.Itcanoccurwhentheulnarnerve(derivedfrom
spinalnervesC8T1)iscompressedattheelbow(inthecubitaltunnel;thisisthemostcommonsite)orthe
wrist(inGuyoncanal).Sensorysymptomsintheulnardistributiontendtopredominateintheformer,
https://t.me/med1917
Соседние файлы в папке Библиотека им академика М.И. Перельмана
