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MCPHSUniversitySchoolofPharmacy– Worcester/Manchester ClinicalPharmacySpecialistinInfectiousDiseases SaintVincentHospital Worcester,Massachusetts

RichardG.Stefanacci,DO,MGH,MBA,AGSF,CMD

Faculty SchoolofPopulationHealth ThomasJeffersonUniversity Philadelphia,Pennsylvania ChiefMedicalOfficer TheAccessGroup BerkeleyHeights,NewJersey SeniorPhysician MercyLIFE TrinityHealthSystem Philadelphia,Pennsylvania

JeffreyRaymondF.Tagle,PharmD,BCPS

ClinicalPharmacist,AnticoagulationCenter DepartmentofPharmacyServices ChristianaCare Newark,Delaware

AngelaThompsonDNP,FNP-C,BC-ADM,CDCES,FAANP

FamilyNursePractitioner HendricksEndocrinology Danville,Indiana MedicalDirector DiabetesYouthFoundationofIndiana Noblesville,Indiana

TyanF.Thomas,PharmD

AssociateProfessorofClinicalPharmacy DepartmentofPharmacyPracticeandPharmacy Administration PhiladelphiaCollegeofPharmacyattheUniversityofthe Sciences ClinicalPharmacySpecialist DepartmentofPharmacy PhiladelphiaVAMedicalCenter Philadelphia,Pennsylvania

KarenJ.Tietze,PharmD

ProfessorofClinicalPharmacy

PhiladelphiaCollegeofPharmacy UniversityoftheSciencesinPhiladelphia Philadelphia,Pennsylvania

RachelTrichtinger,BCPP

Unit-BasedPharmacist-Psychiatry PharmacyDepartment AbingtonJeffersonHealth Abington,Pennsylvania

ElenaM.Umland,PharmD

AssociateDean,AcademicAffairs Professor,PharmacyPractice JeffersonSchoolofPharmacy ThomasJeffersonUniversity Philadelphia,Pennsylvania

SarahF.Uroza,PharmD

AssistantProfessor DepartmentofPharmacyPractice LipscombUniversity ClinicalPharmacist FaithFamilyMedicalClinic Nashville,Tennessee

MichaelWeissberger,MD

Fellow DepartmentofFamilyandCommunityMedicine ThomasJeffersonUniversity Philadelphia,Pennsylvania

VeronicaF.Wilbur,PhD,APRN-FNP,CNE,FAANP

AssistantProfessorofGraduateNursing WestChesterUniversity WestChester,Pennsylvania

PREVIOUSEDITION

CONTRIBUTORS

VirginiaP.Arcangelo,PhD,NP

LauraAykroyd,PharmD

KellyBarranger,MSN,RN,CRNP

JohnBarron,PharmD

LauraL.Bio,PharmD,BCPS

LaurenM.Czosnowski,PharmD,BCPS

QuinnA.Czosnowski,PharmD

DavidDinh,PharmD,BCPS

AmyM.Egras,PharmD,BCPS,BC-ADM

KelleenN.Flaherty,MS

MariaC.Foy,PharmD,BCPS,CPE

StevenP.Gelone,PharmD

AndrewJ.Grimone,PharmD,BCPS-AQID

AnishaB.Grover,PharmD,BCACP

DianeE.Hadley,PharmD,BCACP

EmilyR.Hajjar,PharmD,BCPS,BCACP,CGP

AmaliaM.Issa,PhD,MPH,FCPP

TepM.Kang,PharmD,BCPS

Alice(Lim)Scaletta,PharmD,BCACP

LauraA.Mandos,BS,PharmD,BCPP

LaurenK.McCluggage,PharmD

KarleenMelody,PharmD,BCACP

IsabelleMercier,PhD

CarolGulloMest,PhD,RN,ANP-BC

SamirK.Mistry,PharmD

LorraineNowakowski-Grier,MSN,APRN,BC,CDE

JudithA.O’Donnell,MD

StaciPacetti,PharmD

AndrewM.Peterson,PharmD,PhD,FCPP

LouisR.Petrone,MD

MelodyD.Randle,DNP,FNP-C,MSN,CCNS,CNE

TroyL.Randle,DO,FACC,FACOI

JenniferA.Reinhold,BA,PharmD,BCPS,BCPP

ChristopherC.Roe,MSN,ACNP-BC

CynthiaA.Sanoski,PharmD,BCPS,FCCP

BrianaL.Santaniello,MBA,PharmD

JasonJ.Schafer,PharmD,MPH

ShellyR.Schneider,APN

JeanM.Scholtz,BS,PharmD,BCPS,FASHP

AnitaSiu,PharmD

SarahA.Spinler,PharmD

JoshuaJ.Spooner,PharmD,MS

LindaM.Spooner,PharmD,BCPS,FASHP

RichardG.Stefanacci,DO,MGH,MBA,AGSF,CMD

JamesC.ThigpenJr,PharmD,BCPS

TyanF.Thomas,PharmD

KarenJ.Tietze,PharmD

ElenaM.Umland,PharmD

SarahF.Uroza,PharmD

CraigB.Whitman,PharmD,BCPS

VeronicaF.Wilbur,PhD,APRN-FNP,CNE,FAANP

VincentJ.Willey,PharmD

EricT.Wittbrodt,PharmD,MPH

CONTENTS

Preface Contributors PreviousEditionContributors

UNIT

1 PrinciplesofTherapeutics

IssuesforthePractitionerinDrugTherapy

VeronicaF.Wilbur

PharmacokineticBasisofTherapeuticsandPharmacodynamicPrinciples

AndrewM.PetersonandA.MaggieRandazzo

ImpactofDrugInteractionsandAdverseEventsonTherapeutics

TepM.Kang

PrinciplesofPharmacotherapyinPediatrics,Pregnancy,andLactation

PoojaShahandAnitaSiu

PharmacotherapyPrinciplesinOlderAdults

RichardG.Stefanacci

PrinciplesofAntimicrobialTherapy

StevenP.Gelone,StaciPacetti,andJudithA.O’Donnell

Pharmacogenomics

IsabelleMercierandAmaliaM.Issa

TheEconomicsofPharmacotherapeutics

BrianaL.SantanielloandJoshuaJ.Spooner

UNIT

2 PrinciplesofPainManagement

PharmacotherapyofPainManagement

MariaC.Foy

PainManagementinOpioidUseDisorder(OUD)Patients

RachelTrichtingerandMariaC.Foy

CannabisandPainManagement

AndrewM.PetersonandMilyShah

UNIT

3 PharmacotherapyforSkinDisorders

ContactDermatitis

JeffreyTagleandVirginiaP.Arcangelo

Fungal,Viral,andBacterialInfectionsoftheSkin

ImanI.Aberra,VirginiaP.Arcangelo,andJasonJ.Schafer

Psoriasis

ShellyR.Schneider

AcneVulgarisandRosacea

ShellyR.Schneider

UNIT

4 PharmacotherapyforEyeandEarDisorders

OphthalmicDisorders

JoshuaJ.Spooner

OtitisMediaandOtitisExterna

LauraL.Bio

UNIT

5 PharmacotherapyforCardiovascularDisorders

Hypertension

SamanthaLandolfaandDianeE.Hadley

Hyperlipidemia

ThuyLeandJohnBarron

ChronicStableAnginaandMyocardialInfarction

LaurenIsaacsKarelandChristopherC.Roe

HeartFailure

StephenMayandAndrewM.Peterson

Arrhythmias

AndrewM.Peterson,DanielA.Peterson,andCynthiaA.Sanoski

UNIT

6 PharmacotherapyforRespiratoryDisorders

RespiratoryInfections

SaraJung,KarleenMelody,AnishaB.Grover,andAndrewJ.Grimone

AsthmaandChronicObstructivePulmonaryDisease

TracyS.EstesandKarenJ.Tietze

UNIT

7 PharmacotherapyforGastrointestinalDisorders

Gastric,Functional,andInflammatoryBowelDisorders

VeronicaF.Wilbur

GastroesophagealRefluxDiseaseandPepticUlcerDisease

Alice(Lim)Scaletta

LiverDiseases

RyanG.D’AngeloandJenniferAndres

UNIT

8 PharmacotherapyforGenitourinaryTractDisorders

UrinaryTractInfection

VeronicaF.Wilbur

ProstaticDisordersandErectileDysfunction

VeronicaF.Wilbur

OveractiveBladder

SarahE.Diamond

SexuallyTransmittedInfections

CaraghE.ClaytonandVirginiaP.Arcangelo

UNIT

9 PharmacologyforMusculoskeletalDisorders

OsteoarthritisandGout

RachaelDiMeo,DanielPurzycki,andSarahF.Uroza

Osteoporosis

JolaSalavaciandVirginiaP.Arcangelo

RheumatoidArthritis

LaurenK.McCluggageandKelseyC.Haines

UNIT

10 PharmacotherapyforNeurologicalDisorders

Headaches

KelleenN.Flaherty

SeizureDisorders

JesseChenandQuinnA.Czosnowski

Alzheimer’sDisease

EmilyR.Hajjar,BrookeSalzman,andMichaelWeisberger

Parkinson’sDisease

DavidDinh,KarleenMelody,andAnishaB.Grover

UNIT

11 PharmacotherapyforMentalHealthDisorders

MajorDepressiveDisorderandBipolarDisorders

PriyaM.Shah

AnxietyDisorders

SarahJungandLauraA.Mandos

SleepDisorders

VeronicaF.Wilbur

AttentionDeficitHyperactivityDisorder

KristenM.Audley

SubstanceUseDisorders

AndrewM.Peterson

UNIT

12 PharmacotherapyforEndocrineDisorders

DiabetesMellitus

AngelaThompsonandLorraineNowakowski-Grier

ThyroidandParathyroidDisorders

Alice(Lim)ScalettaandLouisR.Petrone

UNIT

13 PharmacotherapyforImmunology

AllergiesandAllergicReactions

LaurenM.Czosnowski

HumanImmunodeficiencyVirus

LindaM.Spooner

OrganTransplantation

DavidM.Salerno

UNIT

14 PharmacotherapyforThromboembolicDisorders

ThromboembolicDisorders

SarahA.SpinierandLyndsayCarlson

Anemias

CarolineAttiaandKellyBarranger

UNIT

15 PharmacotherapyforHealthPromotion

Immunizations

JeanM.Scholtz

SmokingCessation

TyanF.Thomas

WeightLoss

AmyM.Egras

UNIT

16 PharmacotherapyforWomen’sHealth

Contraception

JennyR.LiuandVirginiaP.Arcangelo

Menopause

JessicaM.LeriandElenaM.Umland

Vaginitis

ImanI.AberraandVirginiaP.Arcangelo

Index

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