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13.4 Which Technique to Use and Why?
https://t.me/medicina_free
% with ≥1
improvement on
CR-SMFRS and
PR-SMFRS
Mild SMF
Placebo: 6.7%
ATX-101: 61.3%
Extreme SMF
Placebo: 13.3%
ATX-101: 89.3%
%with≥ 1
improvement on
PR-SMFRS
Mild SMF
Placebo: 33.3%
ATX-101: 67.7%
Extreme SMF
Placebo: 46.7%
ATX-101: 89.3%
% with ≥1
improvement on
CR-SMFRS
Mild SMF
Placebo: 20%
ATX-101: 72.2%
Extreme SMF
Placebo: 26.7%
ATX-101: 96.4%
90% Not reported Not reported
Table 13.7 (Continued) Clinical results using deoxycholic acid in the submental region
No. of
Dosage Follow-up
Study Design No. of
treatments
after final
treatment
patients
at least 28 days
12 wk 1–6 treatments
2
Placebo,
2 mg/cm
93
Mild SMF
Multicenter,
randomized,
77
Glogau et al
apart
Placebo: 16
ATX-101: 31
Extreme SMF:
Placebo: 16
double-blind,
placebo
controlled
ATX-101: 30
spaced ~2 mo
12 wk 1–4 treatments
2
50 3 mg/cm
Single-center,
single-arm,
78
Shome et al.
2019
apart
open label
Abbreviations: CR-SMFRS, Clinician-Reported Submental Fat Rating Scale; PR-SMFRS, Patient-Reported Submental Fat Rating Scale.
157
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Table 13.8 Submental Fat Rating Scales (SMFRS) used
as outcomes in REFINE-1 and REFINE-2 trials
Grade Clinician-
reported
(CR-SMFRS)
0 Absent No chin fat at all
1 Mild A slight amount of chin fat
2 Moderate A moderate amount of chin fat
3 Severe A large amount of chin fat
4 Extreme A very large amount of chin fat
Patient-reported (PR-SMFRS)
70,71
hematoma/bruising, edema, anesthesia/numbness,
and erythema. In the REFINE clinical trials, more
serious, but temporary, side effects seen included
marginal mandibular nerve injury (4.3% of patients),
dysphagia (1.9% of patients), skin ulceration (0.2% of
patients), and injection-site alopecia (0.4% of pa-
70,72
tients).
In practice, marginal mandibular nerve
injury can mostly be avoided by ensuring no injections are within 1.0 to 1.5cm of the inferior mandibular border.
66
Skin ulceration can also be avoided by
ensuring appropriate injection technique by avoiding
superficial injections placed in the dermis. Although
rare in the clinical trials, real-world experience of 39
men receiving deoxycholic acid had 9 men (23.1%)
with injection-site alopecia lasting 6 weeks to 12
months, showing that this side effect may be more
common than previously reported.
74
Off-label, deoxycholic acid can be used to target
the jowls in certain populations with good results.
A recent single-site prospective study treated 66
adults with excess jowl fat with deoxycholic acid
at a dose of 2 mg/cm
2
with a mean 1.8 treatments
spaced, on average, 8.6 weeks apart. Improvement
in jowls was noted in 65 (98%) of patients. Common side effects included edema, numbness, pain,
and bruising. As it is rare to have increased jowl fat
without associated submental fullness, the use of
deoxycholic acid in jowls is intended to be done in
conjunction with treatment of submental fat. All
patients within the study had the submental area
treated with deoxycholic acid injections prior to or
at the same time as the jowl area.
79
Cryolipolysis
Cryolipolysis (CoolSculpting, Zeltiq Aesthetics/
Allergan, Pleasanton, CA) is a noninvasive
temperature-based treatment targeted at permanent localized fat reduc t ion. CoolSculpting
secured FDA approval for cryolipolysis for the
submental area in 2015. Patients with a history
of cold agglutinin disease, cr yoglobulinemia, or
paroxysmal cold hemoglobinuria should not be
considered for cryolipolysis.
Clinical results are summarized in ▶ Table 13.9.
Submental cryolipolysis treatment parameters in
studies vary and involve one or two separate
treatments, but outside of clinical trials, three
treatments spaced 6 to 10 weeks apart may be
necessary, with full results not appearing until
after 4 months.
68
Unlike with ATX-101, there is
no consensus of outcome measures and therefore
a variety of tools have been us ed including calipers, 3D imaging, radiographic imaging including
magnetic resonance imaging (MRI) or ult rasound,
and physician’s and patient’s subjective evaluations.
Mean fat layer reduction by caliper or radiographic
imaging ranges from 1.78 to 4mm. Calculation of total fat volume reduction has been attempted; however, the two studies using 3D imaging to calculate
this significantly differed in outcomes, likely secondary to the absence of a standardized area of which
80,81
to calculate the volumes from.
Even without
standardization of outcome s, the vast majority of patients were ultimately satisfied with the treatment
and reported at least some improvement.
Side effects of cryolipolysis are generally mild
and include localized erythema, bruising, edema,
80,85
numbness, paresthesia, and mild pain.
Neuropathic pain extending outside treatment area and
lasting up to 1 week has also been reported.
86
Comparison of deoxycholic acid and cryolipoly-
sis as treatment for submental fat is presented in
▶ Table 13.10. Additionally, cryolipolysis can be
combined with deoxycholic acid, with cryolipolysis used first used to reduce the bulk of adipose tissue and deoxycholic acid injections subsequently
used to target the remaining areas and sculpt the
submental area as needed.
87
Laser and Energy-Based Devices
Laser lipolysis uses laser energy to liq uefy adipocytes
with the added benefit of stimulating collagen.
Lasers showing efficacy in the submental region include but are not limited to 980-nm diode, 1,470nm diode, and 1,440-nm Nd:YAG lasers.
1,060-nm diode laser (SculpSure; Cynosure, Westford, MA) was FDA approved for lower face and neck
88,89,90,91
A
158
Patient-reported
https://t.me/medicina_free
results
13.4 Which Technique to Use and Why?
(Continued)
Pleased with results:
76%
Not reported
Reported at least
“some improve-
ment”: 100%
Satisfaction rate: 93%
results
Follow-up Objective
No. of
treatments
parameters
Device Treatment
mean volume
One treatment 12 wk 3D imaging:
45-min treatment
with a maximum
CoolSculpting
reduction:
cooling
System, Allergan
3
fat layer reduc-
tion of 2.3 mm
3D imaging:
mean reduc-
tion in fat
22.30 cm
mean reduc-
tion in meas-
ured region:
−31.1%
fat layer reduc-
tion of 4 mm
Ultrasound:
mean fat layer
reduction of
2.8 mm
thickness of
3.77 mm
Mean volume
reduction:
3
4.82 cm
12 wk Caliper: mean
temperature of
USA Ltd, Dublin,
–11 °C, one cycle
Ireland
One treatment 3 mo Ultrasound:
45-min
treatment,
temperature not
CoolSculpting
System, Allergan
One treatment 8 wk Caliper: mean
stated, two cycles
45-min duration
at a cooling
temperature of
−11 °C, two
cycles
CoolSculpting
System, Zeltiq
Aesthetics
Two treatments
spaced 6 wk
–11 °C, 45-min
cooling cycles, 2
CoolSculpting
apart
cycles except for
system; ZELTIQ
2 patients
receiving 1 cycle
Aesthetics
for second
treatment
35 CoolMini applicator,
patients
Retrospective,
nonrandomized, and
open label,
81
Table 13.9 Clinical results of submental cryolipolysis
Study Design No. of
Jain et al
20 CoolMini applicator,
interventional cohort
study
Prospective, single-
center, nonrandomized,
and open label
82
de Gusmão
et al
10 CoolMini applicator,
interventional cohort
study
Prospective, single-
center, nonrandomized,
and open label
interventional cohort
study
83
Suh et al
14 CoolMini applicator,
Prospective, single-
center, nonrandomized,
and open label
80
Bernstein
and Bloom
interventional cohort
study
159
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Patient-reported
Follow-up Objective
No. of
Satisfaction rate: 80%
results
results
12 wk Caliper: mean
Two treat-
treatments
First treatment:
parameters
fat layer
reduction:
ments spaced
10 wk apart
−12 °C, 45-min
cooling cycle,
3.2 mm
one cycle
MRI: mean fat
Second treat-
layer reduction
ment: −15 °C,
of 1.78 mm
30-min cooling
cycle, one cycle
Satisfaction rate: 83%
mean fat layer
reduction of
2mm
12 wk Ultrasound:
Two
treatments
spaced 6 wk
apart (one
−10 °C, duration
60 min, one
cycle
patient had
one treatment
only)
volume applicator,
CoolSculpting
System, ZELTIQ
Aesthetics,
center, nonrandomized,
and open label
interventional cohort
study
et al
Table 13.9 (Continued) Clinical results of submental cryolipolysis
Device Treatment
patients
Study Design No. of
15 Prototype small-
Prospective, single-
84
Leal Silva
160
Pleasanton, CA
applicator,
60 CoolMini
Multicenter,
prospective, open label,
85
Kilmer et al
CoolSculpting
nonrandomized
system, ZELTIQ
interventional cohort
Aesthetics
study
Abbreviations: MRI, magnetic resonance imaging; 3D, three-dimensional.
13.5 Conclusions
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Table 13.10 Comparison of deoxycholic acid (ATX-101) and cryolipolysis
Deoxycholic acid (ATX-101) Cryolipolysis
Mechanism of action Bile acid-induced adipocyte membrane
destruction
Invasiveness Minimally invasive Noninvasive
Indications Moderate to severe submental fat Submental fat in patients with a BMI
Number of treatments Up to 6 treatments with significant
improvements noted at 2–4 treatments
Procedure length 30 min 45 min
Adverse effects Swelling, bruising, discomfort, necrosis,
dysphagia, temporary nerve damage, and
alopecia
Efficacy 61.3–89.3% of patients ≥1 improvement
on CR-SMFRS and PR-SMFRS
Advantages Minimal downtime and controlled
placement
Disadvantages Multiple treatments necessary, cost of
drug, and inability to accurately control fat
reduction
68
Cold-induced adipocyte apoptosis
of ≤ 46.2
1–3 treatments with average of 2
treatments
Swelling, altered sensation, temporary
nerve damage hyperpigmentation, and
neuropathic pain
Mean submental fat thickness decrease
of 1.78–4mm
Minimal downtime and controlled
placement
Multiple treatments may be necessary,
dedicated room for treatment
required, and inability to accurately
control fat reduction
Durability of results Sustained long term (at least 4 y) Permanent
Absolute contraindications Patients with active submental infection Patients with history of cold agglutinin
Abbreviations: BMI, body mass index ; CR-SMFRS, Clinician-Reported Submental Fat Rating Scale; PR-SMFRS, PatientReported Submental Fat Rating Scale.
contouring in 2017. In the supporting prospective,
multicenter non-placebo-controlled study, 57 subjects were treated with up to two 25-minute treatments with SculpSure. Twelve weeks postfinal
treatment, submental fat was reduced by 1.785mm
a reduction of 5.8mm in submental fat thickness as
seen by ultrasound 6 months posttreatment.
effects were mild and self-resolving and included
erythema, edema, and vesicles without scarring or
hyperpigmentation.
disease, cryoglobulinemia, or
paroxysmal cold hemoglobinuria
93
93
and 100% of the patients were satisfied with the
treatment. Side effects were mild to moderate and
transient in all but one case; these included swelling, pain, erythema, numbness, hair loss, bruising,
firmness, and blisters.
92
Radiofrequency is more recently being utilized
to target submental fat. A high-powered monopolar radiofrequency device (truSculpt, Cutera Inc.,
Brisbane, CA) was shown in an exploratory study to
effectively target the submental area with a cycle of
2 minutes at 43°C and 3 minutes at 45°C. Two treatments spaced 1 month apart on 21 patients yielded
13.5 Conclusions
Numerous noninvasive treatments are available
for neck rejuvenation, allowing for significant improvement to be achieved with less recovery time
and decreased risk of adverse effects compared to
surgical approaches. ▶ Table 13.11 summarizes
our approach, which starts by targeting individual
patient’s concerns and selecting treatments to ensure the best patient outcomes. Most often, a combination of treatments is needed in order to
Side
161
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Table 13.11 Summary of noninvasive neck rejuvenation techniques based on primary concern
Dyschromia Horizontal necklines Platysmal
banding
●
Cosmeceuticals
●
Chemical peels:
TCA, Jessner,
glycolic acid
●
IPL
●
Nonablative
fractional laser:
1,550 ±
1,927 nm
●
Neuromodulators
●
Hyaluronic acid filler
●
Diluted calcium
hydroxylapatite
●
Nonablative fractional
laser: 1,550, 1,440 nm
●
Ablative fractional laser:
10,600 nm
●
MFU-V
●
MRF
●
Neuromodulators
Skin laxity Submental
fullness
●
Hyperdiluted calcium
hydroxylapatite
●
Poly-L-lactic acid
●
MFU-V
●
MRF
●
Radiofrequency
microneedling
●
Chemical peels: TCA,
●
Deoxycholic
acid
●
Cryolipolysis
●
MRF
●
Laser lipolysis:
1,060 nm
diode
Jessner, glycolic acid
●
Dermarolling and
microneedling
●
Platelet-rich plasma
Abbreviations: IPL, intense pulsed light; MFU-V, microfocused ultrasound with visualization; MRF, monopolar capacitivecoupled radiofrequency; TCA, trichloroacetic acid.
achieve desired and lasting results. Further studies
are needed to help identify which specific combination treatments work best when used together.
13.6 Expert Commentary by
Dr. Slavin
This is a comprehensive chapter focusing on dyschromia, skin quality, subcutaneous fat, and contour
irregularities of the head and neck. It is written by
pioneers in developing and applying laser technology for cosmetic improvement of the face. In their
meticulous analysis of facial features—from pigmen-
tary issues to loose skin—they give a systematic,
well-organized approach. These techniques are becoming increasingly important for clinicians going
forward. Although the techniques do not replace
surgery, they provide excellent alternatives, particularly in patients who are not surgical candidates.
13.7 Expert Commentary by
Dr. Lin
The authors bring forth their vast experience of
noninvasive approaches of the skin and underlying
structures. They outline the most commonly addressed areas noninvasively, with structures at the
platysmal layer and above, while comprehensively
outlining the treatments available. Using these as
adjunct procedures with procedures addressing the
deeper structures provides an all-encompassing
approach to the neck.
References
[1] American Society for Dermatologic Surgery. ASDS Survey on
Dermatologic Procedures. Accessed February 5, 2020 at:
https://www.asds.net/medical-professionals/practiceresources/asds-survey-on-dermatologic-procedures
[2] Ellenbogen R, Karlin JV. Visual criteria for success in restoring
the youthful neck. Plast Reconstr Surg. 1980; 66(6):826–837
[3] Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and ex-
trinsic factors in skin ageing: a review. Int J Cosmet Sci. 2008;
30(2):87–95
[4] Flament F, Bazin R, Laquieze S, Rubert V, Simonpietri E, Piot
B. Effect of the sun on visible clinical signs of aging in Caucasian skin. Clin Cosmet Investig Dermatol. 2013; 6:221–232
[5] Ortonne JP. The effects of ultraviolet exposure on skin mela-
nin pigmentation. J Int Med Res. 1990; 18 Suppl 3:8C–17C
[6] Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast col-
lapse and therapeutic implications. Arch Dermatol. 2008;
144(5):666–672
[7] Mashkevich G, Wang J, Rawnsley J, Keller GS. The utility of ul-
trasound in the evaluation of submental fullness in aging
necks. Arch Facial Plast Surg. 2009; 11(4):240–245
[8] Kenkel JM, Jones DH, Fagien S, et al. Anatomy of the cervico-
mental region: insights from an anatomy laboratory and
roundtable discussion. Dermatol Surg. 2016; 42 Suppl 1:
S282–S287
[9] Kligman A. The future of cosmeceuticals: an interview with
Albert Kligman, MD, PhD. Interview by Zoe Diana Draelos.
Dermatol Surg. 2005; 31(7, Pt 2):890–891
[10] Brandt FS, Cazzaniga A, Hann M. Cosmeceuticals: current
trends and market analysis. Semin Cutan Med Surg. 2011; 30
(3):141–143
[11] Boen M, Alhaddad M, Wu DC, Goldman MP. A prospective
double-blind, placebo-controlled clinical trial evaluating the
efficacy of a novel combination of hyaluronic acid serum and
antioxidant cream for rejuvenation of the aging neck. J Clin
Aesthet Dermatol. 2020; 13(11):13–18
[12] Saxena SJ, Duque D, Schirripa MJ. Assessment of a compre-
hensive anti-aging neck cream. J Drugs Dermatol. 2015; 14
(9):997–1002
162
References
https://t.me/medicina_free
[13] Schlessinger J, Green B, Edison BL, Murphy L, Sabherwal Y. A
firming neck cream containing N-acetyl glucosamine significantly improves signs of aging on the challenging neck and
décolletage. J Drugs Dermatol. 2016; 15(1):47–52
[14] Chajchir I, Modi P, Chajchir A. Novel topical BoNTA (Cosme-
Tox, toxin type A) cream used to treat hyperfunctional wrinkles of the face, mouth, and neck. Aesthetic Plast Surg. 2008;
32(5):715–722, discussion 723
[15] Cook KK, Cook WR, Jr. Chemical peel of nonfacial skin using
glycolic acid gel augmented with TCA and neutralized based
on visual staging. Dermatol Surg. 2000; 26(11):994–999
[16] Fulton JE, Rahimi AD, Helton P, Dahlberg K. Neck rejuvenation
by combining Jessner/TCA peel, dermasanding, and CO
resurfacing. Dermatol Surg. 1999; 25(10):745–750
[17] Rendon MI, Berson DS, Cohen JL, Roberts WE, Starker I, Wang
B. Evidence and considerations in the application of chemical
peels in skin disorders and aesthetic resurfacing. J Clin Aesthet Dermatol. 2010; 3(7):32–43
[18] Rusciani A, Motta A, Fino P, Menichini G. Treatment of poiki-
loderma of Civatte using intense pulsed light source: 7 years
of experience. Dermatol Surg. 2008; 34(3):314–319, discussion 319
[19] Weiss RA, Goldman MP, Weiss MA. Treatment of poikiloder-
ma of Civatte with an intense pulsed light source. Dermatol
Surg. 2000; 26(9):823–827, discussion 828
[20] Bernstein EF, Schomacker K, Paranjape A, Jones CJ. Treatment
of poikiloderma of Civatte using a redesigned pulsed dye laser with a 15 mm diameter treatment spot. Lasers Surg Med.
2019; 51(1):54 – 58
[21] Batta K, Hindson C, Cotterill JA, Foulds IS. Treatment of poiki-
loderma of Civatte with the potassium titanyl phosphate
(KTP) laser. Br J Dermatol. 1999; 140(6):1191–1192
[22] Behroozan DS, Goldberg LH, Glaich AS, Dai T, Friedman PM.
Fractional photothermolysis for treatment of poikiloderma of
civatte. Dermatol Surg. 2006; 32(2):298–301
[23] Bencini PL, Tourlaki A, Galimberti M, Pellacani G. Non-
ablative fractionated laser skin resurfacing for the treatment
of aged neck skin. J Dermatolog Treat. 2015; 26(3):252–256
[24] Luebberding S, Alexiades-Armenakas MR. Fractional, nona-
blative Q-switched 1,064-nm neodymium YAG laser to rejuvenate photoaged skin: a pilot case series. J Drugs Dermatol.
2012; 11(11):1300–1304
[25] Jones D, Carruthers A, Hardas B, et al. Development and vali-
dation of a photonumeric scale for evaluation of transverse
neck lines.Dermatol Surg. 2016; 42 Suppl 1:S235–S242
[26] Lee JH, Park YG, Park ES. A prospective observational study
of the effectiveness and safety of bot ulinum toxin in the
horizontal neck lines. Aesthetic Plast Surg. 2018; 42(5):
1370–1378
[27] Jeon H, Kim T, Kim H, Cho SB. Multimodal approach for treat-
ing horizontal neck wrinkles using intensity focused ultrasound, cohesive polydensified matrix hyaluronic acid, and incobotulinumtoxinA. Dermatol Surg. 2018; 44(3):421–431
[28] Chao YY, Chiu HH, Howell DJ. A novel injection technique for
horizontal neck lines correction using calcium hydroxylapatite. Dermatol Surg. 2011; 37(10):1542–1545
[29] Casabona G, Nogueira Teixeira D. Microfocused ultrasound in
combination with diluted calcium hydroxylapatite for improving skin laxity and the appearance of lines in the neck
and décolletage. J Cosmet Dermatol. 2018; 17(1):66–72
[30] Tseng F, Yu H. Treatment of horizontal neck wrinkles with
hyaluronic acid filler: a retrospective case series. Plast
Reconstr Surg Glob Open. 2019; 7(8):e2366– e2366
2
laser
[31] Lee SK, Kim HS. Correction of horizontal neck lines: our pre-
liminary experience with hyaluronic acid fillers. J Cosmet
Dermatol. 2018; 17(4):590–595
[32] Minokadeh A, Black JM, Jones DH. Effacement of transverse
neck lines with VYC-15 L and cohesive polydensified matrix
hyaluronic acid. Dermatol Surg. 2018; 44 Suppl 1:S53–S56
[33] Oram Y, Akkaya AD. Neck rejuvenation with fractional CO
ser: long-term results. J Clin Aesthet Dermatol. 2014; 7(8):
23–29
[34] Vanaman M, Fabi SG, Cox SE. Neck rejuvenation using a com-
bination approach: our experience and a review of the literature. Dermatol Surg. 2016; 42 Suppl 2:S94–S100
[35] Geister TL, Bleßmann-Gurk B, Rzany B, Harrington L, Görtel-
meyer R, Pooth R. Validated assessment scale for platysmal
bands. Dermatol Surg. 2013; 39(8):1217–1225
[36] Brandt FS, Bellman B. Cosmetic use of botulinum A exotoxin
for the aging neck. Dermatol Surg. 1998; 24(11):1232–1234
[37] Matarasso A, Matarasso SL, Brandt FS, Bellman B. Botulinum
A exotoxin for the management of platysma bands. Plast Reconstr Surg. 1999; 103(2):645–652, discussion 653–655
[38] Ascher B, Talarico S, Cassuto D, et al. International consensus
recommendations on the aesthetic usage of botulinum toxin
type A (Speywood unit)—part II: wrinkles on the middle and
lower face, neck and chest. J Eur Acad Dermatol Venereol.
2010; 24(11):1285–1295
[39] Chen DL, Cohen JL. Botulinum toxin: a chemical denervation
for platysmal bands: maximal dosing considerations. J Drugs
Dermatol. 2015; 14(9):931
[40] Sugrue CM, Kelly JL, McInerney N. Botulinum toxin treatment
for mild to moderate platysma bands: a systematic review of
efficacy, safety, and injection technique. Aesthet Surg J. 2019;
39(2):201–206
[41] Levy PM. The “Nefertiti lift”: a new technique for specific re-
contouring of the jawline. J Cosmet Laser Ther. 2007; 9(4):
249–252
[42] de Almeida ART, Romiti A, Carruthers JDA. The facial platys-
ma and its underappreciated role in lower face dynamics and
contour. Dermatol Surg. 2017; 43(8):1042–1049
[43] Awaida CJ, Jabbour SF, Rayess YA, El Khoury JS, Kechichian
EG, Nasr MW. Evaluation of the microbotox technique: an algorithmic approach for lower face and neck rejuvenation and
a crossover clinical trial. Plast Reconstr Surg. 2018; 142(3):
640–649
[44] Leal Silva HG. Facial laxity rating scale validation study. Der-
matol Surg. 2016; 42(12):1370–1379
[45] Alhaddad M, Wu DC, Bolton J, et al. A randomized, split-face,
evaluator-blind clinical trial comparing monopolar radiofrequency versus microfocused ultrasound with visualization
for lifting and tightening of the face and upper neck. Dermatol Surg. 2019; 45(1):131–139
[46] Yutskovskaya YA, Kogan EA. Improved neocollagenesis and
skin mechanical properties after injection of diluted calcium
hydroxylapatite in the neck and décolletage: a pilot study. J
Drugs Dermatol. 2017; 16(1):68–74
[47] de Almeida AT, Figueredo V, da Cunha ALG, et al. Consensus
recommendations for the use of hyperdiluted calcium hydroxyapatite (Radiesse) as a face and body biostimulatory agent.
Plast Reconstr Surg Glob Open. 2019; 7(3):e2160–e2160
[48] Mazzuco R, Hexsel D. Poly-L-lactic acid for neck and chest
rejuvenation. Dermatol Surg. 2009; 35(8):1228–1237
[49] Carruthers J, Fabi S, Weiss R. Monopolar radiofrequency for
skin tightening: our experience and a reviewof the literature.
Dermatol Surg. 2014; 40 Suppl 12:S168–S173
2
la-
163
Neck Rejuvenation: Noninvasive Techniques
https://t.me/medicina_free
[50] Alster TS, Tanzi E. Improvem ent of neck and cheek la xity
with a nonablative radiofrequency device: a lifting experience. Der matol Surg. 2004; 30(4, Pt 1):503–507, discussion
507
[51] Fritz M, Counters JT, Zelickson BD. Radiofrequency treatment
for middle and lower face laxity. Arch Facial Plast Surg. 2004;
6(6):370–373
[52] Kerscher M, Nurrisyanti AT, Eiben-Nielson C, Hartmann S,
Lambert-Baumann J. Skin physiology and safety of microfocused ultrasound with visualization for improving skin laxity.
Clin CosmetInvestig Dermatol. 2019; 12:71–79
[53] Kerscher M, Nurrisyanti AT, Eiben-Nielson C, Hartmann S,
Lambert-Baumann J. Clinical and biophysical outcomes of
combining microfocused ultrasound with visualization and
calcium hydroxylapatite filler for facial treatment. Dermatol
Ther (Heidelb). 2019; 9(1):135–142
[54] Narins RS, Carruthers J, Flynn TC, et al. Validated assessment
scales for the lower face. Dermatol Surg. 2012; 38(2, Spec
no.):333–342
[55] Werschler WP, Werschler PS. Long-term efficacy of micro-
focused ultrasound with visualization for lifting and tightening lax facial and neck skin using a customized vector ing
treatment method. J Clin Aesthet Der matol. 2016; 9(2):27–
33
[56] Oni G, Hoxworth R, Teotia S, Brown S, Kenkel JM. Evaluation
of a microfocused ultrasound system for improving skin laxity and tightening in the lower face. Aesthet Surg J. 2014; 34
(7):1099–1110
[57] Fabi SG, Joseph J, Sevi J, Green JB, Peterson JD. Optimizing pa-
tient outcomes by customizing treatment with microfocused
ultrasound with visualization: gold standard consensus
guidelines from an expert panel. J Drugs Dermatol. 2019; 18
(5):426–432
[58] Consensus recommendations for 4th generation non-
microneedling monopolar radiofrequency for skin tightening: a Delphi Consensus Panel. J Drugs Dermatol. 2020; 19
(1):20–26
[59] Alessa D, Bloom JD. Microneedling options for skin rejuvena-
tion, including non-temperature-controlled fractional microneedle radiofrequency treatments. Facial Plast Surg Clin
North Am. 2020; 28(1):1–7
[60] Tan MG, Jo CE, Chapas A, Khetarpal S, Dover JS. Radiofre-
quency microneedling: a comprehensive and critical review.
Dermatol Surg. 2021; 47(6):755–761
[61] Serdar ZA, Tatlıparmak A. Comparison of efficacy and safety
of fractional radiofrequency and fractional Er:YAG laser in
facial and neck wrinkles: six-year experience with 333 patients. Dermatol Ther. 2019; 32(5):e13054
[62] Alexiades M, Berube D. Randomized, blinded, 3-arm clinical
trial assessing optimal temperature and duration for treatment with minimally invasive fractional radiofrequency.
Dermatol Surg. 2015; 41(5):623–632
[63] Redaelli A, Romano D, Marcianó A. Face and neck revitaliza-
tion with platelet-rich plasma (PRP): clinical outcome in a
series of 23 consecutively treated patients. J Drugs Dermatol.
2010; 9(5):466 – 472
[64] Fabbrocini G, De Vita V, Di Costanzo L, et al. Skin needling in
the treatment of the aging neck. Skinmed. 2011; 9(6):347–
351
[65] American Society for Dermatologic Surgery. ASDS Consumer
Survey on Cosmetic Dermatologic Procedures. 2019. Accessed
April 16, 2020 at: https://www.asds.net/Medical-Professionals/
Practice-Resources/ASDS- Consume r-Sur vey-on-C osmeticDermatologic-Procedures
[66] Jones DH, Kenkel JM, Fagien S, et al. Proper technique for
administration of ATX-101 (deoxycholic acid injection): insights from an injection practicum and roundtable discussion. Dermatol Surg. 2016; 42 Suppl 1:S275–S281
[67] Ascher B, Fellmann J, Monheit G. ATX-101 (deoxycholic acid
injection) for reduction of submental fat. Expert Rev Clin
Pharmacol. 2016; 9(9):1131–1143
[68] Hogan S, Kandula P, Callagan DJ, Dover JS. Submental fat con-
touring: a comparison of deoxycholic acid, cryolipolysis, and
liposuction. In: Branham GH, Dover JS, Furnas HJ, Tenenbaum
MMJ, Wulc AE, eds. Advances in Cosmetic Surgery. Vol. 2.
Philadelphia, PA: Elsevier Health Sciences; 2019:75–87
[69] Rzany B, Griffiths T, Walker P, Lipper t S, McDiarmid J,
Havlickova B. Reduction of unwanted submental fat with
ATX-101 (deoxycholic acid), an adipocytolytic injectable
treatment: results from a phase III, randomized, placebocontrolled study. Br J Dermatol. 2014; 170(2):445–453
[70] Humphrey S, Sykes J, Kantor J, et al. ATX-101 for reduction of
submental fat: a phase III randomized controlled trial. J Am
Acad Dermatol. 2016; 75(4):788–797.e7
[71] Jones DH, Carruthers J, Joseph JH, et al. REFINE-1, a multicen-
ter, randomized, double-blind, placebo-controlled, phase 3
trial with ATX-101, an injectable drug for submental fat reduction. Dermatol Surg. 2016; 42(1):38–49
[72] Dayan SH, Schlessinger J, Beer K, et al. Efficacy and safety of
ATX-101 by treatment session: pooled analysis of data from
the phase 3 REFINE trials. Aesthet Surg J. 2018; 38(9):998–
1010
[73] Behr K, Kavali CM, Munavalli G, et al. ATX-101 (deoxycholic
acid injection) leads to clinically meaningful improvement in
submental fat: final data from CONTOUR. Dermatol Surg.
2020; 46(5):639–645
[74] Shridharani SM. Real-world experience with 100 consecutive
patients undergoing neck contouring with ATX-101 (deoxycholic acid): an updated report with a 2-year analysis. Dermatol Surg. 2019; 45(10):1285–1293
[75] Shridharani SM. Early experience in 100 consecutive patients
with injection adipocytolysis for neck contouring with ATX101 (deoxycholic acid). Dermatol Surg. 2017; 43(7):950–958
[76] Beer K, Weinkle SH, Cox SE, Rubin MG, Shamban A, Somogyif
C. ATX-101 (deoxycholic acid injection) for reduction of submental fat: results from a 12-month open-label study. J Drugs
Dermatol. 2019; 18(9):870–877
[77] Glogau RG, Glaser DA, Callender VD, et al. A double-blind,
placebo-controlled, phase 3b study of ATX-101 for reduction
of mild or extreme submental fat. Dermatol Surg. 2019; 45
(12):1531–1541
[78] Shome D, Khare S, Kapoor R. The use of deoxycholic acid for
the clinical reduction of excess submental fat in Indian patients. J Drugs Dermatol. 2019; 18(3):266–272
[79] Shridharani SM. Improvement in jowl fat following ATX-101
treatment: results from a single-site study. Plast Reconstr
Surg. 2020; 145(4):929–935
[80] Bernstein EF, Bloom JD. Safety and efficacy of bilateral sub-
mental cryolipolysis with quantified 3-dimensional imaging
of fat reduction and skin tightening. JAMA Facial Plast Surg.
2017; 19(5):350–357
[81] Jain M, Savage NE, Spiteri K, Snell BJ. A 3-dimensional quanti-
tative analysis of volume loss following submental cryolipolysis. Aesthet Surg J. 2020; 40(2):123–132
[82] de Gusmão PR, Canella C, de Gusmão BR, Filippo AA, Filippo
GR. Cryolipolysis for local fat reduction in adults from Brazil:
a single-arm intervention study. J Cosmet Dermatol. 2020; 19
(11):2898–2905
164
References
https://t.me/medicina_free
[83] Suh DH, Park JH, Jung HK, Lee SJ, Kim HJ, Ryu HJ. Cryolipolysis
for submental fat reduction in Asians. J Cosmet Laser Ther.
2018; 20(1):24 – 27
[84] Leal Silva H, Carmona Hernandez E, Grijalva Vazquez M, Leal
Delgado S, Perez Blanco A. Noninvasive submental fat reduction using colder cryolipolysis. J Cosmet Dermatol. 2017; 16
(4):460–465
[85] Kilmer SL, Burns AJ, Zelickson BD. Safety and efficacy of cryo-
lipolysis for non-invasive reduction of submental fat. Lasers
Surg Med. 2016; 48(1):3–13
[86] Gregory A, Humphrey S, Varas G, Zachary C, Carruthers J.
Atypical pain developing subsequent to cryolipolysis for noninvasive reduction of submental fat. Dermatol Surg. 2019; 45
(3):487–489
[87] Shah GM, Greenberg JN, Tanzi EL, Monheit GD. Noninvasive
approach to treatment of submental fullness. Semin Cutan
Med Surg. 2017; 36(4):164–169
[88] Leclère FM, Vogt PM, Moreno-Moraga J, et al. Laser-assisted
lipolysis for neck and submental remodeling in Rohrich type
IV patients: fact or fiction? J Cosmet Laser Ther. 2015; 17(1):
31–36
[89] Leclère FM, Moreno-Moraga J, Alcolea JM, et al. Laser assisted
lipolysis for neck and submental remodeling in Rohrich type
I to III aging neck: a prospective study in 30 patients. J Cosmet Laser Ther. 2014; 16(6):284–289
[90] Sarnoff DS. Evaluation of the safety and efficacy of a novel
1440 nm Nd:YAG laser for neck contouring and skin tightening without liposuction. J Drugs Dermatol. 2013; 12(12):
1382–1388
[91] Valizadeh N, Jalaly NY, Zarghampour M, Barikbin B, Haghigh-
atkhah HR. Evaluation of safety and efficacy of 980-nm diode
laser-assisted lipolysis versus traditional liposuction for submental rejuvenation: a randomized clinical trial. J Cosmet
Laser Ther. 2016; 18(1):41–45
[92] Department of Health and Human Services: Food and Drug
Administration. Sculpsure Approval. 2017. Accessed April 29,
2020 at: https://www.accessdata.fda.gov/cdrh_docs/pdf17/
K171992.pdf
[93] Park J-H, Kim JI, Park HJ, Kim WS. Evaluation of safety and
efficacy of noninvasive radiofrequency technology for
submental rejuvenation. L asers Med Sci. 2016; 31(8):
1599–1605
165
https://t.me/medicina_free
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