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1 Thinking about medicine
Randomized controlled trials (
RCT
https://t.me/med1917
In a
RCT
, participants are allocated to an intervention/ exposure (eg new drug treatment) or no intervention (eg placebo, standard care) by a process which equates
to the flip of a coin, ie all participants have an equal chance of being in either arm
of the study. The aim is to minimize bias and attempt to get at the truth as to whether
the intervention is good or not. Both groups are followed up and analysed against
predefined end- points.
Randomizing Done with the aim of eliminating the eects of non- studied factors.
With randomization (and sucient study size) the two arms of the study will be
identical (on average), with the exception of the intervention of interest.
Blinding There is a risk that factors during the trial may aect the outcome, eg
participant or clinician optimism if they know the patient is on active treatment, or
an unwillingness to expose more severe disease to placebo. If the subject does not
know which intervention they are having, the trial is single- blind. Ideally, the experimenter should not know either, and the study is double- blind.
In a good trial, the blind lead the blind.
When a
• Generating new ideas beyond current paradigms (case reports).
• Researching causes of illnesses and prognoses (cohort studies).
• Evaluating diagnostic tests (cohort study and decision model).
• Where the researcher has no idea of the eective dose of a drug (dose- ranging
• When recruiting of patients would be impossible or unethical.
• When personalized medicine is the aim, eg treatments matched to patients’ bio-
In the end, all randomized trials have to submit to the ultimate test when the
statistical collides with the personal: ‘Will this treatment/ procedure benefit me?’
No randomized trial is complete until real- life decisions taken in the light of its
findings are scrutinized.
Remember Osler: ‘no two individuals react alike and behave alike under the ab-
normal conditions which we know as disease. This is the fundamental difficulty of
the physician’. Do not ask for definitive trials: everything is provisional.
Involve service users in all research to improve quality, relevance, accountability,
and transparency.
might not be the best method
design).
marker profiles (adaptive design, cohort study).
Journal club: how good is this
Consider the following:
• Does the study answer a useful question? Does it add to current literature: bigger,
better, dierent target population?
• Does the target population in the study include your patient(s)? Check the inclusion
and exclusion criteria including age and comorbidity.
• Is the intervention well described so it can be replicated in clinical practice?
• Was t he sa mpl e si ze bi g en oug h to dete ct a n eect? Can you find a sample size cal-
culation? Watch out for sub- group analyses without a sample size calculation.
• Were o utc ome m eas ures pre defin ed?
• Is randomization adequate? Look at the baseline data for each group— are there
significant dierences? Are any parameters of interest (that might aect outcome)
not included?
• Who was blinded and how blind were they?
• Are statistical methods reported and appropriate? There should be a measure of
the eect size and its precision (confidence interval;
• Is the eect clinically significant? Watch out for surrogate end- points which do not
directly measure benefit, harm, or the treatment response of interest.
• How long was the follow- up? Was it long enough to determine outcome?
• How complete was the follow- up? How many patients were left at the end of
the follow- up period? Were those who left the study included in the analysis
(intention- to- treat)?
15
RCT
s)
RCT
21
?
p18).

1 Thinking about medicine
Special populations: the older person
https://t.me/med1917
22
To know how to grow old is the master- work of wisdom, and one of the most difficult
chapters in the great art of living
Ageing is the inevitable and irreversible decline in organ function with time, in the
absence of injury or illness, and despite physiological pathways of repair.
Healthy ageing is the maintenance of physical and mental abilities that enable
wellbeing and independence in older age.
Do not presume ageing. Look for preventable and reversible pathology. Old age
does not cause disease (although it can increase vulnerability and recovery time).
Look for ways to reduce disability and support older people in their own homes.
Dierences in the evaluation of the older person
1 Multiple pathologies Older patients have, on average, six diagnosable dis-
orders. Eects may be multiplicative. Treatment must be integrated.
2
Multiple aetiologies One problem may have several causes, eg falls. Treating
each alone may do little good, treating all may be of great benefit.
3
Non- specific/ atypical presentation Delirium, dizziness, falls, mobility problems,
weight loss, and incontinence can be due to disorders in more than one organ
system. Typical signs and symptoms may be absent. Ask about functional decline in activities of daily living— this may be the only symptom.
4
Missed or delayed diagnosis The older person may decline quickly if treat-
ment is delayed. Complications are common. Use a collateral history: what is
the patient usually like?
5
Pharmacy and polypharmacy
hypoglycaemic drugs, and psychoactive drugs can pose particular risks in the
older patient. Double check for interactions. Consider body weight, liver and
kidney function— drug doses may need to be modified. The
detail more than
omissions relevant to the older patient.
6 Prolonged recovery time Anticipate and plan for this. Don’t forget nutrition.
7
Rehabilitation and social factors Essential for healthy ageing.
A quick ward assessment of the older person
History
In addition to routine elements, include function in activities of daily living, continence, and social support. Ask if there is an advanced care directive and nominated proxy healthcare decision- maker.
Examination
• Appearance and aect: hygiene, nutrition, hydration. Briefly assess mood.
• Senses: vision, hearing, assess swallowing with 20mL of water.
• Cognition: brief screening test, eg
• Pulse and bl ood pressure: lyin g/ sitting and stand ing.
• Periph eral neu rologi cal exam : tone, power, wastin g, act ive rang e of move ment.
• Other periphery: pulses, oedema, skin integrity, pressure areas.
• Walki ng: sta nd pa tie nt, bala nce , tra nsfe rs, obse rve gait (be rea dy to ass ist) .
• Other systems: CV, respiratory, abdomen (don’t forget to palpate for a bladder).
Fal l s
50
% aged >80 will fall at least once per year leading to pain, distress, loss of confi-
dence and independence, and mortality.
• History: frequency, context and circumstances, severity, injuries.
• Multifactorial risk assessment: gait, balance, muscle strength, osteoporosis risk, per-
ceived functional ability, fear of falls, vision, cognition, neurological examination, continence, home and hazards, cardiovascular examination, medications.
• Interventions: strength and balance training, home hazard intervention, correct vision,
modification/ withdrawal of medication (cardiovascular, psychotropic), integrated
management of contributing morbidities. Consider barriers to change, eg fear, patient
preference.
. Henri Amiel, Journal Intime,
NSAID
S, anticoagulants, anti- parkinson drugs,
100
potentially inappropriate prescriptions and prescribing
21
STOPP/ START
16
AMTS
(p61), 2- step command.
17
Fragility fractures cost the
NHS
£4.4bn/ year.
Sept
1874
criteria
.

1 Thinking about medicine
Special populations: pregnancy
https://t.me/med1917
Pre- existing conditions and non- obstetric disease cause more maternal deaths in
UK
than obstetric complications.
the
Pregnant patients should receive the same investigations and treatment as non-
pregnant patients, with avoidance of harm to the fetus whenever possible.
Most deficiencies in the management of medical conditions in pregnancy are due
to omission caused by inappropriate weighting of risk and benefit.
Physiological changes in pregnancy
Clinical assessment in pregnancy requires knowledge of the physiological changes
associated with the gravid state. Expected changes and guidance on when to investigate for possible underlying pathology are given in
Table 1.
5
Physiology and pathology in pregnancy
System Normal pregnancy Consider pathology
Cardiovascular Vasodilatation
Respiratory Respiratory alkalosis
Kidney iCreatinine clearance
Endocrine Altered glucose handling
Haematology Haemodilution
Radiology
Image wisely and when required. History and examination will guide. If the uterus
is positioned outside the field of view, the radiation dose to the conceptus is minimal. Exposure is well below the threshold of risk to the fetus in:
• Plain radiographs: chest, extremities, spine.
• CT: head, chest (negligible maternal breast cancer risk with modern
For most imaging, diagnostic benefit is greater than risk.
Ultrasound and
Reassure. Exposure from a chest radiograph is equivalent to 3 days of background
radiation and less than a transatlantic flight. Do not presume it is not required: how
else will you find the widened mediastinum in chest pain?
Medication
For all drugs prescribed in pregnancy, benefit is balanced against risk (table 1.6).
For information on drugs in lactation see:
Table 1.
Class Considered safe Considered unsafe
Antibiotics Penicillins, cephalosporins, macrolides,
Antiemetics Cyclizine, metoclopramide
BP
Analgesia Paracetamol
Anticoagulation
Endocrine Insulin, metformin, thyroxine
Cardiovascular Aspirin, bisoprolol, adenosine Amiodarone
Respiratory Salbutamol, ipratropium, aminophylline,
Immune system
Vaccination
Do not underestimate sepsis in pregnancy. Do not ignore tachypnoea.
Counsel all about the increased risks of influenza and
and oer influenza and
iHeart rate
No change in
No change in respiratory rate
iUrinary protein excretion
MRI
are used preferentially when imaging the abdomen.
6
Common drugs used in pregnancy (T1 = 1st trimester, T3 = 3rd trimester)
metronidazole
Labetalol, nifedipine, methyldopa
LMWH
leukotriene antagonists
Prednisolone, azathioprine,
hydroxychloroquine
Non- live, eg influenza and
SARS- CoV- 2 (COVID- 19
PEFR
18
table 1.5.
BP
≥
140/ 90
, systolic BP <90mmHg
Sustained tachycardia >
Serum bicarbonate <
Decrease in
Respiratory rate >
Creatinine >
PCR
>30mg/ mmol, u
u
Fasting glucose >
10.5
g/ dL, platelets <
Hb <
https://www.ncbi.nlm.nih.gov/books/NBK501922/
PEFR
77
µmol/ L (e
20
5.0
18
/ min
ACR
mmol/ L
CTPA
Tetracyclines, ciprofloxacin,
trimethoprim in
ACE-
i,
ARB
NSAID
S in
T3
Warfarin,
DOAC
CNI
,
SARS- CoV- 2
Mycophenolate,
methotrexate
Live:
MMR, BCG
SARS- CoV- 2 (COVID- 19
) vaccinations.
110
/ min
mmol/ L
GFR
not valid)
>8mg/ mmol
100×109/ L
tec hniqu es).
T1
, varicella
) infection,
23

2
https://t.me/med1917
History and examination
Contents
Taking a history
Systems enquiry
Non- specific symptoms
Method and order for physical
examination
Non- specific signs
Cardiovascular system
History
Examination
Pulses
Jugular venous pressure
Heart sounds
Cardiac murmurs
Respiratory system
History
Examination
Important presentations
Abdomen
Gastrointestinal system: history
Gastrointestinal system: symptoms
and signs
Genitourinary system: history
Examination of the abdomen
Neurological system
History
Examination of the upper limbs
Examination of the lower limbs
Cranial nerve examination
Cranial nerve lesions of the eye
Higher mental function
Mental state examination
Hands
Signs of systemic disease in the hands
Musculoskeletal hand examination
Thyroid examination
Breast examination
Peripheral vascular examination
Arterial
Venous
26
28
30
32
34
36
38
40
46
48
54
60
82
83
41
42
44
50
52
56
58
62
64
66
68
70
72
74
76
78
80
Fig 2.
1
Laennec stethoscope of
era when the blanket diagnosis of ‘hysteria’
could be given to women presenting with
almost any symptom, it was to Laennec’s
credit that he sought a more sophisticated
method of examination. He was unable to
elicit physical signs in the female chest by
percussion and application of the hand
due to breast tissue and subcutaneous fat.
Direct auscultation using the ear was ‘as
uncomfortable for the doctor as it was for
the patient’ and unacceptable to a Catholic
bachelor. And so an improvised rolled- up
piece of paper was honed and perfected to
become a ‘pectrolique’, a ‘medical cornet’,
and a ‘thoraciscope’ before finally being
named the stethoscope. Despite unfavourable peer review, ‘there is something even
ludicrous in a grave physician formally listening through a long tube applied to the
patient’s thorax, as if the disease within
were a living being that could communicate its condition to the sense without’,
its utility meant that the stethoscope became the hallmark of the medical phenotype, slung conventionally around the
neck. Perhaps Laennec used one himself to
‘scope’ his ‘stethos’ (chest) before dying of
tuberculosis.
Attribution 4.0 International (CC BY 4.0).
Source: Wellcome Collection
1819
. In an

2 History and examination
Symptoms and signs
https://t.me/med1917
Symptoms are reported and described by patients.
Signs are elicited on inspection and by physical examination.
Together, they produce a picture of health or disease. Signs and symptoms
evolve over time according to the natural history of disease or due to a response
to treatment.
Throughout this chapter, we discuss symptoms and signs according to organ
systems, or describe them as ‘non- specific’ when they do not conform to this
classification. This is unnatural but it is a good first step in learning how to
diagnose.
All doctors have to know about symptoms and their relief. Part of becoming a
good doctor is learning to link symptoms together, to distinguish those that may
be normal from those that are caused by disease. There is no way to distinguish
what is worrying from what is not: all symptoms may be worrying (to the patient) and some diseases are self- limiting and not worrying (to the doctor).
There are many books and online resources that can help with learning clinical
history taking and physical examination, but there is no substitute for experience. If you aren’t sure, ask for help from someone with more experience.
Remember:
• We as k qu est ions to get info rma tion to help wit h ou r d ierential diagnosis. But we
should also ask questions to find out about the lives our patients live. Rapport and
respect will help you to diagnose and to understand what disease means to the patient in front of you. Only with this understanding can you work with your patient to
select the right treatment for them.
• Patients (and diseas es) rarel y read textb ooks, so d on’t b e sur prise d if some symp-
toms are ambiguous, and others are meaningless. Learn to recognize patterns, but
do not be so presumptuous as to create them when none exist.
• Signs can be easy to detect, or subtle. Some will be found by medical students,
others require experienced ears or eyes. You can be a fine doctor without being able
to elicit every sign— listen and look, listen better and look again (later).
• Finding signs and putting together the clues they oer is to become a doctor. It is
essential that we learn the signs of diseases that we should never miss.
• Learning is a lifelong process.
Finding your way
On paper, history taking seems deceptively easy as if the patient knows the facts
and the only problem is extracting them; but what a patient says may include
hearsay (‘She said I looked pale’), innuendo (‘You know, doctor, down below’),
legend (‘I suppose I must have bitten my tongue; it was a real fit, you know’),
exaggeration (‘I didn’t sleep a wink’), and improbability (‘The Pope put a transmitter in my brain’).
The great skill (and pleasure) in taking a history lies not in ignoring these garbled
messages but in understanding those who voice them, making sense of them,
and using them to direct clinical examination. No two doctors will have identical
examination techniques. Relish this variation and craft your own routine.
25

2 History and examination
Taking a history
SOCRATES
GP
CAGE
BOX
https://t.me/med1917
26
Taking a good history is an art and an essential skill: 80% of diagnoses should be
made on history alone, with the signs you elicit adding an extra
tory may negate the need for invasive tests and irradiation. Do not rely on signs
or investigations for your diagnosis, but use them to confirm what you suspect.
A general approach:
• Introduce yourself and check whether the patient is comfortable.
• Seek consent for everything: to talk, to examine, to perform tests.
• Put the patient at ease: a good rapport may relieve distress.
• Be conversational rather than interrogative.
• Start with open questions and allow the patient to tell their story. Steer them back
towards important diagnostic points later if necessary.
Presenting problem
Use open questions: ‘Why have you come to see me today?’ Record the patient’s
own words rather than medical terms.
History of the presenting problem
When did it start? How did it start: what was the first thing you noticed? How have
things changed since then? Have you ever had it before? For pain use
• Site.
• Onset: gradual, sudden.
• Character: what does it feel like?
• Radiation: where does it move to?
• Associations, eg nausea, sweating.
• Timing: constant, intermittent.
• Exacerbating and alleviating factors: exercise, food, time of day.
• Severity: eg scale of 1– 10, compared with worst ever previous pain.
Direct questioning narrows the list of possible diagnoses. Use specific or ‘closed’
questions about the dierential diagnoses you have in mind. Review relevant sys-
p28). Don’t forget risk factors: travel, occupation, sexual contact.
tems (
Past medica l histo ry
Ever in hospital? Illnesses? Operations? Anaesthetic problems? Previous investigations even if a diagnosis was not made?
Drug history
Tablets, injections, ‘over- the- counter’ drugs, herbal remedies, and contraceptives.
Ask about
(nausea, diarrhoea) from sensitization (rash, wheeze, anaphylaxis).
Social history
Probe without prying. ‘Who else is there at home?’ Daily life: job, meals, self- care, exercise, mobility (walking aids, stairs). Quality of life is subjective, not objective: What
does the patient enjoy? What can they not do because of illness? Utilize the valuable
and unique perspective of the
decades. Do they have an advance directive? Consider smoking (
arettes/ day for
Fam i ly hi st o ry
Ask about health and cause of death in 1st- and 2nd- degree relatives. Include
diseases of relevance to the presenting problem, eg kidney disease, liver disease.
Consider cardiovascular risk factors/ disease and cancer. Draw a family tree (see
some will already have been covered in a good history of the presenting problem.
Ask if your patient has any ideas or concerns about what the problem might
be. You may be able to reassure. Or you might agree: ‘I am also worried that this
might be cancer. I want to find out as soon as possible so we can make a plan for
treatment together.’
Recap with your patient. Ask them to tell you anything you have missed.
Do not hesitate to review the history later: recollections change (often on the
post- take ward round when your consultant asks the same questions).
allergies and what the patient experienced: distinguish side eects
1
year), alcohol (
). Systemic enquiry (p28) helps to uncover undeclared symptoms although
10
%. A good his-
— they may have known them and their family for
questionnaire, p
276
1
pack- year = 20 cig-
), illicit drug use.
:

2 History and examination
Drawing a pedigree of inherited disease
OHCS
Old age
e
https://t.me/med1917
Advances in genetics are touching all branches of medicine. It is increasingly important for doctors to identify patients at high risk of genetic disease, and to
make appropriate referrals. A key skill is drawing a family tree (
you structure a family history:
1
Start with your patient. Draw a square for ♂ and a circle for ♀. Add a small
arrow to show that this person is the propositus/ proband (the person through
whom the family tree is ascertained).
2
Add your patient’s parents, brothers, and sisters. Record basic information
only, eg age and if alive and well (a&w,
death, and pass an oblique stroke through that person’s symbol.
3
Ask the key question, ‘Has anybody else in your family had a similar problem as
yourself, eg heart attack/ angina/ stroke/ cancer?’ Ask about diseases (or possible symptoms of disease) that relate to your patient’s main problem.
4
Extend the family tree upwards to include grandparents. If good information
about grandparents is not available extend to maternal and paternal uncles and
aunts and their children (proband’s cousins). If you haven’t revealed a problem
by now, go no further
inherited disease. The pedigree may need to be extended further for recessive
and sex- linked disease.
5
Ask about consanguinity (shown using a double line) which increases the risk
of recessive disease.
6
Shade those in the family tree aected by the disease. • = an aected female;
= an aected male. This will help demonstrate the pattern of inheritance.
7
If you have identified a familial susceptibility, or your patient has a known
—
you are unlikely to have missed important dominantly
fig
2.2
). If dead, note age and cause of
fig
2.2
) to help
genetic condition, extend the family tree down and across (children, nieces,
nephews) to identify others who may be at risk and may benefit from screening. Refer to a genetics specialist for advice and counselling (
fig
2.2
The family tree (
) shows these ideas at work and indicates that there is evi-
p
274
).
dence for a genetic risk of colon cancer.
74
; a&w
Old age
ca bowel
48
; ca colon
Old ag
27
45
; ca colon
23
a&w
Conventions
a&w = alive and well
Fig 2.
2
Genetic risk of colon cancer in a family tree.
Acknowledgemen t
Thank you to Dr Helen Firth for her contribution to this topic.
17
a&w
Male Female
42
a&w
54
; ca colon
(= male died aged
years and had colon cancer)
36
a&w
54
73
; old age
(female died aged
years from old age)
73

2 History and examination
Systems enquiry
PND
SOCRATES
LMP
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28
Just as skilled acrobats are happy to work without safety nets, so experienced
clinicians may operate without an enquiry covering the spectrum of symptoms
that can arise in disease. To do this you must be skilled enough to understand all
the nuances of the presenting complaint. Until you are sure that you have included
all the symptoms that will help you to achieve/ refine a diagnosis, or when the constellation of symptoms given fails to guide you, try systems enquiry.
General questions
May be the most significant.
• Weigh t lo ss ( p35).
• Fever/ night sweats (p30).
• Lump (p
586
• Fati gu e (p30)/ malaise/ lethargy.
• Sleep (p31).
• Appetite (p35).
• Itch (p31)/ rash.
• Mood (p72).
).
Cardiorespiratory symptoms
• Chest pain (p86).
• Breathlessness: quantify exercise tolerance (before needing to stop due to breathless-
ness) and how it has changed, eg stairs climbed, distance/ speed walked.
• Paroxysmal nocturnal dyspnoea (
flat, a symptom of left ventricular dysfunction). Quantify by number of pillows needed
for sleep.
• Oedema: ask about dependent areas— ankles, legs, lower back if sitting.
• Palpita tions (aware ness of heartbeat ): can they ta p out the rh ythm?
• Syncope/ pre- syncope.
• Cough: sputum, haemoptysis (cou ghing up blo od).
Gastrointestinal symptoms
• Abdominal pain. Use
or dull; radiation; associated factors: eating, bowel motion; timing; exacerbating/ relieving factors; severity.
• Other questions— think of symptoms throughout the GI trac t, fro m mouth to a nus:
• Swallowing (p
• Indigestion (p
• Nausea/ vomiting (p
• Bowel habit (p
• Stool: colour, consistency, blood, mucus, diculty flushing (p
Tenesmus is the feeling of incomplete evacuation (eg due to a tumour).
246
248
254
Melaena is altered (black) blood passed PR (p
oensive smell and tar- like appearance.
Genitourinary symptoms
• Incontinence: stress or urge (p
• Dysuria: painful micturition.
• Haematuria: visible blood or pink urine.
• Froth y u rin e su gg est s p rote in uri a.
• Nocturia: needing to micturate at night.
• Frequ en cy: fre que nt mic tu rit ion .
• Polyuri a: larg e volum es of ur ine.
• Hesitancy: diculty starting micturition.
• Ter m i n a l d r i b b l i n g .
• Vagina l dis char ge: co lour , odo ur.
• Dyspareunia: pain on intercourse (p
• Menses: frequency, regularity, duration, pain, clots. First day of last menstrual pe-
). Number of pregnancies and births. Menarche. Menopause. Any chance
riod (
of pregnancy now?
) due to orthopnoea (breathlessness on lying
(p26): site; onset; character: constant or colicky, sharp
).
).
246
). Haematemesis is vomiting blood.
, p
256
).
252
), with a characteristic
640
).
408
).
262
), urgency.

2 History and examination
Neurological symptoms
HGV
https://t.me/med1917
• Special senses: sight, hearing, smell, and taste.
• Seizures, faints, ‘funny turns’.
• Headache.
• Paraesth esiae (‘p ins and nee dles’).
• Numbness.
• Limb weakness.
• Poor bal ance.
• Speech problems (p70).
• Sphincter disturbance: urinary retention, incontinence.
• Higher mental function and psychiatric symptoms (pp70– 3).
Neurological symptoms always warrant functional assessment: what the patient
can and cannot do at home, work, etc.
Does (and should) the patient drive, and special licence, eg
Musculoskeletal symptoms
• Pain, sti ness, swelling of joints.
• Diurnal variation in symptoms (eg worse in mornings).
• Funct ion al de fici t.
• Symptoms of systemic disease: rashes, mouth ulcers, hair loss, nasal stuness, mal-
aise. Ask, ‘When did you last feel well?’
Thyroid symptoms
Hyperthyroidism
• Heat intolerance/ sweating.
• Anxiety.
• Diarrhoea.
• Oligomenorrhoea.
• iAppetite, weight loss.
• Trem or.
• Palpita tions.
• Visual symptoms due to thyroid eye disease (p78).
Hypothyroidism
• Cold intolerance.
• Low mood.
• Fati gu e .
• Thin ha ir.
• Change in voice.
• Constipation.
• Dry skin.
• Weigh t ga in.
29

2 History and examination
Non- specific symptoms
FBC, ESR, U&E
TFT
TB
T
ESR, TFT, FBC
MSK
CNS:
UTI
MAOI,
MDT
SSRI
NSAID
https://t.me/med1917
30
Non- specific symptoms can be caused by a wide range of conditions, and do not
conveniently direct the physician to a diagnosis.
Fatigue
So common that it is a variant of normality. Only 1 in
sent to a doctor.
Do not miss depression (p72).
Exclude orthopnoea.
Look for common treatable causes: anaemia, hypothyroidism, diabetes.
Ask: when it started and progression over time, length of sleep, diculties going
to sleep or staying asleep, nocturia, sleep during the day, exacerbating/ relieving
factors (eg exercise, pain), eect on daily life, life stressors, medications (and
when they are taken), alcohol, illicit drug use.
Consider:
Sweating
While some night sweating is common, drenching sweats requiring changes of
clothes/ bedding are a more ominous symptom associated with infection (eg
brucellosis), lymphoproliferative disease, and other malignancies. Patterns of
fever may be relevant (
Hyperhidrosis = excessive sweating
• Primary, eg hidradenitis suppurativa. Treatment: antiperspirants (aluminium
20
% = Dr iclor®), sympathectomy, iontophoresis.
chloride
• Secondary to another cause (table 2.1).
Table 2.
1
Secondary causes of sweating
Category Examples
Infection Any— bacterial, viral, fungal. Typical and atypical
Acute trigger Pain, anxiety
Endocrine Hyperthyroidism, acromegaly, phaeochromocytoma, menopause
Infiltrative Malignancy, amyloidosis
Medication
Withdrawal Opioids, gabapentin, alcohol, caeine
Mental health:
Parkinson’s: anticholinesterase inhibitors, eg donepezil
Analgesia: opioids,
Antimicrobials: cephalosporins, quinolones, aciclovir, ribavirin
Endocrine: steroids, levothyroxine, sulfonylureas, insulin
Ask about medications. Consider infection. Examine for lymphadenopathy and
splenomegaly. Any signs of hyperthyroidism?
°,
Check:
Falls
Lead to hospital admission, loss of confidence, and dependence.
•
: osteo/ rheumatoid arthritis, (missed) fracture, eg neck of femur.
•
dvision, cognitive impairment, depression, peripheral neuropathy, Parkinsonism,
myopathy, malignancy, cord lesion/ compression (
• Infection:
• Endocrine: hypothyroidism.
• CV: postural hypotension (p37), arrhythmia.
• Medication: benzodiazepines, sleeping tablets (the ‘Z’s), tricyclics,
psychotics, opioids, anti- epileptics, antihypertensives, antianginals, alcohol.
• Environment: lighting, walking surface.
, pneumonia.
Treatment includes addressing injuries, reducing risk factors, and reducing the
risk of injury, eg osteoporosis (
approach is best including occupational therapists and physiotherapists
An
as most falls are multifactorial.
400
episodes of fatigue pre-
, plasma glucose,
p
438
.
).
S, amitriptyline, haloperidol, clozapine
S
, culture— blood, urine, other as indicated.
p
462
).
p
674
).
anti-
,
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