Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_2589_Библиотеки_им_академика_М_И_Перельмана

While nearly 40–50% of the uveitis entities remain uncharacterized even today, physicians must differentiate infectious uveitis from the more commonly occurring and perhaps better­characterized immune-mediated non-infectious uveitis. Diagnosis of non-infectious uveitis is denitive due to well-characterized ocular phe­notypes often associated with systemic autoin­ammatory/autoimmune disorders. However, frequent recurrences of inammation in these patients pose a major management challenge as they often require long-term anti-inammatory and/or immunosuppressive therapy. However, a large majority of infectious organisms that man­age to break the blood-ocular barrier to set up infection/uveitis in the eye, although they can be controlled with highly effective antibiotics and other chemotherapeutic agents, the tendency for these organisms to sequestrate/hibernate or assume latency in the ocular tissues often results in recurrences. The subject of intensive studies is what triggers these organisms’ latency and reacti­vation to cause recurrent inammation. Detecting organisms responsible for infectious uveitis has also remained a major challenge. Moreover, their phenotypic expression largely depends upon the host’s immune status, the organism’s infectious dose, and the possibility of multiple simultane­ous infections, especially in patients with HIV.Their diagnosis often requires invasive pro­cedures for obtaining ocular uid samples to reach a denitive diagnosis.