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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3612_Библиотеки_им_академика_М_И_Перельмана

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Key Questions in CONGENITAL CARDIAC SURGERY
13 What are the echocardiographic features of atrial
septal defects?
Echocardiography can be used to definitively diagnose the type of
anatomical defect with 2D and 3D images (Figure 9). Colour-flow Doppler is used to quantify the shunt across the atrial
septum (Figure 10).
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Figure 9. Transthoracic echocardiography, with: A) 3D images demonstrating
a large ostium secundum defect with a multi-fenestrated fossa membrane; and 2D images demonstrating: B) an ostium primum defect, with alignment of both atrioventricular valves on the same plane, which is typical of a partial atrioventricular septal defect; and C) an inferior sinus venosus defect. SVC = superior vena cava; IVC = inferior vena cava; RA = right atrium; LA = left atrium; LAVV = left atrioventricular valve; RAVV = right atrioventricular valve.
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13 Atrial septal defects
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Figure 10. Transoesophageal echocardiogram demonstrating
a moderate-large left-to-right shunt across the interatrial septum on colour-flow Doppler. RA = right atrium; LA = left atrium.
461
Echocardiography can also demonstrate the haemodynamic
consequences of the defect, including:
a) right ventricular chamber size and function (degree of dilatation
and dysfunction) (Figure 11); b) right atrial enlargement; c) pulmonary artery dilatation; d) tricuspid regurgitation.
It is also important to identify any associated cardiac abnormalities,
including:
a) cleft mitral and mitral regurgitation (in ostium primum defects); b) persistent left-sided superior vena cava (in coronary sinus
defects); c) anomalous pulmonary venous drainage (in sinus venosus
defects) (Figure 12).
Key Questions in CONGENITAL CARDIAC SURGERY
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Figure 11. Parasternal: A) long-axis; and B) short-axis transthoracic
echocardiographic images demonstrating right ventricular dilatation, secondary to volume overload in a patient with an ostium secundum defect. RV = right ventricle; LV = left ventricle.
462
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Figure 12. Doppler echocardio-
graphy demonstrating flow across the superior cavo-atrial junction, inflow from an anomalous right upper pulmonary vein (RUPV) into the right atrium and a shunt across a sinus venosus defect. SVC = superior vena cava; RA = right atrium; LA = left atrium.
13 Atrial septal defects
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14 Describe the bubble test (Figure 13)
Sterile saline is agitated by passing it between two syringes to
produce tiny bubbles. Following intravenous injection of the saline, echocardiographic
images of the left and right atrium are monitored.
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Figure 13. Bubble test demonstrated
on serial transthoracic apical four­chamber images: A) the right atrium (RA) and ventricle (RV) are filled with bubbles; B) during a Valsalva manoeuvre, the bubbles fill the left atrium (LA) first; and then C) the left ventricle (LV).
463
Key Questions in CONGENITAL CARDIAC SURGERY
If the atrial septum is intact, the bubbles should remain on the right
side. Bubbles within the left atrium indicate a communication between the
atria, suggestive of an atrial septal defect.
15 What are cardiac catheterisation findings of atrial
septal defects?
Routine cardiac catheterisation is unnecessary in children with a
previously diagnosed uncomplicated atrial septal defect. For patients with pulmonary hypertension, associated congenital
abnormalities or age over 40 with suspected coronary artery disease, cardiac catheterisation is an important component of the surgical work-up. Oxygen saturation measurements in the systemic and pulmonary
circulations will reveal a step-up in right ventricular and pulmonary artery oxygen saturations (Table 1).
464
Table 1. Cardiac catheterisation data demonstrating a step-up in right atrial
(RA) oxygen saturations in an adult patient with an ostium secundum defect. SVC = superior vena cava; MPA = main pulmonary artery; LPA = left pulmonary artery; FA = femoral artery; RUPV = right upper pulmonary vein; BCV = brachiocephalic vein; IVC = inferior vena cava; EDP = end-diastolic pressure.
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SVC RA MPA LPA FA RUPV BCV High SVC Low SVC Mid RA Low RA High RA Low IVC High IVC
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13 Atrial septal defects
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High oxygen saturations in the superior vena cava may indicate the
presence of a sinus venosus defect. Cardiac catheterisation also allows the size of the shunt to be
quantified by calculating the shunt fraction.
16 How do you calculate the shunt fraction (Qp:Qs)
(Figure 14)?
Using the Fick principle:
Flow = O2consumption
arteriovenous O2concentration difference
Flow = O2consumption
(arteriovenous O2sats difference x Hb x 1.34 x 10)
Pulmonary flow = O2consumption
[(PV sats - PA sats) x Hb x 1.34 x 10]
465
Systemic flow = O2consumption
[(Ao sats - RA sats) x Hb x 1.34 x 10]
As O2consumption and Hb are the same in both equations Pulmonary flow: systemic flow ratio (shunt ratio)
Qp:Qs = (Ao sats - RA sats)
(PV sats - PA sats)
RA sats = (3 x SVC sats) + (1 x IVC sats)
4
PV = pulmonary vein; PA = pulmonary artery; Ao = aorta; RA = right atrium; SVC = superior vena cava; IVC = inferior vena cava; Hb = haemoglobin; sats = oxygen saturations.
Key Questions in CONGENITAL CARDIAC SURGERY
466
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VVB
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Figure 14. Shunt calculation based on the Fick principle. RA sats = ([3 x
64] + [1 x 68]) / 4 = 65%. Measured PA saturations = 82%. Measured PV saturations = 99%. Assuming aortic and PV saturation are equal, the Qp:Qs shunt in this patient will be: (99 - 65) / (99 - 82) = 34 / 17 = 2:1.
17 What are the therapeutic options for a patient with an
atrial septal defect?
Conservative management:
a) infants with an ostium secundum defect <8mm (as 66% close
within 18 months); b) adults with a Qp:Qs ratio of <1.5; c) patients with severe pulmonary vascular resistance, shunt
reversal and fixed pulmonary hypertension (pulmonary artery
systolic pressure [PASP] >60mmHg, pulmonary vascular
resistance [PVR] >12 WU).
Medical therapy — to optimise patients with atrial arrhythmias and
right ventricular volume overload prior to intervention.
13 Atrial septal defects
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Percutaneous closure.
Surgery.
18 What are the indications for therapeutic closure of an
atrial septal defect?
A Qp:Qs ratio of >2.
Atrial arrhythmia.
Reversible pulmonary hypertension.
Right ventricular dysfunction.
Patent foramen ovale in patients with a demonstrated right-to-left
shunt (by saturations or bubble study) and recurrent paradoxical cerebral emboli.
19 What are the contraindications for therapeutic closure
of an atrial septal defect?
Asymptomatic patient with a clinically insignificant atrial septal defect
(Qp:Qs <1.5). Shunt reversal with fixed pulmonary hypertension (PASP >60mmHg,
PVR >12 WU).
467
20 What are the principles of device closure for an atrial
septal defect (Figure 15)?
Device closure is only suitable in patients with:
a) ostium secundum defects (within the fossa ovalis); b) 5mm rim from the defect to the valves and major veins; c) defect <40mm in size.
General anaesthesia or local anaesthesia with sedation.
Femoral venous access with fluoroscopic and transoesophageal
guidance. The diameter of the defect is measured both by echocardiography
and sizing balloon. Deployment of the occluder device.
There are several types of occluder devices available, including:
a) AMPLATZER™ Septal Occluder (St Jude Medical, St Paul,
MN, USA) (Figure 16);
b) CardioSEAL®Septal Occlusion System (NNMT Medical,
Boston, MA, USA);
c) HELEX®Septal Occluder (Gore, Flagstaff, AZ, USA).
Key Questions in CONGENITAL CARDIAC SURGERY
AB
CD
468
EF
Figure 15. Device closure of an atrial septal defect. Transoesophageal
echocardiographic images demonstrating: A) an ostium secundum defect with a large shunt; B) measurement of the size of the fossa ovalis membrane and assessment of the margins of the defect for positioning of the device; C) partial deployment of the device; and D) complete deployment resulting in a stabilised disc position with no residual shunt demonstrable on colour flow Doppler. Fluoroscopic images demonstrating: E) measurement of the defect diameter by the balloon catheter; and F) deployment of the device.
13 Atrial septal defects
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Figure 16. AMPLATZER™ atrial septal occluder in an
explanted heart.
Medical, Inc. or its related companies. Reproduced with
permission from St. Jude Medical™, © 2013. All rights
reserved.
AMPLATZER is a trademark of St. Jude
21 What are the surgical approaches for an atrial septal
defect (Figure 17)?
Median sternotomy.
Submammary anterior thoracotomy.
Posterolateral thoracotomy.
Robotic or video-assisted minimally invasive thoracoscopic access.
Skin incision Chest wall incision
4th intercostal space
Sternum
I II III
IV
V
VI
469
Figure 17. Common surgical approaches to repair an ASD.