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Chapter 13 Rejuvenation of the aging face and skeleton with implants
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11. Sinsel NK, Opdebeeck H, Guelinckx PJ. The effect of unilateral partial facial paralysis and muscle ablation on craniofacial growth and development: an experimental study in the rabbit. Plast Reconstr Surg 1998;102(6):1894–912.
12. Matic DB, Yazdani A, Wells RG, Lee TY, Gan BS. The effects of masseter muscle paralysis on facial bone growth. J Surg Res 2007;139(2):243–52.
13. Instrum SM. Cephalometric comparison of the craniofacial skeletal morphology between Mobius syndrome and non-syndromic controls. Dissertation University of Toronto, 1999. National Library of Canada; 1999.
14. Staley RN, Bishara SE, Hanson JW, Nowak AJ. Craniofacial development in myotonic dystrophy. Cleft Palate Craniofac J 1992;29(5):456–62.
15. Van den Bosch WA, Leenders I, Mulder P. Topographic anatomy of the eyelids, and the effects of sex and age. Br J Ophthalmol 1999;83(3):347–52.
16. Pessa JE, Zadoo VP, Mutimer KL, et al. Relative maxillary recursion as a natural consequence of aging: combining skeletal and soft-tissue changes into an integrated model of midfacial aging. Plast Reconstr Surg 1998;102(1):205–12.
17. Pessa JE, Desvigne LD, Lambros VS, et al. Changes in ocular globe-to-orbital rim position with age: implications for aesthetic blepharoplasty of the lower eyelids. Aesthetic Plast Surg 1999;23(5):337–42.
18. Shaw Jr RB, Kahn DM. Aging of the midface bony elements: a three dimensional CT study. Plast Reconstr Surg 2007;119(2):675–81; discussion 682–683.
19. Shaw Jr RB, Katzel EB, Koltz PF, Yaremchuk MJ, Girotto JA, Kahn DM, Langstein HN. Aging of the facial skeleton: aesthetic implications and rejuvenation strategies. Plast Reconstr Surg 2011;127(1):374–83.
20. Levine RA, Garza JR, Wang PT, Hurst CL, Dev VR. Adult facial growth: applications to aesthetic surgery. Aesthetic Plast Surg 2003;27(4):265–8.
21. Shaw Jr RB, Katzel EB, Koltz PF, et al. Aging of the mandible and its aesthetic implications. Plast Reconstr Surg 2010;125(1):332–42.
22. Sharabi SE, Hatef DA, Koshy JC, Hollier Jr LH, Yaremchuk MJ. Mechanotransduction: the missing link in the facial aging puzzle? Aesthetic Plast Surg 2010;34(5):603–11.
23. Matros E, Momoh A, Yaremchuk MJ. The aging midfacial skeleton: implications for rejuvenation and reconstruction using implants. Facial Plast Surg 2009;25(4):252–9.
24. Paskhover B, Durand D, Kamen E, Gordon NA. Patterns of change in facial skeletal aging. JAMA Facial Plast Surg 2017;19(5):413–7.
25. Shaw Jr RB, Katzel EB, Koltz PF, Kahn DM, Puzas EJ, Langstein HN. Facial bone density: effects of aging and impact on facial rejuvenation. Aesthet Surg J 2012;32(8):937–42.
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Chapter 14
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Designer faces: CAD/CAM facial implants
INDICATIONS FOR AND ADVANTAGES OF CAD/CAM
Computer-aided design and manufacturing (CAD/CAM) provides added sophistication to facial implant surgery. It provides three-dimensional mil­limeter accuracy in implant design and manufacturing specific to the facial skeleton being addressed. This precision potentially minimizes or eliminates limitations intrinsic to the use of “off-the-shelf” implants and asymmetry of the facial skeleton. CAD/CAM implants are custom made for the individual patient.
CAD/CAM implants are ideal for patients with significant facial asymmetry. Asymmetries are three-dimensional. They can be thought of as twists of the skeleton. As demonstrated in Fig. 14.1, asymmetry in the mandible is more than an asymmetry in lower facial width. Note the difference in ramus height and border inclination.
CAD/CAM implants are also useful to correct skeletal contour irregularities that result after orthognathic surgery. Chapter 15 describes this application in detail.
Fig. 14.1 Three-dimensional CT scan of the facial skeleton showing complex mandible asymmetry.
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Chapter 14 Designer faces: CAD/CAM facial implants
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Nuanced design not possible with off-the-shelf implants is possible with CAD/CAM implants. Note the three-dimensional change in the chin as well as correction of asymmetry in mandible body shown in Fig. 14.2.
The precise fit of the CAD/CAM implant to the underlying skeletal con­tour makes for a more predictable result. There is a fundamental techni­cal problem to placing off-the-shelf bilateral implants in similar positions on opposite sides of the face (Fig. 14.3). Remote incisions routinely provide limi ted access and therefore limited exposure of the areas to be augmented. Furthermore, the surgeon never has the ability to see the position of both implants in a single view. CAD/CAM implants are made to augment precisely defined areas of the facial skeleton, making implant positioning less problematic. These implants can also be designed with registration features, for example, a flange on a malar implant that rests on the infraorbital rim or on the superior edge of the zygomatic arch. Cus­tom implants are designed to avoid any gaps between the posterior surface of the implant and the anterior surface of the skeleton (Fig. 14.4). Gaps are unavoidable when using off-the-shelf implants. These gaps add to the effective projection of the implant. A 2-mm gap beneath a 3-mm implant will result in an unanticipated 5-mm projection. An implant designed and manufactured to have its posterior surface mirror that of the underlying skeleton will avoid that unanticipated contour result. 
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Fig. 14.2 CAD/CAM implant allows desired width, vertical elongation, and sagittal projection of the chin as well as correcting body asymmetry. (A) Frontal view. (B) Lateral view.
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Fig. 14.3 CT scan examples of o-the-shelf and CAD/CAM implants. (A) Frontal view of a three-dimensional CT scan revealing asymmetric
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position of malar implants. (B) Frontal view of CAD/CAM malar implants. Note symmetric placement. (C) Worm’s eye view of CAD/CAM implants that allow symmetry of implant position, as well as symmetry of combined implant plus underlying skeleton projection.
Fig. 14.4 Sagittal section of posterior mandible with
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o-the-shelf implant placed to augment its contour. The posterior surface of the implant does not mimic the contour of the underlying skeleton resulting in gaps between the two surfaces. Gaps result in unanticipated increase in contour.
Implant development
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Fig. 14.5 Implant design using model format. (A) Model obtained from CT DICOM data. (B) Model with implant prototypes fashioned by the treating surgeon.
IMPLANT DEVELOPMENT
Computed tomography (CT) scans are obtained to provide digital imaging and communication in medicine (DICOM) data. DICOM is a standard for handling, storing, printing, and transmitting information in medical imaging. This data is used to create a three-dimensional model of the facial skeleton or a three­dimensional image. The three-dimensional model allows the surgeon to craft with clay the desired implant configuration. The clay is then used as a proto­type for the implant design (Fig. 14.5). DICOM data can also be used to create a three-dimensional image for use in virtual design sessions between surgeon and software engineer to create an implant (Fig. 14. 6). This technique is pre­ferred by the authors because it allows millimeter precision of design. The com­puterized design is then used to computer manufacture an implant. 
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Chapter 14 Designer faces: CAD/CAM facial implants
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Fig. 14.6 Image created using DICOM data to design an implant. (A) Image of facial skeleton. (B) Virtually designed implant.
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PERSONAL DESIGN TECHNIQUE
Critical to the design process is to recognize the patient’s goals. The patient may desire to create angularity, provide symmetry, improve facial balance, or correct irregularities. It is useful for the patient to provide photographs of people who have the desired look. Digital manipulation of patient images can be helpful. The patient should understand that these images are used as guides in the design process and not predictions of the surgical outcome. There is no algorithm that can translate a digitally created change in soft tis­sue to an implant design that will result in the outer contour change. Effec­tive communication between surgeon and patient is invaluable to the design process.
Because the native facial skeleton is not symmetric, implant augmen­tation will provide a “relative symmetry.” Chin implants should create symmetry relative to the midline structures – nasal radix, nasal septum, central incisors, and central lip elements. This symmetry should extend from mental foramen to mental foramen. Lateral to the mental foramen, mandible implants should relate to the width of the upper face. For exam­ple, the extent of lateral augmentation of the mandible angles should relate to the lateral orbital rims in the same way (Fig. 14.7). Designing an implant for one side of the face and mirroring it to create an implant for the opposite side will create mandible symmetry only if the mandible and midface are symmetric prior to augmentation. When augmenting the midface, the goal is to achieve similar implant-plus-skeleton projection (Fig. 14.8). Because the contours of the midface will vary from one side to the other, mirroring one side to the other is unlikely to result in similar contours.
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Personal design technique
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Fig. 14. 7 Design of chin/mandible implant demonstrating “relative symmetry.” Note that the chin component is symmetric to the midline from mental foramen to mental foramen. The mandible angles are augmented in width relative to landmarks of the upper face (lateral orbital rim, in this case).
Fig. 14.8 CAD of implants allows projection of implant plus underlying skeleton to be symmetric, as demonstrated in colorized projection map on implant surface.
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Chapter 14 Designer faces: CAD/CAM facial implants
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Clinical experience has taught the senior author to control the design process. After voicing their goals and preferences, patient participation in the step-by­step design process has proved unrewarding. The design process is inevitably protracted and therefore more expensive when the patient is involved. More importantly, heavily patient-influenced designs have been almost routinely
disappointing to the patient.
Clinical examples are presented in Figs. 14.9–14.12.
PEARL
Limit patient involvement in the ongoing design process. It is often unrewarding for both patient and surgeon.
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Fig. 14.9 Preoperative and postoperative clinical appearance and three-dimensional CT images of a patient who underwent CAD/CAM implant midface and mandible augmentation. (A) Preoperative appearance. (B) Postoperative appearance. (C) Image of native skeleton. (D)
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Image of designed implants.
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Personal design technique
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Fig. 14.10 A 28-year-old man who under­went CAD/CAM implant augmentation of midface and lower jaw as well as rhinoplasty. (A) Preoperative frontal appearance. (B) Postoperative frontal appearance. (C) Pre­operative lateral appearance. (D) Postopera­tive lateral appearance. (E) Frontal view of preoperative skeletal appearance. (F) Frontal view of design of CAD/CAM implants. (G) Lateral view of preoperative skeletal appear­ance. (H) Lateral view of design of CAD/CAM
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Chapter 14 Designer faces: CAD/CAM facial implants
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Fig. 14.11 A 24-year-old woman underwent CAD/CAM implant augmentation of her midface and mandible. (A) Preoperative frontal appearance. (B) Postoperative frontal appearance. (C) Preoperative oblique appearance. (D) Postoperative oblique appearance. (E) Frontal view of preoperative skeletal appearance. (F) Frontal view of design of CAD/CAM implants. (G) Lateral view of preoperative skeletal appearance. (H) Lateral view of design of CAD/CAM implants.
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Personal design technique
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Fig. 14.12 A 26-year-old man underwent CAD/CAM implant augmentation of his midface and mandible. (A) Preoperative frontal appearance. (B) Postoperative frontal appearance. (C) Preoperative oblique appearance. (D) Postoperative oblique appearance. (E) Frontal view of preoperative skeletal appearance. (F) Frontal view of design of CAD/CAM implants. (G) Lateral view of preoperative skeletal appearance. (H) Lateral view of design of CAD/CAM implants.
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