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Fig. 38.3 Resolution of stenosis with use of a stent graft
tion of the stenosis and the patient’s clinical complaints
(Fig.38.3). The stent graft should typically be at least 1 or
2mm larger than the normal graft or stula and should be
extended into an outow vein that is at least as large as the
stent graft.
Accessory Vein Obliteration
Accessory veins can prevent AVF maturation by diverting
blood ow away from the main stula, leading to lower
ows, smaller vessel diameters, and ultimately causing difculty with cannulation or obtaining adequate ows on dialysis. The pressure gradient established after creation of an
AVF will lead to increased blood ow through the vein.
Higher blood ow leads to more shear stress on the vessel
wall leading to vessel dilation and AVF maturation; so any
alteration in blood ow through the AVF can lead to a failure
of maturation [7]. Although accessory veins can signicantly
impact the maturation of AVFs, there are no clear guidelines
on which accessory veins need to be ligated or obliterated.
Traditionally, accessory veins with a diameter of one third or
more of the AVF need to be obliterated; however, there are no
studies that validate this arbitrary number [7]. One study
tried to determine the criteria for accessory vein obliteration
(AVO) by conducting computational uid dynamics and
established the following measures: (1) 60% or greater diameter of the main AVF, (2) 50% diameter of the AVF with at
least one more accessory vein greater than 40% in diameter,
(3) 50% in diameter and divides into branches of same size,
(4) accessory vein likely to interfere with cannulation on
physical examination, and (5) greater than 30% in diameter
and associated with stenosis at site of origin [39]. However,
these criteria were not clinically tested and veried and the
guidelines for managing accessory veins are still evolving.
This lack of selection criteria may explain the results of some
studies that have not shown any benet in performing AVO
[40, 41]. One of these studies was a meta-analysis looking at
patients with immature AVFs undergoing either PTA alone
or PTA with AVO, and there was no benet for PTA with
AVO over PTA alone [40]. It is important to note that there
was no specic selection process in determining which
patient were to receive AVO. Regardless of these ndings,
certain patients with an AVF that has failed to mature may
still benet from AVO. This can be performed surgically
with ligation of the accessory vein, or endovascularly with
coil embolization [7] (Figs.38.4 and 38.5). When comparing
open ligation to coil embolization, there was no signicant
difference in the two techniques, with 64% maturation in the
open group and 61% maturation in the endovascular group
(p=0.84) [42]. Further studies are needed to assess the efcacy of AVO.

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Fig. 38.4 73year old male with a left radiocephalic AVF presents with
difculty with cannulation and low ows even when cannulation is
achieved. The patient was brought to the angiography suite for evalua-
Fig. 38.5 The competing outow vein was cannulated separately in order to minimize trauma to the intended cannulation segment of the AVF,
and the competing outow vein was embolized using two coils with complete cessation of ow
tion, where stulogram through a microcatheter demonstrated dual outow in the forearm
Aneurysms andPseudoaneurysms
Although uncommon, aneurysm and pseudoaneurysm of
AVFs are known complications that cause serious morbidity.
In their systematic review, Al-Jaishi etal. reported an aneurysm incidence of 0.04 per 1000 patient days [43].
Aneurysmal dilation of the AVF has been linked to repeated
cannulation of the stula, with one study nding that alternating puncture sites protects against the formation of pseudoaneurysms [44]. Pseudoaneurysms are perivascular
collections of blood that are in direct continuity with the
AVF lumen and have been also linked to AVF vessel injuries
caused by cannulation [45]. Aneurysms and pseudoaneurysms can both cause overlying skin thinning and ulcer for-

38 Endovascular Techniques toManage Vascular Access Failure
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409
mation, as well as limit the availability of cannulation sites
and, if left untreated, can lead to exsanguination [43, 45].
While the size of an aneurysm/pseudoaneurysm is not an
indication for treatment, the KDOQI recommends evaluation
for new and follow-up on existing aneurysms at each dialysis
session, with use of duplex if needed for evaluation of size,
size progression, presence of stenosis, and impact on dialysis
via the AVF [2]. It is recommended to avoid cannulation
through the dilated segment to avoid further trauma to the
vessel wall and potential vascular access hemorrhage [2, 46].
The KDOQI and Canadian Society of Nephrology hemodialysis guidelines recommend intervention when the skin
overlying the AVF has been compromised (erosion or ulceration), there is a risk of life-threatening hemorrhage, or cannulation sites have become limited [2, 47]. Endovascular
management is similar to that of aneurysms found in other
vascular beds and includes exclusion of the aneurysm or
pseudoaneurysm by inserting a stent graft. Available studies
demonstrate primary patency rates of 100% at 30 days,
72.7% at 3 months, and 36.4% at 6 months [48, 49]. One
study showed a non- signicant higher risk of infection (odds
ratio 5.0, 95% condence interval [0.38, 66.01]) with stent
graft insertion in patients with skin erosion over the pseudoaneurysm [49]. Other authors reported a 28.9% complication
rate including migration, fracture, erosion, or rupture after
stent graft insertion [50]. Further studies are needed to evaluate the role of stent grafts in the treatment of vascular access
circuit aneurysms and pseudoaneurysms.
Central Venous Stenosis
Stenosis of the central veins (including the subclavian vein,
innominate veins, and superior vena cava) can result in signicant morbidity for hemodialysis patients with AVFs and
AVGs. Many patients may have asymptomatic stenosis
which may be incidentally discovered during venography; as
such, the true incidence of central venous stenosis (CVS)
varies widely with reported values ranging from 3 to 60%
among ESKD patients on HD [51–55]. Symptomatic stenosis can present with multiple issues, including difculty with
cannulation, prolonged bleeding following needle removal,
or decrease in clearance [56]. Other ndings suggestive of
CVS include ipsilateral extremity edema, pain, or development of prominent venous varicosities or collaterals [56, 57].
Risk factors associated with the development of CVS include
current or prior presence of central venous catheters, DVT,
and cardiac rhythm devices such as pacemakers [2, 58].
Percutaneous Transluminal Angioplasty
Endovascular techniques are the current mainstay of CVS
treatment, with the KDOQI recommending PTA only for moderate to severe symptoms or when efcacy or clearance is compromised [2] (Figs.38.6 and 38.7). The initial technical success
rates of PTA are high, ranging from 70% to 90% [59]. However,
Fig. 38.6 Left subclavian vein stenosis leading to left arm swelling after left brachial artery to axillary vein AVG placement

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Fig. 38.7 Treatment with balloon angioplasty leads to signicant luminal gain and improvement in left arm swelling
D. B. Semaan et al.
due to venous elastic recoil, restenosis is common and patency
rates at 12months are quite poor, ranging from 12 to 50% [59].
Management of restenosis following PTA may include
repeated balloon angioplasty or possibly stent placement.
With repeated PTA, secondary patency rates have been
reported as high as 60% at 12months, though close monitoring and repeated intervention are often required [60]. If signicant residual stenosis persists after repeated PTA, the
KDOQI guidelines endorse the use of intraluminal stenting
[2], which will be discussed below.
Stenting oftheCentral Venous System
As noted above, current guidelines support the use of stenting for CVS only after multiple unsuccessful rounds of PTA
[2]. Despite high technical success rates, initial studies
employing bare metal stents showed 12-month primary
patency rates of 19–21% [61–63]. When comparing longterm patency of PTA versus PTAS, bare-metal stents have
not demonstrated superior outcomes [61, 64]. Bare-metal
stents are additionally associated with migration, shortening,
and fracture and thus are not recommended for use in the
region of the thoracic outlet due to risk of external compres-
sion [2, 3, 65]. A retrospective analysis investigating the use
of self-expanding bare metal stents in central and peripheral
veins reported a 12-month patency rate of 67% with a mean
patency duration of 14.9months [66]. In a 2007 study, PTAS
was performed in 26 patients with bare metal stents and primary PTA alone was performed in 47 patients. Primary
patency was equivalent between groups with 76% patency
for both groups at 30-day and 12-month rates of 29% for
PTA and 21% for PTAS (p=0.48) [61]. The authors concluded that both PTA and PTAS are safe options which both
often require additional interventions.
More recently, stent grafts have emerged as a promising
option for endovascular treatment of CVS.In several recent
retrospective analyses comparing PTA, bare-metal stents,
and stent grafts, stent grafts consistently demonstrated superior long-term patency. Reported 12-month patency ranged
from 45.1 to 58%, 75 to 78.6%, and 82.4 to 100% for PTA,
bare-metal stents, and stent grafts, respectively [67, 68]. In
both studies, primary patency for stent grafts were superior
to both PTA and bare-metal stents. The advantage of stent
grafts is thought to be related to their relatively inert and
stable nature, providing a platform for endothelialization
while creating a physical barrier that reduces intimal hyperplasia (Kundu 2010).

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Case Presentation
Continued from page 409
The patient was severely hyperkalemic, and a dialysis catheter was placed in order to temporize the patient and provide dialysis access prior to thrombectomy. Due to lack of
available operating room time, a percutaneous approach
was chosen. Tissue plasminogen activator (t-PA, Alteplase)
2mg, buffered in 3000units of heparin and 5mL of sterile
water was injected into the thrombosed AVG through a 22
gauge Angiocatheter, after the fashion of “Lyse and wait”
[20] (Figs.38.8 and 38.9). After several minutes, the AVG
became pulsatile throughout its length.
When an appropriate angiography suite was available, the
patient was brought for stulography, demonstrating a severe
stenosis in the outow (Fig. 38.10), which responded to
aggressive balloon angioplasty, including high pressure balloons up to 40 atmospheres (Fig.38.11). The patient did well
and was discharged home with a functional AVG.
Fig. 38.8 Components of the “Lyse and wait” technique include Alteplase (2mg) and heparin (3000units) [20]

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Fig. 38.9 A 22 gauge angiocatheter directed to the venous anastomosis is used to administer the medications
Fig. 38.10 Initial stulography after lysis demonstrated a severe stenosis in the venous outow and residual thrombus

38 Endovascular Techniques toManage Vascular Access Failure
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Fig. 38.11 Completion stulogram after aggressive plain and high pressure balloon angioplasty exhibits an excellent radiologic result
Table 38.1 Endovascular toolkit for the endovascular management of failing arteriovenous access. These are only a few suggested options based
on the author’s experience
Manufacturer Size/length
Guidewires
Any standard-access wire
Hydrophilic-coated wire Glidewire (Terumo)
ZIPwire (Boston Scientic)
SplashWire (Merit Medical)
Sheaths
Any standard-access sheath, sizing dependent on
requirements for balloon or stent delivery. Short sheaths
can be useful for access, while longer sheaths may be
needed for support when crossing difcult lesions.
Coils
Nestor coils Cook Medical
Stent grafts
Viabahn WL Gore 7–10mm/ length as required to cover the lesion
Flair BD 7–10mm/ length as required to cover the lesion
Covera BD 7–10mm/ length as required to cover the lesion
Thrombectomy devices
Fogarty thru-lumen embolectomy catheter Edwards Lifesciences 4 Fr (9mm inated)
Cleaner XT rotational thrombectomy system Argon Medical Devices 6 Fr/ 65cm
AngioJet thrombectomy system AVX Boston Scientic 6 Fr/ 50cm
Indigo aspiration system/ CAT mechanical
thrombectomy catheter
Multiple 6–9 Fr/6–10cm
Penumbra CATD: 8F (2.67mm, 50cm length)
0.035″
0.035″
6 Fr/25+ cm
0.035″
4, 6, 8mm
5.5 Fr (11mm inated)
413
Conclusion
Endovascular treatment options of vascular access failures
offer a minimally invasive treatment option for ESKD
patients on hemodialysis with malfunctioning and failed
AV access. A well-stocked endovascular toolkit
(Table 38.1) is invaluable. When performed by experi-
enced and well-trained clinicians, percutaneous options
can provide immediate and successful treatment of failing
dialysis access.

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Part VII
https://t.me/medicina_free
Coronary Artery Disease
Соседние файлы в папке Библиотека им академика М.И. Перельмана
