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Nonspecic Abdominal Pain
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Fig. 1 Flowchart for nonspecic acute abdominal pain
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2 First Stage: Baseline Investigations
A thorough physical examination is recommended as the rst step in the diagnostic assessment of acute abdominal pain. Traditionally, based on medical history, physi­cal examination, and laboratory parameters, a physician would decide whether additional investigations are necessary or not. However, it has been demonstrated that clinical evaluation may not be highly accurate and specic in the diagnosis of NSAP.Likewise, diagnostic adjuncts such as laboratory studies seem to not signi­cantly increase the diagnostic accuracy. The literature demonstrates how the diag­nosis based on medical history and physical examination is correct in no more than 43–59% of patients with abdominal pain [1820]), while the rate of correct diagno­sis with the adjunct of laboratory parameters ranges between 46 and 48% [18, 21,
22]). The diagnostic accuracy increased when urgent and nonurgent conditions
were differentiated as primary outcome. A correct anamnesis, physical examina­tion, and laboratory values showed high sensibility for urgent and nonurgent dif­ferentiation while low specicity for a specic diagnosis [21].
The diagnosis of acute NSAP has been highly discussed throughout the years, and many suggestions have been formulated. In 1990, Lavelle and Kanagaratnam introduced usefulness index test for the assessment of usefulness of clinical obser­vations [23, 24]. DeDombal et al. have suggested that the proportion of correct diagnoses can be greatly increased by the use of structured questionnaires and diag­nostic programs on computer [25]. However, although computer-aided diagnosis
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can improve diagnostic rates by at least 20%, these programs are unpopular. In addi­tion, no scoring systems that increase diagnostic accuracy were found for patients with acute abdominal pain. Several factors have been reported to possibly contrib­ute to a low accuracy. First of all, performing a proper physical examination and collecting sufcient information could be difcult in patients belonging to extreme age groups (pediatric and elderly population). Furthermore, an interobserver differ­ence in the diagnostic accuracy has been reported. In daily practice, the resident rst examines the patient, while staff members will examine the patient afterward, usu­ally when the imaging has been already done [18].
The agreement between residents and staff is generally moderate for several aspects of medical history and physical examination (κ= 0.29–0.74) [9, 10]. The agreement between residents and emergency physicians for additional diagnostic imaging is sufcient (κ=0.6) [26].
Generally, residents and tutors are moderately in agreement regarding the anam­nestic assessment of the patients as well as regarding the physical examination, while the agreement on additional diagnostic imaging is considered to be sufcient.
Research of differences in diagnostic accuracy between residents and specialist physicians is hampered by a methodological difculty. The presentation can change over time, and so it can differ between the time of examination. This variability could inuence the reliability of the comparison. For these reasons, some authors have suggested the opportunity to have preliminary examinations carried out by two different observers, ideally under the same circumstances. Outpatient reevaluation of those ones suspected of nonurgent conditions led to a change in diagnosis in 35% of patients after clinical reevaluation, a change in management in 19% of cases, and a change from conservative to surgical treatment in 4.5% of patients [18, 27]. Moreover, outpatient reevaluation of patients suspected of nonurgent conditions after clinical evaluation and the performance of ultrasound led to a change in diag­nosis in 18% of cases, change in management in 13%, and a change from conserva­tive to surgical treatment in 3% of patients [18, 27].
G. Gallo et al.
3 Second Stage: Imaging Studies
Since the rst step of examination is often insufcient to reach a diagnosis, addi­tional imaging modalities could be used to increase diagnostic certainty. Several imaging modalities such as conventional (plain) radiography, ultrasound, CT scan, and magnetic resonance imaging (MRI) have been increasingly used over the years [4, 18]. Plain abdominal radiographs have played fundamental, even though contro­versial, roles in the assessment of NSAP.Some institutions still propose the use of a combination of plain chest radiography and the upright and supine plain abdomi­nal radiographs as known as the acute abdominal series (AAS), as the rst radio­logical screening in all patients with abdominal pain [4, 18]. The purpose of GAPEDES phase 1 study was to determine whether it was possible to derive a sensitive, easy to run, and reproducible clinical guideline for the evaluation of
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NSAP using history, physical examination, commonly available laboratory studies, AAS, and NHCT as potential inputs [6]. However, this guideline demonstrated low sensitivity and accuracy, not higher than 56% [18, 21, 28]. Indeed, it could be mis­leading in the workup of acute abdominal pain [29, 30]. Concerning the ultrasound (US) examination, the rate of correct diagnosis ranges from 53 to 83% of cases, according to the literature [21, 3133]. Not surprisingly, when compared with com­puted tomography, the sensitivity and specicity of ultrasound are denitely lower. However, ultrasound is widely available, cheap, and easy to run; also, during on-call hours, it carries no risk of ionizing radiation exposure or contrast-induced nephrop­athy, despite having a major drawback in the possibility of interobserver variability.
Previous studies have demonstrated how an early use of CT in the diagnostic workup of acute abdominal pain has led to a correct diagnosis in 96.8% of cases [4,
34], when combined with the previous investigations. Ideally, except for few
patients, such as children or pregnant women, in which US or MRI should be con­sidered the method of choice, CT should be considered the gold standard to guide treatment and avoid harmful delays [21, 30].
It is important to remember that computed tomography has major downsides such as the risk of contrast-induced nephropathy and exposure to ionizing radiation. The steering group advises the use of intravenous contrast in preference to other methods of contrast administration. Oral contrast administration delays computed tomography for hours, and other methods of contrast administration provide little additional information. However, the use of intravenous contrast media could lead to contrast-induced nephropathy (CIN) even if this evidence is based on studies with intra-arterial contrast administration. More recent studies have demonstrated that the risk of CIN is minimal when the eGFR (glomerular ltration rate) is above 45mL/min/1.73m2 [3537]. Preventive measures such as prehydration can decrease the risk of CIN.In daily practice, this might not be possible for every patient. In urgent situations, correctly diagnosing the underlying pathology (and subsequently earlier start of treatment) is more important than the possible risk of CIN.Therefore, computed tomography can be performed without preventive measures and without prior ultrasound in critically ill patients [18].
Due to the downsides of CT, an ultrasound is still preferred as the rst imaging modality. Only in critically ill patients, a computed tomography should be per­formed without a prior ultrasound; in other cases, a CT scan is recommended only when the ultrasound is negative or inconclusive [18, 21].
No trials have been performed analyzing the diagnostic value of MRI in patients with acute abdominal pain. Nowadays, some studies have demonstrated that MRI is sufciently accurate to diagnose appendicitis and diverticulitis [18, 38, 39]. The advantage of MRI over computed tomography is that no administration of contrast media is necessary and that there is no ionizing radiation exposure. The downside is that MRI scanners are not yet widely available and that the assessment of MRI images needs specic training [40]. For pregnant women with a suspicion of an urgent cause, an MRI should be contemplated, because of the serious consequences of a missed diagnosis [18, 38, 39].
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It has to be noted that, although the advanced utilization of modern imaging did not decrease the rate of NSAP, the rate of emergency surgery in NSAP was greatly decreased from 4% to 0.5% [15].
G. Gallo et al.
4 Wait andSee Policy
Hospitalization followed by active clinical observation, traditionally dened as “wait and see,” has been the most widely used method in the clinical management of patients with nontypical clinical signs. The predictive value of clinical diagnosis reached with this method, which varies with the underlying cause, has been esti­mated between 68 and 92% [14].
Previous studies demonstrated how approximately half of the patients admitted for observation is likely to undergo a surgical procedure during the rst admission.
However, on the one hand, this method entails risks for the patients because of possible complications such as peritonitis, hemorrhage, or infertility; on the other hand, laparotomy might be unnecessarily performed [16, 41].
A recent RCT (randomized controlled trial) demonstrated how patients who underwent delayed laparoscopy had a mean operative time equal to the mean opera­tive time in early laparoscopy group, and there was no higher morbidity nor mortal­ity. Therefore, the authors concluded that delaying surgery in NSAP patients does not increase operative risks or jeopardize clinical results.
Furthermore, this kind of approach could help avoiding unnecessary surgical procedures under general anesthesia [14, 45], and although patients treated by early laparoscopy had a shorter hospital stay (3.7 vs. 4.7days) and more accurate diagno­sis (83% vs. 45%), the greater accuracy did not show clear clinical benets (recur­rent pain at 12months: 16% vs. 25%, not signicant) [42].
In other words, delaying the decision to submit patients with persistent symp­toms and without a denite diagnosis to a laparoscopy of 24–72h from admissions could reduce the number of unnecessary surgical operations.
5 Third Stage: Diagnostic Laparoscopy
So far, if the diagnosis remains uncertain or CT is not accessible, the next step in the management of NSAP should be represented by diagnostic laparoscopy (DL).
The available studies on the value of diagnostic laparoscopy in case of NSAP have enrolled patient samples not representative for the current clinical practice. These studies have not included preoperative imaging in the diagnostic assessment.
Few RCTs compared the role of early laparoscopy with the traditional “wait and see” approach in the management of NSAP [13, 14, 43].
Two of these studies presented at least one major limitation, such as the limited number of patients, [13] insufcient preoperative evaluation, [43] and enrolling both males and females. Furthermore, in these studies, the diagnostic laparoscopy itself is used as reference diagnosis.
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Another RCT focused on acute right iliac fossa pain in young women and concluded that, on the one hand, early laparoscopy results in a higher number of denite diagnosis and in a shorter hospital stay when compared with active observation. On the other hand, morbidity, mortality, and costs are similar [14]. In addition, in patients submitted to laparoscopy, the policy to remove the appendix, if no other clear causes of pain were found, was adopted in accor­dance with the data showing that the external inspection of the appendix at lapa­roscopy is an unreliable nding for the presence of appendicitis [14, 44]. Greason etal. [44] showed that routine appendectomy during diagnostic lapa­roscopy does not increase morbidity and does not prolong hospital stay. However, the study clearly showed that removing a “normal looking” appendix has a limited clinical role when the follow-up is adequate.
The actual literature has demonstrated that, in selected patient populations where no prior diagnostic imaging has been performed, a diagnostic laparoscopy can accu­rately diagnose the cause of the abdominal pain in 80–94% of patients [14, 18, 41,
43]. Postoperative complications have been reported in 3.5–25% of patients after
diagnostic laparoscopy [18, 41, 42, 44, 45].
Contraindications for DL do not differ from the ones for exploratory laparotomy, except for patients unable to tolerate pneumoperitoneum and those with a tense and distended abdomen (i.e., clinically suspected abdominal compartment syndrome) [14, 46].
In the past few years, imaging modalities have signicantly improved in diag­nostic accuracy. Treatment of the causes of acute abdominal pain has been modi­ed thought the years and it does not always involve a surgical approach. Compared with imaging modalities, diagnostic laparoscopy has a higher risk of complications.
Reported complications range from severe complications such as septic shock and enterocutaneous stula to wound infections.
Therefore, based on the current literature, no conclusions can be drawn on the added value of a laparoscopy in the diagnostic pathway of patients with acute abdominal pain. However, laparoscopy should not be used in the diagnostic path­way of patients when no sufcient prior imaging has been performed. Only in patients with a high suspicion of an underlying life-threatening cause, with incon­clusive imaging, a DL could be contemplated.
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6 Conclusions
Although attempts have been made toward developing consensus guidelines and diagnostic algorithms, no prospective evidence-based clinical guidelines for the exclusion of NSAP have been developed or validated to date [4, 14, 18]. The neces- sity to achieve a correct diagnosis and a systematic approach to NSAP should be useful in order to reduce the admission rate for NSAP because of the costs and morbidity associated with this condition in terms of excessive hospital stay, multiple investigations, and unnecessary surgical explorations [4, 14, 18]. In other words,
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G. Gallo et al.
what Poulin etal. wrote still remains actual: “management of acute NSAP needs to be periodically adjusted to get the best outcomes at the lowest costs and with the least invasive and most appropriate diagnostic tools” [46].
Conict of Interest All authors declare no personal conict of interest.
Ethical Approval Not required.
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Management ofBariatric Surgery Early
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andDelayed Complications
UriKaplan
1 Introduction
According to the World Health Organization (WHO), obesity rates have almost tri­pled in the last four decades [1]. It carries a signicant public health concern and is associated with increased risk to develop chronic diseases such hypertension, diabe­tes mellitus, hyperlipidemia, and obstructive sleep apnea. Obesity negatively inu­ences patient’s morbidity and mortality.
Bariatric surgical procedures have been shown to be the best treatment option for achieving sustained weight loss and remission of obesity-related comorbidities [2,
3]. Nowadays, most bariatric cases are performed in centers of excellence by trained
bariatric surgeons as part of multidisciplinary teams. These factors improve signi­cantly the outcome of bariatric surgery.
The rapid development of laparoscopic instrumentation in the early 1990s had led to surge in bariatric procedures. Data comparing laparoscopic to open gastric bypass found that laparoscopic approach was associated with less complications, shorter hospital stay, and equivalent loss of excess weight [4]. In the last 20years, with further advancement of laparoscopic bariatric surgery, this approach has become the standard of care. Nowadays, postoperative admissions are short, and some bariatric procedures are performed in outpatient clinics.
The aim of this chapter is to review both early and late bariatric procedure com­plications. We’ll provide diagnostic tools and treatment option for patients who present to the emergency department.
U. Kaplan (*) General Surgery B, Emek Medical Center, Afula, Israel
Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 F. Coccolini et al. (eds.), Mini-invasive Approach in Acute Care Surgery, Hot Topics in Acute Care Surgery and Trauma,
https://doi.org/10.1007/978-3-031-39001-2_21
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U. Kaplan
1.1 General
1.2 Epidemiology
Obesity has become a global epidemic and currently is one of the major public health challenges. According to the WHO, in 2016, 39% of adults (more than 1.9billion) in the world were overweight (dened as body mass index (BMI) 25kg/m2) and 13% (over 650million) were obese (dened as BMI 30kg/m2) [1]. In 2014, the global prevalence of morbid obesity (BMI 40 or BMI 35 with at least one obesity-related comorbidity) was 0.64% in men and 1.6% in women [5]. There are disparities in the prevalence of obesity across countries. This trend continues within the country among sex, age, ethnic group, and socioeconomic status [6].
Commonly performed bariatric procedures have a morbidity rate between 5 and 10%. In 5% of them, the complications will happen at home [7]. With that being said, the rate of emergency department (ED) visits of bariatric patients is much higher. The rate of ED visits, within 30days of surgery, is around 11% of patients. The readmission rate is between 4.4 and 5.5%. Around 50% of those visits and readmissions occur in hospitals other than the one where the bariatric procedure was performed [8, 9].
1.3 Types ofBariatric Surgery
Knowledge regarding the gastrointestinal tract anatomical changes post-bariatric sur­gery is a key factor in the management of patients with post-surgical complications.
Historically, bariatric procedures were classied as either restrictive, reducing the volume of food patients can digest; malabsorptive, reducing the absorption of food at the mucosal level; or both. However, it is reasonable to associate the bene­cial inuence of surgery on the body adipose system as the key factor for bariatric surgery success [10]. The inuence of bariatric surgery on the adipose system is beyond the scope of this chapter.
Clinical practice guidelines for bariatric surgery are well established [11, 12]. The fth International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) global registry report contains data from over 60 countries on over 833,000 operations [13]. According to it, in 2019, the four most common operations world­wide were sleeve gastrectomy (SG) (58.6%), Roux-en-Y gastric bypass (RYGB) (31.2%), omega anastomosis gastric bypass/mini gastric bypass (OAGB/MGB) (4.1%), and adjustable gastric band (AGB) (3.7%). Over the last decade, there is a trend toward reduction in gastric banding and RYGB, while there is a rise in SG and OAGB/MGB procedures. Nowadays, almost all bariatric procedures are performed laparoscopically (99.1%) [13]. Currently, there is no evidence regarding which oper­ation suits each patient, and that is the main reason for many operative options.
1.3.1 Sleeve Gastrectomy (SG)
The operation was developed as a rst stage for duodenal switch operation however, due to comparable outcomes, became a stand-alone procedure. Most of the stomach