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The Role ofContrast Media inCTC:
https://t.me/medicina_free
Types, Usage, Allergic Reactions,
andPatient Safety
RachelBaldwin-Cleland andStephenWilson
8
8.1 Introduction
Although CT colonography (CTC) has been
described as safer than optical colonoscopy (OC)
[1, 2], it still has the potential for adverse events
[2]. Departments offering CTC examinations
must have appropriate training and procedure
guidelines to cover events such as colonic perforation, obstruction, and vasovagal reactions.
Images should be reviewed during and after the
procedure for colonic perforation and staff must
be fully trained in recognising the appearance of
a perforation within CTC images. Patients should
be observed for a period of time and ideally be
provided with a beverage before they can safely
leave the hospital [3].
Bowel preparation and techniques for optimising distension are covered in Chaps. 9 and 10.
However, the focus of this chapter is on medications which may be used, patient comfort and
safety during the CTC pathway.
R. Baldwin-Cleland (*)
Intestinal Imaging Unit, London North West
University Healthcare NHS Trust-St Marks Hospital,
Harrow, Middlesex, UK
e-mail: r.baldwin@nhs.net
S. Wilson
Diagnostic Imaging, Peterborough City Hospital,
Peterborough, UK
e-mail: stephen.wilson3@nhs.net
8.2 Oral Contrast Within Bowel
Preparation
The use of oral contrast as a faecal tagging agent
has become integral to the CTC procedure and
has resulted in the increased sensitivity of the
test to rival OC [4]. There remains no standardisation in preparations or protocols for CTC, and
these can further differ between hospitals due to
individual contracts, pharmacy availability, and
clinician preferences. Research has shown that
the use of sodium amidotrizoate 100 mg/meglumine amidotrizoate 660 mg (Gastrogran®) as
both a laxative and faecal tagging agent
combined with an effective 24h low residue diet
[5] or clear liquid diet [6] can result in highly
diagnostic images. The high osmolality of
Gastrogran® draws uid into the colonic lumen
and increases the density of the residual uid
[7]. Further research into this has shown using
Gastrogran® in a split bolus regime (75 mL/25
mL) split 24h prior to the test consistently gives
better colonic lavage and impacts the patient
less, although this study was of 100 patients
with a mean age of 76years [8]. However, with
the use of Gastrogran® any remaining intraluminal uid is of low viscosity, identiable as
‘tagged uid’ and moves easily with the movement of the patient [8]. Therefore, the use of
faecal tagging is recommended by gastrointestinal imaging groups in optimising CTC outcomes [3, 9].
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
J. H. Bortz et al. (eds.), CT Colonography for Radiographers,
https://doi.org/10.1007/978-3-031-30866-6_8
81
82
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R. Baldwin-Cleland and S. Wilson
a b
Fig. 8.1 (a) Residual high-density ‘tagged’ uid (red arrow) is seen as bright white on the supine CTC image. (b)
Untagged uid (red arrow) will be seen as much darker, with an almost soft tissue density
Figure 8.1a, b shows CTC images of tagged
and untagged bowel preparation.
The use of oral contrast, to provide faecal/
uid tagging, enables a reader to more easily
distinguish between faecal residue and colonic
pathology. This improves both positive predictive
values (PPV) for small polyps and the adequacy
rate of the test [5]. Most recent literature on CTC
encourages faecal tagging to help improve reader
condence when reporting and reduce falsepositive ndings [3, 9–11]. As well as increasing
the sensitivity of CTC, faecal tagging decreases
the necessity of a residual dry bowel, as required
in endoscopy procedures [12]. Pathology within
tagged uid can be clearly differentiated when
combined with adequate distension and low faecal residue preparation as shown in Fig.8.2a–d.
An optimum residual uid value of 900–1100
HU increases the readers condence in discounting potential pathology (200 HU) from adhered
faecal matter (900 HU) [8, 13, 14].
With regard to the choice of preparation
regime, cost, image quality, reader accuracy,
patient tolerance, and overall test experience
must be considered. The historic use of sodium
picosulfate (Dulcolax®; Boehringer Ingelheim—
Germany or Picolax®; Ferring Pharmaceuticals
Ltd.—UK), combined with an oral contrast agent
(such as Gastrogran®) or an orally ingested
intravenous (IV) contrast agent (such as
Omnipaque®, Visipaque® or Niopam®), can be
effective, but high sodium preparations can result
in signicant electrolyte imbalance and renal toxicity within the frail patient [10].
The United Kingdom (UK) NHS National
Patient Safety Agency alert issued guidance in
2009 covering the use of Picolax®, Citramag®,
Fleet Phospho-Soda®, Klean Prep® and
Moviprep® along with their distribution prior to
interventional procedures, due to one death and
218 safety incidents occurring after ingestion of
these types of medications prior to a medical procedures [15]. The NHS National patient safety
agency stipulates that a clinical assessment must
be undertaken by the clinician referring and
authorising the CTC (including general practitioners using the direct access route), which must be
documented on the referral form to ensure that
there is no contraindication [15]. The supply of
the medicine must be authorised by a clinical
professional, and each patient must receive written information (including named contact) and an
explanation on the safe use of the product [15].
This is now a compulsory practice in the UK for
distribution of these bowel preparation products.
Gastrogran® was not listed in the alert, but it is
still best practice to include it to ensure the same
safety standards.
Patient bowel preparation instructions should
advise patients to remain hydrated and continue
consuming approximately 250 mL of nondiuretic uids per hour whilst awake [16]. If this
ab
cd
8 The Role ofContrast Media inCTC: Types, Usage, Allergic Reactions, andPatient Safety
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83
Fig. 8.2 (a) Supine image of a patient who was adminis-
tered oral tagging as part of bowel preparation shows two
polyps (red arrows) in the sigmoid colon surrounded by
faecal tagging. (b) Supine image of a patient who was
administered oral tagging as part of bowel preparation
shows an annular carcinoma in the descending colon (red
is not followed, there is a risk of hypokalaemia
(low potassium) and requires prompt medical
attention to restore the uid/electrolyte
imbalance. If left unresolved hypokalaemia can
be serious in the frail and debilitated patient [16].
Previously, it was recommended that a recent
eGFR (estimated glomerular ltration rate) level
within the past 3months should be obtained, and
values less than 40 mL/min/1.73 m2 should be
discussed between consultant clinicians to
decrease the possibility of a contrast-induced
acute kidney injury (contrast nephrotoxicity/
radio-contrast nephropathy) due to dehydration
from the bowel preparation [17]. Newer guidelines do not recommend specic eGFR levels for
patients in relation to oral intake of faecal tagging
contrast media, but do recommend correction of
arrow). (c) Supine image of a patient who was administered
oral tagging as part of bowel preparation shows a lipoma in
the sigmoid colon (red arrow). (d) Supine image of a
patient who was administered oral tagging as part of bowel
preparation shows a very large pedunculated polyp in the
transverse colon lying in a pool of tagged uid (red arrow)
dehydration or severe electrolyte disturbances
prior to the administration of oral iodinated contrast media where possible, with electrolyte monitoring in severely ill patients or those with severe
diarrhoea and/or vomiting [18]. They also recommend the same precautions should be taken as
intravascular contrast use in relation to anaphylactic reactions [18].
The delivery of pharmaceuticals to patients by
special delivery mail within the UK has been successful at specic institutions. However, not all
institutions operate this service so the feasibility
of offering a service of this nature must be discussed with individual departments. Careful
packaging, tracking each individual parcel, clear
medicines label with patient details, and the
inclusion of the appropriate literature with the
84
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R. Baldwin-Cleland and S. Wilson
a
b(i)
c
b(ii)
Fig. 8.3 (a) Patient 1: large polypoidal mass within the
caecum (red arrow) including the ileocaecal valve. This
mass is not obstructing as the small bowel and large bowel
contain very little faecal matter and there is tagging seen
throughout. The patient is still a priority but does not
require emergency admission. Radiographers should however ag this for urgent reporting. (b) (i) and (ii). Patient 2:
images from the same CTC.The patient is imaged in the
left lateral decubitus position (left side down). In (b) (i),
there is no obstructing mass, but the small bowel contains
a large amount of contrast (red arrow). In (b) (ii), both
tagged and untagged faecal matter can be identied in the
enclosed medication are essential to avoid ingestion by an individual other than the intended
recipient. Figure8.3a–c demonstrates the role of
tagging in a CTC study. Staff reviewing images
must be aware of the appearances of tagging contrast within the small bowel and its signicance.
A patient with an iodine allergy or high sensitivity may be referred for a CTC.Historic shellsh or strawberry allergy must not be confused
with a specic iodine allergy, and there remains
no link between high sensitivity and iodine-based
distal sigmoid (red arrow) and untagged faeces (green
arrow) can be seen in the rectum. The untagged faeces in
the rectum suggest noncompliance with the preparation
instructions. This, along with the small bowel tagging is
consistent with either the bowel preparation being ingested
later than instructed, or slow motility such as delayed gastric emptying. Such patients do not need emergency admission. (c) Patient 3: a large amount of tagging remains
within the small bowel accompanied with ascites (red
arrows) within the abdomen and pelvis. The patient has an
obstructing mass and needs urgent surgical review and
should not leave the hospital without this review
oral/IV contrast agents [17, 18]. If a patient has a
documented IV contrast allergy, then an untagged
CTC or a catharsis regime with barium tagging
may be discussed with your clinicians depending
on your department’s protocols [19]. The drawback with untagged studies is residual faecal matter, which may mimic or obscure pathology,
especially within areas of poor distension [12].
Some institutions routinely use barium-based
tagging, but a change in diet and bowel cleansing
must be used in conjunction [20]. Perforation of
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