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11 The Use of Radiofrequency for Facial Rejuvenation
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Erez Dayan and Christopher T. Chia
Abstract
A treatment gap exists among patients who are not candidates for or prefer to not undergo tradi­tional facelift and/or necklift. In these cases, radio­frequency has been shown to achieve approximately 30% soft-tissue contraction through thermal injury to the dermis and underlaying fibroseptal networks. Subsequent collagen remodeling angiogenesis, lym­phangiogenesis, as well as elastin reorganization function to visibly improve soft-tissue laxity in these cases.
Keywords: radiofrequency skin tightening, radio­frequency, FaceTite, bipolar radiofrequency
Key Points
Through impedance of electromagnetic cur­rent, radiofrequency (RF) energy leads to dif­ferential heating across distinct tissue types consistent with Ohms law (energy = current impedance × time). For example, adipose tissue is less conductive than water (higher impedance), and leads to generation of higher temperatures than muscle. Once soft-tissue temperatures reach 50 °C and skin surface reaches from 40 to 42 °C, there is a trigger to induce neocollagenesis, angio­genesis, and elastogenesis.
Through dierent applications of RF energy (i.e., monopolar, bipolar, multipolar, microneedling), subdermal adipose remodeling (SAR) and long­term soft-tissue contraction can be safely and consistently achieved.
2
11.1 Patient Considerations
Radiofrequency (RF) treatment of the face and neck area is intended for the treatment gap patient population (30s–50s). This typically refers to patients who have some soft-tissue laxity that is not severe enough for an excisional procedure (Fig. 11.1 and Fig. 11.2). A detailed medical his­tory and physical is obtained on all patients prior to treatment. Exclusion criteria include the following: pregnancy, open wounds, active infection, dermato­logic conditions, bleeding disorders, immunocom­promised state, and implantable devices. Patients
who have excessive laxity (i.e., advanced age, massive weight loss) require excisional proce­dures and are not optimal ca ndidate for RF skin tightening.
Risks and benefits are discussed at length includ­ing the possibility for thermal injury, sensory and/ or motor nerve injury, or poor contour/scarring. Patients are counseled at length regarding ex­pectations. It is important for patients to have a clear understanding that RF treatments deliver a controlled thermal energy, which ultimately is in­tended to upregulate growth factors such as vascu­lar endothelial growth factor (VEGF) to allow for neocollagenesis, angiogenesis, elastin remodeling, and lymphangiogenesis. and dependent on the patientsoverall soft-tissue contraction after treatment. Often, we counsel pa­tients on excisional options ahead of time as poten­tial revisional procedures (i.e., mini-facelift/neck lift) in the event that the RF treatment does not provide satisfactory soft-tissue contraction.
×
Patients are marked in the sitting position by first identifying the mandibular border and jowls bilaterally. The jowls were subdivided into zone 1 (above the mandibular border) and zone 2 (below the mandibular border). Areas of localized adipos­ity in the lower face and neck region are marked. Nontreatment zones are identified by carrying a line inferiorly perpendicular to the lip commissures (i.e., marionette lines). The area medial to these lines are avoided to preserve marginal mandibular innervation to the depressor anguli oris, mentalis, and depressor labii inferioris. Five access points are identified: (1) the submental midline, (2) 1 to 2 cm inferior to the mandibular parasymphyseal/body junction, and (3) two postauricular sites. Depending on clinical circumstances and patient desires, cases were performed under either general or local anesthesia. In cases of local anesthesia, patients were premedicated with oxycodone (5 mg) and/or benzodiazepine (5 mg).
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
1
The result can be variable
11.2 Technique
The patient is placed in a supine position and is prepped and draped in the standard fashion. Water-soluble sterile ultrasound gel is placed over the treatment areas. Access sites are each injected
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with 2 to 4 mL of 2% lidocaine with epinephrine. Typically, these access ports are inferior to each ear lobule and at the submental midline for full access to the central and lateral neck. A 14-gauge needle is then used to make access ports that are slightly dilated with Stevens scissors. A spinal needle was used to slowly infiltrate tumescent solution (1 g lidocaine per liter of lactated Ringers solution) from deep to superficial, starting in the preplatysmal plane and moving to the subdermal plane (~100– 150 mL of tumescent total). At the conclusion of tu­mescent infiltration, the cannula was passed throu gh the subdermal plane to confirm adequate analgesia and to allow f or discontinuous undermining.
Bipolar RF is performed first using the FaceTite (InMode, Lake Forest, CA) probe. The devices in­ternal and external thermometer is tested on the surgeons hand prior to treatment and confirmed to be appropriately recording temperatures. The RF settings included an internal temperature cutoof 68 °C and external cutoff temperature of 38 °C. These temperatures are preset and the device will automatically regulate temperatures to not exceed these limits. Soft-tissue contraction is a function of time versus temperature in an Arrhenius relation­ship. This means that a similar soft-tissue contrac­tion can be achieved in two scenarios: (1) higher temperature for a shorter time or (2) lower temper­ature for a longer time. We believe that the afore­mentioned temperature settings allow for a safe yet ecient soft-tissue contraction. The RF cannula is used to pretunnel treatment areas for ease of treat­ment and to ensure that the cannula does not become misguided during treatment. The predeter­mined treatment areas are systematically heated row by row to avoid heat loss when treating wide areas. RF application is applied on retrograde move­ment of the cannula and stopped within 1 cm of the access port to prevent overheating this area at each pass. Audible and visual cues from the RF con­sole are used to assess temperature of tissues and treatment is stopped after 1minute of reaching tar­get internal and external temperatures. The device automatically provides a double and subsequent triple beep once target temperatures are reached internally and externally.
Fractional RF (Fractora modif ied to Morpheus8, InMode) is subsequently used at a depth of 4, 3, and 2 mm and energy of 30 with 50% overlap. The handpiece is applied firmly and perpendicular to the treatment area prior to delivery of RF energy pulses. In patients with thinner skin or darker Fitz­patrick types, energy settings are reduced by 20%.
The addition of fractional RF provides subdermal thermal injury, which remodels reticular dermis and also improves soft-tissue texture, as opposed to bipolar RF, which focuses energy on the fibrosep­tal networks. At the conclusion of the treatment, the patients’ facial nerve function is assessed. This is compared to the assessment performed preoper­atively. Specific attention is paid to the patients marginal mandibular nerve function. In cases of neuropraxia, it is noted in the patientsrecord and reassessed in follow-up visits to ensure that it is ei­ther from the local anesthesia eect or temporary due to heat or traction injury. In the authors’ expe- rience, neuropraxia is uncommon (2–3% of cases) and resolves over the coming 4 to 8 weeks. Patients are seen at intervals of 1 week and 1, 3, and 6 months for follow-up.
11.3 Postoperative Care
Patients are seen at 1-week and 1-, 3-, and 6­month intervals.
Patient are instructed to not use any skin prod­ucts for the first 3 to 4 days after fractional RF treatment.
The usual postoperative course involves some edema and ecchymosis. This typically resolves in 1 week.
A facelift-type headwrap with moderate com­pression is applied for 3 to 4 days.
Patients are instructed to not use cold com­presses.
Most patients return to work the next day.
11.4 Common Pitfalls
Proper marking of the patient and identifying danger zones are key to avoid heating distal as­pects of the marginal mandibular nerve.
Avoid patients with excessive soft-tissue laxity who are more fit for excisional procedures.
Use of ample tumescent functions as a heat sinkto avoid thermal injury and also allows for optimal transmission of RF injury.
11.5 Case Examples
11.5.1 Case 1
A 34-y ear-old woman 6 months after radiofrequency-assisted liposuction of the lower face and neck using FaceTite (InMode; Fig. 11.1).
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11.6 Conclusion
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Fig. 11.1 (ae) A 34-year-old woman 6 months after radiofrequency-assisted liposuction of the lower face and neck
using FaceTite (InMode).
11.5.2 Case 2
A 24-year-old woman 8 months after radiofrequency-assisted liposuction of the lower face and neck using FaceTite (InMode; Fig. 11.2).
11.6 Conclusion
Internal and external generation of heat via com­bined bipolar RF and fractional RF serves to initiate neocollagenesis, elastogenesis, and subderm al
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Fig. 11.2 (ae) A 24-year-old woman 8 months after radiofrequency-assisted liposuction of the lower face and neck using FaceTite (InMode).
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References
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Video 11.1 Marking for bipolar radiofrequency of the
lower face and neck.
adipose remodeling. This, in combination with fibroseptal network tightening, allows for safe and consistent soft-tissue contraction to improve lower face and neck soft-tissue laxity. This particu­larly benefits patients who previously may have fallen into a treatment gap.
11.7 Expert Commentary by Dr. Slavin
The advances in this area are impressive in terms of their ability to address the treatment gap on pa­tients who, for a number of reasons, are either not surgical candidates or prefer to not have a mini­facelift or neck lift. The RF technique addresses this growing population of patients that a plastic sur­geon sees daily. It is extending skin tightening to an ever-younger population who may otherwise not seek treatment by plastic surgeons. It is reas­suring that the incidence of nerve injury remains lowestimated by the authors at 2 to 3%and we hope that it continues to decline. We appreciate the authorspoint that a mini-facelift may be re­quired, in addition.
The plastic surgeon will need to determine which patients would best benef it from RF com­pared with the traditional techniques. It will be important to stress to the patients that the results may be variable and we foresee challenges in cau­tioning patients on the degree of improvement that can be delivered. Looking into the f uture, it is reasonable to expect every plastic surgeon per­forming cosmetic surgery on the face and neck to be very knowledgeable about these techniques (Video 11.1 and Video 11.2).
Video 11.2 Fractional radiofrequency using Morpheus8 (InMode; Lake Forest, CA).
11.8 Expert Commentary by Dr. Lin
The authors have addressed an important aspect of caring for the aesthetic patient: those who are not surgical candidates who wish to have treatment who fall into the treatment gap.” Devices for deliv- ering energy have been developed over a long peri­od of time, and in this current state I appreciate the authors’ ability to realistically balance the results of various minimally invasive results. The use of en­ergy in higher Fitzpatrick score patients poses a risk and so the authors describe their treatment modifi­cation in their chapter. In these patients, I would personally consider a test area away from the planned treatment area as an option.
References
[1] Dayan E, Chia C, Burns AJ, Theodorou S. Adjustable depth
fractional radiofrequency combined with bipolar radiofre­quency: a minimally invasive combination treatment for skin laxity. Aesthet Surg J. 2019; 39 Suppl_3:S112–S119
[2] Theodorou SJ, Del Vecchio D, Chia CT. Soft tissue contraction
in bodycontouring with radiofrequency-assisted liposuction: a treatment gap solution. Aesthet Surg J. 2018; 38 suppl_2: S74–S83
[3] Alster TS, Tanzi E. Improvement of neck and cheek laxity
with a nonablative radiofrequency device: a lifting experi­ence. Dermatol Surg. 2004; 30(4, Pt 1):503–507, discussion 507
[4] Bassichis BA, Dayan S, Thomas JR. Use of a nonablative radio-
frequency device to rejuvenate the upper one-third of the face. Otolaryngol Head Neck Surg. 2004; 130(4):397–406
[5] Burns AJ, Holden SG. Monopolar radiofrequency tissue tight-
ening: how we do it in our practice. Lasers Surg Med. 2006; 38(6):575–579
[6] Burns JA. Thermage: monopolar radiofrequency. Aesthet Surg
J. 2005; 25(6):638–642
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[7] Dierickx CC. The role of deep heating for noninvasive skin re-
juvenation. Lasers Surg Med. 2006; 38(9):799–807
[8] Doshi SN, Alster TS. Combination radiofrequency and diode
laser for treatment of facial rhytides and skin laxity. J Cosmet Laser Ther. 2005; 7(1):11–15
[9] Abraham MT, Mashkevich G . Monopolar radiofrequency
skin tightening. Facial Plast Surg Clin North Am. 2007; 15 (2):169–177, v
[10] Abraham MT, Vic Ross E. Current concepts in nonablative ra-
diofrequency rejuvenation of the lower face and neck. Facial Plast Surg. 2005; 21(1):65–73
[11] Alexiades-Armenakas M, Dover JS, Arndt KA. Unipolar versus
bipolar radiofrequency treatment of rhytides and laxity using a mobile painless delivery method. Lasers Surg Med. 2008; 40(7):446–453
[12] Kaplan H, Kaplan L. Combination of microneedle radiofre-
quency (RF), fractional RF skin resurfacing and multi-source non-ablative skin tightening for minimal-downtime, full­face skin rejuvenation. J Cosmet Laser Ther. 2016; 18(8): 438–441
[13] Lee HS, Lee DH, Won CH, et al. Fractional rejuvenation using
a novel bipolar radiofrequency system in Asian skin. Derma­tol Surg. 2011; 37(11):1611–1619
[14] Levy AS, Grant RT, Rothaus KO. Radiofrequency physics for
minimally invasive aesthetic surgery. Clin Plast Surg. 2016; 43(3):551–556
[15] Narurkar VA. Lasers, light sources, and radiofrequency devi-
ces for skin rejuvenation. Semin Cutan Med Surg. 2006; 25 (3):145–150
[16] Sadick N, Rothaus KO. Minimally invasive radiofrequency de-
vices. Clin Plast Surg. 2016; 43(3):567–575
[17] Sadick N, Rothaus KO. Aesthetic applications of radiofre-
quency devices. Clin Plast Surg. 2016; 43(3):557–565
[18] Zelickson BD, Kist D, Bernstein E, et al. Histological and ultra-
structural evaluation of the eects of a radiofrequency-based nonablative dermal remodeling device: a pilot study. Arch Dermatol. 2004; 140(2):204–209
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12 Neck Lift and Fat Grafting to the Neck
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Aris Sterodimas
Abstract
Facial rejuvenation is becoming increasingly chal­lenging because patients request minimally inva­sive surgery and rapid surgical course and recovery, along with fast, tangible, and long-term results. Re ju­venation of face, neck, and periorbital areas needs to be addressed at the same surgery. At our institution, a systematic approach comprising all of these proce­dures has been developed, with consistent results. Our research group has already described the meth­od of stromal enriched lipograft (SEL) in various parts of the body, a procedure combining fat with enzyme-based extraction of the stromal vascular fraction (SVF), with the aim to increase the take and duration of the grafted fat and the related volume, thereby determining a more predictable and stable result in terms of graft survival in the face, and also improving the skin quality. Recently, a helium-based plasma technology has been introduced for the per­cutaneous delivery of plasma energy for the purpose of soft-tissue coagulation and contraction. A signifi­cant skin and soft-tissue contraction in a smooth and even manner is accomplished in the neck area. Facial harmony not only depends on achieving a more natural, tense, and young conformation but also on restoring volumes and improving the quality of the faci al and neck skin.
Keywords: stromal enriched lipograft, fat grafting, face, neck tightening, facelifting, skin tightening, radiofrequency, minimally invasive, helium plasma
Key Points
In this chapter, the technique, the pearls, and the pitfalls of the SEL technique for facial fat grafting and the application of cool helium plas­ma radiofrequency technology for neck tighten­ing are described in detail. A series of patients who underwent contouring of the neck and facial lipotransfer assisted by SEL are presented.
Careful selection of patients and proper surgical technique help avoid contour irregularity, and outcome expectations should be based on real­istic preoperative evaluation of the patients age, skin elasticity, and volume of fat to be transplanted.
The SEL technique aims at filling facial atrophy areas with adipocytes and adipose-derived stem cells that will survive and become incorporated into the recipient bed.
Improvement of the neck contour can be attained and maintained through the application of the percutaneous delivery of plasma energy (Renu­vion) for the purpose of soft-tissue coagulation and contraction.
The SEL technique and the application of Renu­vion technology can play a significant role as minimally invasive techniques for face and neck rejuvenation when properly indicated.
12.1 Introduction
The aging of the face is a complex set of events, determined by skin and superficial musculoapo­neurotic system (SMAS) laxity and redundancy, re­absorption of fat, and diminution of projection on many face prominences, as well as thinning of the dermis and decreased quality of the cutaneous draping. evident in the face. Changes aecting the appear­ance of the neck can include an increase or decrease of subcutaneous fat, platysmal banding, jowling, and skin laxity. Depending on the severity, a range of treatment options is available for use alone or in combination for treating the aging neck. Face rejuvenation is increasingly challenging as patients expect minimally invasive procedures and rapid postt reatment course and recovery, along with fast, tangible, and long-term results. Rejuvenation of the face frequently requires sur­gery to multiple areas (the lateral face, the mid­face, the neck, and periorbital areas), in addition to the increasing procedures of face sculpturing and biostimulation through fat injection. At our insti­tution, a systematic approach including all of these procedures has been developed, with consistent results. involve the traditional facelifting surgical proce­dure, there is a continuous shift toward minimally invasive techniques that have promoted the advent of techniques and devices that oer an alternative to the traditional facelifting techniques.
method of stromal enriched lipograft (SEL) in various
1
The outward signs of aging can be very
2,3
Although the gold standard continues to
Our research group has already described the
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parts of the body, a procedure combining fat with enzyme-based extraction of the stromal vascular fraction (SVF), with the aim to increase the take and duration of the grafted fat and the related volume, thereby determining a more predictable and stable result in terms of graft survival.
4,5,6,7
The debulking of fat with suction-assisted lipo­suction has been shown to provide approximately 10% shrinkage as a result of a simple deflation eect on the skin envelope and nonthermal inflammation of the fibrocollagenous matrix that in turn gener­ates new blood vessels, collagen, and scar tissue. Several technologies including laser, ultrasound, and radiofrequency (RF) have demonstrated some skin tightening after liposuction beyond the normal deflation that accompanies the removal of fat and beyond the nonthermal skin contraction that ac­companies subdermal inflammatory stimulation by the cannulas. The mechanisms of action for subcu­taneous RF devices include the generation of heat through tissue resistance within the dermis and fat that results in neocollagenesis, elastin and dermal matrix remodeling, and mild adipocyte loss. The contraction of the subcutaneous tissue by deeper application of cool helium plasma RF technology is felt to be an additional mechanism that results in additional neck contouring by soft-tissue contrac­tion. The reduction in volume and tissue surface area is the result of protein denaturation and colla­gen contraction after a thermal energy threshold
9
has been transmitted to the tissue.
Recently, a plasma-driven RF device, Renuvion, was introduced and Food and Drug Administration (FDA) cleared for soft-tissue coagulation. The Renuvion system for the neck utilizes cold helium plasma via a gas ion­ization process to produce a stable, focused beam of energy.
12.2 Patients and Methods
Accurate photographic documentation has become essential in cosmetic plastic surgery for both clinical and scientific purposes. Generally, informed con­sent requires that a patient be informed of the risks of treatment, prognosis, and alternative treatments before consenting to treatment. Surgical consent is an ongoing process of communication that contin­ues throughout preoperative, perioperative, and postoperative care. Areas to be treated typically are marked with a circle in a topographic pattern. Zones of adherence and areas to avoid are marked with hash marks. Grid markings are made in order
to standardize resection and reduce contour irregu­larities. Incisions should be placed in natural creases to minimize visibility. It is important to re­view all markings and access incision locations with patients in front of a mirror before performing the surgical procedure.
12.3 Surgical Technique and Fat Processing and Grafting
Markings of the neck area to be lipoaspirated
8
and treated with Renuvion are made while the patient is in the standing position, as well as markings on the face lipograft recipient sites.
Preoperative sedation in the surgical suite is administered. The procedure is performed under sedation, in the supine position. Intra­operative intravenous cefazolin is administered at induction.
After injecting into the neck subcutaneous tissue normal saline wetting solution c ontainin g 1:500,000 of adrenaline by a small-bore cannula and waiting 15 minutes, a 20-mL syringe attached to a 2-mm blunt cannula is inserted through small incisions in the postauricular crease. Fat is aspirated by a 2-mm four-hole aspiration blunt­tip cannula connected to a 20-mL Luer-Lok syringe. The distal openings of the harvesting can­nula are of an appropriate size and shape for har­vesting the largest intact fatty tissue parcels that can readily pass through the lumen of a Luer-Lok syringe. The combination of slight negative pres­sure and the curetting action of the cannula’s motion through the tissues allows parcels of fatty tissue to move through the cannula, through the Luer-Lok aperture, and into the barrel of the syringe with min imal mechanical damage.
When liposuction is done, the specific Renuvion probe for the neck region produced by Apyx Medical (Clearwater, FL) is then used. The cool helium plasma RF technology has been adapted to draw skin closer to underlying fascia via coag­ulation of the interstitial connective tissue bands. In the Renuvion system, RF energy from an electrosurgical generator unit is delivered to a handpiece and used to energize an electrode. Helium plasma is generated as helium gas passes over the energized electrode, allowing heat to be applied to tissue in two dierent and distinct ways. The plasma beam provides heat through the ionization and rapid neutralization of helium atoms. A portion of RF energy that
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passes through the tissue impedance generates a small amount of additional heat. The device is activated until a preset subcutaneous tempera­ture in the range of 75 to 85 °C is achieved and maintained. The neck tissue being treated must be maintained at that temperature for greater than 120 seconds for maximal contraction to occur. The handpiece is moved in the subdermal plane in a manner similar to that of a liposuc­tion cannula. Emitted energy is fractional. The pistol grip device is deployed in a retrograde
Video 12.1 Performing neck liposuction using the syringe method.
manner. The system provides a total of 40 W, and the energy can be changed based on a per­centage of the 40W. Sixty percent setting is rec­ommended for the neck.
10
Once engaged, the device is drawn backward from the end of the treatment area toward the entry site. No more than five strokes are performed for every 2 cm. The device is disengaged 2 cm from the entry site to prevent incision burns. The helium gas needs at least two stab incision sites to have ad­equate space to escape. The author typically ex­pels the gas manually between moving areas and uses the 2-mm cannula for liposuction to gently suction out the helium once completed in order to reduce the risk of subcutaneous em­physema (Video 12.1).
The adipose tissue aspirated by liposuction is processed in the following manner, as previ­ously described in the medical literature. two-thirds of the aspirated fat are used to iso­late the SVF (Fig. 12.1). Digestion is obtained with 0.075% collagenase type II GMP grade (ClZyme AS), produced by VitaCyte LLC (Indian­apolis, IN) in buered saline, and agitation for 45 minutes at 37 °C is performed. Separation of
11
First,
Aspirated fat
Saline
purification
Fig. 12.1 Schematic representation of stromal enriched lipograft.
Collagenase
digestion
Centrafugation
Stem cell-rich
fat graft
Concentrated
adipose-derived
stem cells (ADSC)
Stromal vascular
fraction (SVF)
Purified fat
Stromal enriched lipograft
ready for injection
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the SVF containing adipose-derived stem cells (ADSCs) is then done by using centrifugation at 1,200 rpm for 5 minutes, according to the proto­col already published.
12
The SVF is located in the pellet derived from the centrifuged fat at the bottom of the lipoaspirate. All of these stages of fat procession are obtained through the Automatic Cell Station, produced by BSL Ltd (Seoul, Korea). The SVF is derived from the fat processed in automated cell processing unit (Video 12.2). The remaining one-third of the aspirated fat is treated in the following way: with the syringe held vertically with the open end down, the fat and fluid are separated. Isotonic sal­ineisaddedtothesyringe,thefatandsalineare separated, and the exudate discarded. The proce­dure is repeated until the fat becomes yellow in color, free of blood and other contaminants,
Video 12.2 The adipose tissue aspirated by liposuction is processed.
purified, and concentrated. No emulsification is performed, as this portion of tissue will act as the scaold for the processed fraction; therefore, it is treated as delicately as possible to maintain an in­tact architecture. The process only involves wash­ing and gravity separation. SVF containing ADSCS and the purified fat are finally mixed and trans­ferred into 20-mL syringes for application. Each syringe contains 1.5 mL of SVF and 18.5 mL of pu­rified fat and then transferred into 1-mL syringes ready for injection. This whole procedure is done inside the operating theater, by two tissue engi­neers, and the time required is approximately 45 minutes.
Upon completion of the liposuction procedure, access to the face regions is gained through inci­sions in the malar, lower mandibular, perioral, and neck regions (Fig. 12.2).
The adipose tissue graft enriched with SVF is injected through the incisions. The lipograft is injected at various levels of depth, from the sub­cutaneous–dermal junction, down to the deep subcutaneous fat, until the desired project ion; therefore, a structural sculpturing and symme­try between the two facial sides are obtained. The fat is introduced as the cannula is with­drawn. Fat molding is performed by gentle digital manipulation to achieve a uniform distribution (Video 12.3).
Immediate postoperative dressing is applied in the neck area that was lipoaspirated.
The patient remains hospitalized for 24 hours. Analgesics and anti-inflammatory medications
Fig. 12.2 Schematic representation of autologous fat transplantation to the face and neck.
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