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Incidence: 0.3% of newborns. Most common
location is on the face.
3:1 female:male ratio.
Treatment
Observation is appropriate although important to note
Lesions do not regress. Can progress to “cobblestone” appearance.
Pulsed dye laser
Typically requires multiple treatments. 70%-80% of patients respond with decrease in pigmentation of the lesion. More favorable results on the lateral face as compared to midface, trunk, and extremities.
Surgical excision: must be used for management of soft tissue/skeletal hypertrophy to address contour deformity
Venous malformation → low-flow lesion
Appearance: bluish, soft, compressible lesion,
which swells on dependent positioning; cluster of
thin-walled veins with smooth muscle surrounding,
many veins lack valves.
Changes in hormone levels can cause enlargement.
Must monitor for coagulopathy: Always perform
coagulation profile studies as patients can develop
Disseminated intravascular coagulation.
Treatment
Observation Compression therapy
Useful for pain and edema Minimizes phlebothrombosis
Sclerotherapy: most effective if performed on small cutaneous lesions using ethanol
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Side effects: blistering, full-thickness necrosis, neural deficits. Make sure no important neural structures are nearby if using ethanol sclerotherapy.
Surgical excision: performed most commonly after sclerotherapy to improve cosmetic appearance or remove mass tissue to optimize function
Lymphatic malformation → low-flow lesion
Appearance: Anomalous lymphatic channels filled
with lymphatic tissue, which may be clustered into
vesicles.
Further classified as microcystic vs macrocystic
Most common cause of macroglossia,
macrocheilia in children. Can also cause facial
asymmetry, distortion of surrounding tissue, soft
tissue/skeletal hypertrophy.
Treatment
Observation
Intralesional bleeding can be treated with NSAIDs for pain control and rest. Antibiotics indicated for cellulitis/other infections.
Sclerotherapy (mainstay treatment)
Lesion is instilled with ethanol, doxycycline, sodium tetradecyl sulfate. Can be used effectively when macrocysts are present (large volumes of lymphatic fluid without small loculations as seen on US or MRI). Microcystic disease, in which many small loculations are present, is not readily amenable to sclerotherapy.
Surgical resection
Direct excision can be effective but carries a high likelihood of significant complications.
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Suction-assisted lipectomy has been used to debulk lesions. Complications often include the following
Cellulitis Hematoma Persistent drainage Recurrence of vesicular lesions Need for skin graft depending on extent of excision
Arteriovenous malformation → high-flow lesion
Appearance: abnormal connections between
arteries and veins
Arteries have thick, fibromuscular veins with prominent elastic lamina and stroma. Veins are “arterialized” and hyperplastic.
Clinical features
Intracranial AVMs are more common than
extracranial AVMs.
Always present at birth, but NOT always apparent. Puberty and trauma can stimulate
enlargement.
Schobinger stages of development
Stage 1 Quiescence—bluish discoloration and warmth of skin with AV shunting noted on Doppler examinations Stage 2 Expansion—AVM begins to enlarge and demonstrates bruit, thrill, and pulsations Stage 3 Destruction—begins to bleed, cause pain, and destroy surrounding tissue Stage 4 Decompensation—persistent destruction to surrounding tissue with cardiac failure
Associated syndromes
Bannayan-Zonana syndrome: AVM + microcephaly + lipomas
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Riley-Smith syndrome: AVM + microcephaly + pseudopapilledema Osler-Weber-Rendu disease
Multiple cutaneous telangiectasias with visceral AVMs (most commonly in lungs, liver, brain) Often presents as frequent nosebleeds
Treatment
Observation: used for small, clinically stable, asymptomatic lesions Embolization with surgical excision
Used for stage 3-4 lesions. Ligation/embolization of proximal feeding vessels must never be performed. Can cause recruitment of nearby vessels to exacerbate AVM. Wide local excision is necessary to minimize recurrence rates. Reconstruction with flaps is often necessary after excision.
Malformations associated with other anomalies
Klippel-Trenaunay syndrome: capillary and/or lymphatic venous malformation (patchy port-wine stain on an extremity); skeletal and soft tissue hypertrophy (axial/transverse) of an extremity Parkes Weber syndrome: capillary malformation + AVM with associated soft tissue/skeletal hypertrophy Servelle-Martorell syndrome: similar to Klippel-Trenaunay syndrome with limb hypertrophy secondary to venous malformation, occasionally arterial, with skeletal hypoplasia
Sturge-Weber syndrome
Port-wine stain (capillary malformation) in V1/V2 distribution of the face Leptomeningeal malformations
Seizures
Contralateral hemiplegia
Warrants MRI of the head
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Developmental delay Glaucoma and retinal detachment: screen using biannual fundoscopic and tonometry examinations for 1-3 years, then yearly examinations
Maffucci syndrome: enchondromatosis with multiple cutaneous hemangiomas Cobb syndrome: capillary malformation localized to the trunk; associated with spinal AVM
Combined: involves more than two types of vascular malformation in one lesion
PEARLS
1. The lymphatic system is collects and transports fluid back to the venous system, transports antigens and immune cells and transports fat, lipids and chylomicrons from the GI tract.
2. Imaging with lymphoscintigraphy, MR lymphangiography and ICG lymphography are important to staging, monitoring and surgical planning.
3. Surgical success in management of lymphedema is dependent on patient selection; determining if the patient has edema, adipose deposition and/or functional lymphatics will aid in selection of a physiologic or excisional procedure.
4. Determining if the vascular anomaly was present at birth (eg vascular malformation) vs present after birth (eg hemangioma) is key to diagnosis.
QUESTIONS YOU WILL BE ASKED
1. What is the most common cause of secondary lymphedema in developing and developed countries? In the developing world, it is filariasis caused by W bancrofti (120 million cases). In the developed world, it is the result of cancer treatment, specially lymph node dissection.
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1.
2.
3.
4.
5.
2. What is the difference between the timing of presentation of hemangiomas vs vascular malformations? Vascular malformations are present at birth and continue to grow as the child ages. They do not involute. Infantile hemangiomas present after birth and continue to grow until approximately 1 year of age after which time they often begin to involute. The exception is congenital hemangiomas, which are present at birth.
3. What are the indications to perform operative intervention on a hemangioma? (1) Obstruction or deformation of critical structures such as the eye or airway. (2) Bleeding or ulceration that is unresponsive to pharmacologic management. (3) Easily excisable area with potential for an acceptable scar.
4. What nerve distribution do port-wine stains usually affect? V1 and V2 branches of cranial nerve V
5. Name the different syndromes associated with hemangiomas and vascular malformations along with associated signs. See sections on pages 7, 10 and 11.
Recommended Readings
Couto RA, Maclellan RA, Zurakowski D, Greene AK. Infantile hemangioma. Plast Reconstr Surg. 2012;130(3):619624. doi:10.1097/PRS.0b013e31825dc129
Cox JA, Bartlett E, Lee EI. Vascular malformations: a review. Semin Plast Surg. 2014;28(2):5863. doi:10.1055/s-0034-1376263 Kung T, Champaneria M, Maki J, Neligan P. Current concepts in the surgical management of lymphedema. Plast Reconstr Surg. 2017;139(4):1003e1013e. doi:10.1097/PRS.0000000000003218
Rockson SG, Keeley V, Kilbreath S, Szuba A, Towers A. Cancer-associated secondary lymphoedema. Nat Rev Dis Primers. 2019;5(1):22. doi:10.1038/s41572-019-0072-5 Schaverien M, Coroneos C. Surgical treatment of lymphedema. Plast Reconstr
Surg. 2019;144(3):738758. doi:10.1097/PRS.0000000000005993
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*
Denotes common in-service examination topics.
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9 Lasers in Plastic Surgery
Naomi Briones
OVERVIEW
DEFINITIONS
Laser is an acronym for light amplification by stimulated emission of radiation Light Characteristics
Monochromaticity: light emitted is of a well-defined wavelength. Coherence: light waves are in phase temporally and spatially. Collimation: light waves travel in parallel without spreading.
There are four outcomes when laser light hits the skin
Reflection: character of target material’s surface. No biological effect. Absorption: light hits appropriate target (chromophore) and transforms to heat through tissue interaction. Transmission: light passes through tissue unaltered. Scattering: incoming beam is spread in all directions; limits depth of penetration.
Lasers are selected based on indication and the target chromophore
Chromophores (eg, pigment, water, melanin, hemoglobin) absorb the light, and heat is produced to
create the clinical effect.
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If no heat is produced, no clinical effect. If excess heat is produced, scarring can result from thermal injury. For example, darker skin has a greater amount of melanin and greater chromophore concentration. Therefore, it is more likely to generate heat and thermal damage with laser therapy compared with lighter skin tones.
PROPERTIES
Key Parameters
Wavelength: laser dependent and determined by target chromophore.
Fluence (J/cm2): amount of energy delivered per unit area. Spot size: diameter of surface beam. Increase for deeper penetration. Pulse width (duration): how long the tissue is exposed to the laser. Cooling: extracts heat at skin surface and minimizes epidermal damage.
Lasers can be delivered in several modes
Continuous mode: a constant, uninterrupted beam (eg, argon lasers). Quasicontinuous: rapid succession of low-energy pulses; behaves like continuous mode (eg, 1064 nm ND:YAG) Pulsed mode (Hz): single or train of pulses (eg, pulsed dye laser [PDL]) Q-switched mode: high-power, short-pulse duration (eg, Q­switched ruby)
LASER PHYSICS
All lasers have four essential parts
A medium (gas, liquid, solid, semiconductor), through which energy excites atoms. Power supply or a source of energy to excite the medium.
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Mirrors for amplification. Delivery system to deliver light to the target.
Selective photothermolysis is the primary principle behind laser surgery
Wavelength must penetrate to depth of skin target and correspond to absorption by chromophores within that target. The time of laser exposure (pulse duration) is shorter or equal to thermal relaxation time (cooling time) of the chromophore.
Thermal relaxation time (proportional to the square of the target diameter): time required for the heated tissue to lose half of its heat. If a pulse duration is longer than the thermal relaxation time, heat is not confined to target structure and can damage surrounding tissue.
LASER APPLICATIONS (TABLE 9-1)
Table 9-1 Common Applications of Lasers in Plastic Surgery
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