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Ординатура / Офтальмология / Учебные материалы / Vitreoretinal Surgery Farenc Kuhn Springer.pdf
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26.3 Physiology: What Keeps the Retina Attached?

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The distance between the limbus and the ora serrata varies by quadrant: 6.5 mm temporally, 6.1 mm superiorly, 5.7 mm nasally, and 6.2 mm inferiorly. The distances are larger in myopic and shorter in hyperopic eyes. The distance between the limbus and the equator is ~13 mm.

The extraocular muscles insert into the sclera at the following distances from the limbus: medial rectus, 5.5 mm; inferior, 6.6 mm; lateral, 6.9 mm; and superior, 7.5 mm.

Pearl

The insertion of the extraocular muscles is slightly anterior to the ora serrata, but this is a close enough approximation for clinical purposes.

The seven vortex veins (fewer temporally than nasally) penetrate the sclera 3–6 mm posterior to the equator internally and 14–25 mm from the limbus externally.

The corneal diameter is 12 mm horizontally and 11 mm vertically; its thickness varies from 0.55 mm centrally to 0.7 mm in the periphery.

26.3Physiology: What Keeps the Retina Attached?

In primate experiments it appears that a force as minimal as 0.25 mmHg is sufficient to detach the retina. In the human, clinical experience26 tells you the opposite: an attached retina is difficult to separate from the RPE. This leads to the obvious question: What are the forces that prevent RD development under normal circumstances?

26.3.1 The RPE Pump

The RPE is the main factor in maintaining retinal attachment by constantly removing fluid from the subretinal space27 toward the choriocapillaris; it is often referred to as a suction force.

In eyes with high myopia and a posterior staphyloma, reduced pumping by the RPE is assumed to play a role in the development of the central RD (see

Chap. 56).

Drugs that interfere with the RPE’s active transport reduce retinal adhesiveness.

Retinas detach postmortem when the pump stops working.

26Intentionally detaching the retina in eyes undergoing full-rotation macular translocation is not easy.

27Thus virtual.

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26 Anatomy and Physiology: What the VR Surgeon Must Know

 

 

26.3.2 The IPM

The interphotoreceptor matrix acts as a glue, which helps the neuroretina stick to the RPE.

Enzymes, given experimentally into the vitreous or directly into the IPM, degrade the IPM’s proteoglycans and result in significant weakening of the retinal adhesion.

The IPM requires time to regain its adhesive power. Clinical experience teaches the VR surgeon that once broken, the glue will not regain its efficacy for a few days postoperatively.28

In diabetic eyes, intraoperative RD occasionally occurs when the surgeon works close to the retinal periphery and the vacuum/flow is not reduced.29 No retinal break is present and the RD spontaneously resolves within a few hours or even intraoperatively, but the RD recurs when the surgeon returns to the same area later during the case.30

26.3.3 Presence of the Vitreous Gel

The vitreous body is an indirect supportive force: it mechanically prevents retinal separation as long as it maintains its true gel consistency and fills the vitreous cavity completely.

After cataract extraction, the gel will not be able to fill the extra space vacated by the lens, even if an IOL has been implanted; there is room for vitreous movement. This is the underlying cause of pseudophakic RDs.

26.3.4 IOP

Possibly contributing by “pushing” the retina back toward its foundation, the RPE

28It will certainly not work again during surgery, i.e., it is not a “superglue.”

29If PPV is done using the same parameters in non-diabetic eyes, this phenomenon is almost never seen.

30Reduced pumping by the RPE may also contribute.

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