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Ординатура / Офтальмология / Учебные материалы / Vitreoretinal Surgery Farenc Kuhn Springer.pdf
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Uveitis, Posterior

61

 

Uveitis has many possible etiologies, but whatever the cause, the intraocular consequences1 that can lead to loss of vision are rather similar:

Abnormal IOP, both high and low.

Cataract.2

Vitreous opacity, ranging from floaters to hemorrhage. The debris may get stuck to the lens capsule.

EMP.

ME.

RD: tractional, exudative, occasionally rhegmatogenous.

Traditionally, the treatment is medical: local3 steroids, intravitreal steroid injections and implants, and systemic steroids and immunosuppressive drugs. PPV is often not even listed as an option (and then only as a late, if-all-else-fails choice), although it has tangible benefits:

Yielding a diagnostic specimen.

Removal of the vitreous gel.4

Treatment of virtually all of the coexisting or consequent pathologies (VH, ME, RD etc.).

Reduction in, often complete elimination of, the frequency and severity of the recurrences.

The possibility that the systemic medications, which often have very serious side effects, can be withdrawn or maintained at a reduced dose.5

1The severity of the anatomical and functional abnormalities shows a wide range.

2The treatment (steroids) may also play a role here.

3Topical, subconjunctival, peribulbar.

4A reservoir for the inflammatory debris, including mediators and immunocompetent cells.

5See the Appendix, Part 2.

© Springer International Publishing Switzerland 2016

507

F. Kuhn, Vitreoretinal Surgery: Strategies and Tactics,

DOI 10.1007/978-3-319-19479-0_61

508

61 Uveitis, Posterior

 

 

Pearl

The key to the success of PPV for uveitis is to do it early, not as a last resort when nothing else seems to work or when severe TRD has already occurred.

Surgery is fairly straightforward; only a few caveats are mentioned here:

The systemic therapy must be increased prior to the operation so that the eye is not “hot.”

To avoid a rebound effect, the systemic medication/s should be tapered slowly.

The vitreous gel appears to have more structure to it, and its removal takes longer than usual.

The vitrectomy should be subtotal or total.

Remove the posterior cortical vitreous and all preretinal membranes, the anterior cortical vitreous (which may be thickened), and all membranes covering the ciliary body (see Fig. 61.1).6

Fig. 61.1 Debulking of the ciliary body. Scissors (as well as forceps and the probe, neither shown here) is used to separate a cyclitic membrane (seen as a whitish line) from the ciliary body. Leaving such membranes, which can contract or develop into real scar tissue, on the tissue is a possible cause of hypotony and phthisis. The scissors used here is a 20 g vertical one; it has long blades and the shaft does not bend

Pay special attention when working close to the retinal surface: avoid causing any iatrogenic retinal injury since this increases the risk of PVR.7

Whether you should also remove the subretinal membranes or exudates is less straightforward and requires an individual decision (see Sect. 32.4), especially because a retinotomy would be necessary.

6These may be so severe as to cause detachment of the ciliary body; aqueous production can cease with time.

7PVR in these eyes may be extremely fulminant, cause irreversible damage fast, and be inoperable even at first presentation. This clinical observation confirms the role inflammation plays in the pathogenesis of PVR.

61 Uveitis, Posterior

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Consider as a destructive force laser treatment or cryopexy, especially at the vitreous base.

Have a low bar to silicone oil tamponade.

Leave steroid in the vitreous cavity at the conclusion of the surgery, either as an injection or as a slow-release implant.

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