- •Contents
- •General Introduction
- •Objectives
- •Organization
- •Topography
- •Disease Process
- •General Diagnosis
- •Differential Diagnosis
- •2 Wound Repair
- •General Aspects of Wound Repair
- •Healing in Specific Ocular Tissues
- •Cornea
- •Sclera
- •Limbus
- •Uvea
- •Lens
- •Retina
- •Vitreous
- •Eyelid, Orbit, and Lacrimal Tissues
- •Histologic Sequelae of Ocular Trauma
- •3 Specimen Handling
- •Communication
- •Orientation
- •Transillumination
- •Gross Dissection
- •Processing and Staining
- •Fixatives
- •Tissue Processing
- •Tissue Staining
- •4 Special Procedures
- •Immunohistochemistry
- •Flow Cytometry
- •Molecular Pathology
- •Diagnostic Electron Microscopy
- •Special Techniques
- •Fine-Needle Aspiration Biopsy
- •Frozen Section
- •5 Conjunctiva
- •Topography
- •Congenital Anomalies
- •Choristomas
- •Hamartomas
- •Inflammations
- •Papillary Versus Follicular Conjunctivitis
- •Granulomatous Conjunctivitis
- •Infectious Conjunctivitis
- •Noninfectious Conjunctivitis
- •Pyogenic Granuloma
- •Degenerations
- •Pinguecula and Pterygium
- •Amyloid Deposits
- •Epithelial Inclusion Cyst
- •Neoplasia
- •Squamous Lesions
- •Melanocytic Lesions
- •Lymphocytic Lesions
- •Glandular Lesions
- •Other Neoplasms
- •6 Cornea
- •Topography
- •Introduction to Corneal Pathology
- •Congenital Anomalies
- •Congenital Hereditary Endothelial Dystrophy
- •Posterior Polymorphous Dystrophy
- •Dermoid
- •Peters Anomaly
- •Inflammations
- •Infectious Keratitis
- •Noninfectious Keratitis
- •Degenerations and Dystrophies
- •Degenerations
- •Dystrophies
- •Neoplasia
- •7 Anterior Chamber and Trabecular Meshwork
- •Topography
- •Congenital Anomalies
- •Primary Congenital Glaucoma
- •Anterior Segment Dysgenesis
- •Degenerations
- •Iridocorneal Endothelial Syndrome
- •Secondary Glaucoma With Material in the Trabecular Meshwork
- •8 Sclera
- •Topography
- •Episclera
- •Stroma
- •Lamina Fusca
- •Congenital Anomalies
- •Choristoma
- •Nanophthalmos
- •Inflammations
- •Episcleritis
- •Scleritis
- •Degenerations
- •Senile Calcific Plaque
- •Scleral Staphyloma
- •Neoplasia
- •Fibrous Histiocytoma
- •Nodular Fasciitis
- •9 Lens
- •Topography
- •Capsule
- •Epithelium
- •Cortex and Nucleus
- •Zonular Fibers
- •Congenital Anomalies
- •Congenital Aphakia
- •Lens Coloboma
- •Anterior Lenticonus (Lentiglobus)
- •Posterior Lenticonus (Lentiglobus)
- •Inflammations
- •Phacoantigenic Uveitis
- •Phacolytic Glaucoma
- •Propionibacterium acnes Endophthalmitis
- •Degenerations
- •Cataract and Other Abnormalities
- •Neoplasia and Associations With Systemic Disorders
- •Pathology of Intraocular Lenses
- •10 Vitreous
- •Topography
- •Congenital Anomalies
- •Persistent Fetal Vasculature
- •Bergmeister Papilla
- •Mittendorf Dot
- •Prepapillary Vascular Loops
- •Vitreous Cysts
- •Inflammations
- •Degenerations
- •Syneresis and Aging
- •Posterior Vitreous Detachment
- •Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy
- •Macular Holes
- •Hemorrhage
- •Asteroid Hyalosis
- •Vitreous Amyloidosis
- •Neoplasia
- •Intraocular Lymphoma
- •11 Retina and Retinal Pigment Epithelium
- •Topography
- •Neurosensory Retina
- •Retinal Pigment Epithelium
- •Congenital Anomalies
- •Albinism
- •Myelinated Nerve Fibers
- •Vascular Anomalies
- •Congenital Hypertrophy of the RPE
- •Inflammations
- •Infectious
- •Noninfectious
- •Degenerations
- •Typical and Reticular Peripheral Cystoid Degeneration and Retinoschisis
- •Lattice Degeneration
- •Paving-Stone Degeneration
- •Ischemia
- •Specific Ischemic Retinal Disorders
- •Diabetic Retinopathy
- •Retinopathy of Prematurity
- •Age-Related Macular Degeneration
- •Polypoidal Choroidal Vasculopathy
- •Macular Dystrophies
- •Diffuse Photoreceptor Dystrophies
- •Neoplasia
- •Retinoblastoma
- •Retinocytoma
- •Medulloepithelioma
- •Fuchs Adenoma
- •Combined Hamartoma of the Retina and RPE
- •Adenomas and Adenocarcinomas of the RPE
- •12 Uveal Tract
- •Topography
- •Iris
- •Ciliary Body
- •Choroid
- •Congenital Anomalies
- •Aniridia
- •Coloboma
- •Inflammations
- •Infectious
- •Noninfectious
- •Degenerations
- •Rubeosis Iridis
- •Hyalinization of the Ciliary Body
- •Choroidal Neovascularization
- •Neoplasia
- •Iris
- •Choroid and Ciliary Body
- •Metastatic Tumors
- •Other Uveal Tumors
- •Trauma
- •13 Eyelids
- •Topography
- •Congenital Anomalies
- •Distichiasis
- •Phakomatous Choristoma
- •Dermoid Cyst
- •Inflammations
- •Infectious
- •Noninfectious
- •Degenerations
- •Xanthelasma
- •Amyloid
- •Cysts
- •Epidermoid and Dermoid Cysts
- •Ductal Cysts
- •Neoplasia
- •Epidermal Neoplasms
- •Dermal Neoplasms
- •Appendage Neoplasms
- •Melanocytic Neoplasms
- •14 Orbit
- •Topography
- •Bony Orbit and Soft Tissues
- •Congenital Anomalies
- •Dermoid and Other Epithelial Cysts
- •Inflammations
- •Noninfectious
- •Infectious
- •Degenerations
- •Amyloid
- •Neoplasia
- •Lacrimal Sac Neoplasia
- •Lacrimal Gland Neoplasia
- •Lymphoproliferative Lesions
- •Soft-Tissue Tumors
- •Vascular Tumors
- •Tumors With Fibrous Differentiation
- •Tumors With Muscle Differentiation
- •Nerve Sheath Tumors
- •Adipose Tumors
- •Bony Lesions of the Orbit
- •Metastatic Tumors
- •15 Optic Nerve
- •Topography
- •Congenital Anomalies
- •Colobomas
- •Inflammations
- •Infectious
- •Noninfectious
- •Degenerations
- •Optic Atrophy
- •Drusen
- •Neoplasia
- •Melanocytoma
- •Glioma
- •Meningioma
- •17 Melanocytic Tumors
- •Introduction
- •Iris Nevus
- •Nevus of the Ciliary Body or Choroid
- •Melanocytoma of the Iris, Ciliary Body, or Choroid
- •Iris Melanoma
- •Melanoma of the Ciliary Body or Choroid
- •Diagnostic Evaluation
- •Differential Diagnosis
- •Classification
- •Metastatic Evaluation
- •Treatment
- •Prognosis and Prognostic Factors
- •Pigmented Epithelial Tumors of the Uvea and Retina
- •Adenoma and Adenocarcinoma
- •Acquired Hyperplasia
- •Combined Hamartoma
- •18 Angiomatous Tumors
- •Hemangiomas
- •Choroidal Hemangiomas
- •Retinal Angiomas
- •Arteriovenous Malformation
- •19 Retinoblastoma
- •Genetic Counseling
- •Diagnostic Evaluation
- •Clinical Examination
- •Differential Diagnosis
- •Classification
- •Associated Conditions
- •Retinocytoma
- •Trilateral Retinoblastoma
- •Treatment
- •Enucleation
- •Chemotherapy
- •Photocoagulation and Hyperthermia
- •Cryotherapy
- •External-Beam Radiation Therapy
- •Plaque Radiotherapy (Brachytherapy)
- •Targeted Therapy
- •Spontaneous Regression
- •Prognosis
- •20 Ocular Involvement in Systemic Malignancies
- •Secondary Tumors of the Eye
- •Metastatic Carcinoma
- •Direct Intraocular Extension
- •Lymphomatous Tumors
- •Primary Intraocular Lymphoma
- •Uveal Lymphoid Infiltration
- •Ocular Manifestations of Leukemia
- •Basic Texts
- •Related Academy Materials
- •Requesting Continuing Medical Education Credit
CHAPTER 9
Lens
Topography
Figure 9-1 Posterior aspect of the crystalline lens, depicting its relationship to the peripheral iris and ciliary body. (Courtesy of
Hans E. Grossniklaus, MD.)
Figure 9-2 Microscopic appearance of the adult lens. (Courtesy of Tatyana Milman, MD.)
Figure 9-3 Posterior lenticonus. (Courtesy of Hans E. Grossniklaus, MD.)
Figure 9-4 Phacoantigenic endophthalmitis, in which inflammatory reaction surrounds the lens (lower left). The torn capsule can be observed in the pupillary region (arrow). Also note corneal scar (arrowhead), representing the site of ocular penetration.
Figure 9-5 Phacoantigenic endophthalmitis. Acute and granulomatous inflammation, including giant cells (arrow), surrounds inciting lens fibers (asterisk).
Figure 9-6 Clinical photograph of eye with P acnes endophthalmitis. Note injection of the conjunctiva and small hypopyon.
(Courtesy of William C. Lloyd III, MD, and Ralph C. Eagle, Jr, MD.)
Figure 9-7 Histology of a lens capsule from a case of P acnes endophthalmitis. A, Colonies of bacteria are sequestered within the PAS-positive capsular bag (asterisks). B, Gram-positive coccobacilli (P acnes) within the capsular bag (asterisk).
(Part A courtesy of William C. Lloyd III, MD, and Ralph C. Eagle, Jr, MD; part B courtesy of Tatyana Milman, MD.)
Figure 9-8 Anterior and posterior subcapsular cataracts. A, Gross photograph shows white anterior (arrow) and posterior (arrowhead) subcapsular plaques located centrally. B, Fibrous plaque (asterisk) is present posterior to the original lens
capsule (arrowhead). (Part A courtesy of Tatyana Milman, MD; part B courtesy of Hans E. Grossniklaus, MD.)
Figure 9-9 Posterior subcapsular cataract. A, Viewed at the slit lamp. B, Wedl cells. Note the large, round, nucleated bladder or Wedl cells (arrows) and the smaller lens epithelial cells lining the posterior lens capsule (arrowhead). (Part A courtesy of CIBA
Pharmaceutical Co., division of CIBA-GEIGY Corp. Reproduced with permission from Clinical Symposia. Part B courtesy of Robert H. Rosa, Jr, MD.)
Figure 9-10 Elschnig pearls. A, Clinical appearance using retroillumination to demonstrate posterior capsule opacities. B, Histology depicting proliferating lens epithelium (arrows) on posterior capsule. (Part A courtesy of Sander Dubovy, MD; part B courtesy
of Debra J. Shetlar, MD.)
Figure 9-11 Soemmering ring cataract. A, Doughnut-shaped white cataractous material is present in the equatorial region of the lens capsule and surrounds one lens haptic (arrows). The lens optic and a second haptic are positioned in front of the lens capsular bag, in the sulcus. B, Ring cataract, photomicrograph (arrows). (Part A courtesy of Tatyana Milman, MD.)
Figure 9-12 Cataract. A, Extensive cortical changes are present (asterisk). B, Cortical degeneration. Lens cell fibers (asterisk) have swollen and fragmented to form morgagnian globules (arrowheads). The lenticular fragments are opaque and will increase osmotic pressure within the capsule. (Courtesy of Hans E. Grossniklaus, MD.)
Figure 9-13 Morgagnian cataract. A, The brunescent nucleus has sunken inferiorly within the liquefied cortex. B, The lens cortex is liquefied, leaving the lens nucleus (asterisk) floating free within the capsular bag. C, Note the artifactitious, sharply angulated clefts (arrows) in this nuclear sclerotic cataract. A zone of morgagnian globules (M) is identified.
Bradford Tannen, MD; part B courtesy of Debra J. Shetlar, MD.)
Figure 9-14 Surgically extracted lens nuclei showing varying degrees of brunescence and opacification. (Courtesy of Hans E.
Grossniklaus, MD.)
