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Hagerstown, MD: Harper & Row; 1983:2.)

Optical Coherence Tomography

The resolution of ultrasound is limited by the long wavelength of sound. Light has much shorter wavelengths than sound, allowing for finer resolution, but direct electronic measurement of the extremely short time it takes light to bounce in and out of an eye is not feasible. Interferometry enables us to overcome this difficulty in the following manner. If we split a beam of light and bring the 2 parts back together after they have traveled paths that take very slightly different amounts of time, interference patterns are observable. In optical coherence tomography (OCT), a superluminescent diode emits a beam of light with long (red) wavelengths—reds being chosen because they are scattered in tissue less than is blue light. A superluminescent diode is used, rather than a laser, because it emits a broader spectrum of color, which gives the instrument greater sensitivity to the differences in time the 2 beams have traveled than would be achieved with only one frequency of light. When the beam is split, the reference beam is aimed at a mirror, and the other portion is aimed at one of the reflective interfaces within the tissue being examined (Fig 7-34).

Figure 7-34 Optical coherence tomography based on the principle of the Michelson interferometer. (Courtesy of Neal H.

Ateb ara, MD. Redrawn b y C. H. Wooley.)

In time-domain OCT, the position of the mirror is adjusted so that interference patterns show up whenever the 2 beams have traveled almost the same amount of time. Results similar to the ultrasound’s A-scan are generated, as light is reflected at interfaces between layers of tissue.