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17 Ophthalmic Instruments and Diagnostic Tests 501

The sensory retina’s avascular portion consists of the outer plexiform layer (OPL), the outer nuclear layer (ONL), and rod and cone photoreceptor cells. These structures receive m etabolic support from the choroidal vessels via the pigm ent epithelial cells.

Optical Coherence Tomography

Optical coherence tom ography (OCT) is an im aging m odalit y that perform s high-reso- lution, m icrom eter-scale cross sections of the eye and other biological structures.

At th is t im e th e tech n ology is an alogou s to B-scan ult rasoun d . Its ut ilit y to th e clin ician lies in th e abilit y to accurately m ake n on invasive an atom ical m easure- m en ts in vivo (Fig. 17.12). Prior to th e developm en t of OCT, th e m ain stays of clin ical exam in at ion for m any ret in al diseases w ere slit-lam p biom icroscopy, fun du s ph o- tography, fluorescein angiography, an d in docyan in e green angiography. Alth ough th ese diagn ost ic tech n iques rem ain essen t ial to diagn osis an d m an agem en t , OCT h as em erged as an invalu able diagn ost ic tool as w ell, providing quan t itat ive an d qualit at ive in form at ion th at w as previou sly un at t ain able.

In addit ion to presen t ing a clearer pict ure of th e path ophysiology of disease, OCT h as been ext rem ely u seful in determ in ing respon se to th erapy. Mult ip le st u d - ies, for exam ple, h ave u sed OCT to exam in e ocu lar respon se follow ing m acu lar t reat m en ts determ in ing th at th ere is an in it ial in crease in su bret in al an d in t raret i- n al flu id, follow ed by a gradual declin e over th e n ext days.

Lasers In Ophthalmology

Laser Peripheral Iridectomy

Becau se of th e coagu lat ing effect of argon laser ligh t , iridectom y perform ed by argon laser offers advan t ages over in cision al iridectom y or n eodym ium :yt t rium - alu m in u m -garn et (Nd:YAG) laser iridectom y in pat ien t s predisposed to bleeding con dit ion s, such as th ose taking an t icoagulan t s or w ith kn ow n blood -clot t ing disorders. Th e laser iridectom y is perform ed as an office p rocedu re in a closed eye—a con siderable advan t age over surgical iridectom y (Fig. 17.13).

Fig . 17.12 Optical coherence tomography of a macular hole.

502 Color Atlas of Ophthalm ology

Fig . 17.13 Iridectomy with argon laser—opening a narrow angle in chronic, narrow angle glaucoma. A laser iridectomy is the procedure of choice for narrow angle glaucoma except in cases such as (A) where the pe - ripheral iris lies too close to the cornea for treatment. Laser applications (D) are placed in the midstroma area of the iris to open the angle. These nonperforative laser applications cause heat, which in turn causes shrinkage of the iris collagen fibres in the direction of the arrow. The iris sphincter muscle (S) and the laser beam (L) are shown in (B), shrinkage from laser applications (D) has opened the angle to an acceptable position (C). A peripheral laser iridectomy is then executed. The normal iris location is shown on dot ted line (N). The angle is now sufficiently open for laser trabeculoplast y if indicated. Laser beam

(L) is shown producing burns (E) in the now visible trabeculum . (From

Boyd, BF, Lunt z, M. Acute and chronic angle closure. In: Innovations in the glaucomas. Highlights of Ophthalmology, 2002, 277. Courtesy Jaypee Highlights Medical Publishers Inc., Panama.)

It is an effective w ay of producing an open ing in th e iris but should n ot be used w hile the eye is congested or in flam ed . Clear m edia are essent ial. Th e eye is prepared w ith topical an esth esia. The surgeon sh ould have com fortable arm supports.

Th e Abrah am tech n ique is h igh ly u seful an d effect ive. Th ese bu rn s im m ediately cause iris con t ract ion an d put th e iris cr ypt on st retch . Oth er surgeon s fin d th at th e st retch burn is gen erally u n n ecessar y if th e Abrah am con tact len s is used .

In th e m ajorit y of cases, an iridectom y is ach ieved at th e first session . As p en - et rat ion of th e iris st rom a reach es th e pigm en ted epith elium of th e iris, bu rst s of p igm en t appear in th e an terior ch am ber (“sm oke sign als”). Pow er is th en reduced, an d fu r th er burn s are applied u n t il a m ush room clou d of aqueous an d pigm en t balloon s th rough th e iridectom y, in dicat ing pen et rat ion of th e iris.

Argon Laser Trabeculoplasty

Th e Glaucom a Laser Trial, a m ajor prospect ive, ran dom ized st udy, con cluded th at laser t rabeculoplast y as an in it ial t reat m en t for op en -angle glaucom a is as safe an d as effect ive as m edical t reat m en t . In som e cases, it m ay be m ore appropriate as in it ial th erapy. Th ese cases in clude (1) pat ien ts w h o can n ot or w ill n ot com p ly

17 Ophthalmic Instruments and Diagnostic Tests 503

w ith prescribed m edical th erapy, (2) areas of th e w orld w h ere adequ ate m edical t reat m en t is un feasible because of povert y.

In all cases, to be su ccessful, th e angle does h ave to be open , th e m edia m u st be clear, an d on e m u st h ave access to th e t rabecular m esh w ork. Jam es B. Wise, M.D., w h o developed argon laser t rabecu loplast y (argon laser t rabecu loplast y), h as obser ved th at populat ion group s of ph akic pat ien ts do bet ter th an aph akic. It ap pears th at aph akia does in terfere w ith respon se to th e laser, probably by th e in fluen ce of vit reous in th e an terior ch am ber an d th e t rabecu lar m esh w ork. In terest ingly en ough , p seu doph akic pat ien t s resp on d to th e laser ver y sim ilarly th an ph akic pa- t ien t s. Th at is, th e presen ce of th e posterior ch am ber len s im plan t keeping th e vitreou s out of th e an terior ch am ber greatly im p roves th e respon se to th e laser. Eyes w ith an terior ch am ber len ses an d glaucom a u sually sh ow a p oor laser respon se du e to uveit is an d t rabecu lar dam age from th e len s (Fig. 17.14).

Fig. 17.14 Applying laser burns correctly in argon laser trabeculoplast y. Cross section to the left; cornea (E), Schlemm canal (C), scleral spur (S), Schwalbe line (G), anterior corneoscleral meshwork (A), pigmented band (P), and uveal meshwork (U). Proper placement of the 50 µm laser burn (L) is shown at the posterior margin of the pigmented band (P). To the right is a gonioscopic view with iris (I) below. Properly placed 50 µm laser burn at the posterior pigment band (P) shown at (1). Another burn is shown at (2) along the posterior margin of the pigment band (P). An oversized burn is shown at (3), spanning the entire pigment band. A slightly misplaced burn is shown at (4) in the middle of the pigment band. Aseriously misplaced burn into the uveal meshwork (5). (From Boyd, BF, Luntz, M. Argon

laser trabeculoplast y. In: Innovations in the glaucomas. Highlights of Ophthalmology, 2002, 149. Courtesy Jaypee Highlights Medical Publishers Inc., Panama.)

504 Color Atlas of Ophthalm ology

Retinal Laser Photocoagulation

Many sign ifican t applicat ion s h ave been discovered for clin ical use of th e laser in oph th alm ology. Th e un ique feat u res of th e eye allow ing in t raocular t ran sm ission an d select ive absorpt ion of ligh t en ergy accoun t for a w ide range of laser t reat- m en ts.

Essen t ially, t reat m en t m ay be categorized in to five gen eral effect s: (1) in du ct ion of ch orioret in al bu rn s or ret in al scar th at lead to (possible ph arm acological) n eu - t ralizat ion of isch em ia-in duced ret in al n eovascu larizat ion ; (2) redu ct ion in ret in al vascu lar perm eabilit y via direct vascular closu re or un kn ow n m ech an ism s; (3) ablat ion of un desired t issue su ch as ch oroidal n eovascu larizat ion , t u m ors, abn orm al n at ive vessels, or aqu eou s-produ cing t issu e; (4) in du ct ion of a ch orioret in al scar th at m ay ser ve as a barrier to exten sion of subret in al fluid; an d (5) lysis of t rac- t ion -in ducing or m edia-opacifying t issu es (Fig. 17.15).

Th e tech n iques of laser ph otocoagu lat ion in clu de th e follow ing broad categories: scat ter t reat m en t , focal t reat m en t , ablat ive t reat m en t , dem arcat ing t reat- m en t , an d cut t ing t reat m en t .

Focal Macular Treatment

Macu lar edem a occurs from a variet y of disease m ech an ism s, bu t th e feat u re com - m on to each is in creased ret in al vascular perm eabilit y. Con t ribut ing factors in - clude ret in al isch em ia, in flam m at ion , an d t ract ion . Som e en t it ies in th e first of

Fig . 17.15 Argon laser treatm ent of a retinal tear (T). (From Cortez, R.

Managem ent of retinal detachment. In: Retinal and vitreoretinal surgery. Highlights of Ophthalmology, 2002, 402. Courtesy Jaypee Highlights Medical Publishers Inc., Panama.)

17 Ophthalmic Instruments and Diagnostic Tests 505

th ese categories are resp on sive to focal laser t reat m en t: clin ically sign ifican t diabet ic m acular edem a an d bran ch vein occlu sion -associated m acu lar edem a. Macu - lar edem a du e to cen t ral vein occlusion m ay resolve after t reat m en t , but th is is n ot usually accom pan ied by a visu al ben efit .

Nd:YAG Laser Posterior Capsulotomy

Posterior capsu le opacificat ion (PCO) is curren tly th e m ost frequ en t postoperat ive com plicat ion in cat aract su rger y.

Th e u se of hypoton ic solu t ion an d preser vat ive free lidocain e are being invest i- gated in th e preven t ion of PCO. St udies w ith in vivo sp ecular m icroscopy suggest th at a hydrop h ilic acr ylic in t raocu lar len s w ou ld h ave h igh er biocom pat ibilit y th an th e hydroph obic acr ylic len s, con t rar y to som e p reviou s st udies, w h ich affirm ed th at hydroph obic acr ylic len s h ad h igh er biocom pat ibilit y.

Opacificat ion of the posterior capsule is an in adequ ate term becau se it is n ot th e capsule th at opacifies bu t an opaque m em bran e th at grow s, origin at ing from th e epith elial cells th at w ere ret ain ed, w h ich proliferate an d m igrate on th e posterior capsule (Fig. 17.16).

Th e pearls of Elsch n ig origin ate from th e superim p osed epith elial cells of th e flexible w ing of th e an terior capsu le an d m igrate to th e posterior capsu le.

Opacificat ion of th e posterior capsu le is t reated w ith Nd:YAG laser, w h ich is a ph otodisru ptor laser. In oth er w ords, it u ses a h igh p ulse of ion izing elect rom ag- n et ic en ergy to break th e t issue.

To ach ieve th e open ing of th e capsu le, begin from th e periph er y at 12 o’clock an d go to 6 o’clock w ith a size larger th an th e pupil (un dilated). Make th e in cision going from 3 o’clock to 9 o’clock u sing th e Abrah am len s. Fin ally clean th e residues to avoid leaving float ing fragm en t s.

Fig . 17.16 Nd:YAG laser posterior capsulotomy.

506 Color Atlas of Ophthalm ology

Cryoprobes

Cr yoprobes are used for perip h eral ret in opexy in pat ien ts w ith periph erally located ret in al breaks an d tears, in th e t reat m en t of ret in al t u m ors an d ret in al vascular m alform at ion s. Th ey h ave also been u sed for perform ing cyclocr yoth erapy in en d -st age glaucom as.

Th e t ip of th e probe is placed over th e globe at th e edge of th e break w h ile visu - alizing w ith th e in direct oph th alm oscope. Th e freezing is th en applied un t il th ere is w h iten ing of th e ret in a (freezing of th e vit reous sh ou ld be avoided). On ce th e t ip h as th aw ed, it is rem oved an d th e n ext ap plicat ion is m ade (Fig. 17.17).

Fig . 17.17 Cryoprobe.

Index

Note: Page n um bers follow ed by f an d t in dicate figures and t ables, respect ively.

A

Ablepharon, differen tial diagn osis, 51 Abscess

differen t ial d iagn osis, 47 orbital, 72f, 95f

su bp eriosteal, 71–73 presen tat ion , 71

Acantham oeba kerat itis, 147–149, 148f differen t ial d iagn osis, 146, 149, 192

Accom m odat ive esot rop ia, 341–342, 341f high , 341f, 342

part ially, 342

Acetam ide, for cen t ral ret in al arter y occlu sion , 268

Acet ic acid bu rn , 5–7 Acid bu rn s, 5–7

Acn e rosacea, 100–101 differen t ial d iagn osis, 192 episclerit is in , 123

Acroch ord on , 52

Act in ic keratosis, 52–53, 53f differen t ial d iagn osis, 52, 54, 62

Act inom yces canaliculit is, 65

Acu te m u lt ifocal p osterior p lacoid p igm en t epith eliopathy, 204–205, 205f

Acu te m yeloid leu kem ia, orbit al involvem en t in , 94

Acu te ret in al n ecrosis syn drom e, 209 Aden oid cyst ic carcin om a, lacrim al glan d,

98, 99f Aden om a

ciliar y body, 325

pleom orp h ic, lacrim al glan d, 97–98, 97f Aden oviral conju n ct ivit is, 101–103, 102f Age-related m acular degen eration , 276–278,

277f

differen t ial d iagn osis, 269, 272, 274, 276, 279

exu dat ive, 276, 277f

an d vit reou s h em orrh age, 270 m an agem en t , 276–278

non exudat ive, 276, 277f presen t at ion , 276

risk factors for, 276

Age-related m aculopathy, 276 Albinism , 285

Alkali burn s, 5–7

differen t ial d iagn osis, 112

an d recu rren t corn eal erosion , 156 Alkapton uria, blue sclera in , 134 Allergic conjun ct ivit is, 45

Allergy, 47

an d eyelid ed em a, 47, 69, 72 Alph a- Cor, 188

Am aurosis fugax, 267, 268

Am blyopia, vit reou s h em orrhage an d, 19 Am iodaron e, corn eal vert icillata caused by,

180, 181f

Am m on ium hydroxide burn s, 5–7 AMPPPE. See Acute m ult ifocal posterior

placoid p igm en t ep ith eliopathy Am yloid degen erat ion

conju n ct ival, 120

corn eal, p olym orph ic, 178, 179f Am yloidosis

differen t ial d iagn osis, 57, 128, 191, 192 orbital, 128

prim ar y, 191

An em ia, 261. See also Sickle cell anem ia An esth et ics, topical, an d n eurot ropic

keratopathy, 155 Angioedem a, 69, 72

Angioid st reaks, 270–271, 271f causes, 270

differen t ial d iagn osis, 21, 271, 272, 276, 281, 282

m an agem en t , 271 presen t at ion , 270–271

Angiom a, facial, 130

Angle kappa, 339, 339f, 340 An iridia, 135

an d len s su blu xat ion , 13

An kylosing spondylit is, ocular involvem en t in, 194

An terior basem en t m em bran e dyst rophy, and recurren t corn eal erosion , 156

Anterior cham ber cleavage syndrom e, 192, 258 An terior ch am ber dysgen esis syn drom es, 157 An terior corneal dyst rophy(ies), 158–161

An terior em br yotoxon, 157, 158 An terior sclerit is, 124

An terior segm en t t ransplan tat ion , for anterior st aphylom a, 189–191, 190f

An terior uveit is, 10

Aph akia, and ret in al detach m en t , 296–297 Apocrine hydrocystom a, 57, 58f

Apon eurosis repair, for ptosis, 38

“Apple peeling” techn iqu e, for rem oval of intern al lim it ing m em bran e, 318, 319f

Arcu s juven ilis, 173 Arcu s senilis, 173, 174f

differen t ial d iagn osis, 157, 158 ARM. See Age-related m aculopathy

ARMD. See Age-related m acular degen erat ion Ar teriosclerosis, an d m acroan eur ysm , 269

Ar terioven ou s m alform at ion , 90 cavern ous sin us, 128

ret in al, 337, 337f

Ar terioven ou s n icking, 260 Ar tificial tears, 114–115 Aspergillus kerat it is, 149, 150

Ast rocytom a, retin al, 335, 336, 337 Ath erosclerosis, an d ocu lar isch em ic

syn drom es, 268–269

Atop ic keratoconju n ct ivit is, 45, 110, 112, 153 Atopy

episclerit is in , 123

an d filam en tar y kerat it is, 154 an d keratocon u s, 171

At rial sept al d efect , 353 At rop h ic bu lbi, 136

At rop h ic retin al h oles, 297, 297f

Autoim m u ne disorders, 110. See also speci c disorder

Avellino dyst rophy, 161

AVM. See Ar terioven ous m alform at ion Axen feld an om aly syndrom e, 135 Axen feld Reiger syn drom e, 157, 158

B

Bacillus

corn eal ulcer caused by, 146

traum at ic en doph thalm it is caused by, 213

539

540 Index

Bacterial corn eal ulcer, 146–147, 146f Bacterial in fect ion

differen t ial d iagn osis, 192

endogenous en dophth alm itis caused by, 215 traum at ic en doph thalm it is caused by, 213

Bacterial keratit is, 9, 143, 147, 149 Ballet sign , 76t

Ban d keratopathy, 176–177, 177f Bardet-Biedl syn drom e, and retin it is

pigm en tosa, 285

Basal cell carcin om a, 59–61, 60f

differen t ial d iagn osis, 51, 53, 54, 56, 62, 64 Bassen -Korn zw eig syndrom e, an d ret in it is

pigm en tosa, 285 Bear-t rack lesion s, 332

Behçet syn drom e, ocular involvem en t in , 212–213, 212f

Berlin edem a, 275 Best disease, 280–281

Biet t i’s cr yst alline retin opathy, 280 Birdsh ot ch orioret in it is, 280

Birdsh ot ret in och oroidopathy, 206–207.207f Birth t raum a, corn eal involvem en t in, 166,

170, 192

Bleeding disorders, an d hyph em a, 15 Bleph aritis, 100–101

differen t ial d iagn osis, 46, 63, 64 infect iou s, 100, 100f

pem p h igoid an d, 112 seborrh eic, 100

st aphylococcal, 100, 106 an d trich iasis, 64

Bleph arophim osis syn drom e, 33, 38, 48, 48f, 49

Bleph aroptosis, 48 Bleph arospasm

in congen ital glaucom a, 134–135 differen t ial d iagn osis, 35

Blood vessels, dilated, 125–126, 126f

in St u rge-Weber syn drom e, 126–127, 127f Blow -ou t fract ures, orbit al, 26–28, 27f

Blue sclera causes, 134

in osteogen esis im p erfect a, 133–134, 134f Bon e m arrow t ran splan tat ion , and

conju n ct ivalization of corn ea, 136 Boston sign, 76t

Brain t um or surger y, and n eu rotropic keratopathy, 155

Bran ch ret in al arter y occlusion , 265–266 differen t ial d iagn osis, 19, 266

Bran ch ret in al vein occlusion , 265f differen t ial d iagn osis, 261, 263, 269

BRAO. See Bran ch ret inal ar ter y occlusion Breast can cer, orbit al m et astases, 94 Bron ch ial carcin om a

orbital m etast ases, 94

ret in op athy secon dar y to, 217 Brow n -McLean syn drom e, 236 Brow n syn drom e, 353–354, 353f Brucellosis, 101

Bruch m em bran e, defect s, 20 Brush field spot s, 325

BRVO. See Bran ch ret in al vein occlusion Bullae, subepith elial, Fuch s endoth elial dyst rophy an d, 168f

Bullous keratopathy

ap h akic, 167, 169, 192

differen t ial d iagn osis, 167, 169, 192 pseu dop h akic, 167, 169, 192

Buph th alm os

in congen ital glau com a, 134–135, 135f differen t ial d iagn osis, 157, 158

Burn(s) acid, 5–7

alkali, 5–7, 112, 156

ch em ical, 5–7, 6f, 64, 110, 112, 113, 136, 155, 192

an d sym bleph aron , 116 th erm al, 6, 112, 192

C

Calcific band keratopathy, 176–177, 177f Calcium hydroxide bu rn s, 5–7

Can alicular lacerat ions, 2, 3f Can aliculit is, 65, 66f, 68

Candida albicans, n eon at al en dogen ous en doph th alm it is caused by, 215

Candida kerat it is, 149, 149f

Can did iasis, ocu lar involvem en t in , 201 Can d lew ax d rip p ings, 199

Cap illar y h em angiom a, 81–84, 84f, 85t differen tial diagn osis, 59, 86

opt ic disk, 334, 335f ret inal, 334–335, 335f

differen tial diagn osis, 329, 335, 336, 337 exop hyt ic, 329

presen tat ion , 334 Capsular ten sion ring, 220

Carbogen th erapy, for cen t ral ret in al arter y occlu sion , 268

Cardiac failure, h igh -out put , 84

Carot id cavern ou s fist ula, 90–93, 92f, 127–129, 128f

differen t ial d iagn osis, 30, 72 high -flow, 90, 93

low -flow, 90, 92f, 93

post t rau m at ic, 31–32, 31f, 90, 93 traum at ic, 31–32, 31f, 90, 93

Cast roviejo square graft , 186f Cat aract

an d d egen erat ive m yop ia, 272

hyperm at ure, an d len s sublu xat ion , 13 m at ure, 222–223, 223f–226f

m iot ic pupil, 220–221, 221f posterior polar, 218–219, 218f posterior su bcap su lar, an d ret in it is

pigm en tosa, 285 sen ile, 226–227, 226f–229f

differen t ial d iagn osis, 13 su blu xated, 219–220, 219f traum at ic, 11–13, 12f

Cataract surger y. See also In t raocular len s corn eal edem a after, 236–237

an d cystoid m acu lar edem a, 238–239, 239f, 274, 275f

elevated in t raocu lar p ressu re after, 238 en doph th alm it is after, 240–242, 241f hypotony after, 237–238

int raoperat ive com plicat ion s, 234–236 iridodialysis in , 235, 235f

posterior cap su lar ru pt u re in , 234–235, 235f

postop erat ive com p licat ion s, 236–243 ret in al detach m en t after, 239–240, 240f sph in cter-involving tech n ique, 221, 221f sph in cter-sparing tech n ique, 221

su b 1 m m 700-m icrom eter (Microph akon it), 218f, 219

w oun d leak after, 237–238

Cavern ous h em angiom a, 85t, 90, 91f differen t ial d iagn osis, 81, 335, 336, 337 iris, an d hyph em a, 15

ret in al, 335, 336, 336f, 337 Cavern ous sin us

arterioven ou s m alform at ion , 128 th rom bosis, 71–73

differen t ial d iagn osis, 69, 76, 78, 93, 128 presen t at ion , 71

Cavern ous sin us syndrom e, 128 CCF. See Carot id cavern ous fist ula Cellu lit is

Index 541

acu te st reptococcal, 69 orbital, 69, 71–73, 73t

adjacen t in fect ion an d , 71

differen t ial d iagn osis, 30, 47, 66, 69, 73t , 76, 78, 87, 128

m an agem en t, 73 post t rau m at ic, 71 presen tat ion , 71 sin u s-related, 71

w arning signs w ith , 73 presept al, 69–71

w ith allergic react ion , 70f w ith bacterial infect ion, 70f w ith dacr yocyst it is, 67f differen t ial d iagn osis, 47

w ith fungal infect ion, 70f

Cen t ral cloudy dyst rophy of Fran çois (corn eal), 165, 165f, 175

Cen t ral cr ystallin e dyst rophy of Schnyder, 164, 164f, 175

Cen t ral ret inal ar ter y occlusion , 266–268, 267f

differen t ial d iagn osis, 19, 266

w ith du rat ion of on set less th an 24 h ours, 268

m an agem en t, 268

Cen t ral ret inal vein occlusion , 264, 265f differen t ial d iagn osis, 261, 263, 264, 269 m an agem en t, 264

presen tat ion , 264, 265f

Cen t ral serou s ch orioret in opathy, 273–274, 273f

differen t ial d iagn osis, 274 epidem iology, 273

m an agem en t, 274

precip itat ing factors, 273 presen tat ion , 273

Cen t ral serou s ret in opathy, 263

CFEOM. See Ext raocular m uscle(s), congenit al fibrosis

Chalazion , 45–46, 45f bleph arit is an d, 100

differen t ial d iagn osis, 46, 51, 62, 63, 69, 72 Chalcosis, 24

Chan dler syn drom e, 167, 258 Chem ical burn s, 5–7, 6f

an d conju n ct ivalizat ion of corn ea, 136 differen t ial d iagn osis, 110, 112, 113, 136,

192

an d dist ich iasis, 64

an d n eurot ropic keratopathy, 155 Chem osis, 138–140

in acute bacterial conjun ct ivit is, 105 causes, 138t

m assive, 139f m ild, 139f

Chen ey syndrom e, blue sclera in , 134 Cherr y-red spot , 267

Chickenpox, 143

Child abuse, t raum at ic vit reou s h em orrhage in , 18

Chlam ydia t rach om a, 106–109

Chlam ydia t rachom at is, 106, 150 Chloroquin e, corneal vert icillata caused by,

180

Chorioret inal scarring, 332 Chorioret init is

syphilit ic, 198

Toxoplasm a, 200–202, 201f t uberculous, 201

vit iligin ous, 206–207.207f

Chorioret inopathy, cen t ral serous, 273–274, 273f

differen t ial d iagn osis, 274 epidem iology, 273

m an agem en t, 274

precip itat ing factors, 273 presen tat ion , 273

Ch oroid

at rophy, age-related, 272

cavern ous h em angiom a, 330–331, 330f dyst roph ies, 285

hem angiom a, 327, 328, 329 m elanocytom a, 332

m elanom a, 132, 327–329, 328f

am elan ot ic, differen t ial diagn osis, 329 differen t ial d iagn osis, 216, 327, 328,

330–333, 338 m an agem en t, 329

presen tat ion , 327–329, 328f vit reous h em orrhage in, 18

m et astat ic t um or, 329–330, 329f differen t ial d iagn osis, 327–331

neovascularizat ion

an d cystoid m acu lar edem a, 274 differen t ial d iagn osis, 21, 275

nevus, 326–327, 327f

differen t ial d iagn osis, 328, 330, 331, 332 osteom a, 327, 331–332, 331f

differen t ial d iagn osis, 327–331 rupt ure

differen t ial d iagn osis, 276 traum at ic, 20–21, 20f

t um ors, 326–332

Ch oroidal det ach m en t , 316–317 expulsive, 317

hem orrh agic, 317 serous, 316

in t raop erat ive, 316 postop erat ive, 316 trau m at ic, 316

Ch oroiderem ia, 285 differen t ial d iagn osis, 286

Ch oroidit is

m ult ifocal, 203

serpigin ous, 205–206, 206f Ch rom ic acid bu rn , 5–7

Ch rom osom al deletion /duplication , 135 Cicatrizing disorders, 111–116

Ciliar y body aden om a, 325 cyst , 325

m elanom a, 325–326 differen t ial d iagn osis, 322

vit reous h em orrhage in, 18 m et astat ic lesion s, 325

t um or, 323, 325–326

CIN. See Corn eal in t raepith elial n eoplasia Cleft palate, 353

Cleidocran ial dysplasia, blu e sclera in , 134 CME. See Cystoid m acular edem a

CNV, 283

CNV m em bran es, 276–278

Coat s disease, 286, 335, 336, 337 Cobbleston e degen erat ion , 290–291, 291f Cockayn e syn d rom e, an d recu rren t corn eal

erosion , 156

Cogan m icrocyst ic edem a, 158–159, 159f Cogan -Reese syn d rom e, 258, 322

Cogan syn drom e, 150 Collagen vascu lar disease

differen t ial d iagn osis, 143, 172, 261 perip h eral u lcerat ive keratit is in , 182

Colobom a(s), 50–51, 50f, 219, 219f congen it al, 201

syn drom es associated w ith , 51 Com m ot io ret in ae, 19–20, 19f Con e dyst rop h ies, 281–282

differen t ial d iagn osis, 282 genet ics, 281

m an agem en t, 282 presen tat ion , 282

542 Index

Congen ital an om aly(ies), corn eal, 157–158 Congen ital h ereditar y corneal dyst rophy, 192 Conju n ct iva

am yloid degen erat ion , 120 edem a, 138. See also Ch em osis foreign body, 5f

lacerat ion , 4–5, 5f

lip oid/lip id d egen erat ion , 120–121, 121f m elanom a, 132–133, 132f

m et aplasia, in ectropion, 137, 137f m et astases to, 133

neoplasm s

differen t ial d iagn osis, 118, 120 w ith secon dar y h em orrh age, 3

pigm en ted lesion s, 129–133 reten t ion cyst , 121–122, 121f differen t ial d iagn osis, 118

salm on p atch in , 79, 79f Conju n ct ivit is, 101–111

acu te bacterial, 105–106, 106f

acu te h em orrh agic, 101, 103–104, 103f aden oviral, 101–103, 102f

differen t ial d iagn osis, 112

adu lt in clu sion , 106, 107t–108t, 109 differen t ial d iagn osis, 112

allergic, d ifferen t ial diagn osis, 45 atop ic, differen t ial diagn osis, 111

bacterial, associated w ith eyelid edem a, 105, 106f

ch lam ydial (in clu sion ), 106, 107t–108t, 109 differen t ial d iagn osis, 112

ch ron ic, 109–110

w ith bleph arit is, 100 differen t ial d iagn osis, 62, 63

differen t ial d iagn osis, 3, 66, 101, 114, 124, 125

gian t papillar y, 110–111, 111f differen t ial d iagn osis, 45

gon ococcal, 105–106

m ucopurulen t , in Steven s-Joh n son syn drom e, 113

neon atal, ch lam ydial, 106

pseu dom em bran ou s, in Steven s-Joh n son syn drom e, 113

recu rren t , 109–110

toxic, differen tial diagn osis, 192 vern al, 110–111, 111f

differen t ial d iagn osis, 111, 192 viral, 101, 104

associated w ith eyelid edem a, 69, 72 Con n ect ive t issu e disease (CTD), perip h eral

ulcerat ive kerat it is in , 182 Con stan t exot rop ia, 344, 344f

Con t act derm at it is, d ifferen tial d iagn osis, 69, 72

Con t act len ses

clean ing solu tion s, an d kerat it is, 147, 149 corn eal scarring caused by, differen t ial

diagn osis, 171 for dr y eye, 115

gian t p ap illar y conju n ct ivit is of, 110–111 over w ear, keratit is caused by, 154

differen t ial d iagn osis, 152

an d recu rren t corn eal erosion , 156 use, differen t ial diagn osis, 192

Con t recou p inju r y(ies), 11, 19 Convergen ce in sufficiency, 343 Corn ea

abrasion s, 7–8, 7f

differen t ial d iagn osis, 9, 10, 105 recu rren t , 109–110

cen t ral clou dy dystrop hy of Fran çois, 165, 165f

differen t ial d iagn osis, 175

cen t ral cr ystallin e dyst rop hy of Sch nyder, 164, 164f

differen t ial d iagn osis, 175

ch em ical bu rn . See Ch em ical burn s congen it al an om alies, 157–158 conju n ct ivalization , 136, 136f degen erat ion , 173–180

polym orp h ic am yloid , 178, 179f Salzm an n n odular, 177–178, 177f sph eroidal, 178

den drite

in EBV in fect ion , 145 in HSV kerat it is, 141f in HZV in fect ion , 144f

dep osits in , 173–180

dyst rophy. See Corneal dyst rophy(ies) ectat ic disorders, 170–173

edem a

after cataract ext ract ion , 236–237 in congen ital h ered itar y en doth elial

dyst rophy, 170, 170f

Fuchs en dothelial dyst rophy an d, 167, 168f

in posterior polym orph ous dyst rophy, 169, 169f

en larged n er ves in, 191 differen t ial d iagn osis, 163

en largem en t , in congen ital glaucom a, 134–135

erosion s, trau m at ic, differen tial diagn osis, 159, 160

farin ata, d ifferen t ial d iagn osis, 178 Fleck dyst rophy, 164–165

differen t ial d iagn osis, 166 foreign body, 8–9, 8f

differen t ial d iagn osis, 7

Fuchs en dothelial dyst rophy, 167, 168f differen t ial d iagn osis, 167, 169, 191, 192

graft reject ion , 188, 188f gu t tae, 167, 168f

differen t ial d iagn osis, 160, 178 hydrops

in keratocon us, 171

in keratoglobu s, 171, 172f infect ion s, 141–150

in flam m at ion , 150–153 differen t ial d iagn osis, 192

injur y, an d recu rren t corneal erosion , 156 keloid, 175–176, 176f

lacerat ion , 9–10, 9f

lip oid/lip id d egen erat ion , 120–121, 121f neovascularizat ion , in Steven s-Joh n son

syn drom e, 113 perforat ion

differen t ial d iagn osis, 7

in Steven s-Joh n son syn drom e, 113 recu rren t erosion , 156

scarring

cen t ral, 164

in HSV kerat it is, 141f

in terst it ial kerat it is an d , 150, 151f in Steven s-Joh n son syn drom e, 113

surface disorders, 150–153

th inn ing. See also Keratocon us; Pellucid m argin al degen erat ion (corn ea)

perip h eral, 180–185 ulcer, 7

from Acantham oeba, 147, 148f bacterial, 146–147, 146f differen t ial d iagn osis, 7, 143 fu ngal, 149, 149f

herpet ic, differen t ial diagn osis, 192 herpet ic dendrit ic, 104f

im m u n e-m ediated , 146, 147, 153 infect iou s, differen t ial diagn osis, 153

margin al

in HSV in fect ion , 142

st aphylococcal, 177, 182