- •Foreword
- •Preface
- •Contents
- •Contributors
- •Acronyms
- •1.1 Introduction
- •1.2 Epidemiology
- •1.3 Risk Factors
- •1.3.1 Duration of Diabetes Mellitus
- •1.3.2 Glycemic Control
- •1.3.3 Hypertension
- •1.3.4 Ethnic Differences
- •1.3.5 Obesity
- •1.3.6 Socioeconomic Status
- •1.3.7 Other Risk Factors
- •1.4 Pathophysiology
- •Conclusion
- •References
- •2: Non-proliferative Diabetic Retinopathy
- •2.1 Clinical Overview
- •2.1.1 Clinical Findings
- •2.1.2 Classification of NPDR
- •2.1.3 Atypical Forms of NPDR
- •2.2 Diagnostic Tools
- •2.2.1 Telemedicine
- •2.2.2 Fundus Photography
- •2.2.3 Fluorescein Angiography
- •2.2.4 Ultrasonography
- •2.2.5 Optical Coherence Tomography
- •2.2.6 Adaptive Optics Scanning Laser Ophthalmoscope
- •2.2.7 Multifocal Electroretinogram
- •2.2.8 Pattern Visual Evoked Potentials
- •2.2.9 Other Diagnostic Tools
- •2.3 Present Therapies
- •2.3.1 Primary Interventions
- •2.3.1.1 Glycemic Control
- •2.3.1.2 Blood Pressure Control
- •2.3.1.3 Lipid-Lowering Therapy
- •2.3.2 Secondary Interventions
- •2.3.2.1 Protein Kinase C Inhibitors
- •2.4 Evolving Algorithms
- •2.4.1 Screening
- •2.4.2 Laser Photocoagulation
- •2.5 New Frontiers
- •References
- •3: Diabetic Macular Edema
- •3.1 Clinical Overview
- •3.1.1 Clinical Findings
- •3.1.2 Biomicroscopic Classification of DME
- •3.2 Diagnostic Tools
- •3.2.1 Fluorescein Angiography
- •3.2.2 Optical Coherence Tomography
- •3.2.3 Fundus Photography
- •3.2.4 Microperimetry
- •3.2.5 Multifocal Electroretinogram
- •3.2.6 Other Imaging Under Investigation
- •3.3 Present Therapies
- •3.3.1 Laser Photocoagulation
- •3.3.2 Intravitreal Pharmacotherapies
- •3.3.2.1 Intravitreal Steroids
- •3.3.2.2 Intravitreal Anti-VEGF
- •3.3.3 Pars Plana Vitrectomy
- •3.4 Evolving Algorithms
- •3.4.1 Therapeutic Algorithms
- •3.4.2 Factors Associated with Favorable Response to the Therapy
- •3.4.3 Treatment of DME Associated with Macular Ischemia
- •3.5 New Frontiers
- •References
- •4: Proliferative Diabetic Retinopathy
- •4.1 Clinical Overview
- •4.1.1 Clinical Findings
- •4.1.2 Classification of PDR
- •4.2 Diagnostic Tools
- •4.2.1 Fluorescein Angiography
- •4.2.2 Fundus Photography
- •4.2.3 Ultrasonography
- •4.2.4 Optical Coherence Tomography
- •4.2.5 Perimetry
- •4.2.6 Further Diagnostic Tools
- •4.3 Present Therapies
- •4.3.1 Panretinal Laser Photocoagulation
- •4.3.2 Intravitreal Injections
- •4.3.2.1 Intravitreal Steroids
- •4.3.2.2 Intravitreal Anti-VEGF Agents
- •4.4 Evolving Algorithms
- •4.5 New Frontiers
- •References
- •5.1 Introduction
- •5.2 Pathophysiology
- •5.3 Neovascular Glaucoma
- •5.4 Tractional Retinal Detachment
- •5.5 Treatment
- •5.5.1 Panretinal Laser Photocoagulation
- •5.5.2 Pars Plana Vitrectomy and Endophotocoagulation
- •5.5.4 Silicone Oil Tamponade
- •5.5.4.1 Viscodissection
- •Conclusion
- •References
Diabetic Macular Edema |
3 |
|
Francesco Bandello, Ilaria Zucchiatti, Rosangela Lattanzio,
and Chiara Preziosa
Contents
3.1 |
Clinical Overview ......................................................................................................... |
66 |
|
|
3.1.1 |
Clinical Findings............................................................................................. |
66 |
|
3.1.2 Biomicroscopic Classification of DME .......................................................... |
67 |
|
3.2 |
Diagnostic Tools............................................................................................................ |
71 |
|
|
3.2.1 |
Fluorescein Angiography................................................................................ |
71 |
|
3.2.2 |
Optical Coherence Tomography ..................................................................... |
74 |
|
3.2.3 |
Fundus Photography ....................................................................................... |
77 |
|
3.2.4 |
Microperimetry ............................................................................................... |
77 |
|
3.2.5 |
Multifocal Electroretinogram.......................................................................... |
78 |
|
3.2.6 Other Imaging Under Investigation................................................................. |
78 |
|
3.3 |
Present Therapies .......................................................................................................... |
79 |
|
|
3.3.1 |
Laser Photocoagulation................................................................................... |
79 |
|
3.3.2 |
Intravitreal Pharmacotherapies ....................................................................... |
85 |
|
3.3.3 |
Pars Plana Vitrectomy..................................................................................... |
101 |
3.4 |
Evolving Algorithms..................................................................................................... |
104 |
|
|
3.4.1 |
Therapeutic Algorithms .................................................................................. |
104 |
|
3.4.2 Factors Associated with Favorable Response to the Therapy......................... |
107 |
|
|
3.4.3 Treatment of DME Associated with Macular Ischemia.................................. |
107 |
|
3.5 |
New Frontiers................................................................................................................ |
111 |
|
References.................................................................................................................... |
............ |
113 |
|
F. Bandello, MD, FEBO (*) • I. Zucchiatti, MD • R. Lattanzio, MD • C. Preziosa, MD Department of Ophthalmology, University Vita-Salute,
Scientific Institute San Raffaele, via Olgettina 60, Milan 20132, Italy e-mail: bandello.francesco@hsr.it; ilaria.zucchiatti@gmail.com; lattanzio.rosangela@hsr.it; preziosachiara@gmail.com
F. Bandello et al. (eds.), Clinical Strategies in the Management of Diabetic Retinopathy, |
65 |
DOI 10.1007/978-3-642-54503-0_3, © Springer-Verlag Berlin Heidelberg 2014 |
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