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XIII |
|
Abkürzungsverzeichnis |
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ABCA1 |
ATP-bindendes Transportprotein |
GA |
Geographische Atrophie |
||
AGE |
Advanced glycation end products |
GCL |
Ganglion cell layer (Ganglionzellschicht) |
||
ALA |
Alphalinolensäure |
GK |
Glaskörper |
||
AMD |
Altersabhängige Makuladegeneration |
GWAS |
Genomweite Assoziationsstudie |
||
APC |
Alternative pathway of complement (alternativer |
HDL-c |
High-density lipoprotein cholesterol |
||
|
Komplementweg) |
HTRA1 |
High temperature requirement factor A1 |
||
APOE |
Apolipoprotein E |
ICG |
Indozyaningrün |
||
AREDS |
Age-Related-Eye-Disease Studie |
ICAM |
Intracellular adhesion molecules (intrazelluläre |
||
ARM |
Age-related maculopathy (altersabhängige |
|
Adhäsionsmoleküle) |
||
|
Makulopathie) |
ICS |
Innere kollagene Schicht |
||
ARMS2 |
Age-related maculopathy susceptibility 2 |
IPE |
Irispigmentepithel |
||
BCEA |
Bivariate contour ellipse calculated area |
IV |
Inverse Varianz |
||
|
(bivariable Konturanalyse) |
IVB |
Intravitreales Bevacizumab |
||
BCVA |
Best corrected visual acuity (bestkorrigierter |
IVR |
Intravitreales Ranibizumab |
||
|
Visus) |
IVTA |
Intravitreales Triamcinolon |
||
BLD |
Basal laminar deposits |
LCPUFA |
Long-chain polyunsaturated fatty acids |
||
BM |
Bruch-Membran |
|
(langkettige mehrfach ungesättigte Fett- |
||
BRF |
Bevorzugter retinaler Fixationsort |
|
säuren) |
||
CC |
Choriocapillaris |
LDL |
Low-densitity lipoprotein |
||
CCD |
Charge-coupled device |
LF |
Lipofuszin |
||
CDCV |
Common disease – common variant |
LIPC |
Lipase C |
||
CDRV |
Common disease – rare variant |
LLUS |
Late leakage of undetermined source (späte |
||
CEP |
Carboxyethylpyrrole |
|
Leckage unklarer Herkunft) |
||
CETP |
Cholesterinester-Transferprotein |
logMAR |
Logarithm of the minimum angle of resolution |
||
CFB |
Complement factor B (Komplementfaktor B) |
LSC |
Long spaced collagen |
||
CFH |
Complement factor H (Komplementfaktor H) |
MAF |
Minor allele frequency |
||
CFI |
Complement factor I (Komplementfaktor I) |
MCP |
Membrane cofactor protein |
||
CHS |
Cardiovascular-Health-Studie |
MHC |
Major histocompatibility complex (Haupthisto- |
||
CI |
Konfidenzintervall |
|
kompatibilitätskomplex) |
||
CNP |
Copy number polymorphism (Kopienzahl- |
MMP |
Matrixmetalloproteinase |
||
|
Polymorphismus) |
MPOD |
Makuläre optische Pigmentdichte |
||
CNTF |
Ciliary neutrophic factor |
NH |
Netzhaut |
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CNV |
Chorioidale Neovaskularisation |
NV-AMD |
Neovaskuläre altersabhängige Makula- |
||
CRP |
C-reaktives Protein |
|
degeneration |
||
CRT |
Central retinal thickness (zentrale Retinadicke) |
OCT |
Optische Kohärenztomographie |
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cSLO |
Konfokales Scanning-Laser-Ophthalmoskop |
OR |
Odds Ratio |
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DA |
Disc area |
ORCA |
Occult retinal choroidal anastomosis |
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DAF |
Decay-accelerating factor |
PAR |
Populationsbezogenes attributables Risiko |
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DHA |
Docosahexaensäure |
Patch |
Pigmentepithel-Aderhaut-Translokation |
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ECM |
Extracellular matrix (extrazelluläre Matrix) |
PCV |
Polypoide chorioidale Vaskulopathie |
||
EDI-OCT |
Enhanced-Depth-Imaging-optische Kohärenz- |
PD |
Pupillardistanz |
||
|
tomographie |
PDT |
Photodynamische Therapie |
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ETDRS |
Early Treatment Diabetic Retinopathy Study |
PE |
Pigmentepithel |
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EPA |
Eicosapentaensäure |
PED |
Pigment epithelium detachment (Pigment- |
||
ESR |
Erythrozytensedimentationsrate |
|
epithelabhebung) |
||
FAF |
Fundusautofluoreszenz |
PEDF |
Pigment epithelium derived factor |
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FAZ |
Foveoläre avaskuläreZone |
PFCL |
Perfluorocarbon liquid (flüssiges Perfluorkarbon) |
||
FVPED |
Fibrovascular pigment epithelial detachment |
PHP |
Preferential hyperacuity perimeter |
||
|
(fibrovaskuläre Pigmentepithelabhebung) |
PLGF |
Placental growth factor |
||
XIV Abkürzungsverzeichnis
PLEKHA1 |
Pleckstrin homology domain-containing protein |
|
family A member 1 |
PON1 |
Paraoxonase-1-Gens |
POS |
Photoreceptor outer segment (Photorezeptor- |
|
Außensegment) |
PRN |
Pro re nata |
PRR |
Pattern-recognition-Rezeptoren |
PVR |
Proliferative Vitreoretinopathie |
RAP |
retinal angiomatous proliferation (retinale angio- |
|
matöse Proliferation) |
RBP |
Retinol-bindendes Protein |
RCOphth |
Royal College of Ophthalmologists |
RCT |
Randomized controlled trial |
RNFL |
Retinal nerve fiber layer (retinale Nervenfaser- |
|
schicht) |
ROS |
Reactive oxygen species (reaktive Sauerstoffs- |
|
pezies) |
RPE |
Retinales Pigmentepithel |
RTK |
Rezeptor-Tyrosinkinasen |
rTPA |
Recombinant tissue plasminogen activator |
RVAC |
Retinal vascular anomalous complexes (retinale |
|
vaskuläre anomale Komplexe) |
SD-OCT |
Spectral-Domain-optische Kohärenztomographie |
SLD |
Superlumineszente Diode |
SLO |
Scanning-Laser-Ophthalmoskop |
SNP |
Single nucleotide polymorphism (Einzelnukle- |
|
otid-Polymorphismus) |
SOD2 |
Superoxid-Dismutase-2 |
Sr-90 |
Strontium-90 |
SS-OCT |
Swept-Source-optische Kohärenztomographie |
TD-OCT |
Time-Domain-optische Kohärenztomographie |
TIMP |
Tissue inhibitor of metalloproteinases (Metallo- |
|
proteinase-Inhibitor) |
TLR |
Toll-like receptor (Toll-like-Rezeptor) |
UTR |
Untranslated region (untranslatierte Region) |
VA |
Sehschärfe |
VCM |
Visual cycle modulators |
VEGF |
Vascular endothelial growth factor (vaskulärer |
|
endothelialer Wachstumsfaktor) |
VPDT |
Photodynamische Therapie mit Verteporfin |
ZMÖ |
Zystoides Makulaödem |
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XV |
|
Autorenverzeichnis |
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Dr. Mark R. Barakat |
Dr. S. Foran |
Prof. Dr. Paulus V.M. de Jong |
||
Cole Eye Institute |
Eye Clinic |
Erasmus Medical Center |
||
Cleveland Clinic Foundation |
Westmead Hospital |
‘S-Gravendijkwal 230 |
||
9500 Euclid Avenue, Mail Code: i-32 |
Hawkesbury Road |
3015 CE Rotterdam |
||
Cleveland, OH 44195 |
Westmead, NSW 2145 |
Niederlande |
||
USA |
Australien |
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|
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|
Prof. Dr. Peter K. Kaiser |
||
Prof. Dr. Alan C. Bird |
Dr. Ulrike Friedrich |
Cole Eye Institute |
||
Institute of Ophthalmology |
Institut für Humangenetik |
Cleveland Clinic Foundation |
||
Moorfields Eye Hospital |
Universität Regensburg |
9500 Euclid Avenue, Mail Code: i-32 |
||
City Road, London EC1 V 2PD |
Franz-Josef-Strauss-Allee 11 |
Cleveland, OH 44195 |
||
Großbritannien |
93054 Regensburg |
USA |
||
Prof. Dr. Michael E. Boulton |
Dr. Lars G. Fritsche |
Prof. Dr. Bernd Kirchhof |
||
Institute for Anatomy and Cell |
Institut für Humangenetik |
Klinik für Augenheilkunde |
||
Biology |
Universität Regensburg |
Universitätsklinikum Köln |
||
University of Florida |
Franz-Josef-Strauss-Allee 11 |
Kerpenerstrasse 62 |
||
1600 SW Archer Road |
93054 Regensburg |
50924 Köln-Lindenthal |
||
Gainesville |
|
|
|
|
PO Box 100235 |
Prof. Dr. Salvatore Grisanti |
Dr. Caroline W. Klaver |
||
USA |
Klinik für Augenheilkunde |
Erasmus Medical Center |
||
|
Universitätsklinikum Schleswig- |
‘S-Gravendijkwal 230 |
||
Prof. Dr. Emily Y. Chew |
Holstein |
3015 CE Rotterdam |
||
National Eye Institute |
Campus Lübeck |
Niederlande |
||
National Institutes of Health |
Ratzeburger Allee 160 |
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|
|
Bethesda, MD (301)496-6583 |
23538 Lübeck |
Dr. Nupura Krishnadev |
||
USA |
|
National Eye Institute |
||
|
Dr. Lintje Ho |
National Institutes of Health |
||
Prof. Dr. Victor N. Chong |
Erasmus Medical Center |
Bethesda, MD (301)496-6583 |
||
Oxford Eye Hospital |
‘S-Gravendijkwal 230 |
USA |
||
The University of Oxford |
3015 CE Rotterdam |
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|
|
Oxford, OX3 9DU |
Niederlande |
Dr. Redmer van Leeuwen |
||
Großbritannien |
|
Erasmus Medical Center |
||
|
Prof. Dr. Frank G. Holz |
‘S-Gravendijkwal 230 |
||
Dr. Martha Dietzel |
Klinik für Augenheilkunde |
3015 CE Rotterdam |
||
Augenabteilung |
Universitätsklinikum Bonn |
Niederlande |
||
St. Franziskus Hospital |
Ernst-Abbe-Strasse 2 |
|
|
|
Hohenzollernring 74 |
53127 Bonn |
Dr. Albrecht Lommatzsch |
||
48145 Münster |
|
St. Franziskus Hospital |
||
|
PD Dr. Peter Charbel Issa |
Augenabteilung |
||
Dr. Monika Fleckenstein |
Nuffield Laboratory of Ophthalmology |
Hohenzollernring 74 |
||
Klinik für Augenheilkunde |
University of Oxford |
48145 Münster |
||
Universitätsklinikum Bonn |
John Radcliffe Hospital |
|
|
|
Ernst-Abbe-Strasse 2 |
Oxford, OX3 9DU |
Dr. Julia Lüke |
||
53127 Bonn |
Großbritannien |
Klinik für Augenheilkunde |
||
|
|
Universitätsklinikum Schleswig-Holstein |
||
|
|
Campus Lübeck |
||
|
|
Ratzeburger Allee 160 |
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|
|
23538 Lübeck |
||
XVI Autorenverzeichnis
Dr. Dhanu A. Meleth |
Prof. Dr. Philip J. Rosenfeld |
Prof. Dr. Susanne Trauzettel- |
National Eye Institute |
Bascom Palmer Eye Institute |
Klosinski |
National Institutes of Health |
900 NW 17th St. |
Klinik für Augenheilkunde |
Bethesda, MD |
Miami, FL 33136 |
Universität Tübingen |
(301)496-6583 |
USA |
Schleichstr. 12–16 |
USA |
|
72076 Tübingen |
|
PD Dr. Steffen Schmitz- |
|
Prof. Dr. Edoardo Midena |
Valckenberg |
Dr. Johannes R. Vingerling |
Department of Ophthalmology |
Klinik für Augenheilkunde |
Erasmus Medical Center |
University of Padova |
Universitätsklinikum Bonn |
‘S-Gravendijkwal 230 |
via Giustiniani 2 |
Ernst-Abbe-Strasse 2 |
3015 CE Rotterdam |
I-35128 Padua |
53127 Bonn |
Niederlande |
Italien |
|
|
|
Prof. Dr. Hendrik P.N. Scholl |
Dr. Susanne Wasmuth |
Prof. Dr. Paul Mitchell |
Wilmer Eye Institute |
Augenabteilung |
Eye Clinic |
Johns Hopkins University |
St. Franziskus Hospital |
Westmead Hospital |
748 Maumenee Building |
Hohenzollernring 74 |
Hawkesbury Road |
600 N. Wolfe Street |
48145 Münster |
Westmead, NSW 2145 |
Baltimore, MD 21287-9277 |
|
Australien |
USA |
Prof. Dr. Bernhard H.F. Weber |
|
|
Institut für Humangenetik |
Prof. Dr. Daniel Pauleikhoff |
Prof. Dr. Gisèle Soubrane |
Universität Regensburg |
Augenabteilung |
Clinique Ophtalmologique |
Franz-Josef-Strauss-Allee 11 |
St.-Franziskus Hospital |
Universitaire |
93054 Regensburg |
Hohenzollernring 74 |
Centre Hospitalier Intercommunal |
|
48145 Münster |
40, Avenue de Verdun |
Prof. Dr. Dr. Sebastian Wolf |
|
Créteil 94010 |
Universitätsklinik für Augenheilkunde |
Prof. Dr. Swaantje Peters |
Frankreich |
Inselspital |
Klinik für Augenheilkunde |
|
Universität Bern |
Universitätsklinikum Schleswig-Holstein |
Prof. Dr. Richard F. Spaide |
Freiburgstrasse |
Campus Lübeck |
Vitreous-Retina-Macula Consultants |
CH-3010 Bern |
Ratzeburger Allee 160 |
of New York |
Schweiz |
23538 Lübeck |
519 E. 72nd St. |
|
|
New York, NY 10021 |
Dr. Zohar Yehoshua |
Dr. Elisabetta Pilotto |
USA |
Bascom Palmer Eye Institute |
Department of Ophthalmology |
|
900 NW 17th St. |
University of Padova |
Dr. Nathan Steinle |
Miami, FL 33136 |
Via Giustiniani 2 |
Cole Eye Institute |
USA |
I-35128 Padua |
Cleveland Clinic Foundation |
|
Italien |
9500 Euclid Avenue, Mail Code: i-32 |
|
|
Cleveland, OH 44195 |
|
Dr. Veena R. Raiji |
USA |
|
Department of Ophthalmology |
|
|
George Washington University |
Dr. Janet S. Sunness |
|
Washington, DC (202)741-2825 |
Hoover Low Vision Rehabilitation |
|
USA |
Services |
|
|
Greater Baltimore Medical Center |
|
Prof. Dr. Klaus Rohrschneider |
6569 North Charles St, PPW305 |
|
Klinik für Augenheilkunde |
Baltimore, MD 21204 |
|
Universitätsklinikum Heidelberg |
USA |
|
Im Neuenheimer Feld 400 |
|
|
69120 Heidelberg |
|
|
I
I Pathophysiologie
Kapitel 1 |
Epidemiologie der AMD – 3 |
|
L. Ho, R. van Leeuwen, P.T.V.M. de Jong, J.R. Vingerling, C.C.W. Klaver |
|
Übersetzt von T. Boll |
Kapitel 2 |
Genetik – 33 |
|
U. Friedrich, L.G. Fritsche, B.H.F. Weber |
Kapitel 3 |
Alterung der Netzhaut und des retinalen Pigmentepithels – 45 |
|
M.E. Boulton |
|
Übersetzt von T. Boll |
Kapitel 4 |
Das Komplementsystem bei der AMD – 65 |
|
P. Charbel Issa, N.V. Chong, H.P.N. Scholl |
Kapitel 5 |
Histopathologie – 79 |
|
A. Lommatzsch, S. Wasmuth, D. Pauleikhoff, F.G. Holz, A.C. Bird |