- •Foreword
- •Preface
- •Glossary
- •1. Introduction
- •2. Historical Considerations
- •2.1 Arteriovenous Fistula and Pulsating Exophthalmos
- •2.2 Angiography
- •2.3 Therapeutic Measures
- •2.4 Embolization
- •References
- •3.1 Osseous Anatomy
- •3.1.1 Orbit
- •3.2 Anatomy of the Dura Mater and the Cranial Nerves
- •3.2.1 Autonomic Nervous System
- •3.3 Vascular Anatomy
- •3.3.1 Arterial Anatomy
- •3.3.1.1 Internal Carotid Artery
- •Meningohypophyseal Trunk (MHT)
- •Ophthalmic Artery
- •Ethmoidal Arteries
- •3.3.1.2 External Carotid Artery
- •3.3.1.2.1 Ascending Pharyngeal Artery
- •3.3.1.2.2 Internal Maxillary Artery
- •3.3.1.2.3 Middle Meningeal Artery
- •3.3.1.2.4 Accessory Meningeal Artery
- •3.3.2 Venous Anatomy
- •3.3.2.1.1 Embryology
- •3.3.2.1.2 Anatomy and Topography
- •Orbital Veins
- •Superior Ophthalmic Vein
- •Inferior Ophthalmic Vein
- •Central Retinal Vein (No Direct CS Tributary)
- •Uncal Vein, Uncinate Vein
- •Sphenoparietal sinus (Breschet), Sinus alae parvae, Sinus sphenoidales superior (Sir C. Bell)
- •Intercavernous Sinus, Sinus intercavernosus, Sinus circularis (Ridley), Sinus ellipticus, Sinus coronarius, Sinus clinoideus (Sir C. Bell), Sinus transversus sellae equinae (Haller)
- •Meningeal Veins
- •Veins of the Foramen Rotundum, Emissary Vein
- •Inferior Petrosal Sinus, Sinus petrosus profundus, Sinus petro-occipitalis superior (Trolard)
- •Venous Plexus of the Hypoglossal Canal, Anterior Condylar Vein
- •Posterior Condylar Vein
- •Lateral Condylar Vein
- •Inferior Petroclival Vein
- •Petro-occipital Sinus, Sinus petro-occipitalis inferior, petro-occipital vein (Padget)
- •Transverse Occipital Sinus (Doyen)
- •Basilar Plexus (Virchow)
- •Marginal Sinus
- •Foramen Ovale Plexus (Trigeminal Sinus), Sphenoid Emissary, “Rete” of the Foramen Ovale
- •Vein of the Sphenoid Foramen (Foramen Venosum, Foramen of Vesalius)
- •Foramen Lacerum Plexus
- •Pterygoid Plexus
- •3.3.2.4 Other Veins of Importance for the CS Drainage or for Transvenous Access to the CS
- •Facial Vein
- •Frontal Vein
- •Angular Vein
- •Middle Temporal Vein
- •Internal Jugular Vein
- •The External Jugular Vein
- •Vertebral Vein, Vertebral Artery Venous Plexus
- •Deep Cervical Vein
- •References
- •Introduction
- •4.1.1 Dural Arteriovenous Fistulas (DAVFs)
- •4.1.2 Cavernous Sinus Fistulas (CSFs)
- •References
- •Introduction
- •5.1 Etiology and Pathogenesis of Type A Fistulas
- •5.2 Etiology and Pathogenesis of Type B–D Fistulas
- •5.2.1 Pregnancy
- •5.2.2 Hormonal Factors
- •5.2.3 Thrombosis
- •5.2.4 Venous Hypertension
- •5.2.5 Trauma
- •5.2.6 Embolization
- •5.2.7 Congenital
- •5.2.8 Other Potential Factors
- •5.2.9 Various
- •5.3 Prevalence
- •5.3.1 Natural History
- •References
- •Introduction
- •6.1 Extraorbital Ocular Symptoms
- •6.1.1 Orbital Pain
- •6.2 Orbital Symptoms
- •6.2.1 Exophthalmos
- •6.2.2 Conjunctival Engorgement and Chemosis
- •6.2.2.1 Retinal Hemorrhage
- •6.2.3 Corneal Damage
- •6.2.4 Orbital Bruit
- •6.2.6 Secondary Glaucoma and Visual Loss
- •6.3 Other and Neurological Symptoms
- •References
- •7. Radiological Diagnosis of DCSFs
- •7.1 Non-invasive Imaging Techniques
- •7.1.2 Doppler and Carotid Duplex Sonography
- •7.2 Intra-arterial Digital Subtraction Angiography (DSA)
- •7.2.1 Introduction
- •7.2.2 Technique
- •7.2.3 Angiographic Protocol for DCSFs
- •7.2.4 Angiographic Anatomy of the Cavernous Sinus
- •7.2.5 Flat Detector Technology in Neuroangiography
- •7.2.6 Rotational Angiography and 3D-DSA
- •7.2.6.1 Dual Volume Technique (DVT)
- •7.2.6.2 Angiographic Computed Tomography (ACT), DynaCT (Siemens), C-arm Flat Detector CT (FD-CT), Flat Panel CT (FP-CT) or Cone Beam CT
- •7.2.6.3 Image Post-Processing
- •7.2.6.4 3D Studies of the Cavernous Sinus Region
- •References
- •8. Endovascular Treatment
- •8.1 Techniques of Transvenous Catheterization
- •8.1.1 Inferior Petrosal Sinus Approach
- •8.1.2 Alternative Approaches to the Cavernous Sinus
- •8.1.3 Other Techniques
- •8.2 Embolic Agents
- •8.2.1 Polyvinyl Alcohol (PVA) and Embospheres
- •8.2.2 Stainless Steel Coils
- •8.2.5 Stents
- •8.3.1 Approaches (Benndorf et al. 2004)
- •8.3.2 Angiographic and Clinical Outcome
- •8.4 Discussion of Transvenous Occlusions
- •8.4.1 Approaches
- •8.4.1.1 IPS Approaches
- •8.4.1.6 Transfemoral Pterygoid Plexus Approach (PP Approach)
- •8.4.1.7 Transfemoral Cortical Vein Approach
- •8.4.1.10 Direct Puncture of the Foramen Ovale
- •8.4.2 Embolic Materials
- •8.4.2.1 Particles
- •8.4.2.2 Coils
- •HydroCoils (Hydrogel)
- •8.4.2.4 Ethylene-Vinyl Alcohol Copolymer (OnyxTM)
- •8.4.2.5 Stents and Covered Stents
- •8.4.3 Anatomic Results, Clinical Outcome and Complications of Transvenous Occlusions and Transarterial Embolizations
- •8.5 Conclusion
- •References
- •9. Alternative Treatment Options
- •9.1 Spontaneous Thrombosis
- •9.2 Manual Compression Therapy
- •9.4 Radiotherapy
- •9.5 Surgery
- •References
- •10. Hemodynamic Aspects of DCSFs
- •10.1 Introduction
- •10.2 Basic Hemodynamic Principles
- •10.3 Invasive Assessment of Hemodynamics
- •10.4 Flow Velocity and Pressure Measurements in Brain AVMs and DAVFs
- •10.5 Hemodynamics and Pathophysiology in CSFs
- •Comments
- •References
- •11. Summary
- •Subject Index
8.2 Embolic Agents 197
distally with silicon vascular loops. These loops are passed through small pediatric feeding tubes to control the bleeding while advancing the catheter using a two-person technique (Miller 2007).
For all SOV approaches, the packing of coils is performed in the reverse order compared to the IPS approach, starting at the most posterior aspect of the CS and finishing the coil packing at the SOV–CS junction. In this manner, the coil packing begins at the posterior or contralateral compartment of the CS; the disconnection between CS and SOV is done as the last step. At the end of the procedure, the vein is manually compressed for a few minutes before the skin is sutured.
8.1.2.3
Transorbital Puncture of the Superior or Inferior Ophthalmic Vein (Case Report VI)
Failure of all previously described approaches justifies a more aggressive technique, in the same or a subsequent session. A bi-plane road map is obtained using the 4-F diagnostic catheter demonstrating the course of the vein deep in the orbit. Under sterile conditions, a 21or 22-gauge needle (e.g. Terumo UTW 21 or micropuncture set) is gently advanced along the medial wall of the orbit posterior to the globe, using bi-plane fluoroscopy. When the needle reaches the deep orbit, the SOV or the IOV is carefully cannulated and a small microcatheter (Tracker-10) is introduced. The IOV is punctured by advancing the needle along the inferior orbital rim (White et al. 2007). After the microcatheter is advanced into the CS, coils are deployed, as described above. Puncturing an arterialized vein within the orbit is a delicate maneuver. Stabilizing the needle is crucial while manipulating a microcatheter or pushing coils into the CS. Losing this access can not only jeopardize the procedure, but may also cause intraorbital hemorrhage with potential vision loss. Avoiding excessive tension on the fragile venous wall by a lesser dense packing within the SOV may be advisable.
8.1.3
Other Techniques
For alternative transfemoral, transcutaneous and transorbital CS approaches, including the superior petrosal sinus (SPS), pterygoid plexus (PP), the facial vein (FV), the middle temporal vein (MTV), the frontal vein (FV), superficial middle cerebral vein (SMCV) and direct puncture of the CS, see discussion below.
8.2
Embolic Agents (Figs. 8.5–8.13)
To cover the wide range of various embolic materials and their handling is beyond the scope of this chapter. Embolic agents of particular interest for transarterial or transvenous occlusions of dural CSFs will be described below.
8.2.1
Polyvinyl Alcohol (PVA) and Embospheres
PVA particles (Contour PVA, Boston Scientific, Fremont; TruFillTM PVA, Cordis Endovascular, Miami Lakes, FL) have been employed for a long time in a wide range of applications and are used frequently in preoperative embolization of vascularized tumors such as meningiomas, glomus tumors or capillary hemangiomas (Bendszus et al. 2000; Manelfe et al. 1976; Wright et al. 1982; Berenstein and Graeb
1982; Kerber et al. 1978). In the 1980s and early 1990s, PVA was also used for embolizing brain AVMs (Scialfa and Scotti 1985). PVA particles can be injected wherever liquid embolic agents are considered unsafe, and coils are unsuitable for anatomic or hemodynamic reasons (Wright et al. 1982; Kerber et al. 1978; Jack et al. 1985). The particles are manufactured by different vendors in a size between 45–150 μm and up to 700–2000 μm, and are selected based on the caliber of the vessel in the targeted territory. One longstanding disadvantage of PVA has been the fact that these particles not only varied in size (ranges), but also had an irregular surface causing aggregation, clumping and occlusion of catheters and proximal vessel segments. In addition, the particles showed a tendency to swell after being in a contrast suspension for some time and usually had to be replaced by a new mixture several times throughout the treatment session.
Newer PVA particle types come as hydrophilic microspheres in a calibrated size (Contour-SE, Boston Scientific). They are naturally opaque with a more uniform size distribution, a wider range of sizes and come pre-hydrated in saline in a prefilled syringe.
Alternatively, Trisacryl gelatin microspheres (Embospheres, Guerbet Biomedical, Louvres, France) can be used and may offer some advantages because they are precisely calibrated at 100–300 μm and have fewer tendencies to aggregate (Laurent et al. 2005; Beaujeux et al. 1996; Derdeyn 1997). A recent comparison has shown that they produce less
