- •Foreword
- •Preface
- •Glossary
- •1. Introduction
- •2. Historical Considerations
- •2.1 Arteriovenous Fistula and Pulsating Exophthalmos
- •2.2 Angiography
- •2.3 Therapeutic Measures
- •2.4 Embolization
- •References
- •3.1 Osseous Anatomy
- •3.1.1 Orbit
- •3.2 Anatomy of the Dura Mater and the Cranial Nerves
- •3.2.1 Autonomic Nervous System
- •3.3 Vascular Anatomy
- •3.3.1 Arterial Anatomy
- •3.3.1.1 Internal Carotid Artery
- •Meningohypophyseal Trunk (MHT)
- •Ophthalmic Artery
- •Ethmoidal Arteries
- •3.3.1.2 External Carotid Artery
- •3.3.1.2.1 Ascending Pharyngeal Artery
- •3.3.1.2.2 Internal Maxillary Artery
- •3.3.1.2.3 Middle Meningeal Artery
- •3.3.1.2.4 Accessory Meningeal Artery
- •3.3.2 Venous Anatomy
- •3.3.2.1.1 Embryology
- •3.3.2.1.2 Anatomy and Topography
- •Orbital Veins
- •Superior Ophthalmic Vein
- •Inferior Ophthalmic Vein
- •Central Retinal Vein (No Direct CS Tributary)
- •Uncal Vein, Uncinate Vein
- •Sphenoparietal sinus (Breschet), Sinus alae parvae, Sinus sphenoidales superior (Sir C. Bell)
- •Intercavernous Sinus, Sinus intercavernosus, Sinus circularis (Ridley), Sinus ellipticus, Sinus coronarius, Sinus clinoideus (Sir C. Bell), Sinus transversus sellae equinae (Haller)
- •Meningeal Veins
- •Veins of the Foramen Rotundum, Emissary Vein
- •Inferior Petrosal Sinus, Sinus petrosus profundus, Sinus petro-occipitalis superior (Trolard)
- •Venous Plexus of the Hypoglossal Canal, Anterior Condylar Vein
- •Posterior Condylar Vein
- •Lateral Condylar Vein
- •Inferior Petroclival Vein
- •Petro-occipital Sinus, Sinus petro-occipitalis inferior, petro-occipital vein (Padget)
- •Transverse Occipital Sinus (Doyen)
- •Basilar Plexus (Virchow)
- •Marginal Sinus
- •Foramen Ovale Plexus (Trigeminal Sinus), Sphenoid Emissary, “Rete” of the Foramen Ovale
- •Vein of the Sphenoid Foramen (Foramen Venosum, Foramen of Vesalius)
- •Foramen Lacerum Plexus
- •Pterygoid Plexus
- •3.3.2.4 Other Veins of Importance for the CS Drainage or for Transvenous Access to the CS
- •Facial Vein
- •Frontal Vein
- •Angular Vein
- •Middle Temporal Vein
- •Internal Jugular Vein
- •The External Jugular Vein
- •Vertebral Vein, Vertebral Artery Venous Plexus
- •Deep Cervical Vein
- •References
- •Introduction
- •4.1.1 Dural Arteriovenous Fistulas (DAVFs)
- •4.1.2 Cavernous Sinus Fistulas (CSFs)
- •References
- •Introduction
- •5.1 Etiology and Pathogenesis of Type A Fistulas
- •5.2 Etiology and Pathogenesis of Type B–D Fistulas
- •5.2.1 Pregnancy
- •5.2.2 Hormonal Factors
- •5.2.3 Thrombosis
- •5.2.4 Venous Hypertension
- •5.2.5 Trauma
- •5.2.6 Embolization
- •5.2.7 Congenital
- •5.2.8 Other Potential Factors
- •5.2.9 Various
- •5.3 Prevalence
- •5.3.1 Natural History
- •References
- •Introduction
- •6.1 Extraorbital Ocular Symptoms
- •6.1.1 Orbital Pain
- •6.2 Orbital Symptoms
- •6.2.1 Exophthalmos
- •6.2.2 Conjunctival Engorgement and Chemosis
- •6.2.2.1 Retinal Hemorrhage
- •6.2.3 Corneal Damage
- •6.2.4 Orbital Bruit
- •6.2.6 Secondary Glaucoma and Visual Loss
- •6.3 Other and Neurological Symptoms
- •References
- •7. Radiological Diagnosis of DCSFs
- •7.1 Non-invasive Imaging Techniques
- •7.1.2 Doppler and Carotid Duplex Sonography
- •7.2 Intra-arterial Digital Subtraction Angiography (DSA)
- •7.2.1 Introduction
- •7.2.2 Technique
- •7.2.3 Angiographic Protocol for DCSFs
- •7.2.4 Angiographic Anatomy of the Cavernous Sinus
- •7.2.5 Flat Detector Technology in Neuroangiography
- •7.2.6 Rotational Angiography and 3D-DSA
- •7.2.6.1 Dual Volume Technique (DVT)
- •7.2.6.2 Angiographic Computed Tomography (ACT), DynaCT (Siemens), C-arm Flat Detector CT (FD-CT), Flat Panel CT (FP-CT) or Cone Beam CT
- •7.2.6.3 Image Post-Processing
- •7.2.6.4 3D Studies of the Cavernous Sinus Region
- •References
- •8. Endovascular Treatment
- •8.1 Techniques of Transvenous Catheterization
- •8.1.1 Inferior Petrosal Sinus Approach
- •8.1.2 Alternative Approaches to the Cavernous Sinus
- •8.1.3 Other Techniques
- •8.2 Embolic Agents
- •8.2.1 Polyvinyl Alcohol (PVA) and Embospheres
- •8.2.2 Stainless Steel Coils
- •8.2.5 Stents
- •8.3.1 Approaches (Benndorf et al. 2004)
- •8.3.2 Angiographic and Clinical Outcome
- •8.4 Discussion of Transvenous Occlusions
- •8.4.1 Approaches
- •8.4.1.1 IPS Approaches
- •8.4.1.6 Transfemoral Pterygoid Plexus Approach (PP Approach)
- •8.4.1.7 Transfemoral Cortical Vein Approach
- •8.4.1.10 Direct Puncture of the Foramen Ovale
- •8.4.2 Embolic Materials
- •8.4.2.1 Particles
- •8.4.2.2 Coils
- •HydroCoils (Hydrogel)
- •8.4.2.4 Ethylene-Vinyl Alcohol Copolymer (OnyxTM)
- •8.4.2.5 Stents and Covered Stents
- •8.4.3 Anatomic Results, Clinical Outcome and Complications of Transvenous Occlusions and Transarterial Embolizations
- •8.5 Conclusion
- •References
- •9. Alternative Treatment Options
- •9.1 Spontaneous Thrombosis
- •9.2 Manual Compression Therapy
- •9.4 Radiotherapy
- •9.5 Surgery
- •References
- •10. Hemodynamic Aspects of DCSFs
- •10.1 Introduction
- •10.2 Basic Hemodynamic Principles
- •10.3 Invasive Assessment of Hemodynamics
- •10.4 Flow Velocity and Pressure Measurements in Brain AVMs and DAVFs
- •10.5 Hemodynamics and Pathophysiology in CSFs
- •Comments
- •References
- •11. Summary
- •Subject Index
196 8 Endovascular Treatment
sistence, or even worsening by rerouting of the venous drainage that is associated with increased risk of intracranial hemorrhage. At the end of the procedure, occluding the IPS itself should be avoided as it may be needed as an access route in a subsequent session. Secondly, an occlusion of the IPS may, if it serves as drainage for the CS, compromise the normal cerebral circulation of the posterior fossa. Although a 4-F or 5-F guiding catheter can be advanced into the IPS, one should remember that, especially in cases with cortical venous drainage, such a maneuver may elevate venous pressure sufficent enough to cause intracerebral hemorrhage as recently reported (Theaudin et al. 2007).
The angiographic endpoint of the endovascular procedure is either subtotal or complete occlusion of the fistula. If there is a minimal residual AV shunt visible, the procedure can usually be stopped, because the postoperative normalization of the ACT will further promote ongoing thrombosis within the CS. Ongoing thrombosis in the CS may be impeded by the heparinization of the patient during the procedure. Subtotal occlusion is often sufficient and will lead to complete occlusion within a few days or even 24 h when the coagulation system is normalized (Case Reports II and IV). Whenever possible, it is advisable to avoid overpacking the CS.
Additional particulate embolization using PVA or Embospheres after TVO, although performed by some investigators, has rarely been necessary in the author’s experience. After extubation, the patients are usually transferred to a post-anesthesia care unit, and then to a normal unit. Only if adverse effects or signs of visual deterioration are observed, will the patient be heparinized for 48 h. Some operators suggest reversal of systemic heparinization with protamine sulfate (10 mg per 1000 U) (Vinuela et al. 1997). In order to avoid post-procedural complications, the additional use of a closure device such as Angio-SealTM (St. Jude Medical Inc.) is increasingly practiced by many operators.
Postoperative headaches due to mechanical pressure induced by the coils can usually be controlled with analgesics (300 mg ASA daily). If postoperative CN palsy occurs, additional corticosteroids can be administered (e.g. Decadron 4–8 mg every 6). Every patient should undergo an ophthalmological exam a few days after the procedure. Many times, symptoms improve during the first 24 h. The patient may be discharged either the next day or after 2–3 days, and is then seen for clinical follow-up after 3 months with at least one angiographic follow-up after 6–9 months.
8.1.2
Alternative Approaches to the Cavernous Sinus
8.1.2.1
Transfemoral Superior Ophthalmic Vein Approach (Case Report IV)
When the ipsior contralateral IPS approach clearly fails, a transfemoral SOV approach may be performed during the same or a subsequent session. This is done in the following way: A 4-F guiding catheter (0.038s inner lumen) is introduced into the facial vein and navigated as distally as possible. The closer the tip of this catheter is placed to the angular vein, the easier the catheterization of the SOV will be with a microcatheter. A too proximally placed guide often requires more microcatheter manipulations in the facial and angular veins. These veins tend to become more mobile within the subcutaneous soft tissue, making advancing the microcatheter through a tortuous SOV difficult. A slightly stiffer microcatheter, such as the braided Rapid Transit 18, may be feasible. The use of a triaxial catheter systems (8 F-4 F-2 F), although never employed by the author, can also be helpful (Suzuki et al. 2006).
8.1.2.2
Transcutaneous Superior Ophthalmic Vein Approach (Cannulation, Case Report V)
This approach is chosen if both the IPS and the transfemoral SOV approach fail to provide access. Under general anesthesia, the patient gets prepared in the surgical OR, or (under sterile conditions) in the angiography suite. An experienced ophthalmic surgeon, ophthalmologist or, as in the author’s practice, a max- illo-facial surgeon should perform an upper-lid or sub-brow cut to mobilize the angular vein. The vessel is then gently held with a suture and cannulated with a 20or 21-G thin or ultra-thin wall needle (e.g. Terumo UTW 21). A small microguidewire, preferably a 0.010s wire, is carefully introduced and navigated into the distal SOV. The the blunt plastic cannula is stabilized with a suture until the end of the procedure. Then, the patient may be transferred to the OR (if not already prepared in the angiography suite). A small 0.010s microcatheter (Tracker-10, Excelsior SL-10) is introduced and navigated into the proximal SOV or CS, which is usually possible without difficulties.
Some operators suggest a slightly different technique, where the microcatheter is directly introduced into the vein, which has been ligated proximally and
