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Editor-in-Chief:

Benjamin F. Boyd, M.D., FACS

Associate Editor-in-Chief:

Amar Agarwal M.S.; F.R.C.S.; F.R.C.Ophth.

Editors

Jorge L. Alio, M.D., PhD

Ronald R. Krueger, M.D., MSE

Steven E. Wilson, M.D.

 

 

 

PUBLISHING

© Copyright, English Edition, 2003 for Highlights of

 

Ophthalmology

Executive Vice President

Andres Caballero, Ph.D

Assistant, Exec. Vice President

Joyce Ortega

EDITORIAL

Associate Editor

Samuel Boyd, M.D.

Editorial Assistant

Kayra Mejia

PRODUCTION

Production Director

Kayra Mejia

Chief, Digital Composition

Laura Duran

Art Director

Eduardo Chandeck

MARKETING

Marketing & Sales Director

Tomas Martinez

Marketing Manager

Eric Pinzon

Distribution Manager

Miroslava Bonilla

Customer Service Manager

Dania Barria

Boyd, Benjamin F.; M.D., F.A.C.S.; Agarwal, Amar, M.D.

All rights reserved and protected by Copyright. No part of this publication may be reproduced, stored in retrieval system or transmitted in any form by any means, photocopying, mechanical, recording or otherwise, nor the illustrations copied, modified or utilized for projection without the prior, written permission of the copyright owner.

Due to the fact that this book will reach ophthalmologists from different countries with different training, cultures and backgrounds, the procedures and practices described in this book should be implemented in a manner consistent with the professional standards set for the circumstances that apply in each specific situation. Every effort has been made to confirm the accuracy of the information presented and to correctly relate generally accepted practices. The authors, editors, and publisher cannot accept responsibility for errors or exclusions or for the outcome of the application of the material presented herein. There is no expressed or implied warranty for this book or information imparted by it.

Any review or mention of specific companies or products is not intended as an endorsement by the authors or the publisher.

“Wavefront Analysis, Aberrometers & Corneal Topography”

ISBN Nº. 9962-613-18-3

Published for :

Highlights of Ophthalmology International

City of Knowledge

International Technopark, Bldg. 207

Gaillard Highway, Clayton

P. O. Box 6-3299, El Dorado

Panama Rep. of Panama

Phone: (507) 317-0160 / Fax: (507) 317-0155

E-mail: cservice@thehighlights.com

Worldwide Web: www.thehighlights.com

ii

EDITOR IN CHIEF

BENJAMIN F. BOYD, M.D., D.SC. (HON), F.A.C.S.

Doctor Honoris Causa

Immediate Past President, Academia Ophthalmologica Internationalis

Honorary Life Member, International Council of Ophthalmology

Designated “Illustrious Citizen of the Republic of Panama”

Editor-in-Chief and Author, HIGHLIGHTS OF OPHTHALMOLOGY, 28 Hard Cover Volumes and 17 million copies of HIGHLIGHTS OF OPHTHALMOLOGY (Journal) in six major languages.

Recipient of the Duke-Elder International Gold Medal Award (International Council of Ophthalmology), the Barraquer Gold Medal (Barcelona), “for major influence of his publications worldwide”, “the First Benjamin F. Boyd Humanitarian Award and Gold Medal for the Americas (Pan American) for “Contributions to Humanity”; the Leslie Dana Gold Medal (St. Louis Society for the Blind) and the National Society for Prevention of Blindness Gold Medal (United States), Moacyr Alvaro Gold Medal (Brazil), the Jorge Malbran Gold Medal (Argentina), Colombia Ophthalmological Foundation Alvaro Rodriguez Medal, the Favaloro Gold Medal (Italy). the “You Made a Difference Award”, Singapore.

First Professor of Ophthalmology and Former Dean, University of Panama School of Medicine. Recipient of The Great Cross Vasco Nuñez de Balboa, Panama's Highest National Award.

ASSOCIATE EDITOR IN CHIEF

AMAR AGARWAL M.S.;F.R.C.S.;F.R.C.Ophth

Developer of “No Anesthesia Cataract Surgery”, “Phakonit” (cataract removal through a 0.9 mm incision)" and "Favit" a new technique to remove dropped nuclei. Co-Head, Dr.Agarwal’s Eye Hospital, Chennai (Madras), India.

(Dr. Agarwal’s Eye Hospital at Chennai is the only eye hospital in the world built in the shape of an eye and has been included in Ripley’s Believe it or not Series).

EDITORS

JORGE L. ALIO, M.D.

Research, Development and Innovation Department, Ophthalmologic Institute of Alicante and the School of Medicine, University Miguel Hernández, Spain.

RONALD R. KRUEGER, M.D.

Medical Director, Department of Refractive Surgery, The Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, Ohio.

STEPHEN WILSON, M.D.

Professor and Chair, Department of Ophthalmology, Grace E. Hill Chair in Vision Research, University of Washington, Seattle, Washington.

iii

CONTRIBUTING

AUTHORS

Agarwal, Amar, MD. M.S.; F.R.C.S.; F.R.C.Ophth

Ambrósio Jr, Renato, MD

Eye Research Centre & Dr. Agarwal's

Department of Ophthalmology,

Group of

Eye Hospitals

University of Washington, Seattle, WA.

Chennai

(India), Bangalore (India),

Department of Ophthalmology;

Trichy (India) And Dubai (UAE)

University of São Paulo, São Paulo, Brazil.

 

 

Clínica e Microcirugia Oftalmológica Renato

Agarwal, Athiya, M.D, F.R.S.H, D.O.

Ambrósio,

Dr. Agarwal’s Eye Hospital,

Rio de Janeiro, Brazil

Chennai-600 086, Tamilnadu, India

 

 

Apple, David J., M.D.

Agarwal, J., MD, F.I.C.S., D.O.M.S., F.O.R.C.E.

Professor of Ophthalmology and Pathology,

Dr. Agarwal’s Eye Hospital,

David J. Apple, MD. Laboratories for

Chennai-600 086, Tamilnadu, India

Ophthalmic Devices Research,

 

John A. Moran Eye Center,

Agarwal, Sunita, MD, M.S., F.S.V.H., F.R.S.H., D.O.

Department of Ophthalmology and Visual Sciences,

Dr. Agarwal’s Eye Hospital,

University of Utah,

Chennai-600 086, Tamilnadu, India

Salt Lake City, Utah

Agarwal, T., MD, F.I.C.S., D.O, F.O.R.C.E.

Border, Andrea D., O.D.

Dr. Agarwal’s Eye Hospital,

Discover Vision Centers

Chennai-600 086, Tamilnadu, India

Kansas City, Missouri, U.S.A.

Alió, Jorge L., MD, PhD

Boyd, Benjamin F., M.D., F.A.C.S.

Research, Development and Innovation Department,

Editor in Chief

Ophthalmologic Institute of Alicante, Spain.

Highlights of Ophthalmology

School of Medicine,

Panama, Rep. of Panama

University Miguel Hernández,

 

Spain

Boyd, Samuel, MD.

 

Associate Editor

Alpins, Noel, MD. FRACO. FRCOphth. FACS.

Highlights of Ophthalmology

Medical Director NewVision Clinics Melbourne

Director, Laser Section and

Founding Member, Melbourne University

Associate Director, Retina and

Excimer Laser Group; Protocol and Ethics

Vitreous Department,

Committee.

Clinica Boyd Ophthalmology Center

 

Panama, Rep. of Panama.

iv

Contributing Authors

Carvalho, L. A., MD.

Instituto de Física de São Carlos (IFSC - USP), Brazil

Carvalho, L. A. V., Ph.D.

Instituto de Ciências Matemáticas e de Computação de São Carlos (ICMC-USP), Brazil

Castro, J. C., MD.

Instituto de Física de São Carlos (IFSC - USP), Brazil

Centurion, Virgilio, MD

Chief of the Institute for Eye Diseases, Sao Paulo, Brazil

Cigales, Melania, M.D.

Instituto Oftalmologico Hoyos

Sabadell, Spain

Chamon, W., MD.

Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo, Brazil

Denning, James A., B.A., B.S.

Discover Vision Centers

Kansas City, Missouri, U.S.A.

Doane, John F., M.D.

Discover Vision Centers

Kansas City, Missouri, U.S.A.

Doshi, Ashish, MD, M.S, F.E.R.C.

Dr. Agarwal’s Eye Hospital,

Chennai, Tamilnadu, India

Doshi, Sonika, MD, M.S., F.E.R.C.

Dr. Agarwal’s Eye Hospital,

Chennai, Tamilnadu, India

EuDaly, Lon S., O.D.

Discover Vision Centers

Kansas City, Missouri, U.S.A.

Feinerman, Gregg, M.D., F.A.C.S.

Feinerman Vision Center

Newport Beach, California

Fujieda, Masanao, MA,

Nidek Ltd., Co.,

Japan

Ginis, Harilaos S, BSc,

Physicist

Department of Ophthalmology

School of Medicine

University of Crete

Heraklion, Crete

Greece

Goes, Frank Jozef, MD

Refractive Surgery-Cataract Surgery Eye Centre Antwerp Belgium. Honorary Academic Consultant University Ghent, Belgium.

International Belgian representative at ISRS “The International Society of Refractive Surgery”

Hamam, Habib, MD.

Associate Professor

Faculty of Engineering

Dept. of Electrical Ingineering

University of Moncton

Moncton, New Brunswick

Canada

Hardten, David R., MD

Director of Refractive Surgery,

Minnesota Eye Consultants,

Associate Clinical Professor of Ophthalmology,

University of Minnesota,

Minneapolis, Minnesota

Director of Refractive Surgery and

Residency Programs

Regions Medical Center

St. Paul, Minnesota

Hoyos, Jairo E., M.D.

Medical Director

Instituto Oftalmologico Hoyos

Sabadell, Spain

Hoyos-Chacon, Jairo, M.D.

Instituto Oftalmologico Hoyos

Sabadell, Spain

v

Contributing Authors

Jacob, Soosan, MD, MS, DNB, FERC

Dr. Agarwal’s Eye Hospital &

Eye Research Centre,

Chennai-. Tamil Nadu, India.

Jain, Mukesh, PhD

Nidek Ltd., Co.,

Japan

Kanjani, Nilesh, MD, M.B.B.S. D.O. F.E.R.C.

Dr. Agarwal’s Eye Hospital,

Chennai-600 086, Tamilnadu, India

Katsanevaki, Vikentia J., MD,

Department of Ophthalmology

School of Medicine

University of Crete

Heraklion, Crete

Greece

Keller, Peter, PhD,

Department of Optometry &

Vision Sciences

University of Melbourne,

Australia

Krueger, Ronald R., M.D.

Medical Director,

Department of Refractive Surgery

The Cleveland Clinic Foundation

Cole Eye Institute

Cleveland, Ohio

Lindstrom, Richard L., MD

Medical Director,

Phillips Eye Center for Teaching and Research Clinical Professor,

University of Minnesota,

Minneapolis, Minnesota

Martiz, Jaime R., MD.

Refractive Surgery Consultant

The Laser Center, Houston, Texas;

Course Director & President

International LASIK Course

Houston, Texas

Montés-Micó, Robert, OD, MPhil

Research, Development and Innovation

Department, Ophthalmologic

Institute of Alicante and the

School of Medicine,

University Miguel Hernández,

Spain

Morris, Scot, O.D.

Discover Vision Centers

Kansas City, Missouri, U.S.A.

Netto, Marcelo V., MD

Department of Ophthalmology,

University of Washington,

Seattle, WA

Pallikaris, Ioannis G, MD, PhD.

Professor in Ophthalmology,

Department of Ophthalmology

School of Medicine

University of Crete

Heraklion, Crete

Greece

Panagopoulou, Sophia I, BSc,

Physicist

Department of Ophthalmology

School of Medicine

University of Crete

Heraklion, Crete

Greece

Pandey, Suresh K., M.D.

Instructor,

David J. Apple, MD Laboratories for Ophthalmic Devices Research,

John A. Moran Eye Center, University of Utah,

Salt Lake City, UT,

vi

Contributing Authors

Plainis, Sotiris, PhD,

Simón, Jr., José Mª , MD.

Vision Scientist

Anterior Segment Unit

Department of Ophthalmology

Simon Eye Clinic

School of Medicine

Barcelona, Spain

University of Crete

 

Heraklion, Crete

Simón, Sarabel, MD.

Greece

Chief Posterior Segment Unit

 

Simon Eye Clinic

Probst, Louis E. MD

Barcelona, Spain

Medical Director

 

The Laser Eye Centers,

Slade, Stephen G., MD.

Chicago, Illinois

The Laser Center,

 

Houston, Texas

Schor, P., MD.

 

Escola Paulista de Medicina (EPM),

Walsh, Gemma, B.Optom.

Universidade Federal de São Paulo, Brazil

University of Melbourne;

 

Senior Optometrist

Sharma, Vidushi, M.D., F.R.C.S. (Edin).

New Vision Clinics, Melbourne, Australia.

Senior Resident,

Postgraduate Diploma in Advanced

Dr. Rajendra Prasad Center for

Clinical Optometry.

Ophthalmic Sciences, All India Institute of

 

Medical Sciences, New Delhi, India;

Werner, Liliana, M.D., PhD

 

Assistant Professor,

Simón, Cristina, MD.

David J. Apple, MD Laboratories for

Contact Lens Service

Ophthalmic Devices Research,

Simon Eye Clinic

John A. Moran Eye Center,

Barcelona, Spain

University of Utah,

 

Salt Lake City, UT

Simón, Guillermo L., MD.

 

Chief Anterior Segment and

Wilson, Steven E., MD

Refractive Surgery Unit

Professor and Chair

Simon Eye Clinic

Department of Ophthalmology,

Barcelona, Spain

Grace E. Hill Chair in Vision Research

 

University of Washington,

Simón, José Mª, MD.

Seattle, WA

Chairman

 

Glaucoma Senior Consultant

 

Simon Eye Clinic

 

Barcelona, Spain

 

vii

CONTENTS

SECTION I

FUNDAMENTAL CONCEPTS AND DEVELOPMENTS

CHAPTER 1

 

CHAPTER 2

THE REFRACTIVE MEDIA OF

 

PREOPERATIVE CONSIDERATIONS

THE HUMAN EYE:

 

Benjamin F. Boyd, MD., FACS

Optical Properties, Relevant

 

 

Samuel Boyd, MD.

Anatomico-physiological

 

 

Important Preoperative Assessments

Consideration and Clinical Application

 

Vidushi Sharma, MD, FRCS (Edin)

 

Biomicroscopy

 

 

Detection of Corneal Problems

Suresh K. Pandey, MD

 

 

Dry Eye Patients

Liliana Werner, MD, PhD

 

 

IMPORTANT CONTRIBUTIONS OF

David J. Apple, MD

 

 

COMPUTARIZED CORNEAL

 

 

THE REFRACTIVE MEDIA OF THE EYE

5

TOPOGRAPHY

 

How Computerized Corneal

The Human Cornea

5

Topography

Works

Applied Anatomy and Histology

 

 

Importance of

the Tear Film

of the Human Cornea

6

During Computerized Corneal

The Aqueous and Vitreous Humor

9

Topography

 

The Human Crystalline Lens

10

 

The Role of Contact Lenses

Refractive Properties and Relevant

 

 

Types of Computerized Topography

Anatomy-Histology

10

Systems

 

Lens Capsule

11

 

The Most Important Developments

Lens Epithelial Cells

11

 

 

SECTION II

TOPOGRAPHY

15

15

15

16

18

19

19

19

20

21

CHAPTER 3

FUNDAMENTALS ON CORNEAL

TOPOGRAPHY

Guillermo L. Simón, MD., Sarabel Simón, MD., José Mª Simón, MD., José Mª Simón, Jr., MD., Cristina Simón, MD.

Human Optics and the Normal Cornea

25

Instruments to Measure the Corneal Surface

26

1-

Keratometry

26

2-

Keratoscopy or Photokeratoscopy

26

3- Computerized Videokeratoscopy:

 

Modern Corneal Topographers

27

Causes of Artefacts of the Corneal

 

Topography Map

30

Understanding and Reading Corneal

 

Topography

31

Topographic Scales

32

Computer Displays: Presentation of

 

Topographic Information

32

Common Corneal Maps

36

Special Software Applications and Displays

39

viii

Contents

Topography Maps of the Normal Cornea Comparing Displays

Brief Atlas of Corneal Topography

Special Topographic Conditions

Brief Atlas of Corneal Topography Special Cases

TOPOGRAPHERS CURRENTLY AVAILABLE

ASTRAMAX™ 3-D Stereo Topographer (Lasersight®)

Zeiss Humphrey Systems® ATLAS™ Corneal Topography System Models 993 and Eclipse 995

Color Ellipsoid Topometer, by Technomed®

MEDMONT E-300

DICON® CT200 by Dicon Vismed Inc.- PARADIGM, USA

KERATRON™ Corneal Topographer (Optikon 2000® S.p.A, Italy -Europe)

EYE SYS® 2000

ET-800 Corneal Topography System EYE MAP EH-290 ALCON® Corneal

Topography System

TOMEY® Autotopographer TMS-3 OCULUS® Keratograph™ and

HAAG-STREIT® Keratograph CTK 922 ORBSCAN IIz™ - Bausch & Lomb®

Surgical, Inc. (USA) Nidek OPD-SCAN 10000

THE FUTURE OF CORNEAL TOPOGRAPHY IN EVERYDAY PRACTICE

The Future of Refraction

43

CHAPTER 4

46

TOPOGRAPHY SYSTEMS

47

Part 1

Orbscan

 

59

(Bausch & Lomb)

Amar Agarwal, MD. M.S.; F.R.C.S.; F.R.C.Ophth

63Nilesh Kanjani, MD. D.O; Dip N B; F E R C Athiya Agarwal, MD. M.D.; F.R.S.H. ; D.O.

64Sunita Agarwal, MD. M.S.; F.S.V.H.; D.O.

65

Paraxial Optics

98

Raytrace or Geometric Optics

98

 

67

Elevation

98

ORBSCAN I AND II

99

67

Specular vs Back-Scattered Reflection

99

 

68

IMAGING IN THE ORBSCAN

100

Map Colours Conventions

101

 

72

Analysis of the Normal Eye by the

 

Orbscan Map

102

74

Clinical Applications

103

74

 

 

75

Part 2

 

The Alcon EyeMap® EH-290 Corneal

 

76

 

 

Topography System (Placido Disc Pattern)

77

Samuel Boyd, MD

 

 

 

82

Optical Properties of the Cornea

108

90

Corneal Topography – Principles

109

 

 

INTERPRETATION OF TOPOGRAPHIC

 

90

MAPS

109

Surface Curvature Measurements in

 

91

 

Topography

110

 

 

Elevation Map

110

 

Relative vs. Absolute Scales

111

 

Other Topography Systems

112

 

Most Important Clinical Applications of

 

 

Corneal Topography

112

ix

Contents

SECTION III

CLINICAL APPLICATIONS

OF TOPOGRAPHY

CHAPTER 5

 

 

CHAPTER 7

 

THE USE OF TOPOGRAPHY IN

 

 

ANTERIOR KERATOCONUS

 

DIAGNOSING CORNEAL DISORDERS

 

 

J. Agarwal, MD, FICS; DO;FORCE

 

 

 

 

 

Renato Ambrósio Jr, MD.; Marcelo V. Netto, MD

T. Agarwal, MD, FICS;DOMS;FORCE

 

Steven E. Wilson, MD

 

Amar Agarwal, MD, M.S., F.R.C.S., F.R.C.OPHTH.

 

 

Nilesh Kanjani, MD, M.B.B.S. D.O. F.E.R.C.

 

COLOR-CODED MAPS

 

 

Ashish Doshi, MD, M.S, F.E.R.C.

 

 

 

Sonika Doshi, MD, M.S., F.E.R.C.

 

AND THE IMPORTANCE OF

 

 

 

 

Sunita

Agarwal, MD, M.S., F.S.V.H., F.R.S.H., D.O.

STANDARIZED COLOR SCALES

117

 

Athiya Agarwal, M.D, F.R.S.H, D.O.

 

Quantitative Descriptors and Artificial

 

 

 

 

 

 

 

Intelligence Programs

119

Orbscan

Topography

139

The Normal Prolate Cornea

120

ANTERIOR KERATOCONUS

140

Ectatic Diseases of The Cornea and

 

 

 

 

 

Contact Lens-Induced Warpage

122

 

CHAPTER 8

 

KERATOCONUS AND PELLUCID

 

 

 

 

CORNEAL TOPOGRAPHY IN IRREGULAR

MARGINAL CORNEAL DEGENERATION

122

ASTIGMATISM: DIAGNOSTIC TOOL IN

Other Corneal Disorders

127

THE EVALUATION OF THE QUALITY OF

Terrien's Marginal Degeneration

127

 

VISION

 

Pterygium

127

 

 

 

 

 

 

 

 

Jorge L. Alió, MD, PhD

 

CHAPTER 6

 

 

Robert Montés-Micó, OD, MPhil

 

PRIMARY POSTERIOR CORNEAL

 

 

 

 

ELEVATION

 

Introduction to Irregular Astigmatism

145

Amar Agarwal, M.D, M.S., F.R.C.S., F.R.C.OPHTH

CORNEAL TOPOGRAPHY PATTERNS

 

OF IRREGULAR ASTIGMATISM

145

Nilesh Kanjani, M.D, M.B.B.S. D.O. F.E.R.C.

 

 

A.- Irregular Astigmatism with

 

Ashish Doshi, M.D, M.S, F.E.R.C.

 

 

 

 

Defined Pattern

146

Sonika Doshi, M.D, M.S., F.E.R.C.

 

 

Sunita Agarwal, M.D, M.S., F.S.V.H., F.R.S.H., D.O.

B.- Irregular Astigmatism with

 

Athiya Agarwal, M.D, F.R.S.H, D.O.

 

 

Undefined Pattern

146

J. Agarwal, M.D, F.I.C.S., D.O.M.S., F.O.R.C.E.

Quantitative Analysis of Irregular

 

T. Agarwal, M.D, F.I.C.S., D.O, F.O.R.C.E.

 

Astigmatism from Topography

149

Orbscan Corneal Topography System

131

Fourier Analysis applied to

 

 

Corneal Topography

150

PRIMARY POSTERIOR CORNEAL

 

Corneal Aberration Identification

 

ELEVATION

132

 

from Topography

152

x