CONTENTS |
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Preface..................................................................................................................... |
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v |
Contributors ............................................................................................................ |
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xiii |
Part I Living with Diabetic Retinopathy |
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1 |
Living with Diabetic Retinopathy: The Patient’s View .................... |
3 |
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Heather Stuckey |
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Part II How Is Diabetic Retinopathy Detected? |
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2 |
Diabetic Retinopathy Screening: Progress or Lack of Progress....... |
17 |
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Peter Scanlon |
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3 |
Functional/Neural Mapping Discoveries in the Diabetic Retina: |
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Advancing Clinical Care with the Multifocal ERG.......................... |
31 |
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Anthony J. Adams and Marcus A. Bearse Jr. |
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Part III How Does Diabetes Affect the Eye? |
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4 |
Corneal Diabetic Neuropathy ........................................................... |
45 |
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Edoardo Midena |
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5 |
Clinical Phenotypes of Diabetic Retinopathy................................... |
53 |
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José Cunha-Vaz, Rui Bernardes, and Conceição Lobo |
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6 |
Visual Psychophysics in Diabetic Retinopathy ................................ |
69 |
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Edoardo Midena and Stela Vujosevic |
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7 |
Mechanisms of Blood–Retinal Barrier Breakdown |
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in Diabetic Retinopathy .................................................................... |
105 |
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Ali Hafezi-Moghadam |
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8 |
Molecular Regulation of Endothelial Cell Tight Junctions |
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and the Blood-Retinal Barrier........................................................... |
123 |
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E. Aaron Runkle, Paul M. Titchenell, and David A. Antonetti |
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9 |
Capillary Degeneration in Diabetic Retinopathy.............................. |
143 |
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Timothy S. Kern |
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10 |
Proteases in Diabetic Retinopathy .................................................... |
157 |
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Sampathkumar Rangasamy, Paul McGuire, and Arup Das |
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11 |
Proteomics in the Vitreous of Diabetic Retinopathy Patients........... |
173 |
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Edward P. Feener |
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12 |
Neurodegeneration in Diabetic Retinopathy..................................... |
189 |
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Alistair J. Barber, William F. Robinson, |
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and Gregory R. Jackson |
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xi
xii |
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Contents |
13 |
Glucose-Induced Cellular Signaling in Diabetic Retinopathy.......... |
211 |
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Zia A. Khan and Subrata Chakrabarti |
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14 |
IGFBP-3 as a Regulator of the Growth-Hormone/Insulin-Like |
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Growth Factor Pathway in Proliferative Retinopathies .................... |
233 |
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Andreas Stahl, Ann Hellstrom, Chatarina Lofqvist, |
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and Lois Smith |
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15 |
Neurotrophic Factors in Diabetic Retinopathy ................................. |
245 |
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Anne R. Murray and Jian-xing Ma |
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16 |
The Role of CTGF in Diabetic Retinopathy..................................... |
261 |
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R.J. van Geest, E.J. Kuiper, I. Klaassen, C.J.F. van Noorden, |
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and R.O. Schlingemann |
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Part IV How Can Vision Loss Be Limited: Experimental Therapies |
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17 |
Ranibizumab and Other VEGF Antagonists for Diabetic |
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Macular Edema................................................................................. |
289 |
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Ben J. Kim, Diana V. Do, and Quan Dong Nguyen |
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18 |
Neurodegeneration, Neuropeptides, and Diabetic Retinopathy........ |
307 |
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Cristina Hernández, Marta Villarroel, and Rafael Simó |
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19 |
Glial Cell–Derived Cytokines and Vascular Integrity in Diabetic |
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Retinopathy....................................................................................... |
325 |
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Shuichiro Inatomi, Hiroshi Ohguro, Nami Nishikiori, |
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and Norimasa Sawada |
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20 |
Impact of Islet Cell Transplantation on Diabetic Retinopathy |
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in Type 1 Diabetes ............................................................................ |
339 |
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Iain S. Begg, Garth L. Warnock, and David M. Thompson |
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Index ......................................................................................................... |
367 |
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CONTRIBUTORS
ANTHONY J. ADAMS • School of Optometry, University of California, Berkeley, CA, USA
DAVID A. ANTONETTI • Departments of Cellular and Molecular Physiology and Ophthalmology, Penn State College of Medicine, Hershey, PA, USA
ALISTAIR J. BARBER • Departments of Ophthalmology and Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA
MARCUS A. BEARSE JR. • School of Optometry, University of California, Berkeley, CA, USA
IAIN S. BEGG • Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
RUI BERNARDES • AIBILI, Azinhaga Santa Comba, Celas, Coimbra, Portugal SUBRATA CHAKRABARTI • Department of Pathology, University of Western Ontario,
London, ON, Canada
JOSÉ CUNHA-VAZ • AIBILI, Azinhaga Santa Comba, Celas, Coimbra, Portugal ARUP DAS • Division of Ophthalmology, University of New Mexico School
of Medicine, Albuquerque, NM, USA
DIANA V. DO • Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA EDWARD P. FEENER • Joslin Diabetes Center, Boston, MA, USA
THOMAS W. GARDNER • Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA
ALI HAFEZI-MOGHADAM • Department of Radiology, Harvard Medical School, Center for Excellence in Functional and Molecular Imaging Brigham and Women’s Hospital, Boston, MA, USA
ANN HELLSTROM • Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, Boston, MA, USA
CRISTINA HERNÁNDEZ • Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d’Hebron, Barcelona, Spain
SHUICHIRO INATOMI • Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan
GREGORY R. JACKSON • Departments of Ophthalmology and Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA
TIMOTHY S. KERN • Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH, USA
ZIA A. KHAN • Department of Pathology, University of Western Ontario, London, ON, Canada
BEN J. KIM • Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
I.KLAASSEN • Department of Ophthalmology, Ocular Angiogenesis Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
xiii
xiv |
Contributors |
E.J. KUIPER • Department of Ophthalmology, Ocular Angiogenesis Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
CONCEIÇÃO LOBO • AIBILI, Azinhaga Santa Comba, Celas, Coimbra, Portugal CHATARINA LOFQVIST • Department of Ophthalmology, Harvard Medical School,
Children’s Hospital Boston, Boston, MA, USA
JIAN-XING MA • Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
PAUL MCGUIRE • Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
EDOARDO MIDENA • Department of Ophthalmology, University of Padova, Padova, Italy and Fondazione GB Bietti per l’Oftalmologia IRCSS, Rome, Italy
ANNE R. MURRAY • Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
QUAN DONG NGUYEN • Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
NAMI NISHIKIORI • Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan
HIROSHI OHGURO • Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan
SAMPATHKUMAR RANGASAMY • Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA WILLIAM F. ROBINSON • Departments of Ophthalmology, Penn State College
of Medicine, Hershey, PA, USA
E. AARON RUNKLE • Department of Pathology,, Penn State College of Medicine, Hershey, PA, USA
NORIMASA SAWADA • Department Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
PETER SCANLON • Harris Manchester College, University of Oxford, Oxford, UK R.O. SCHLINGEMANN • Department of Ophthalmology, Ocular Angiogenesis Group,
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
RAFAEL SIMÓ • Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d’Hebron, Barcelona, Spain
LOIS SMITH • Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, Boston, MA, USA
ANDREAS STAHL • Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, Boston, MA, USA
HEATHER STUCKEY • Department of Medicine, Penn State University College of Medicine, Hershey, PA, USA
DAVID M. THOMPSON • Department of Medicine, University of British Columbia, Vancouver, BC, Canada
PAUL M. TITCHENELL • Department of Cellular & Molecular Physiology,, Penn State College of Medicine, Hershey, PA, USA
Contributors |
xv |
R.J. VAN GEEST • Department of Ophthalmology, Ocular Angiogenesis Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
C.J.F. VAN NOORDEN • Department Cell Biology and Histology, Ocular Angiogenesis Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
MARTA VILLARROEL • Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d’Hebron, Barcelona, Spain
STELA VUJOSEVIC • Department of Ophthalmology, University of Padova, Padova, ItalyFondazione GB Bietti per l’Oftalmologia IRCSS, Rome, Italy
GARTH L. WARNOCK • Department of Surgery, University of British Columbia, Vancouver, BC, Canada
Part I
Living with Diabetic Retinopathy