typically bracketed by gly his and trp asp (GH WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Family members are involved in a variety of cellular processes, such as proliferation, signal transduction, apoptosis, and gene regulation. Two mRNA transcripts for WDR36 were observed at 5.9 and 2.5 kb, which were preferentially expressed in heart, placenta, liver and smooth muscle (Monemi et al., 2005). By RT PCR, expression was found in basically all ocular tissues (Monemi et al., 2005). WDR36 was identified as one of the genes that are upregulated upon T cell activation and was highly co regulated with interleukin 2 (Mao et al., 2004). A specific function is unknown, but may be related to the biogenesis of ribosomal RNA (rRNA), as its homologue in yeast, Utp21, is a protein of the small subunit (SSU) processome which is a large ribonucleoprotein required for the biogenesis of 18S rRNA and with putative roles in both pre rRNA processing and ribosome assembly (Bernstein et al., 2004).

IX. CONCLUSION

As of today, several molecules have been identified that appear to be involved in the pathogenetic processes of POAG. Since an increase in fibrillar ECM in the JCT of the TM is the most characteristic pathological finding in patients with POAG, many of these molecules are involved in the control mechanisms of ECM turnover in the TM outflow pathways. Other molecules have been identified from genetic studies applying linkage analysis and positional cloning. Studies that lead to more complete understanding of these molecules should provide the key to clarify the molecular mechanisms that govern aqueous humor outflow through the TM and the pathogenetic mechanisms of POAG.

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