CHAPTER 7

Aqueous Humor Dynamics I

Measurement Methods and Animal Studies

Carol B. Toris

Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, 68198 5840

I. Overview

II.Components of Aqueous Humor Dynamics and Measurement Techniques

A.Intraocular Pressure

B.Aqueous Humor Flow

C.Outflow Resistance

D.Uveoscleral Outflow

E.Episcleral Venous Pressure

III. Aqueous Humor Dynamics in Research Animals

A.Mice

B.Rats

C.Rabbits

D.Cats

E.Dogs

F.Nonhuman Primates IV. Summary

References

I.OVERVIEW

Intraocular pressure (IOP) is maintained by the dynamics of ocular aqueous

humor that involves its secretion, circulation throughout the anterior chamber, and drainage into the iridocorneal angle. The measurable components of