- •Series Editors
- •Contributors
- •Preface
- •Previous Volumes in Series
- •Relationship of Solute and Water Secretion
- •Centrality of NaCl Secretion
- •Transcellular and Paracellular Components of Secretion
- •Uptake of Stromal NaCl
- •Passage of NaCl from PE to NPE Cells Through Gap Junctions
- •Extrusion of NaCl from NPE Cells to Aqueous Humor
- •Transfer of Water from Stroma to Aqueous Humor
- •Potential Unidirectional Reabsorption of Aqueous Humor
- •Transport Components Underlying Potential Transcellular Reabsorption Across the Ciliary Epithelium
- •References
- •References
- •The Role of Gap Junction Channels in the Ciliary Body Secretory Epithelium
- •Overview
- •General Properties of Connexins Including those Composing the Ciliary Body Epithelium Gap Junctions
- •Animal Models Support a Role for Gap Junctions in Fluid Transport by Ocular Epithelia
- •References
- •Relationship of the EMPA Findings to the Consensus Model for Aqueous Humor Secretion
- •References
- •Functional Modulators Linking Inflow with Outflow of Aqueous Humor
- •Overview
- •Sources of Neuropeptides and Peptide Hormones in the AqH
- •Expression in the Human CB of Glutamate Transporters of the Excitatory Amino Acid Transporters Family
- •Potential Neuroendocrine Entrainment of Circadian Rhythms: AqH Secretion and IOP
- •References
- •Aqueous Humor Outflow Resistance
- •References
- •Aqueous Humor Dynamics I
- •Measurement Methods and Animal Studies
- •Overview
- •Components of Aqueous Humor Dynamics and Measurement Techniques
- •Tonometry
- •Manometry
- •Telemetry
- •Fluorophotometry
- •Confocal Microscopy
- •Aqueous Humor Sampling Method
- •Tonography
- •Fluorophotometry
- •Perfusion Methods
- •Mathematical Calculation
- •Intracameral Tracer Methods
- •Episcleral Venomanometry
- •Direct Cannulation
- •Intracameral Microneedle Method
- •Acknowledgment
- •References
- •Aqueous Humor Dynamics II
- •Dopaminergic Agonists and Antagonists
- •Regulators of the Actin Cytoskeleton
- •Serotonin Agonists
- •References
- •Effects of Circulatory Events on Aqueous Humor Inflow and Intraocular Pressure
- •References
- •Overview
- •Nitric Oxide
- •Glutamate
- •Purines
- •References
- •What is Functional Genomics Teaching us about Intraocular Pressure Regulation and Glaucoma?
- •Functional Genomics: Microarrays, Proteomics and Protein Modification
- •The Trabecular Meshwork Tissue: Expressed Genes (CDNA) and Proteins Obtained by Direct Sequencing and Mass Spectrometry
- •References
- •Molecular Approaches to Glaucoma: Intriguing Clues for Pathology
- •References
- •Outflow Signaling Mechanisms and New Therapeutic Strategies for the Control of Intraocular Pressure
- •Trabecular Pathway
- •Uveoscleral Pathway
- •Carbonic Anhydrase Inhibitors
- •Cholinergics
- •Epinephrine and Analogs
- •Prostaglandin Analogs
- •Cytochalasins
- •Latrunculins
- •Swinholide A
- •Ethacrynic Acid
- •Protein Kinase Inhibitors
- •Broad Spectrum Kinase Inhibitors
- •ROCK Inhibitors
- •CTGF
- •Cochlin
- •References
- •Index
Current Topics in Membranes, Volume 62
Series Editors
Dale J. Benos
Department of Physiology and Biophysics
University of Alabama
Birmingham, Alabama
Sidney A. Simon
Department of Neurobiology
Duke University Medical Centre
Durham, North Carolina
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To Judith: my wife, friend and inspiration
Contributors
Numbers in parentheses indicate the pages on which the authors’ contributions begin.
Nicholas W. Baetz (47) Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85711
Teresa Borra´s (323) Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Peter R. Brink (71) Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794
Carl B. Camras (231) Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, 68198-5840
Mortimer M. Civan (1, 97) Departments of Physiology and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19101-6085
Abbot F. Clark (427) Glaucoma Research, Alcon Research, Ltd., Fort Worth, Texas, USA; Department of Cell Biology and Genetics University North Texas Health Science Center Fort Worth, Texas, USA
Miguel Coca-Prados (123) Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510
Thomas F. Freddo (161) School of Optometry, University of Waterloo, Ontario N2L 3G1, Canada
Sikha Ghosh (123) Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510
Mark Johnson (161) Departments of Biomedical Engineering and Ophthalmology, Northwestern University, Illinois 60208
Jeffrey W. Kiel (273) Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229
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Contributors |
Wennan Lu (301) Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Anthony D. C. Macknight (97) Department of Physiology, University of Otago Medical School, Dunedin, New Zealand
Richard T. Mathias (71) Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794
Claire H. Mitchell (301) Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Iok-Hou Pang (427) Glaucoma Research, Alcon Research, Ltd., Fort Worth, Texas, USA
Herbert A. Reitsamer (273) Department of Ophthalmology, Paracelsus Medical University, Salzburg, Austria
W. Daniel Stamer (47) Department of Pharmacology, The University of Arizona, Tucson, Arizona 85711; Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, Arizona 85711
Ernst R. Tamm (379) Institute of Human Anatomy and
Embryology, University of Regensburg, 93053 Regensburg,
Germany
Carol B. Toris (193, 231) Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, 681985840
Thomas W. White (71) Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794
Andrea J. Yool (47) Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85711; Discipline of Physiology, University of Adelaide, SA 5005, Australia; Department of Pharmacology, The University of Arizona, Tucson, Arizona 85711
