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Ординатура / Офтальмология / Английские материалы / Step by Step Minimally Invasive Glaucoma Surgery_Garg, Melamed, Bovet, Pajic, Carassa, Dada_2006

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212 Step by Step Minimally Invasive Glaucoma Surgery

Fig. 12.10: Stripping of the floor of the canal is done if insufficient filtration is found

Fig. 12.11: Refining the descement window is done using the drill and the milling is done applying no pressure

Milling Trabeculoplasty 213

7.In case of glaucoma implant the implant should be inserted at this level of the surgery and sutures to sclera as in conventional deep sclerectomy.14

8.The flap is gently laid in its normal anatomic position (Fig. 12.12). Two 10-0 nylon stitches were placed at both edges of the superficial flap and tied fairly (not very tight and not very loose). The suture ends were cut and the knots were parried to prevent the suture tips from eroding the conjunctiva. After closing the scleral flap repositioning of the conjunctiva was then done with 2 lateral 10/0 nylon stitches (Figs 12.13 to 12.15).

Fig. 12.12: The scleral flap is reposted at the end of the surgery

214 Step by Step Minimally Invasive Glaucoma Surgery

Fig. 12.13: Slit-lamp photo of the postoperative bleb obtained at 6-months in group I

Fig. 12.14: Slit-lamp photo of the postoperative bleb obtained at 6-months in group II (Phaco-milling)

Milling Trabeculoplasty 215

Fig. 12.15: The diffuse filtering bleb as appeared at the end of the 6th month in group II

POSTOPERATIVE FOLLOW-UP

Treatment

Antibiotic-steroidal combination; Tobradex® (Lab Alcon Cusi, Inc. Barcelona. Spain) eyedrops were instilled postoperatively 4 times daily for 1 week and slowly withdrawn over one month period. No viscoelastics was injected into the Schlemm canal, and the procedure was completed without the use of collagen device or mitomycin C at any stage of the surgery in our series.

Follow-up

Patients were scheduled for follow-up visits at 1 day, 1 week then 1, 3 and 6 months after surgery. The postoperative evaluation included the IOP, presence of

216 Step by Step Minimally Invasive Glaucoma Surgery

functioning bleb, gonioscopy, visual acuity status and possible surgical and postoperative complications.

RESULTS

The study performed by the authors included 41 eyes (41 patients). The mean age of the patients was 67.9 ± 10.9 (range 50 to 80) years. The preoperative diagnoses had confirmed that all eyes have medically uncontrolled primary open-angle glaucoma. The mean preoperative cup/disk ratio was 0.7 ± 0.25. The mean angle grading as reported by gonioscopic findings was 3.6 ± 0.61 according to shaffer grading system.

The eyes were divided into 2 groups: group I (20 eyes) underwent milling procedure and group II (21 eyes) underwent combined procedure, milling and phacoemulsification procedures. In both groups, the milling procedure was done without the use of collagen device or MMC. The other eye of each patient was operated by conventional deep sclerectomy and combined phaco and deep sclerectomy and their results are behind the scope of this chapter.

The past medical history of the patients included hypertension in 36 percent patients, and one patient had history of diabetes mellitus. Among the eyes included in the study, 23.7 percent had history of cataract extraction and IOL implantation, 7.2 percent had history of previous glaucoma surgery (deep sclerectomy). Preoperative history of anti-glaucoma therapy is shown in Figures 12.16A and B.

The study included 16 eyes (10 right and 6 left) of 13 patients. The mean age of the patients was 67.9 ± 10.9 (range 50 to 80) years. The patients included female, and 8 male. All eyes were diagnosed as having primary open angle glaucoma medically uncontrolled. Only one eye 1/16

Milling Trabeculoplasty 217

Fig. 12.16: Graph showing the percent of preoperative combination of antiglaucoma treatment in (A) Group I and (B) Group II

218 Step by Step Minimally Invasive Glaucoma Surgery

(6.25%) had a previous unsuccessful glaucoma surgery (deep sclerectomy). The data of the 6th month postoperative visits are available for 100 percent of the eyes, and those for the 1st year follow up visits are available only for 37.5 percent of the eyes.

Group I (Milling Procedure)

Visual results and refractive results of this group: refer to Table 12.1. Intraocular pressure (IOP) and its results during the study are shown in Table 12.2. Figure 12.17 shows the IOP results of both groups during the follow-up period of the study.

Table 12.1: Shows the results of group I, milling trabeculoplasty

Group I:

 

 

 

 

Range

Milling

 

N

Mean ± SD

Standard

Maxi-

Mini-

trabeculoplasty

 

 

error

m u m

m u m

 

 

 

 

 

 

 

Pre-op

 

 

 

 

 

 

refraction

BCVA

20

0.828 ± 0.279

0.0624

1

0.05

 

Sphere

 

0.025 ± 0.648

0.145

1.5

-1.5

 

Cylinder

 

-0.675 ± 1.067

0.239

0

-4

 

SE

 

-0.313 ± 0.512

0.115

0.5

-1.5

 

Defocus

 

0.725 ± 0.786

0.176

2.500

0.000

 

equivalent

 

 

 

 

 

Post-op

BCVA

20

0.792 ± 0.258

0.0578

1

0.05

refraction

Sphere

 

-0.025 ± 0.858

0.192

1.25

-2

at 1M

Cylinder

 

-0.0875 ± 2.507 0.561

10

-3

 

SE

 

-0.069 ± 1.302

0.291

4.5

-2.25

 

Defocus

 

0.713 ± 0.762

0.170

2.500

0.000

 

equivalent

 

 

 

 

 

Post-op

BCVA

20

0.835 ± 0.262

0.0587

1

0.05

refraction

Sphere

 

0.1 ± 0.357

0.0799

1

-0.5

at 6M

Cylinder

 

-0.713 ± 0.964

0.216

0

-4

 

SE

 

-0.257 ± 0.336

0.0752

0.13

-1

 

Defocus

 

0.625 ± 0.750

0.168

3.000

0.000

 

equivalent

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Milling Trabeculoplasty

 

219

 

 

 

Table 12.2: Shows the results of IOP in group I,

 

 

milling trabeculoplasty

 

 

 

 

 

 

 

Range

Variable

N

Mean ± SD

Standard

Maxi-

Mini-

 

 

 

error

m u m

m u m

Initial IOP

20

23.9 ± 7.166

1.602

50

16

Basal IOP

20

32.640 ± 7.151

1.599

50.0

22.0

Objective IOP

20

20.650 ± 3.99

0.894

26.60

14.4

IOP at 1m

20

12.65 ± 4.945

1.106

22

2

Reduction IOP at 1m

20

-7.994± 5.853

1.309

6.50

-15.95

% Reduction IOP at 1m

20

47.205 ± 15.039 3.282

88.89

19.23

IOP at 1m

20

14.45 ± 3.379

0.756

24

10

Reduction IOP at 6m

20

-6.200± 4.148

0.928

1.5

-14.6

% Reduction IOP at 6m

20

36.821 ± 17.252 3.765

64

-5.26

 

 

 

 

 

 

 

Fig. 12.17: Graph showing the IOP changes during the follow-up period in both groups

220 Step by Step Minimally Invasive Glaucoma Surgery

Group II (Milling Procedure combined with Phaco)

Visual results and refractive results of this group: refer to Table 12.3. Intraocular pressure (IOP) and its results during the study are shown in Table 12.4. Figure 12.17 shows the IOP results of both groups during the follow-up period of the study.

DISCUSSION

Non-penetrating glaucoma surgeries including viscocanalostomy and deep sclerectomy are difficult to perform, need a high learning curve and time consuming. In both non-penetrating glaucoma surgeries and milling

Table 12.3: Shows the results of group II, milling trabeculoplasty plus phacoemulsification at the same session

Group II:

 

 

 

 

Range

Milling+

 

N

Mean ± SD

Standard

Maxi-

Mini-

Phaco

 

 

 

error

m u m

m u m

Pre-op

BCVA

21

0.298 ± 0.217

0.0473

0.8

0.01

refraction

Sphere

 

-2.821 ± 5.946

1.298

2.5

-16

 

Cylinder

 

-1.012 ± 1.1

0.24

0.5

-3.25

 

SE

 

-3.328 ± 6.17

1.346

1.25

-17.5

 

Defocus

 

4.024 ± 6.339

1.383

19.000

0.000

 

equivalent

 

 

 

 

 

Post-op

BCVA

21

0.571 ± 0.313

0.0682

1

0.01

refraction

Sphere

 

-0.464 ± 1.004

0.219

1.5

-2.5

at 1m

Cylinder

 

-1.179 ± 1.151

0.251

0

-4.5

 

SE

 

-1.055 ± 1.247

0.272

0.5

-4.75

 

Defocus

 

 

 

 

 

 

equivalent

 

1.714 ± 1.603

0.350

7.000

0.000

Post-op

BCVA

21

0.636 ± 0.304

0.0663

1

0.05

refraction

Sphere

 

-0.238 ± 0.835

0.182

1.5

-1.5

at 6m

Cylinder

 

-1.19 ± 0.898

0.196

0

-3

 

SE

 

-0.835 ± 0.867

0.189

0.5

-3

 

Defocus

 

1.524 ± 1.006

0.220

4.500

0.000

 

equivalent

 

 

 

 

 

 

 

 

 

 

 

 

Milling Trabeculoplasty 221

Table 12.4: Shows the results of IOP in group II, milling trabeculoplasty plus phacoemulsification at the same session

 

 

 

 

Range

Variable

N

Mean ± SD

Standard

Maxi-

Mini-

 

 

 

error

m u m

m u m

Initial IOP

21

22.952 ± 7.619

1.663

42

10

Basal IOP

21

33.310 ± 14.487 3.161

65.1

13.0

Objective IOP

21

23.319± 10.154

2.216

25.2

6

IOP at 1 m

21

15.762 ± 5.761

1.257

38

10

Reduction IOP at 1 m

21

-7.546± 9.047

1.974

6.9

-27.9

% Reduction IOP at 1 m 21

25.906 ± 28.22

6.017

56.67

-60

IOP at 1 m

21

15.19 ± 3.473

0.758

23

10

Reduction IOP at 6 m

21

-8.11± 8.607

1.878

6.9

-24.8

% Reduction IOP at 6 m 21

27.91 ± 26.897

5.734

56

-60

 

 

 

 

 

 

surgery, both the postoperative recovery and follow-up are faster and the level of IOP reduction achieved is satisfactory when compared with the results of trabeculectomy.

Milling trabeculoplasty in this prospective, pilot study on 41 eyes has shown good results as it led to a 30-40 percent reduction of IOP in both groups operated with the technique. The percent of success of surgery at the 6th month without the use of collagen device or MMC was 60 percent for group I and 80 percent for group II (Fig. 12.18). The rate of postoperative bleb fibrosis and the use of postoperative anti-glaucoma therapy was found to be similar to that found with deep sclerectomy.

The followings are the potential advantages of the Milling trabecuoloplasty over the non-penetrating glaucoma surgeries:

1.Facilitate the surgical procedure of nonpenetrating technique as the refining is carried anteriorly and down until the roof of Schlemm´s canal can barely be visible. Unlike deep non-penetrating sclerectomy,