- •Preface
- •Contributors
- •Dedication
- •INFECTIOUS DISEASES
- •ACINETOBACTER
- •BACILLUS SPECIES INFECTIONS
- •ESCHERICHIA COLI
- •GONOCOCCAL OCULAR DISEASE
- •INFECTIOUS MONONUCLEOSIS
- •MICROSPORIDIAL INFECTION
- •MOLLUSCUM CONTAGIOSUM
- •MORAXELLA
- •PROPIONIBACTERIUM ACNES
- •PROTEUS
- •PSEUDOMONAS AERUGINOSA
- •STREPTOCOCCUS
- •VARICELLA AND HERPES ZOSTER
- •PARASITIC DISEASES
- •PEDICULOSIS AND PHTHIRIASIS
- •NUTRITIONAL DISORDERS
- •INFLAMMATORY BOWEL DISEASE
- •DISORDERS OF CARBOHYDRATE METABOLISM
- •MUCOPOLYSACCHARIDOSIS IH
- •MUCOPOLYSACCHARIDOSIS IH/S
- •MUCOPOLYSACCHARIDOSIS II
- •MUCOPOLYSACCHARIDOSIS III
- •MUCOPOLYSACCHARIDOSIS IV
- •MUCOPOLYSACCHARIDOSIS VI
- •MUCOPOLYSACCHARIDOSIS VII
- •DISORDERS OF LIPID METABOLISM
- •HEMATOLOGIC AND CARDIOVASCULAR DISORDERS
- •CAROTID CAVERNOUS FISTULA
- •DERMATOLOGIC DISORDERS
- •ERYTHEMA MULTIFORME MAJOR
- •CONNECTIVE TISSUE DISORDERS
- •PSEUDOXANTHOMA ELASTICUM
- •RELAPSING POLYCHONDRITIS
- •UVEITIS ASSOCIATED WITH JUVENILE IDIOPATHIC ARTHRITIS
- •WEGENER GRANULOMATOSIS
- •WEILL–MARCHESANI SYNDROME
- •SKELETAL DISORDERS
- •PHAKOMATOSES
- •NEUROFIBROMATOSIS TYPE 1
- •STURGE–WEBER SYNDROME
- •NEUROLOGIC DISORDERS
- •ACQUIRED INFLAMMATORY DEMYELINATING NEUROPATHIES
- •CREUTZFELDT–JAKOB DISEASE
- •NEOPLASMS
- •JUVENILE XANTHOGRANULOMA
- •LEIOMYOMA
- •ORBITAL RHABDOMYOSARCOMA
- •SEBACEOUS GLAND CARCINOMA
- •SQUAMOUS CELL CARCINOMA
- •MANAGEMENT OF SCLERAL RUPTURES 871.4 AND LACERATIONS 871.2
- •IRIS LACERATIONS 364.74, IRIS HOLES 364.74, AND IRIDODIALYSIS 369.76
- •ORBITAL IMPLANT EXTRUSION
- •SHAKEN BABY SYNDROME
- •PAPILLORENAL SYNDROME
- •ANTERIOR CHAMBER
- •CHOROID
- •ANGIOID STREAKS
- •CHOROIDAL DETACHMENT
- •SYMPATHETIC OPHTHALMIA
- •CONJUNCTIVA
- •ALLERGIC CONJUNCTIVITIS
- •BACTERIAL CONJUNCTIVITIS
- •LIGNEOUS CONJUNCTIVITIS
- •OPHTHALMIA NEONATORUM
- •CORNEA
- •BACTERIAL CORNEAL ULCERS
- •CORNEAL MUCOUS PLAQUES
- •CORNEAL NEOVASCULARIZATION
- •FUCHS’ CORNEAL DYSTROPHY
- •KERATOCONJUNCTIVITIS SICCA AND SJÖGREN’S SYNDROME
- •LATTICE CORNEAL DYSTROPHY
- •NEUROPARALYTIC KERATITIS
- •PELLUCID MARGINAL DEGENERATION
- •EXTRAOCULAR MUSCLES
- •ACCOMMODATIVE ESOTROPIA
- •CONVERGENCE INSUFFICIENCY
- •MONOFIXATION SYNDROME
- •NYSTAGMUS
- •EYELIDS
- •BLEPHAROCHALASIS
- •BLEPHAROCONJUNCTIVITIS
- •EPICANTHUS
- •FACIAL MOVEMENT DISORDERS
- •FLOPPY EYELID SYNDROME
- •MARCUS GUNN SYNDROME
- •SEBORRHEIC BLEPHARITIS
- •XANTHELASMA
- •GLOBE
- •BACTERIAL ENDOPHTHALMITIS
- •FUNGAL ENDOPHTHALMITIS
- •INTRAOCULAR PRESSURE
- •ANGLE RECESSION GLAUCOMA
- •GLAUCOMA ASSOCIATED WITH ELEVATED VENOUS PRESSURE
- •GLAUCOMATOCYCLITIC CRISIS
- •NORMAL-TENSION GLAUCOMA (LOW-TENSION GLAUCOMA)
- •IRIS AND CILIARY BODY
- •ACCOMMODATIVE SPASM
- •LACRIMAL SYSTEM
- •LACRIMAL HYPOSECRETION
- •DISLOCATION OF THE LENS
- •LENTICONUS AND LENTIGLOBUS
- •MICROSPHEROPHAKIA
- •MACULA
- •CYSTOID MACULAR EDEMA
- •EPIMACULAR PROLIFERATION
- •OPTIC NERVE
- •ISCHEMIC OPTIC NEUROPATHIES
- •TRAUMATIC OPTIC NEUROPATHY
- •ORBIT
- •EXTERNAL ORBITAL FRACTURES
- •INTERNAL ORBITAL FRACTURES
- •OPTIC FORAMEN FRACTURES
- •RETINA
- •ACQUIRED RETINOSCHISIS
- •ACUTE RETINAL NECROSIS
- •DIFFUSE UNILATERAL SUBACUTE NEURORETINITIS
- •RETINOPATHY OF PREMATURITY
- •SCLERA
- •SCLEROMALACIA PERFORANS
- •VITREOUS
- •VITREOUS WICK SYNDROME
- •Index
Eyelids • 21 SECTION
susceptibility to infectious corneal infiltration that could lead to scarring or progress to endophthalmitis.
Patients typically present with complaints of eye irritation, photophobia, and foreign body sensation. Occasionally, patients have noticed the in-turning of the lid and lashes; they may be using tape to keep the lid everted. With appropriate surgical management, the prognosis for full recovery is excellent with rare recurrence after surgery. Cicatricial variants (e.g. cicatricial pemphigoid) progress, and treatment tends to be more aggressive and have a lower long-term success rate. Associated corneal abnormalities usually require topical antibiotics and tear substitutes.
DIAGNOSIS
●A broad classification scheme includes congenital, cicatricial, spastic and involutional.
●The differential diagnosis includes epiblepharon, epicanthal folds, trichiasis and distichiasis.
●The history includes pain, irritation, chronic allergies, chronic glaucoma medication use, eyelid observed turning in, and associated systemic disease.
●The physical examination reveals lower eyelid laxity, conjunctival scarring with or without keratinization, eyelid observed turning in, trichiasis and superficial punctate keratitis.
●If actual lower eyelid turning-in is not see, the clinician should have the patient look up and the grasp the patient’s preseptal muscle as in a ‘snap test.’ Then, the patient should look down, squeezing orbicularis, as the clinician lets go. This will demonstrate the entropion.
incision to accomplish the same thing, particularly if there is no significant horizontal lid laxity and horizontal shortening is not necessary.
Correction of cicatricial entropion generally involves the placement of a spacer in the posterior aspect of the lower lid after transconjunctival incision. Acellular dermis or hard palate mucosa is an excellent choice; others include sclera, fascia, autogenous tarsus, nasal septal mucosa, and buccal mucosa.
COMMENTS
Involutional and cicatricial entropion requires definitive surgical treatment to avoid sight-threatening secondary corneal complications. The success rate of this surgery when performed by experienced physicians is extremely high.
REFERENCES
Anderson RL: The tarsal strip. In: Transactions of the New Orleans Academy of Ophthalmology. St Louis, CV Mosby, 1982:352–363.
D’Ostroph AO, Dailey RA: Cicatricial entropion associated with chronic dipivefrin application. Ophthalmic Plast Reconstr Surg 17(5):328–31, 2001.
Jones LT, Reeh MJ, Wobig JL: Senile entropion. A new concept for correction. Am J Ophthalmol 74:321–329, 1972.
Quickert MH, Wilkes DI, Dryden RM: Non-incisional correction of epiblepharon and congenital entropion. Arch Ophthalmol 101:778–781, 1981.
Weiss FA: Surgical treatment of entropion. J Int Coll Surg 21:758–760, 1954.
TREATMENT
Medical
Be sure to manage any associated ocular surface problems with the appropriate topical antibiotics and/or lubricants. Temporary taping of the eyelid into a better position will help avoid further keratitis until a more definitive procedure can be performed.
Surgical
Quickert sutures can be placed with the use of local anesthesia. This is a quick method to relieve the entropion and can be done in the examination lane or at the bedside. It should not be considered definitive but can last for weeks to months. One needle of double-armed suture of 5-0 chromic catgut or 5-0 Vicryl suture is placed deep in the conjunctival fornix and brought anteriorly and superiorly through the lid tissues so it exits the skin near the lid margin, beneath the lash line. The second needle is then passed in a similar fashion 3 to 4 mm lateral. Two additional double-armed sutures are placed: one medially and one laterally. The sutures are tied, causing an eversion of the lid margin.
A definitive approach to involutional entropion involves a lateral cantholysis followed by transconjunctival incision just inferior to the tarsus. The inferior retractors are then isolated and reattached to the anterior/inferior portion of the tarsus with multiple interrupted sutures. The lid then can be shortened using a tarsal strip procedure. The lateral canthus is reformed with tarsus-to-lateral rim periosteal sutures, ensuring that the tarsus is slightly posterior to the rim. Closure of the skin is completed. An alternative would be to use a subciliary
239 EPICANTHUS 743.63
Roger A. Dailey, MD
Portland, Oregon
John D. Ng, MD, MS, FACS
Portland, Oregon
The term epicanthus refers to a vertical fold of skin that is located between the medial canthus and the nose and may cover part or all of the inner canthus of the eye.
ETIOLOGY/INCIDENCE
●Epicanthal folds are common in infants and children of all races but are a characteristic finding in persons of all ages with Asian ancestry.
●Fetal alcohol syndrome often exhibits epicanthus.
●Rarely, the blepharophimosis tetrad can occur as a developmental anomaly, but more commonly it is transmitted as an autosomal dominant trait, linked to the 3q21-24 gene, with 100% penetrance.
●Structurally, the folds appear to be related to tension in underlying excessive orbicularis muscle, with a relative lack of attachment of the skin to the underlying structures. Differential growth rates of skin in the medial canthal area and tension placed on the skin by the underlying orbicularis also may play roles.
440
COURSE/PROGNOSIS
●The majority of children of Asian ancestry will lose these folds during and after puberty, but the folds persist in 2% to 5% of whites.
●Surgical management relieves the condition in as many as 90% of cases.
●Surgical complications include visible scars, asymmetry, recurrence, and, rarely, infection.
DIAGNOSIS
●The diagnosis of epicanthus is easily made on external examination.
●Amblyopia is rare in association with epicanthus and is usually associated with other problems, such as anisometropia and astigmatism.
●No spinal abnormalities have been reported from patients who have had compensatory head tilt from blepharoptosis for many years.
Types of epicanthus
Epicanthus supraciliaris is a vertical fold of skin that extends from just below the brow to an area just over the infraorbital rim, usually obscuring the caruncle.
In epicanthus palpebralis, the skin fold extends from the medial aspect of the upper lid to the medial aspect of the lower lid in a nearly symmetric fashion and often obscures the caruncle. This is the most common configuration.
Epicanthus tarsalis refers to a condition in which a fold begins laterally and extends over the entire eyelid, ending in the medial canthus. This is the typical Asian upper lid configuration. Epiblepharon of the upper lids is distinguished from epicanthus tarsalis by its lack of true superior palpebral fold and the presence of a fold of skin that overlaps the eyelid margin and presses the lashes against the cornea.
Epicanthus inversus is similar to epicanthus tarsalis but involves the lower lid. It usually occurs as a part of Komoto’s tetrad of blepharoptosis, blepharophimosis, telecanthus, and epicanthus inversus; blepharophimosis refers to narrowing of the palpebral aperture in its horizontal dimension.
TREATMENT
Surgical
In general, epicanthus tarsalis, palpebralis, and supraciliaris will diminish with age as the child’s nasal dorsum becomes more prominent. If ptosis repair must be performed and significantly worsens the fold, the fold can be repaired simultaneously. Often, consideration is given to surgery before the child is of school age or soon after starting school to avoid or at least minimize some of the psychologic problems regarding body image and self-esteem that can arise. Older children can be operated on with mild sedation, and the results are more predictable.
●Skin resection should be avoided in the surgical management of epicanthus tarsalis, palpebralis, and supraciliaris because it can actually accentuate the anomaly. A preferred approach is to incise the skin directly over the fold, remove the orbicularis muscle in this area, and close the skin with deep attachments to maintain a crease and remove the fold. The crease will soften with time, but the fold should not recur.
●Epicanthus inversus typically shows little improvement with age. In these children, the skin tends to be very stiff
at an early age and difficult to work with surgically but becomes more amenable to intervention at a later age. This condition generally responds best to Verwey’s Y-to-V operation, double Z-plasty, Mustard’s technique, or the five-flap procedure. Spaeth’s technique, which involves excision of a portion of the fold of skin, is generally reserved for mild cases of epicanthus inversus.
●In 1989, Anderson and Nowinski described the five-flap technique, which they consider to be the best application for epicanthus inversus. This is a modified Y-to-V procedure combined with a double Z-plasty. It has the advantage of being simple to mark out on the lid, and the flaps are small and relatively easy to transpose.
●In cases in which there is associated telecanthus, it should be repaired at the same time with medial canthal tendon resection or transnasal wiring. It is important to avoid injuring the canaliculus or lacrimal sac. A lateral canthoplasty can be performed at the same time in cases of blepharophimosis.
COMMENTS
Epicanthus supraciliaris, palpebralis, and tarsalis tend to regress spontaneously with maturity and only occasionally require surgery. Typically, this requires only resection of underlying muscle and then deep skin fixation. Epicanthus inversus rarely improves with age and generally responds to surgical managements such as a Y-to-V procedure, Z-plasties, or the five-flap technique. Amblyopia can occur in these patients and should be checked for at regular examinations in the early years of the patient’s life.
REFERENCES
Callahan A: Surgical correction of the blepharophimosis syndromes. Trans Am Acad Ophthalmol Otolaryngol 77:687–695, 1973.
Hughes WL: Surgical treatment of congenital palpebral phimosis: the Y-V operation. Arch Ophthalmol 54:586–590, 1955.
Johnson CC: Epicanthus and epiblepharon. Arch Ophthalmol 96:1030– 1033, 1978.
Jordan DR, Anderson RL: Epicanthal folds: a deep tissue approach. Arch Ophthalmol 107:1532–1535, 1989.
Stromland K: Visual impairment and ocular abnormalities in children with fetal alcohol syndrome. Addict Biol 9:153–7, 2004.
240 EYELID CONTUSIONS 921.1, LACERATIONS 870.8, AND AVULSIONS 871.3
Robert C. Della Rocca, MD, FACS
New York, New York
David A. Della Rocca, MD
New York, New York
John Nassif, MD
Clearwater, Florida
John Koh, MD
Southfield, Michigan
Eyelid contusions, lacerations, and canthal avulsions may result in severe functional or structural abnormalities. Complete
Avulsions and Lacerations, Contusions, Eyelid • 240 CHAPTER
441
Eyelids • 21 SECTION
ocular evaluation and prompt determination of the extent of adnexal injury and the absence or presence of canalicular laceration allows for appropriate and timely repair of the injury. This will promote optimum functional and cosmetic results while limiting the possibility of early and late complications.
DIAGNOSIS
Clinical signs and symptoms
On inspection of the eyelids and periorbital region, ecchymosis and edema can be very significant, obscuring the location and extent of lacerations. It is important to rule out direct or indirect ocular injury. A careful history will help in raising suspicion that systemic, ocular or orbital injury may have occurred. Visual assessment, including visual acuity testing and pupil and ocular motility evaluation should be done, in addition to slit lamp microscopy, tonometry and ophthalmoscopy. This assessment, which should include adnexal evaluation, may be limited by significant periorbital and eyelid edema. Supportive measures including the use of cool compresses can be helpful prior to detailed ocular and adnexal examination. In some cases, thorough evaluation must be delayed until anesthesia is available in the operating room. Canalicular involvement and canthal displacement must be recognized to allow for appropriate surgical planning. Ptosis is common with upper eyelid lacerations and may be due to edema or direct injury to the levator complex.
Laboratory findings
Computed tomography scanning is advised if an orbital fracture is suspected. Orbital fractures are suggested by the presence of extraocular motility dysfunction, infraorbital anesthesia, globe displacement, marked periorbital edema or signs of orbital emphysema. Magnetic resonance imaging (MRI) gives excellent soft tissue contrast, but is less effective in defining orbital fractures. B-scan ultrasonography or the other scanning modalities listed above are helpful in evaluation of the globe and optic nerve if the eyelids can not be opened secondary to edema.
TREATMENT
Severe pain is uncommon with injury to adnexal tissue. If pain control is needed we recommend acetaminophen or acetaminophen in combination with codeine. Tetanus immunization may be necessary if the patient has not had a tetanus booster within the last 5 years. Broad-spectrum antibiotics are recommended, especially in the context of animal or human bites.
If a wound is older than 2 days, we consider debridement of the granulation tissue from the wound edges at the start of the case. We recommend primary repair of the tissues unless there is significant bacterial contamination or extensive tissue loss.
Simple partial lacerations of the skin can be repaired with 6-0 nylon or silk sutures in an interrupted fashion. Full thickness lacerations are repaired in a stepwise fashion. First, the lid margin is closed using 6-0 silk sutures in 3 interrupted passes through the meibomian gland orifices, lash line and at the grey line sequentially. It is important to make sure that the placement of the first silk suture approximates the tarsal plate neatly. These three sutures are tied and left long for later tying to the skin closing sutures (away from the cornea). Next, the tarsal
plate, distal to the lid margin, is closed with 5-0 absorbable suture. Last, the skin is closed with interrupted 6-0 silk sutures.
Full thickness tissue loss is uncommon and can be mimicked by edema and wound contracture. Minimal tissue loss characterized by loss of up to one-quarter of the eyelid may be managed by a full thickness closure combined with a lateral canthotomy and cantholysis. Moderate tissue loss (one quarter to one half of the eyelid) might necessitate a skin advancement flap of Tenzel to extend the length of the eyelid prior to closure. Severe tissue loss of greater than half of the eyelid length would usually necessitate an eyelid sharing procedure such as the Hughes procedure for inferior eyelid loss or the Cutler–Beard flap for upper eyelid loss.
Avulsions or lacerations of the canthus indicate the reattachment of the tissues to the appropriate level of periostium. Injury to the lateral canthus can be repaired by the creation of a lateral tarsal strip with or without a periostial flap. A medial avulsion requires the reattachment of the posterior limb of the medial canthal tendon to the posterior lacrimal crest periorbita. The use of transnasal wiring may be necessary if there is severe tissue or bone destruction.
COMPLICATIONS
●Ptosis: due to levator complex injury, severe traumatic edema (levator aponeurosis stretching and dehiscence), or on a neurogenic basis.
●Epiphora: due to canalicular laceration, lacrimal sac injury, or punctal eversion.
●Corneal exposure: due to post-repair eyelid malpositions or lagophthalmos.
●Eyelid malpositions: ectropion, entropion, eyelid retraction.
●Scar hypertrophy or depigmentation.
COMMENTS
On an emergent basis, concurrent with adnexal and canthal injuries, the presence of symptomatic and compressive orbital hemorrhage must be treated promptly with a lateral canthotomy and cantholysis. Following the cantholysis, the periorbita is opened to evacuate the hemorrhage and clots.
When possible, avoid discarding apparently devitalized tissue, whether partially or completely avulsed. Periorbital tissue has extensive vascularity and may survive trauma otherwise deemed unsurvivable. This tissue may be reattached at the site of the defect.
REFERENCES
Collin JR, Tyers AG: Colour atlas of ophthalmic plastic surgery. Churchill Livingstone, 1998:9–16:11–26.
Della Rocca RC, Bedrossian EH, Arthurs BP: Ophthalmic plastic surgery: decisions making and techniques. New York, McGraw-Hill, 2002:25–41:153–161:181–187.
Lemke BN, Della Rocca RC: Surgery of the eyelid and orbit an anatomical approach. Norwalk, Appleton and Lange, 1990:199–212.
Smith BC, Della Rocca RC, Nesi FA, Lisman RD: Ophthalmic plastic and reconstructive surgery. St Louis, CV Mosby, 1976:8–17:39–78:129– 140.
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241 FACIAL MOVEMENT DISORDERS
(Benign Essential Blepharospasm
333.81, Hemifacial Spasm 351.8)
John R. Samples, MD
Portland, Oregon
occurs to such a degree that it interferes with the patient’s lifestyle or vision. Symptoms are typically made worse by stress, fatigue, bright lights, and driving, and symptoms are usually relieved by sleep and relaxation. Patients may have idiosyncratic factors that precipitate or alleviate their symptoms.
Hemifacial spasm tends to be more idiosyncratic in terms of its onset. Spasms are often precipitated or made worse by fatigue and stress.
ETIOLOGY/INCIDENCE
Benign essential blepharospasm and hemifacial spasm are facial movement disorders that primarily affect older individuals. Benign essential blepharospasm is virtually always bilateral, but hemifacial spasm is usually unilateral. Hemifacial spasm begins with twitches in a single region of the orbicularis muscle that lasts from seconds to minutes; typically, the twitches are rather irregular and tonic in pattern. The spasm rarely recruits or extends over seconds or minutes. In contrast, benign essential blepharospasm is characterized by involuntary, tonic, sometimes-forceful closure of the eyelids that can be either intermittent or continuous. It is often associated with orofacial dyskinesia and may be associated with other movement disorders involving the trunk and the neck. These disorders are almost always axial. It is helpful to differentiate these disorders from other causes of facial spasm. Some individuals have a psychogenic cause for their blepharospasm and other individuals have dry eye conditions and other types of keratitis that stimulate a blepharospasm, particularly in response to light.
Benign essential blepharospasm is related to a central nervous system disorder that remains poorly understood.
It is sometimes part of, or found in conjunction with, Parkinson’s disease and it is assumed that a common cause is shared with Parkinson’s disease in these cases.
Hemifacial spasm is attributed to compression of the facial nerve by an aberrant blood vessel. It may also be caused by lesions that compress the facial nerve extra-axially, by an aneurysm or an arteriovenous malformation, or by a neoplasm that involves the cerebellopontine angle.
COURSE/PROGNOSIS
All of these conditions are usually slowly progressive but may occasionally spontaneously remit. Waxing and waning over months is not unheard of.
When a patient has hemifacial spasm, serious central nervous conditions must be ruled out. Synkinesis is observed with hemifacial spasm but not with facial myokymia. Facial myokymia is almost always a benign condition that involves a single muscle. Some patients with multiple sclerosis or brain stem tumors may have facial myokymia as a presenting sign; in this case, it usually persists indefinitely. More benign myokymias are always intermittent.
DIAGNOSIS
The hallmark of benign essential blepharospasm is the involuntary, tonic, and forceful closure of the eyelids. Often, this
TREATMENT
Systemic
Anticholinergic agents, such as trihexyphenidyl hydrochloride (Artane), may be useful in treating many patients with benign essential blepharospasm. Typically, this drug is used at a dosage of 2 mg PO b.i.d., which is slowly increased. Many patients who titrate the medicine appropriately will be able to tolerate the blepharospasm and find the medicine useful; however, side effects, including dry mouth, dry eye and drowsiness, limit the usefulness of this drug.
After anticholinergic therapy, a trial with other drugs, such as clonazepam, is sometimes warranted, but many patients are happier proceeding to botulinum toxin.
No medication has been identified as specifically curative for this condition, although medical failures are often due more to failures to attempt medical titration than to failure of the medicine to work.
For hemifacial spasm, there is virtually no successful systemic therapy, although carbamazepine has been estimated to benefit as many as 30 patients with this disorder.
Local
Injections with botulinum toxin type A provide relief for most patients with benign essential blepharospasm and hemifacial spasm. The toxin works by interfering with acetylcholine release from nerve terminals. It may provide relief from spasm for 3 months or longer. It is generally well tolerated, although some patients develop ptosis or diplopia, especially if doses are given centrally or along the midline. A typical pattern of injection places 5 units SC at each of the two sites over the brow, 5 units at each of two sites well off the midline in the upper lid, and 5 units at each of two sites in the lower lid, for a total of six injections on a side. Injections can be tailored to the individual patient’s spasm.
Complications of botulinum toxin type A include ptosis, ectropion, corneal exposure, and tearing. It appears that a tolerance to toxin does not develop. Antibodies to botulinum toxin type A do not develop with the dose commonly used for these conditions.
Surgical
In benign essential blepharospasm, surgery should be reserved for individuals for whom trials with medication and botulinum toxin type A were not successful. Also, patients need to be cautioned that they may not obtain complete relief.
The most effective technique is to resect the orbicularis oculi muscles. This was initially popularized by Gillum and Anderson in 1981. The technique involves the meticulous extirpation of all of the accessible orbicularis oculi, procerus, corrugator, superciliaris, and facial nerves in post orbicular fascia. Numerous refinements have been discussed.
Disorders Movement Facial • 241 CHAPTER
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