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CANAL-BASED SURGERY

There has long been an interest in enhancing aqueous drainage such that the formation of a subconjunctival bleb is not necessary. At the time of this publication, two procedures were gaining popularity in the United States. Canaloplasty uses an ab externo approach, whereas thermal ablation of the trabecular meshwork using the Trabectome has an ab interno approach. Many other procedures presented are of largely historical interest but demonstrate that the fundamental concepts behind canaloplasty and Trabectome have been investigated for several decades.

Incisional Trabeculotomy

In 1960, Burian (345) and Smith (346) independently described techniques for incising the trabecular meshwork from an ab externo approach. The procedure was modified by Harms and Dannheim (347), who reported success in adults as well as children, although the primary application of trabeculotomy has been with the management of childhood glaucomas (348) (discussed in detail in Chapter 40).

Basic Technique

The following technique, described by McPherson (349), encompasses aspects of the procedures developed by Allen and Burian (350) and Harms and Dannheim (347).

A conjunctival flap is prepared, and a partial-thickness scleral flap is dissected. A radial incision is then made across the sclerolimbal junction until the Schlemm canal is entered. One arm of a McPherson, or a Harms, trabeculotome is threaded into the Schlemm canal, using the other, parallel arm as a guide (Fig.

36.10). The trabeculotome is then rotated so that the arm within the canal tears through trabecular meshwork into the anterior chamber. The same procedure is then performed on the other side of the radial incision. The scleral and conjunctival flaps are closed in the same manner as for filtering procedures.

A trabeculotome can also be introduced into the Schlemm canal through an external collecting channel for better localization (351). A modified trabeculotome, corresponding to corneal diameters of 10, 12, and 14 mm, has been described (352).

Variations

Suture Trabeculotomy

In this technique, originally described by Smith (346), a nylon or Prolene suture is threaded into the Schlemm canal for 360 degrees, or between incisions 180 degrees apart, and the exposed ends are pulled taut, causing the suture to rupture

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through the trabecular meshwork into the anterior chamber (353). A suture trabeculotomy can be transformed into a traditional trabeculotomy at any time (354).

Figure 36.10 Trabeculotomy. The internal arm (a) of a trabeculotome is threaded into the Schlemm canal, using the external, parallel arm (b) as a guide; inset shows the gonioscopic appearance of the internal arm as it moves through the canal (arrow).

Combined Trabeculotomy-Trabeculectomy

If the Schlemm canal cannot be located with certainty, the procedure can be converted to a trabeculectomy by removing a block of deep limbal tissue beneath the scleral flap. In addition, the two procedures can be combined by first performing the trabeculotomy and then creating the fistula beneath the scleral flap. In some situations, such as with the Sturge-Weber syndrome, in which the exact mechanism of the glaucoma is uncertain (see Chapter 21), the combined procedure may offer the best chance of success (355, 356, 357, 358, 359 and 360). Bilateral combined trabeculotomy-trabeculectomy and trabeculotomy in combination with deep sclerectomy have been reported (361, 362). Combined trabeculotomy-trabeculectomy may be particularly useful in eyes with corneal opacification (363). Combined Trabeculotomy-Cataract Surgery

Cataract surgery can be combined with trabeculotomy in patients with coexisting glaucoma and cataract to reduce the occurrence of flat anterior chamber (364, 365, 366, 367 and 368). However, in low-tension glaucoma, the combination may not always sufficiently lower the IOP (369). Combined trabeculotomycataract surgery also appears more likely to reduce IOP in patients who are 70 years of age or older (370). Although hypotony is seen infrequently, hyphema may often occur; it was seen in 20% of the

eyes in one retrospective study (369). However, the combination of phacoemulsification with trabeculotomy appears to decrease the frequency of hyphema, compared with trabeculotomy alone (371). IOP spikes of more than 30 mm Hg, pro bably related to hyphema, have been reported in 10% to 25% of eyes (369,

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Shields > SECTION III - Management of Glaucoma >

37 - Principles of Incisional Surgery

Authors: Allingham, R. Rand

Title: Shields Textbook of Glaucoma, 6th Edition Copyright ©2011 Lippincott Williams & Wilkins

> Table of Contents > SECTION III - Management of Glaucoma > 37 - Principles of Incisional Surgery 37

Principles of Incisional Surgery

Adivision between laser surgery for glaucoma and the more traditional glaucoma operations is becoming more and more artificial. The latter surgical category was originally distinguished by the term “conventional surgery,” although laser techniques h ave now become the more conventional forms of surgery for glaucoma, prompting the need to reconsider the terminology. “Invasive surgery” is not a satisfactory alternative, because invading the eye with a laser beam can cause just as much tissue alteration as invading it with a knife. The term “i ncisional surgery,” as used in this text, is not fu lly satisfactory either, because some of the newer laser procedures include incisional techniques. The fact is that as laser technology continues to expand, the day may come when all glaucoma surgery will include laser instruments. For these reasons, the chapters that follow combine laser and incisional procedures under general surgical categories, and this chapter, although it pertains primarily to incisional techniques, actually relates to both disciplines of glaucoma surgery.

WOUND HEALING

The incision of any tissue is followed by a complex process that attempts to heal the wound. The desire in most operations is to achieve complete, strong wound healing. For the glaucoma surgeon who is performing a filtering procedure, however, excessive wound healing can be a detriment, leading to failure of the operation. This chapter considers general aspects of wound healing. (Specifics related to filtering surgery and measures to prevent excessive scarring are discussed in Chapter 38.)

Wound healing is typically considered to occur in three phases: inflammation, proliferation, and remodeling. However, it may help to think of this complex, and only partially understood, process in four overlapping phases: (a) clot phase, (b) proliferative phase, (c) granulation phase, and (d) collagen phase.

Clot Phase

Almost immediately after a tissue incision, blood vessels constrict and leak blood cells, platelets, and plasma proteins, which include fibrinogen, fibronectin, and plasminogen. In addition, blood-vessel rupture stimulates platelet aggregation and activation of various tissue growth factors, which are chemotactic to inflammatory cells, stimulating the intrinsic coagulation cascade (1, 2, 3 and 4). As a result, these blood elements clot to form a gellike fibrin-fibronectin matrix (1, 5).

Proliferative Phase

Inflammatory cells, including monocytes and macrophages, along with fibroblasts and new capillaries, migrate into the clot within a few days after the surgery. In a rabbit model of filtering surgery, fibroblasts were seen to migrate from episcleral tissue, epimysium of the superior rectus, and subconjunctival connective tissue (6), and in a monkey model, they were proliferating along the walls of the limbal fistula by day 6 (7). By using the incorporation of tritiated thymidine as a marker of cell division to study the time course of cellular proliferation after filtering surgery in monkeys,

incorporation was detected as early as 24 hours postoperatively, peaked in 5 days, and returned to baseline by day 11 (8). Angiogenesis, or proliferation of new blood vessels, also takes place during this phase (9).

Granulation Phase

As the fibrin-fibronectin clot is degraded by inflammatory cells, the fibroblasts begin to synthesize fibronectin, interstitial collagens, and glycosaminoglycans to form young fibrovascular connective tissue, or granulation tissue (5). In the rabbit model, granulation tissue was seen in the fistula by the third day (6), whereas in the monkey model, it was lining the fistula by at least day 10 (7). Collagen Phase

Procollagen is synthesized intracellularly by fibroblasts (10), and it is then secreted into the extracellular spaces, where it undergoes biochemical transformation into tropocollagen. Approximately 2 weeks after surgery, the tropocollagen molecules aggregate into immature soluble collagen fibrils, and over the next few months undergo cross-linking to form mature collagen. The amount of collagen in the wound is the result of collagen synthesis and degradation. The degradation process is controlled by the family of proteolytic enzymes, called matrix metalloproteinases (11, 12, 13, 14 and 15). Although the matrix metalloproteinases have been found in healthy subconjunctival tissues and aqueous humor (16, 17 and 18), their elevated levels have been associated with more aggressive scarring in the eye (19). Eventually, blood vessels are partially reabsorbed, and fibroblasts largely disappear, probably by apoptosis (20), leaving a collagenous scar with scattered fibroblasts and blood vessels (5).

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ANESTHESIA

Although most laser procedures require only topical anesthesia, incisional surgery and some glaucoma laser operations require local anesthesia. General anesthesia is usually reserved for children or adults in whom cooperation or other considerations do not permit surgery under local anesthesia.

Local Anesthesia Retrobulbar Injection

Commonly used injectable anesthetics include lidocaine, bupivacaine, and mepivacaine. When compared on the basis of induced lid akinesia, these three agents were found to be similar with regard to onset (less than 6 minutes) and depth of anesthesia, whereas bupivacaine had the longest duration of effect (up to 6 hours, compared with 90 minutes for mepivacaine and 15 to 30 minutes for lidocaine) (21). In an evaluation of combined agents, bupivacaine, 0.5%, lidocaine, 2%, and 1:100,000 epinephrine were more effective in producing lid and globe akinesia than bupivacaine alone or the two anesthetics without epinephrine (22). Bupivacaine alone was slower in producing anesthesia but was more effective in producing akinesia than the two anesthetics combined without epinephrine. The three combinations were similar with regard to frequency of pain during a 30-minute operation and the need for analgesia 6 hours postoperatively.

Epinephrine may enhance the effect of local anesthetics, presumably by minimizing systemic spread from the injection site by its vasoconstrictive action. However, it may also impose an additional risk in glaucomatous eyes by reducing vascular perfusion to an already compromised optic nerve head. Another supplement to local anesthesia that does appear to be safe and effective is hyaluronidase, which serves to improve local tissue spread within the injection site by breaking down the connective tissue ground substances. In recent years, however, hyaluronidase has become difficult to obtain commercially. Although retrobulbar and orbicularis anesthesia were traditionally given as separate injections, it was shown that the retrobulbar injection alone provides adequate facial akinesia, because of the decreased stimulus for orbicularis contraction in the vast majority of cases (23). For the retrobulbar injection, an Atkinson needle has the advantages of being short and blunt, both of which help avoid retrobulbar hemorrhage (24). An injection of 3 to 5 cc of a 50:50 mixture of 0.75% bupivacaine and 2% to 4% lidocaine with hyaluronidase, if available, usually provides adequate anesthesia and akinesia. Complications of retrobulbar anesthesia may include retrobulbar hemorrhage, extraocular muscle injury, perforation of the eye globe, and optic nerve injury. Firm pressure to the globe for 30 seconds after the

injection may also help minimize retrobulbar hemorrhage by tamponading any small, bleeding vessel. Other Types of Local Anesthesia

Some surgeons prefer to avoid the risks associated with retrobulbar anesthesia by using peribulbar (transconjunctival injection near the equator of the globe without entering the muscle cone), sub-Tenon (more anterior placement near the surgical site), subconjunctival, or topical anesthesia (25, 26, 27, 28 and 29). The last three methods may be the safest of these approaches in patients with glaucoma, because both retrobulbar and peribulbar injections can cause significant IOP elevations (30, 31). In a study of 104 eyes with and without glaucoma receiving retrobulbar or peribulbar anesthesia for intraocular surgery, the 40 eyes with glaucoma had higher and more persistent increases in IOP (30). One minute after injection, the IOP was 10 mm Hg or more above baseline in 35% of the glaucomatous eyes, and 20 mm Hg or more in 10%. The mean IOP elevation after 5 minutes was greater with retrobulbar anesthesia, although ocular compression significantly reduced the IOP at 5 minutes.

A reported technique for sub-Tenon anesthesia involves the injection of lidocaine, 2%, over the superior, medial, and lateral rectus muscles in conjunction with a lid block and standard sedative (32). In a randomized trial comparing this approach with retrobulbar anesthesia, the sub-Tenon anesthesia required a smaller volume of local anesthetic, less additional anesthesia, and less postoperative analgesia (32). Subconjunctival anesthesia by using a 1- to 2-mL injection of 1:1 mixture of mepivacaine, 2%, and bupivacaine, 0.75%, in the superotemporal quadrant was found to be an effective alternative to peribulbar anesthesia for trabeculectomy (33).

Topical anesthesia appears to provide optimal conditions for the surgeon and similar amounts of patient comfort, compared with retrobulbar anesthesia (28, 29); however, in another study, patients who experienced both topical anesthesia and retrobulbar block appeared to prefer the retrobulbar anesthesia (34). The techniques can be combined by starting the conjunctival incision under topical anesthesia, followed by sub-Tenon or even retrobulbar delivery by following the sclera plane posteriorly with a blunt irrigating cannula.

Adjuncts to Local Anesthesia

Although general anesthesia is not commonly used in glaucoma surgery, it is advisable to routinely use the assistance of an anesthesiologist or anesthetist to monitor the patient's vital signs and to provide adjunctive medications. The latter may include short-acting analgesics, such as propofol and fentanyl citrate, and short-acting central nervous system depressants, such as midazolam HC1, for sedation. The addition of alfentanil to midazolam has also been shown to be advantageous (35). Remifentanil is another, relatively new, ultrashort-acting opioid that can be rapidly titrated and individualized for various levels of surgical interventions. Although it is expensive, and respiratory depression and postoperative nausea are considerations, studies have shown that respiratory depression with remifentanil is mild, and remifentanil sedation for retrobulbar blocks appeared to be superior to sedation with propofol (36). A combination of remifentanil and propofol has provided excellent relief of pain and anxiety with the fewest adverse effects (37, 38).

In addition, ultrashort-acting barbiturate anesthetics such as methohexital sodium (Brevital) can be administered intravenously to provide a few minutes of sleep while the retrobulbar injection is being given.

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BASIC TECHNIQUES AND INSTRUMENTS Eyelid Separation

Good exposure of the surgical field is critical to a successful glaucoma operation. This begins with the selection of an appropriate eyelid speculum. Instruments are available in a wide range of designs, each with certain advantages and disadvantages. A desirable speculum, however, is one that not only separates the eyelids but also lifts them from the globe and allows the surgeon to adjust the degree of lid separation. Lateral canthotomy may also be performed to improve exposure in selected eyes.

Traction Sutures

Because most glaucoma surgery is performed in the superior quadrants, the next step toward good

exposure is to rotate the eye down, which is usually accomplished with a traction (or bridle) suture. A traditional technique is the superior rectus traction suture, in which a 4-0 silk suture is passed transconjunctivally beneath the muscles and then attached to the head of the surgical drape with a clamp (Fig. 37.1). Potential complications with this approach include subconjunctival hemorrhage, conjunctival defects, scleral perforation, patient discomfort, and postoperative ptosis. A corneal traction suture, in which a 7-0 silk or polyglactin (e.g., Vicryl) suture on a cutting needle (i.e., S-29 for silk sutures) is passed through approximately three-fourths thickness, superior, peripheral cornea and attached to the drape over the cheek (Fig. 37.2), provides good exposure while eliminating the foregoing complications (39, 40). However, it can distort the cornea and anterior chamber when the eye is soft. Hemostasis

As noted earlier in this chapter, bleeding is the first step in the wound healing process, which can lead to excessive, detrimental scarring especially in glaucoma filtering surgery. It is desirable, therefore, in all surgical procedures to minimize bleeding. It is helpful to stop use of anticoagulants, such as aspirin, nonsteroidal anti-inflammatory drugs, and sodium warfarin (Coumadin), if possible, before surgery. During surgery, the surgeon should try to avoid large vessels, such as the anterior ciliary arteries near the insertions of the rectus muscles. When bleeding does occur, it should be continuously flushed from the surgical site with a gentle stream of balanced salt solution. Small bleeders may eventually close spontaneously, although most require cauterization. An ideal cautery unit for glaucoma surgery is a small-diameter, tapered, blunt, bipolar cautery instrument (41) (Fig. 37.3). This provides adequate cauterization of episcleral bleeders without excessive tissue charring or tissue contraction and can be used at lower energy levels to cauterize intraocular bleeding as from the ciliary body or iris.

27 - Principles of Medical Therapy and Management Page 131 of 267

Figure 37.1Eye rotated down by superior rectus traction suture and attached to head of surgical drape.

Figure 37.2 Eye rotated down by corneal traction suture and attached to surgical drape over cheek. Tissue Handling

Most glaucoma surgery is performed on the extraocular tissues of the anterior ocular segment. Gentle handling of these tissues is essential to avoid tearing the conjunctiva or cutting more tissue than necessary, which can also increase the risks of excessive scarring. When possible, it is best to grasp the Tenon capsule and avoid direct contact of the instrument with the conjunctiva. When it is necessary to grasp the conjunctiva, it should be done with smooth-tipped (nontoothed) forceps to avoid piercing or tearing the conjunctiva. When dissecting conjunctiva, it is best to use a blunt dissecting instrument, when possible, and to cut tissue with scissors or a blade only when necessary. (Details regarding P.486

specific instruments for the various surgical procedures are provided in the following chapters that deal with those operations.)

Figure 37.3 Cauterization of sclera with tapered, blunt tip, bipolar cautery instrument. Suturing

To minimize excessive inflammatory reaction and subsequent scarring, select suture material with the least tendency to induce tissue reaction. For corneoscleral suturing, 9-0 or 10-0 nylon on a fine, cutting needle can be effective; however, manually removing nonabsorbable nylon sutures in the postoperative period is often necessary. For the conjunctiva, however, polyglycolic acid or polyglactin sutures are nearly as nonreactive as nylon and have the advantage of being biodegradable. It is also important to use a needle that will not tear or leave a large hole in the conjunctiva. Fine, tapered, noncutting, or vascular needles are useful for closing conjunctival tissues.

KEY POINTS

The wound healing process after the incision of a tissue includes clot formation, cellular proliferation, granulation tissue formation, and the synthesis and maturation of collagen.

Most incisional glaucoma surgery is performed under local anesthesia, with agents such as lidocaine and bupivacaine.

Epinephrine, as a supplement, is usually avoided because of the risk to the optic nerve head,

although hyaluronidase may be useful as a tissue-spreading factor.

Basic techniques and instruments for incisional glaucoma surgery include attention to good surgical exposure with an appropriate eyelid speculum and traction suture, adequate hemostasis, gentle wound handling, and the proper suture and needle for wound closure.

REFERENCES

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41.Shields MB. Evaluation of a tapered, blunt, bipolar cautery tip for trabeculectomy. Ophthalmic Surg. 1994;25:54-56.

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Shields > SECTION III - Management of Glaucoma >

38 - Filtering Surgery

Authors: Allingham, R. Rand

Title: Shields Textbook of Glaucoma, 6th Edition Copyright ©2011 Lippincott Williams & Wilkins

> Table of Contents > SECTION III - Management of Glaucoma > 38 - Filtering Surgery 38

Filtering Surgery

The incisional operation most frequently used for chronic forms of glaucoma, especially in adults, is