Ординатура / Офтальмология / Английские материалы / Retinal Degenerations biology, diagnostics, and therapeutics_Tombran-Tink, Barnstable_2007
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CONTENTS
Preface ............................................................................................................................ |
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Contributors.................................................................................................................. |
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xv |
Companion CD............................................................................................................ |
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xix |
I. LIVING WITH RETINAL DEGENERATION |
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1 |
Coping With Retinal Degeneration: A Patient's View ..................... |
3 |
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Gordon Cousins and James Cape |
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II. DEGENERATIVE DISEASES OF THE RETINA |
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2 |
Epidemiology of Age-Related Macular Degeneration |
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Early in the 21st Century ............................................................ |
23 |
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Jie Jin Wang, Paul Mitchell, and Ronald Klein |
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3 |
Leber Congenital Amaurosis: A Hereditary Childhood Form |
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of Blindness and a Model to Elucidate Retinal Physiology |
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and Development ........................................................................ |
61 |
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Robert K. Koenekoop |
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4 |
Macular Degeneration: Aging Changes and Novel Therapies ...... |
91 |
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Peter E. Liggett and Alejandro J. Lavaque |
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5 |
Stargardt Disease: From Gene Discovery to Therapy ................. |
105 |
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Rando Allikmets |
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6 |
X-Linked Juvenile Retinoschisis .................................................. |
119 |
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Bernhard H. F. Weber and Ulrich Kellner |
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7 |
Retinal Degeneration in Usher Syndrome .................................... |
137 |
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David S. Williams |
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8 |
Mouse Models of Retinitis Pigmentosa ....................................... |
149 |
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Bo Chang, Norman L. Hawes, Muriel T. Davisson, and |
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J.R. Heckenlively
III.MECHANISMS UNDERLYING RETINAL DEGENERATIONS
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The Impact of Diabetes on Neuronal, Glial, and Vascular Cells |
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of the Retina: Implications for the Pathogenesis |
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of Diabetic Retinopathy.............................................................. |
165 |
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Sylvia B. Smith |
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10 |
Statins and Age-Related Maculopathy ......................................... |
185 |
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Gerald McGwin, Jr. and Cynthia Owsley |
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The Role of Drusen in Macular Degeneration |
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and New Methods of Quantification ........................................ |
197 |
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R. Theodore Smith and Umer F. Ahmad |
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Contents |
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RPE Lipofuscin: Formation, Properites, |
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and Relevance to Retinal Degeneration .................................. |
213 |
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Janet R. Sparrow |
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13 |
Genetic Modifiers That Affect Phenotypic Expression |
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of Retinal Diseases ................................................................... |
237 |
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Malia M. Edwards, Dennis M. Maddox, Jungyeon Won, |
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Jürgen K. Naggert, and Patsy M. Nishina |
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14 |
X-Linked Retinal Dystrophies and Microtubular Functions |
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Within the Retina ...................................................................... |
257 |
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Alan F. Wright and Xinhua Shu |
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Synaptic Remodeling in Retinal Degeneration ............................ |
269 |
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You-Wei Peng and Fulton Wong |
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IV. DEVELOPING THERAPUTIC STRATEGIES |
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FOR RETINAL DEGENERATIVE DISEASES |
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On the Suppression of Phtoreceptor Cell Death |
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in Retinitis Pigmentosa ............................................................. |
293 |
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Fiona Kernan, Alex G. McKee, G. Jane Farrar, |
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and Peter Humphries |
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17 |
Cell-Based Therapies to Restrict the Progress |
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of Photoreceptor Degeneration ................................................ |
319 |
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Raymond D. Lund and Shaomei Wang |
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Current Status of IPE Transplantation |
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and its Potential as a Cell-Based Therapy |
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for Age-Related Macular Degeneration |
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and Retinal Dystrophies ........................................................... |
345 |
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Makoto Tamai |
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Recent Results in Retinal Transplantation Give Hope |
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for Restoring Vision ................................................................. |
365 |
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Robert B. Aramant, Norman D. Radtke, |
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and Magdalene J. Seiler |
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Stem Cells and Retinal Transplantation ....................................... |
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Joanne Yau, Henry Klassen, Tasneem Zahir, |
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and Michael Young |
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Application of Encapsulated Cell Technology |
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for Retinal Degenerative Diseases ........................................... |
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Weng Tao and Rong Wen |
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22 |
Effective Treatment for the Canine RPE65 Null Mutation, |
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a Hereditary Retinal Dystrophy Comparable |
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to Human Leber's Congenital Amaurosis ................................ |
415 |
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Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger |
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Contents |
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xiii |
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The Use of Neuroprotective Factors |
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in Retinal Degenerations .......................................................... |
433 |
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Joyce Tombran-Tink and Colin J. Barnstable |
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Carbonic Anhydrase Inhibitors as a Possible Therapy for RP17, |
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an Autosomal Dominant Retinitis Pigmentosa Associated |
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With the R14W Mutation, Apoptosis, |
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and the Unfolded Protein Response ......................................... |
455 |
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George Rebello, Jacuqie Greenberg, and Raj Ramesar |
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Macular Degeneration-An Addendum ......................................... |
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Joyce Tombran-Tink and Colin J. Barnstable |
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Index ........................................................................................................................... |
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CONTRIBUTORS
UMER F. AHMAD, MD • Edward S. Harkness Eye Institute, Columbia University, New York, NY
RANDO ALLIKMETS, PhD • Ophthalmology, Columbia University Eye Institute Research, New York, NY
ROBERT B. ARAMANT, PhD • Department of Anatomical Sciences and Neurobiology, University of Louisville, Ocular Transplantation LLC, Louisville, KY
COLIN J. BARNSTABLE, DPhil • Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT
JAMES K. CAPE • Republic of South Africa
BO CHANG, PhD • The Jackson Laboratory, Bar Harbor, ME GORDON F. COUSINS, MD • Republic of South Africa
MURIEL T. DAVISSON, PhD • The Jackson Laboratory, Bar Harbor, ME MALIA M. EDWARDS, PhD • The Jackson Laboratory, Bar Harbor, ME
G. JANE FARRAR, PhD • Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
JACQUIE GREENBERG, PhD • Division of Human Genetics, University of Cape Town, Cape Town, South Africa
NORMAN L. HAWES • The Jackson Laboratory, Bar Harbor, ME
J. R. HECKENLIVELY, MD • W. K. Kellogg Eye Center, The University of Michigan, Ann Arbor, MI
PETER HUMPHRIES, PhD • Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
ULRICH KELLNER, MD • Eye Centre Siegburg, Siegburg, Germany
FIONA KERNAN, PhD • Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
HENRY KLASSEN, MD, PhD • Children’s Hospital of Orange County, University of California, Irvine, Orange, CA
RONALD KLEIN, MD, MPH • Ophthalmology and Visual Science, University of Wisconsin-Madison, Madison, WI
ROBERT K. KOENEKOOP, MD, PhD • McGill Ocular Genetics Laboratory, Montreal Children’s Hospital, Montreal, Quebec, Canada
ALEJANDRO J. LAVAQUE, MD • New England Retina Research and Education, Spring Glen Medical Center, Hamden, CT
PETER E. LIGGETT, MD • New England Retina Research and Education, Spring Glen Medical Center, Hamden, CT
RAYMOND D. LUND, PhD • Casey Eye Institute, Oregon Health Sciences University, Portland, OR
DENNIS M. MADDOX, PhD • The Jackson Laboratory, Bar Harbor, ME
GERALD MCGWIN, JR., MS, PhD • Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL
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Contributors |
ALEX G. MCKEE, PhD • Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin, Republic of Ireland
PAUL MITCHELL, MD, PhD • Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead, N.S.W., Australia
JÜRGEN K. NAGGERT, PhD • The Jackson Laboratory, Bar Harbor, ME
KRISTINA NARFSTRÖM, DVM, PhD • University of Missouri-Columbia, Columbia, MO PATSY M. NISHINA, PhD • The Jackson Laboratory, Bar Harbor, ME
CYNTHIA OWSLEY, MSPH, PhD • Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL
YOU-WEI PENG, PhD • Department of Ophthalmology, Duke University Medical Center, Durham, NC
NORMAN D. RADTKE, MD • Retina Vitreous Resource Center, Norton Audubon Hospital, Department of Ophthalmology, University of Louisville, Louisville, KY
RAJKUMAR RAMESAR, PhD • Division of Human Genetics, University of Cape Town, Cape Town, Republic of South Africa
GEORGE REBELLO, PhD • Division of Human Genetics, University of Cape Town, Cape Town, Republic of South Africa
MATHIAS SEELIGER, MD, PhD • Department of Pathophysiology of Vision and Neuroophthalmology, University Eye Hospital, Tubingen, Germany
MAGDALENE J. SEILER, PhD • Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA
XINHUA SHU, PhD • MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
R. THEODORE SMITH, MD, PhD • Edward S. Harkness Eye Institute, Columbia University, New York, NY
SYLVIA B. SMITH, PhD • Medical College of Georgia, Department of Cellular Biology and Anatomy, Augusta, GA
JANET R. SPARROW, PhD • Department of Ophthalmology, Columbia University, New York, NY
MAKOTO TAMAI, MD, PhD • Department of Ophthalmology, Tohoku University, School of Medicine, Sendai, Japan
WENG TAO, MD, PhD • Neurotech USA, Lincoln, RI
JOYCE TOMBRAN-TINK, PhD • Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT
GREGORY E. TULLIS, PhD • Molecular Microbiology and Immunology, Life Sciences Center, University of Missouri-Columbia, Columbia, MO
JIE JIN WANG, MMED, PhD • Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead, N.S.W., Australia
SHAOMEI WANG, PhD • Casey Eye Institute, Oregon Health Sciences University, Portland, OR
BERNHARD H. F. WEBER, PhD • University of Regensburg, Institute of Human Genetics, Regensburg, Germany
RONG WEN, MD, PhD • Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA
Contributors |
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DAVID S. WILLIAMS, PhD • Departments of Pharmacology and Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA
JUNGYEON WON, PhD • The Jackson Laboratory, Bar Harbor, ME
FULTON WONG, PhD • Department of Ophthalmology, Duke University Medical Center, Durham, NC
ALAN F. WRIGHT, PhD • MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, UK
JOANNE YAU • The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA
MICHAEL J. YOUNG, PhD • The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA
TASNEEM ZAHIR, PhD • The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA
Companion CD ROM
All illustrations, both black and white and color, are contained on the accomapnying CD ROM.