- •Foreword
- •Preface
- •Contents
- •Contributors
- •Introduction
- •Noninfectious Retinal Manifestations
- •Cytomegalovirus Retinitis
- •Necrotizing Herpetic Retinitis (by Varicella Zoster)
- •Toxoplasmic Retinochoroiditis
- •Syphilitic Uveitis, Papillitis, and Retinitis
- •Candida Vitritis and Retinitis
- •Pneumocystis carinii Choroiditis
- •Cryptococcus neoformans Chorioretinitis
- •Mycobacterium Choroiditis
- •B-Cell Lymphoma
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Etiologic Agent
- •Toxocara canis
- •Ancylostoma caninum
- •Baylisascaris procyonis
- •Trematodes
- •Mode of Transmission
- •Diagnosis and Pathogenesis
- •Early Stage
- •Late Stage
- •Ancillary Tests
- •Serologic Test
- •Fluorescein Angiography
- •Visual Field Studies
- •Scanning Laser Ophthalmoscopy (SLO)
- •Optic Coherence Tomography (OCT)
- •GDx® Nerve Fiber Analyzer
- •Differential Diagnosis
- •Management
- •Laser Treatment
- •Oral Treatment
- •Pars Plana Vitrectomy (PPV)
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Epidemiology
- •Etiology and Pathogenesis
- •Systemic Manifestations
- •Clinical Intraocular Manifestations
- •Diagnosis
- •Treatment
- •Surgical Technique
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Pathogenesis and Life Cycle
- •Clinical Manifestations
- •Epidemiology
- •Diagnosis
- •Differential Diagnosis
- •Management
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Current Epidemiology
- •Eyelid Tuberculosis
- •Conjunctival Tuberculosis
- •Scleral Tuberculosis
- •Phlyctenulosis
- •Corneal Tuberculosis
- •Uveal Tuberculosis
- •Anterior Uveitis
- •Intermediate Uveitis
- •Posterior Uveitis (Choroidal Tuberculosis)
- •Orbital Tuberculosis
- •Retinal Tuberculosis
- •Retinal Vascular Disease
- •Tuberculous Panophthalmitis
- •Neuro-ophthalmological Aspects
- •Ocular Tuberculosis Associated with Mycobacterium bovis
- •Rare Presentations
- •Isolated Macular Edema
- •Isolated Ocular Tuberculosis
- •Intraocular Infection with Pigmented Hypopyon
- •Ocular Tuberculosis After Corticosteroid Therapy
- •Systemic Investigations
- •Ocular Investigations
- •Corticosteroid Therapy
- •Antitubercular Therapy
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Pathogenesis
- •Clinical Manifestations
- •Epidemiology
- •Diagnosis
- •Differential Diagnosis
- •Management
- •Pyrimethamine
- •Sulfonamides
- •Folinic Acid
- •Clindamycin
- •Azithromycin
- •Trimethoprim and Sulfamethoxazole
- •Spiramycin
- •Atovaquone
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Bartonellosis
- •Epidemiology
- •Microbiology
- •Clinical Findings in Cat Scratch Disease
- •Systemic Manifestations
- •Ocular Manifestations
- •Parinaud’s Oculoglandular Syndrome (POGS)
- •Retinal and Choroidal Manifestations and Complications
- •Neuroretinitis (Leber’s Neuroretinitis)
- •Multifocal Retinitis and Choroiditis
- •Vasculitis and Vascular Occlusion
- •Peripapillary Bacillary Angiomatosis
- •Uveitis
- •Diagnosis
- •Biopsy and Testing
- •Therapy
- •Controversies and Perspectives
- •Clinical Pearls
- •Lyme Disease
- •Diagnosis
- •Ocular Manifestations
- •Intermediate Uveitis
- •Retinal Vasculitis, Branch Retinal Artery, Retinal Vein Occlusion, and Cotton-Wool Spots
- •Neuroretinitis
- •Other Ocular Manifestations
- •Cystoid Macular Edema and Macular Pucker
- •Retinal Pigment Epithelial Detachment
- •Retinitis Pigmentosa-Like Retinopathy
- •Choroidal Neovascular Membrane
- •Acute Posterior Multifocal Placoid Pigment Epitheliopathy-Like Picture
- •Retinal Tear
- •Ciliochoroidal Detachment
- •Therapy
- •Controversies and Perspectives
- •Clinical Pearls
- •Syphilis
- •Ocular Manifestations
- •Retina and Choroid
- •Retinal Vasculature
- •Optic Disk
- •Association Between HIV and Syphilis
- •Clinical Importance of Ocular Syphilis
- •Therapy
- •Controversies and Perspectives
- •Clinical Pearls
- •References
- •Introduction
- •Acute Retinal Necrosis
- •Causative Virus
- •Epidemiology
- •Virological Diagnosis
- •Clinical Course
- •Treatment
- •Cytomegalovirus
- •Diagnosis
- •Staging and Progression
- •Laboratory Findings
- •Treatment
- •Pharmacologic
- •Surgical
- •Patient Follow-up
- •Epidemiology
- •Diagnosis
- •HIV Disease
- •HIV Therapy
- •Ocular Manifestations of HIV
- •Progressive Outer Retinal Necrosis
- •Diagnosis
- •Etiology
- •Therapy
- •Rubella
- •West Nile Virus
- •Other Systemic Illnesses
- •Controversies and Perspectives
- •What Is the Best Surgical Approach for Repair of Secondary Retinal Detachment?
- •Focal Points
- •References
- •Introduction
- •Causative Organisms
- •Candidiasis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Aspergillus Retinitis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Cryptococcal Chorioretinitis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Coccidioides immitis Chorioretinitis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Histoplasma Chorioretinitis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Sporothrix schenckii Chorioretinitis
- •Risk Factors
- •Pathogenesis
- •Clinical Features
- •Diagnosis
- •Treatment
- •Controversies and Perspectives
- •Focal Points
- •References
- •10: Endogenous Endophthalmitis
- •Introduction
- •Clinical Findings
- •Diagnosis
- •How to Culture
- •Polymerase Chain Reaction
- •Treatment
- •Systemic Antibiotics
- •Intravitreous Antibiotics
- •Corticosteroid Therapy
- •Vitrectomy
- •Prognosis
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Etiology
- •Genetic Features
- •Immunopathogenesis
- •Diagnosis
- •Posterior Segment Findings
- •Management
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Epidemiology
- •Prevalence and Incidence
- •Age of Onset
- •The Gender Factor
- •Etiopathogenesis
- •Clinical Features and Diagnosis
- •Ocular Involvement
- •Posterior Segment Involvement
- •Fluorescein Angiography
- •Indocyanine Green Angiography
- •Optical Coherence Tomography
- •Other Ocular Manifestations
- •Complications
- •Histopathology
- •Prognosis of Ocular Disease
- •Juvenile Behçet’s Disease
- •Pregnancy and Behçet’s Disease
- •Differential Diagnosis
- •Management of Ocular Disease
- •Medical Treatment
- •Colchicine
- •Corticosteroids
- •Intravitreal Triamcinolone
- •Cyclosporin A and Tacrolimus (FK506)
- •Anti-tumor Necrosis Factor Treatment
- •Cytotoxic and Other Immunosuppressive Agents
- •Tolerization Therapy
- •Laser Treatment
- •Plasmapheresis
- •Cataract Surgery
- •Trabeculectomy
- •Vitrectomy
- •Controversies and Perspectives
- •Pearls
- •References
- •13: Intraocular Lymphoma
- •Introduction
- •Historical Background
- •Epidemiology
- •Etiology
- •Imaging
- •Diagnosis and Pathology
- •Treatment
- •Controversies and Perspectives
- •Focal Points
- •Acknowledgments
- •References
- •14: Choroidal and Retinal Metastasis
- •Introduction
- •Primary Cancer Sites Leading to Intraocular Metastasis
- •Intraocular Metastasis Onset
- •Choroidal Metastases
- •Ciliary Body Metastases
- •Iris Metastases
- •Retinal Metastases
- •Optic Disk Metastases
- •Vitreous Metastases
- •Ocular Paraneoplastic Syndromes
- •Diagnostic Evaluation for Ocular Metastasis
- •Systemic Evaluation
- •Fluorescein Angiography
- •Indocyanine Green Angiography
- •Ultrasonography
- •Optical Coherence Tomography
- •Computed Tomography
- •Magnetic Resonance Imaging
- •Fine-Needle Aspiration Biopsy
- •Surgical Biopsy
- •Pathology of Ocular Metastasis
- •Observation
- •Radiotherapy
- •Surgical Excision, Enucleation
- •Patient Prognosis
- •Controversies and Perspective
- •Pearls
- •References
- •Introduction
- •CAR Cases
- •CAR Case 1: CAR Secondary to Esthesioneuroblastoma (Olfactory Neuroblastoma)
- •CAR Case 2: CAR Associated with Metastatic Breast Cancer
- •CAR Case 3: Paraneoplastic Optic Neuritis and Retinitis Associated with Small Cell Lung Cancer
- •Paraneoplastic Retinopathy: Melanoma-Associated Retinopathy (MAR)
- •MAR Case
- •Pearls
- •References
- •Introduction
- •Epidemiology
- •Pathophysiology
- •Clinical Presentation
- •Ulcerative Colitis
- •Crohn’s Disease
- •Ocular Manifestations
- •Posterior Segment Lesions
- •Treatment of Ocular Manifestations
- •Whipple’s Disease
- •Diagnosis
- •Extraintestinal Manifestations
- •Central Nervous System
- •Others
- •Treatment
- •Avitaminosis A
- •Pancreatitis
- •Familial Adenomatous Polyposis
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Demographics
- •Genetics
- •Fundus Manifestations
- •Management
- •Demographics
- •Genetics
- •Ophthalmologic Features
- •Fundus Manifestations
- •Management
- •Demographics
- •Genetics
- •Fundus Manifestations
- •Management
- •Genetics
- •Ophthalmologic Features
- •Fundus Manifestations
- •Management
- •Genetics
- •Fundus Manifestations
- •Management
- •Genetics
- •Fundus Manifestations
- •Controversies and Perspectives
- •References
- •Pathogenesis and Laboratory Findings
- •Innate Immune System Activation
- •Increased Availability of Self-antigen and Apoptosis
- •Adaptive Immune Response
- •Damage to Target Organs
- •General Clinical Findings
- •Ocular Symptoms
- •Posterior Ocular Manifestations
- •Mild Retinopathy
- •Vaso-occlusive Retinopathy
- •Lupus Choroidopathy
- •Anterior Visual Pathway
- •Posterior Visual Pathway
- •Oculomotor System
- •Anterior Ocular Manifestations
- •Drug-Related Ocular Manifestations
- •General Management
- •Controversies and Perspectives
- •Focal Points
- •References
- •19: Vogt–Koyanagi–Harada Disease
- •Introduction
- •History
- •Epidemiology
- •Immunopathogenesis
- •Histopathology
- •Immunogenetics
- •Clinical Features
- •Extraocular Manifestations
- •Ancillary Test
- •Fluorescein Angiography (FA)
- •Indocyanine Green Angiography (ICGA)
- •Cerebrospinal Fluid Analysis (CSF)
- •Ultrasonography (USG)
- •Ultrasound Biomicroscopy (UBM)
- •Magnetic Resonance Image (MRI)
- •Electrophysiology
- •Differential Diagnosis
- •Sympathetic Ophthalmia
- •Primary Intraocular B-Cell Lymphoma
- •Posterior Scleritis
- •Uveal Effusion Syndrome
- •Sarcoidosis
- •Lyme Disease
- •Treatment
- •Complications
- •Prognosis
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •General
- •Genetics
- •Pathogenesis
- •Ocular Pathology
- •Lens
- •Retina
- •Lens Subluxation
- •Clinical Findings
- •Pathogenesis
- •Differential Diagnosis
- •Treatment
- •Retinal Detachment
- •Clinical Findings
- •Pathogenesis
- •Therapy
- •Controversies and Perspectives
- •Focal Points
- •References
- •21: Diabetic Retinopathy
- •Introduction
- •Pathogenesis
- •Risk Factors
- •Duration of Disease
- •Glucose Control
- •Blood Pressure Control
- •Lipid Control
- •Other Factors
- •Proliferative Diabetic Retinopathy
- •Advanced Eye Disease
- •Diabetic Macular Edema
- •Management
- •Glycemic Control
- •Blood Pressure Control
- •Serum Lipid Control
- •Aspirin Treatment
- •Laser Photocoagulation
- •Vitrectomy
- •Pharmacotherapy
- •Corticosteroids
- •Triamcinolone Acetonide
- •Fluocinolone Acetonide
- •Extended-Release Dexamethasone
- •Pegaptanib
- •Ranibizumab
- •Bevacizumab
- •Controversies and Perspectives
- •Focal Points
- •References
- •Introduction
- •Hypertensive Retinopathy
- •Hypertensive Choroidopathy
- •Indirect Effects
- •Controversies and Perspectives
- •Summary
- •Focal Points
- •References
- •Introduction
- •Anemia
- •Aplastic Anemia
- •Hemoglobinopathies
- •Sickle Cell Disease
- •Thalassemia
- •Deferoxamine Toxicity
- •Autoimmune Hemolytic Anemia
- •Antiphospholipid Antibody Syndrome
- •Hemophilia and Platelet Disorders
- •Myelodysplastic Disorders
- •Myeloproliferative Disorders
- •Chronic Myelogenous Leukemia
- •Polycythemia Vera
- •Essential Thrombocythemia
- •Leukemias
- •Acute Myeloid Leukemia
- •Lymphoid
- •Lymphomas
- •B Cell Lymphoma
- •Hodgkin’s Lymphoma
- •Plasma Cell Disorders
- •Plasmacytoma/Multiple Myeloma
- •Plasma Cell Leukemia
- •T Cell Lymphomas
- •Controversies/Perspectives
- •Roth Spots
- •Anti-VEGF Therapy
- •Focal Points
- •Anemia
- •Hemoglobinopathies
- •Myelodysplastic Syndrome
- •Myeloproliferative Neoplasms
- •Leukemia
- •Lymphoma
- •References
- •24: The Ocular Ischemic Syndrome
- •Introduction
- •Demography
- •Etiology
- •Symptoms
- •Loss of Vision
- •Amaurosis Fugax
- •Pain
- •Visual Acuity
- •Signs
- •External
- •Anterior Segment Changes
- •Posterior Segment Findings
- •Diagnostic Studies
- •Fluorescein Angiography
- •Electroretinography
- •Carotid Artery Imaging
- •Others
- •Systemic Associations
- •Differential Diagnosis
- •Treatment
- •Systemic Therapy: Carotid Artery
- •Ophthalmic Therapy
- •Controversies and Perspectives
- •Focal Points
- •References
- •25: Ocular Manifestations of Pregnancy
- •Introduction
- •Physiologic Changes
- •Intraocular Pressure
- •Cornea
- •Pathologic Conditions
- •Pregnancy-Induced Hypertension
- •Clinical Features
- •Ocular Manifestations
- •HELLP Syndrome
- •Management of PIH
- •Prognosis
- •Central Serous Retinopathy
- •Occlusive Vascular Disorders
- •Purtscher’s-Like Retinopathy
- •Disseminated Intravascular Coagulation (DIC)
- •Thrombotic Thrombocytopenic Purpura (TTP)
- •Amniotic Fluid Embolism
- •Preexisting Conditions
- •Diabetic Retinopathy
- •Progression
- •Factors Associated with Progression
- •Pathophysiology of Progression
- •Treatment Criteria for Diabetic Retinopathy
- •Follow-up Guidelines
- •Intraocular Tumors
- •Uveal Melanoma
- •Choroidal Osteoma
- •Choroidal Hemangioma
- •Ocular Medications
- •Topical Drops
- •Diagnostic Agents
- •Summary
- •Focal Points
- •References
- •Introduction
- •Toxicity with Diffuse Retinal Changes
- •Toxicity with Pigmentary Degeneration
- •Quinolines
- •Phenothiazines
- •Deferoxamine
- •Toxicity with Crystalline Deposits
- •Tamoxifen
- •Canthaxanthine
- •Toxicity Without Fundus Changes
- •Cardiac Glycosides
- •Phosphodiesterase Inhibitors
- •Toxicity with Retinal Edema
- •Methanol
- •Toxicity with Retinal Vascular Changes
- •Talc
- •Oral Contraceptives
- •Interferon
- •Toxicity with Maculopathy
- •Niacin
- •Sympathomimetics
- •Toxicity with Retinal Folds
- •Sulfanilamide-Like Medications
- •Summary
- •Focal Points
- •References
- •Introduction
- •Diabetes
- •Vascular Disease
- •Hypertensive Retinopathy
- •Hypertensive Optic Neuropathy
- •Thrombotic Microangiopathy
- •Dysregulation of the Alternative Complement Pathway with Renal and Ocular Fundus Changes
- •Papillorenal Syndrome
- •Ciliopathies
- •Senior-Loken Syndrome and Related Syndromes with Nephronophthisis
- •Other Rare Metabolic Diseases
- •Congenital Disorders of Glycosylation (CDG)
- •Cystinosis
- •Fabry Disease
- •Peroxisomal Diseases: Refsum Disease
- •Neoplastic Diseases with Kidney and Ocular Involvement
- •von Hippel-Lindau Disease
- •Light Chain Deposition Disease
- •Controversies and Perspectives
- •Focal Points
- •References
- •Index
Contributors
Eric S. Ahn, M.D. Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA
J. Fernando Arévalo, M.D., F.A.C.S. Chief of Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of
Saudi Arabia
Professor of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA
Leyla S. Atmaca, M.D. Professor of Ophthalmology, Ankara University, Ankara, Turkey
Pelin Atmaca-Sonmez, M.D. Nurlu Eye Center, Ankara, Turkey
Alay S. Banker, M.D. Director, Retina, Vitreous and Uvea Department, Banker’s Retina Clinic and Laser Centre, Ahmedabad, Gujarat, India
Rubens Belfort Jr., M.D., Ph.D. Head Professor of Ophthalmology, Department of Ophthalmology, Hospital São Paulo, Universidad Federal de São Paulo, São Paulo, Brazil
Sergio Bonafonte-Royo, M.D. Director, Department of Ophthalmology, Centro de Oftalmología Bonafonte, Barcelona, Spain
Gary C. Brown, M.D., M.B.A. Professor of Ophthalmology, Director of the Retina Service, Jefferson Medical College, Wills Eye Hospital, Philadelphia, PA, USA
Melissa M. Brown, M.D., M.N., M.B.A. Professor of Ophthalmology, Research Department, Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USA
CEO, Center for Value-Based Medicine®, Flourtown, PA, USA
Alexander J. Brucker, M.D. Professor of Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Mariana Cabrera, M.D. Resident, Research Staff, Fundacion Oftalmologica Nacional, Bogotá, DC, Colombia
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Contributors |
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Roomasa Channa, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Rohan Chauhan, D.O.` Doctor, Retina, Vitreous and Uvea Department, Banker’s Retina Clinic and Laser Centre, Navrangpura, Ahmedabad, Gujarat, India
Luz Elena Concha-del-Río, M.D. Inflammatory Eye Disease Clinic, Hospital “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la Ceguera en Mexico, Mexico, D.F., Mexico
Emmett T. Cunningham Jr., M.D., Ph.D., M.P.H. The Uveitis Service,
Department of Ophthalmology, California Pacific Medical Center,
San Francisco, CA, USA
Janet L. Davis, M.D., M.A. Professor of Ophthalmology, Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, Miami, FL, USA
Carlos Alexandre de Amorim Garcia, M.D., Ph.D. Chairman, Associate Professor, Department of Ophthalmology, Federal University of Rio Grande de Norte, Tirol, Natal, Rio Grande do Norte, Brazil
Maria de Lourdes Arellanes-García, M.D. Inflammatory Eye Disease
Clinic, Hospital “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la
Ceguera en Mexico, Mexico, D.F., Mexico
Maria del Carmen Preciado-Delgadillo, M.D., Ph.D. Inflammatory Eye Disease Clinic, “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la Ceguera en México, México, D.F., Mexico
Diana V. Do, M.D. Associate Professor of Ophthalmology, Assistant Head of Retinal Fellowship Training Program, Diseases of the Retina and Vitreous, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Emilio Dodds, M.D. Hospital Juan A. Fernandez and Consultores Oftalmologicos, Buenos Aires, Argentina
Juan V. Espinoza, M.D. Department of Vitreous and Retina, Clinica Oftalmológica de Antioquia, Medellin, Antioquia, Colombia
Carlos F. Fernandez, M.D. Chief, Clinica Oftalmologica Oftalmolaser, Retina and Vitreous Service, Lima, Peru
Valentina Franco-Cardenas, M.D. Asociación para Evitar la Ceguera en México, Hospital “Dr. Luis Sánchez Bulnes”, Coyoacan, México, México
International Fellow Retina and Surgical Research, Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
William R. Freeman, M.D. Director UCSD Jacobs Retina Center, Department of Ophthalmology, University of California, San Diego, Shiley Eye Center, La Jolla, CA, USA
Contributors |
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Rafael A. Garcia, |
M.D. Retina and Vitreous Department, Centro |
Oftalmologico de Cordoba, Monteria, CO, Colombia
Reinaldo A. Garcia, M.D. Retina and Vitreous Department, Clínica Oftalmológica El Viñedo, Valencia, Carabobo, Venezuela
Elham Hatef, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Erick Hernandez-Bogantes, M.D. Retina Service, Instituto de Cirugia Ocular, San Jose, Costa Rica
Mohamed Ibrahim, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Afsheen A. Khwaja, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Derek Kuhl, M.D. The Retina Center, Bryan, TX, USA
Andre Luiz Land Curi, M.D., Ph.D. Researcher in Ophthalmology – Infectious Uveitis, Instituto de Pesquisa Clínica Evandro Chagas – IPEC, Fundação Oswaldo Cruz – Fiocruz, Centro Hospitalar, Rio de Janeiro, Brazil
Andres F. Lasave, M.D. Ophthalmologist, Retina and Vitreous Service, Clinica Oftalmológica Centro Caracas, San Bernardino, Caracas, DF, Venezuela
Anita M. Leys, M.D., Ph.D. Professor, Department of Ophthalmology, Medical Retina, University Hospital Leuven, Leuven, Belgium
Anat Loewenstein, M.D., M.H.A. Director, Vice Dean, Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Nikolas J.S. London, M.D. Retina Service Department, Wills Eye Institute, Philadelphia, PA, USA
Naresh Mandava, M.D. Professor and Chair of Ophthalmology, Department of Ophthalmology, University of Colorado Denver, Aurora, CO, USA
Salil Mehta, M.S., D.N.B. Department of Ophthalmology, Lilavati Hospital and Research Center, Bandra, Mumbai, Maharashtra, India
William F. Mieler, M.D. Professor and Vice-Chairman, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA
John J. Miller, M.D. Georgia Retina, Atlanta, GA, USA
Cristina Muccioli, M.D., Ph.D. Professor of Ophthalmology, Department of Ophthalmology, São Paulo Hospital – Universidad Federal de São Paulo, São Paulo, Brazil
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Contributors |
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Quan Dong Nguyen, M.D. Associate Professor of Ophthalmology, Diseases of the Retina and Vitreous, and Uveitis, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Fernando Orefice Professor Titular de Oftalmologia da UFMG, Diretor da Divisão de Uveites do Centro Brasileiro de Ciências Visuais, Department of Oftalmologia, Hospital São Geraldo, HC/UFMG, Belo Horizonte, Minas Gerais, Brazil
Graciela Prado, M.D. Department of Ophthalmology, Hospital México, San Jose, Costa Rica
Hugo Quiroz-Mercado, M.D. Department of Ophthalmology, Denver Health Medical Center, Professor of Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado, Denver, CO, USA
Narsing A. Rao, M.D. Professor, Department of Ophthalmology, Doheny Eye Institute, Los Angeles, CA, USA
Claudia Recillas-Gipsert, M.D. Departamento de Oftalmología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico, Distrito Federal, Mexico
Breno da Rocha Lima, M.D. Department of Ophthalmology, Cleveland Clinic, Cole Eye Institute, Cleveland, OH, USA
Francisco J. Rodriguez, M.D. Assistant Professor of Ophthalmology, Facultad de Medicina, Retina and Vitreous Department, Universidad del Rosario, Fundación Oftalmológica Nacional, Bogotá, DC, Colombia
Andrew P. Schachat, M.D. Vice Chairman for Clinical Affairs, Department of Ophthalmology, Cleveland Clinic – Cole Eye Institute, Cleveland, OH, USA
Susan Schneider, M.D. Bausch & Lomb, Rochester, NY, USA
Stephen G. Schwartz, M.D., M.B.A. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA
Nathaniel C. Sears, B.S. Chemistry. Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA
Yasir J. Sepah, M.B.B.S. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Sanjay Sharma, M.D., M.Sc. (epid.), M.B.A. Professor of Ophthalmology and Epidemiology, Queens Medical College, Kingston, ON, Canada
Bhavna P. Sheth, M.D. The Eye Institute, Medical College of Wisconsin, Milwaukee, WI, USA
Contributors |
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Carol L. Shields, M.D. Co-Director, Oncology Service, Professor of Ophthalmology, Wills Eye Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Jerry A. Shields, M.D. Director, Oncology Service, Professor of Ophthalmology, Wills Eye Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Matthew Shulman, B.A. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Leigh H. Spielberg, M.D. Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, BH, The Netherlands
Luis Suarez Tata, M.D. Vitreoretinal Service, Clínica Oftalmológica El Viñedo, Valencia, Carabobo, Venezuela
Ahmad Bakir Tarabishy, M.D. Resident, Cleveland Clinic – Cole Eye Institute, Cleveland, OH, USA
Peykan Turkcuoglu, M.D. Assistant Professor, Department of Ophthalmology, Inonu University School of Medicine, Malatya, Turkey
Lihteh Wu, M.D. Associate Surgeon Retina Service, Instituto de Cirugía Ocular, San José, Costa Rica
Shalini Yalamanchi M.D. Uveitis Fellow, Uveitis and Intraocular Inflammation Service, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Lawrence A. Yannuzzi, M.D. The Vitreous, Retina, Macula Consultants of New York, The LuEsther T. Mertz Retina Research Center, Manhattan, Eye, Ear, and Throat Hospital, New York, NY, USA
Careen Yen Lowder, M.D., Ph.D. Full Professional Staffl, Cleveland Clinic, Cole Eye Institute, Cleveland, OH, USA
David G. Zeballos, M.D. Ophthalmologist, Department of Ophthalmology, Clínica Kennedy Alborada, Guayaquil, Guayas, Ecuador
Dinah Zur, M.D. Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel
Retinal and Choroidal |
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Manifestations of HIV/AIDS |
J. Fernando Arévalo, Rafael A. García,
Nikolas J.S. London, Emmett T. Cunningham Jr.,
Rubens Belfort Jr., and William R. Freeman
Abstract
The human immunodeficiency virus (HIV) pandemic has continued despite the advent of new antiviral therapies; this is responsible for an increase in the number of patients with this entity and its survival. The majority of ocular manifestations of HIV infection involve the posterior segment of the eye. Prior to the introduction of highly active antiretroviral therapy (HAART), retinal microvasculopathy and cytomegalovirus (CMV) retinitis accounted for more than 80% of the ocular complications in HIV-positive patients. To date, HIV disease and CMV retinitis have become chronic diseases. Many challenges remain to be addressed. HAART has indeed decreased the incidence of some ophthalmic problems, such as CMV retinitis, and it has brought with it new challenges, such as immune recovery uveitis (IRU). Ocular disorders associated with HIV disease remain important problems in the world, despite HAART, and increasingly are more significant and frequent. The approach to diagnosis and management of different pathological presentations at the posterior pole is very important.
J.F. Arévalo, M.D., F.A.C.S. ( )
Chief of Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
Professor of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA e-mail: arevalojf@jhmi.edu
R.A. García, M.D.
Retina and Vitreous Department, Clínica Oftalmológica El Viñedo, Av. Andres Eloy Blanco con calle
139. El Viñedo, Valencia, Carabobo 2001, Venezuela e-mail: rafagarcia77@yahoo.com
N.J.S. London, M.D.
Retina Service Department, Wills Eye Institute,
1840 Walnut St. Suite 1020, Philadelphia, PA 19102, USA e-mail: nik.london@gmail.com
E.T. Cunningham Jr., M.D., Ph.D., M.P.H.
The Uveitis Service, Department of Ophthalmology,
California Pacific Medical Center, San Francisco,
CA, USA
e-mail: Emmett_cunningham@yahoo.com
R. Belfort Jr., M.D., Ph.D.
Department of Ophthalmology, Hospital São Paulo, Universidad Federal de São Paulo, Rua Botocatu, 821, São Paulo, São Paulo 04023-062, Brazil
e-mail: prof.belfort@clinicabelfort.com.br
W.R. Freeman, M.D.
Department of Ophthalmology, University of California, San Diego, Shiley Eye Center, 9415 Campus Point Drive, La Jolla, CA 92037, USA
e-mail: freeman@eyecenter.ucsd.edu
J.F. Arévalo (ed.), Retinal and Choroidal Manifestations of Selected Systemic Diseases, |
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DOI 10.1007/978-1-4614-3646-1_1, © Springer Science+Business Media New York 2013 |
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