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Contributors

Eric S. Ahn, M.D. Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

J. Fernando Arévalo, M.D., F.A.C.S. Chief of Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of

Saudi Arabia

Professor of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA

Leyla S. Atmaca, M.D. Professor of Ophthalmology, Ankara University, Ankara, Turkey

Pelin Atmaca-Sonmez, M.D. Nurlu Eye Center, Ankara, Turkey

Alay S. Banker, M.D. Director, Retina, Vitreous and Uvea Department, Banker’s Retina Clinic and Laser Centre, Ahmedabad, Gujarat, India

Rubens Belfort Jr., M.D., Ph.D. Head Professor of Ophthalmology, Department of Ophthalmology, Hospital São Paulo, Universidad Federal de São Paulo, São Paulo, Brazil

Sergio Bonafonte-Royo, M.D. Director, Department of Ophthalmology, Centro de Oftalmología Bonafonte, Barcelona, Spain

Gary C. Brown, M.D., M.B.A. Professor of Ophthalmology, Director of the Retina Service, Jefferson Medical College, Wills Eye Hospital, Philadelphia, PA, USA

Melissa M. Brown, M.D., M.N., M.B.A. Professor of Ophthalmology, Research Department, Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USA

CEO, Center for Value-Based Medicine®, Flourtown, PA, USA

Alexander J. Brucker, M.D. Professor of Ophthalmology, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Mariana Cabrera, M.D. Resident, Research Staff, Fundacion Oftalmologica Nacional, Bogotá, DC, Colombia

xiii

xiv

Contributors

 

 

Roomasa Channa, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Rohan Chauhan, D.O.` Doctor, Retina, Vitreous and Uvea Department, Banker’s Retina Clinic and Laser Centre, Navrangpura, Ahmedabad, Gujarat, India

Luz Elena Concha-del-Río, M.D. Inflammatory Eye Disease Clinic, Hospital “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la Ceguera en Mexico, Mexico, D.F., Mexico

Emmett T. Cunningham Jr., M.D., Ph.D., M.P.H. The Uveitis Service,

Department of Ophthalmology, California Pacific Medical Center,

San Francisco, CA, USA

Janet L. Davis, M.D., M.A. Professor of Ophthalmology, Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, Miami, FL, USA

Carlos Alexandre de Amorim Garcia, M.D., Ph.D. Chairman, Associate Professor, Department of Ophthalmology, Federal University of Rio Grande de Norte, Tirol, Natal, Rio Grande do Norte, Brazil

Maria de Lourdes Arellanes-García, M.D. Inflammatory Eye Disease

Clinic, Hospital “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la

Ceguera en Mexico, Mexico, D.F., Mexico

Maria del Carmen Preciado-Delgadillo, M.D., Ph.D. Inflammatory Eye Disease Clinic, “Dr. Luis Sánchez Bulnes”, Asociación para Evitar la Ceguera en México, México, D.F., Mexico

Diana V. Do, M.D. Associate Professor of Ophthalmology, Assistant Head of Retinal Fellowship Training Program, Diseases of the Retina and Vitreous, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Emilio Dodds, M.D. Hospital Juan A. Fernandez and Consultores Oftalmologicos, Buenos Aires, Argentina

Juan V. Espinoza, M.D. Department of Vitreous and Retina, Clinica Oftalmológica de Antioquia, Medellin, Antioquia, Colombia

Carlos F. Fernandez, M.D. Chief, Clinica Oftalmologica Oftalmolaser, Retina and Vitreous Service, Lima, Peru

Valentina Franco-Cardenas, M.D. Asociación para Evitar la Ceguera en México, Hospital “Dr. Luis Sánchez Bulnes”, Coyoacan, México, México

International Fellow Retina and Surgical Research, Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA

William R. Freeman, M.D. Director UCSD Jacobs Retina Center, Department of Ophthalmology, University of California, San Diego, Shiley Eye Center, La Jolla, CA, USA

Contributors

xv

 

 

Rafael A. Garcia,

M.D. Retina and Vitreous Department, Centro

Oftalmologico de Cordoba, Monteria, CO, Colombia

Reinaldo A. Garcia, M.D. Retina and Vitreous Department, Clínica Oftalmológica El Viñedo, Valencia, Carabobo, Venezuela

Elham Hatef, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Erick Hernandez-Bogantes, M.D. Retina Service, Instituto de Cirugia Ocular, San Jose, Costa Rica

Mohamed Ibrahim, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Afsheen A. Khwaja, M.D. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Derek Kuhl, M.D. The Retina Center, Bryan, TX, USA

Andre Luiz Land Curi, M.D., Ph.D. Researcher in Ophthalmology – Infectious Uveitis, Instituto de Pesquisa Clínica Evandro Chagas – IPEC, Fundação Oswaldo Cruz – Fiocruz, Centro Hospitalar, Rio de Janeiro, Brazil

Andres F. Lasave, M.D. Ophthalmologist, Retina and Vitreous Service, Clinica Oftalmológica Centro Caracas, San Bernardino, Caracas, DF, Venezuela

Anita M. Leys, M.D., Ph.D. Professor, Department of Ophthalmology, Medical Retina, University Hospital Leuven, Leuven, Belgium

Anat Loewenstein, M.D., M.H.A. Director, Vice Dean, Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Nikolas J.S. London, M.D. Retina Service Department, Wills Eye Institute, Philadelphia, PA, USA

Naresh Mandava, M.D. Professor and Chair of Ophthalmology, Department of Ophthalmology, University of Colorado Denver, Aurora, CO, USA

Salil Mehta, M.S., D.N.B. Department of Ophthalmology, Lilavati Hospital and Research Center, Bandra, Mumbai, Maharashtra, India

William F. Mieler, M.D. Professor and Vice-Chairman, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA

John J. Miller, M.D. Georgia Retina, Atlanta, GA, USA

Cristina Muccioli, M.D., Ph.D. Professor of Ophthalmology, Department of Ophthalmology, São Paulo Hospital – Universidad Federal de São Paulo, São Paulo, Brazil

xvi

Contributors

 

 

Quan Dong Nguyen, M.D. Associate Professor of Ophthalmology, Diseases of the Retina and Vitreous, and Uveitis, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Fernando Orefice Professor Titular de Oftalmologia da UFMG, Diretor da Divisão de Uveites do Centro Brasileiro de Ciências Visuais, Department of Oftalmologia, Hospital São Geraldo, HC/UFMG, Belo Horizonte, Minas Gerais, Brazil

Graciela Prado, M.D. Department of Ophthalmology, Hospital México, San Jose, Costa Rica

Hugo Quiroz-Mercado, M.D. Department of Ophthalmology, Denver Health Medical Center, Professor of Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado, Denver, CO, USA

Narsing A. Rao, M.D. Professor, Department of Ophthalmology, Doheny Eye Institute, Los Angeles, CA, USA

Claudia Recillas-Gipsert, M.D. Departamento de Oftalmología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico, Distrito Federal, Mexico

Breno da Rocha Lima, M.D. Department of Ophthalmology, Cleveland Clinic, Cole Eye Institute, Cleveland, OH, USA

Francisco J. Rodriguez, M.D. Assistant Professor of Ophthalmology, Facultad de Medicina, Retina and Vitreous Department, Universidad del Rosario, Fundación Oftalmológica Nacional, Bogotá, DC, Colombia

Andrew P. Schachat, M.D. Vice Chairman for Clinical Affairs, Department of Ophthalmology, Cleveland Clinic – Cole Eye Institute, Cleveland, OH, USA

Susan Schneider, M.D. Bausch & Lomb, Rochester, NY, USA

Stephen G. Schwartz, M.D., M.B.A. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA

Nathaniel C. Sears, B.S. Chemistry. Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA

Yasir J. Sepah, M.B.B.S. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Sanjay Sharma, M.D., M.Sc. (epid.), M.B.A. Professor of Ophthalmology and Epidemiology, Queens Medical College, Kingston, ON, Canada

Bhavna P. Sheth, M.D. The Eye Institute, Medical College of Wisconsin, Milwaukee, WI, USA

Contributors

xvii

 

 

Carol L. Shields, M.D. Co-Director, Oncology Service, Professor of Ophthalmology, Wills Eye Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA

Jerry A. Shields, M.D. Director, Oncology Service, Professor of Ophthalmology, Wills Eye Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA

Matthew Shulman, B.A. Retinal Imaging Research and Reading Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Leigh H. Spielberg, M.D. Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, BH, The Netherlands

Luis Suarez Tata, M.D. Vitreoretinal Service, Clínica Oftalmológica El Viñedo, Valencia, Carabobo, Venezuela

Ahmad Bakir Tarabishy, M.D. Resident, Cleveland Clinic – Cole Eye Institute, Cleveland, OH, USA

Peykan Turkcuoglu, M.D. Assistant Professor, Department of Ophthalmology, Inonu University School of Medicine, Malatya, Turkey

Lihteh Wu, M.D. Associate Surgeon Retina Service, Instituto de Cirugía Ocular, San José, Costa Rica

Shalini Yalamanchi M.D. Uveitis Fellow, Uveitis and Intraocular Inflammation Service, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA

Lawrence A. Yannuzzi, M.D. The Vitreous, Retina, Macula Consultants of New York, The LuEsther T. Mertz Retina Research Center, Manhattan, Eye, Ear, and Throat Hospital, New York, NY, USA

Careen Yen Lowder, M.D., Ph.D. Full Professional Staffl, Cleveland Clinic, Cole Eye Institute, Cleveland, OH, USA

David G. Zeballos, M.D. Ophthalmologist, Department of Ophthalmology, Clínica Kennedy Alborada, Guayaquil, Guayas, Ecuador

Dinah Zur, M.D. Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel

Retinal and Choroidal

1

Manifestations of HIV/AIDS

J. Fernando Arévalo, Rafael A. García,

Nikolas J.S. London, Emmett T. Cunningham Jr.,

Rubens Belfort Jr., and William R. Freeman

Abstract

The human immunodeficiency virus (HIV) pandemic has continued despite the advent of new antiviral therapies; this is responsible for an increase in the number of patients with this entity and its survival. The majority of ocular manifestations of HIV infection involve the posterior segment of the eye. Prior to the introduction of highly active antiretroviral therapy (HAART), retinal microvasculopathy and cytomegalovirus (CMV) retinitis accounted for more than 80% of the ocular complications in HIV-positive patients. To date, HIV disease and CMV retinitis have become chronic diseases. Many challenges remain to be addressed. HAART has indeed decreased the incidence of some ophthalmic problems, such as CMV retinitis, and it has brought with it new challenges, such as immune recovery uveitis (IRU). Ocular disorders associated with HIV disease remain important problems in the world, despite HAART, and increasingly are more significant and frequent. The approach to diagnosis and management of different pathological presentations at the posterior pole is very important.

J.F. Arévalo, M.D., F.A.C.S. ( )

Chief of Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

Professor of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA e-mail: arevalojf@jhmi.edu

R.A. García, M.D.

Retina and Vitreous Department, Clínica Oftalmológica El Viñedo, Av. Andres Eloy Blanco con calle

139. El Viñedo, Valencia, Carabobo 2001, Venezuela e-mail: rafagarcia77@yahoo.com

N.J.S. London, M.D.

Retina Service Department, Wills Eye Institute,

1840 Walnut St. Suite 1020, Philadelphia, PA 19102, USA e-mail: nik.london@gmail.com

E.T. Cunningham Jr., M.D., Ph.D., M.P.H.

The Uveitis Service, Department of Ophthalmology,

California Pacific Medical Center, San Francisco,

CA, USA

e-mail: Emmett_cunningham@yahoo.com

R. Belfort Jr., M.D., Ph.D.

Department of Ophthalmology, Hospital São Paulo, Universidad Federal de São Paulo, Rua Botocatu, 821, São Paulo, São Paulo 04023-062, Brazil

e-mail: prof.belfort@clinicabelfort.com.br

W.R. Freeman, M.D.

Department of Ophthalmology, University of California, San Diego, Shiley Eye Center, 9415 Campus Point Drive, La Jolla, CA 92037, USA

e-mail: freeman@eyecenter.ucsd.edu

J.F. Arévalo (ed.), Retinal and Choroidal Manifestations of Selected Systemic Diseases,

1

DOI 10.1007/978-1-4614-3646-1_1, © Springer Science+Business Media New York 2013