Ординатура / Офтальмология / Английские материалы / Retinal and Choroidal Angiogenesis_Penn_2008

552

Aqueous humor, 105, 194, 311, 317, 319, 480

Astrocytes, 3, 4, 9, 14, 26, 60, 120, 130–132, 134, 232, 234, 250

Basement membrane, 4, 12, 14, 16, 50, 67, 69, 72, 83, 85, 86, 88, 90, 91, 144, 187, 188, 191, 193, 194, 196, 246, 259, 260, 299, 372, 447, 462, 468, 473

Blindness, 2, 41, 57, 58, 81, 103, 139, 151, 163, 187, 214, 235, 246, 364, 412, 414, 446, 447, 485

Blood-retina barrier, 13, 14, 45, 132, 143, 144, 263, 328–330, 349, 400, 414, 421, 433, 453, 527, 528, 535, 539

Branch retinal vein occlusion, 103–115, 159, 177, 420, 470

Cancer, 71, 177, 211–215, 241, 247, 261, 265, 267–269, 289–291, 293, 294, 303, 316, 319, 329, 409, 421, 425, 458, 460, 461, 469

Capillary, 4–7, 9, 10, 12–14, 16, 18, 21, 22, 26, 27, 62, 63, 66, 73, 81–86, 88–94, 112, 121, 123, 124, 126, 127, 152, 159, 161, 171, 178, 188, 192, 193, 207, 214, 224, 225, 230, 233, 245, 251, 259, 265, 266, 270, 292, 293, 296, 327, 348, 351, 352, 354, 355, 372, 392–394, 399, 401, 402, 411, 412, 447, 462, 467, 477

Carbogen, 161, 162

Carbon dioxide, 156, 162, 279–281, 286 Choriocapillaris, 42, 230, 483 Choroid, 43, 47–49, 52, 91, 127, 312,

316–318, 325, 371, 373, 403, 419, 429, 432, 433, 456, 460, 483, 486, 528

Choroidal neovascularization (CNV), 25, 41–53, 259, 263, 271, 312, 319, 328, 349, 372, 394, 408, 412, 413, 420, 424, 429, 457, 527

Index

Conjunctiva, 422, 476 Controlled release, 422, 423 Cryotherapy, 370, 371, 378, 380

Cyclooxygenase, 71, 159, 241–243, 411, 476

Depot, 425, 429, 472, 473, 485 Devices, 106, 330, 421, 422, 426,

428–434

Diabetes, 23, 81, 83–94, 103, 145, 155, 156, 159, 161, 163, 187–189, 191–196, 203, 215, 350, 351, 409, 410, 413, 414, 429, 447, 459, 466, 467, 476, 480, 538

Diabetic retinopathy, 1, 2, 13, 15, 17, 24, 28, 42, 68, 70, 81–94, 120, 139, 140, 142–145, 152, 153, 155, 159, 161, 171, 187–192, 196, 214, 215, 241, 246, 250, 262, 263, 290, 294, 311, 312, 319, 326, 343, 348, 349, 394, 403, 407–414, 420, 446, 447

Dilatation, 92

Dog, 83–85, 88–90, 106, 120, 190, 221–223, 226–234, 341, 372, 476

Drusen, 50, 51, 487, 527, 534, 535

Endothelial cell, 1–21, 23–27, 44, 62, 67–72, 82–84, 89–91, 109, 121, 123, 126–129, 131, 132, 140, 141, 143, 156, 159, 169–171, 189, 190, 192–194, 203, 204, 207–211, 213–215, 221, 223–227, 232, 233, 245–248, 251, 252, 259–266, 269, 270, 285, 289–299, 301, 303, 311, 316, 321–323, 327, 329, 339–343, 345–347, 349, 350, 352, 355, 372, 379, 389, 394, 399, 409, 410, 413, 445–447, 450, 460, 461, 466–468, 470, 473, 477–482, 486, 529–535, 538

Ephrin, 70, 71, 203–215, 486 Euglycemia, 145, 190

Extracellular matrix, 1, 4, 16–18, 66, 105, 189, 191, 204, 246, 247,

Index

259–261, 290, 299, 318, 324, 326, 446, 447, 467, 529–536

Extravasation, 13, 16, 69, 72, 328, 349

Fenestration, 6, 43, 44, 47, 52, 109 Fibroblast growth factor, 246, 289–297,

316, 322, 343, 389, 408, 446, 529 FITC, 48, 49, 61, 64, 134, 433 Fluorescein, 14, 43, 44, 46–48, 83,

107, 109, 112–114, 155, 161, 191, 251, 271, 328, 389, 394, 411, 433, 449, 450, 455, 456, 458

Fovea, 112, 124–126, 130, 372, 449, 452, 484

Fundus, 41, 43, 45, 48, 53, 106, 108, 109, 264, 369, 376

Ganglion cell, 86, 87, 120, 123, 227, 249, 321

Gavage, 281–284

Gene therapy, 330, 407, 412, 480 Gestation, 58, 60, 123, 169, 170, 318,

365–368, 372, 377, 378

Glial cell, 2, 14, 22, 23, 25, 26, 86, 87, 322, 323, 413

Glycosaminoglycans, 313, 325, 326 Growth Factor, 1–4, 7–9, 11–13, 17,

19, 26, 44, 46, 48, 49, 51, 52, 58, 59, 61, 66, 89–91, 93, 105, 107, 111, 113, 120, 131, 139–142, 169, 178, 204, 225, 226, 245, 247, 260, 264, 266, 269, 272, 280, 286, 289, 303, 313, 316, 322, 342, 343, 347, 351, 355, 357, 367, 368, 379–381, 389, 397, 407, 408, 411–414, 429, 446, 453, 459–461, 465, 466, 470, 472, 478, 485, 528–537

Hematopoiesis, 343

Hematopoietic stem cell, 10, 11, 341, 345, 346, 349, 460, 535

Hepatocyte growth factor, 11, 67, 290, 414

Histology, 109, 156, 282

553

HUVEC, 6, 21, 223, 226, 292, 296, 321, 327

Hyperglycemia, 2, 84, 85, 88, 90, 139, 144, 187, 189–194, 196, 350, 410, 462

Hyperoxia, 12, 62, 63, 65, 67, 68, 132, 140, 141, 170, 229, 230, 233, 234, 279, 280, 408

Hypoxia, 2, 4, 5, 14, 18, 23–27, 58, 59, 65, 67–69, 84, 105, 107, 119, 120, 126, 130, 131, 140–142, 145, 151–163, 169, 178, 204, 221–225, 232, 246, 249–252, 279, 280, 285, 291, 297, 302, 326, 346, 347, 367, 380, 389, 391, 403, 407, 408, 411, 412, 453, 461, 469, 476, 480, 482, 528, 530, 532, 533

Hypoxia inducible factor-1 alpha, 68, 169–178, 224, 232, 291, 380, 469, 482

Infection, 279, 284–286, 391 Inflammation, 48, 94, 103, 113, 159,

163, 244, 245, 345, 411, 434, 453, 456, 469, 476, 480, 483, 486, 530, 534, 538

Insulin-Like Growth Factor, 11, 67, 68, 89, 111, 142, 156, 248, 279, 297, 411, 446

Integrin, 69, 131, 204, 248, 259, 260, 269, 425, 468, 478

Interleukin, 4, 67, 225, 290, 316, 323, 348

Intrascleral, 425

Intravitreal, 45, 47, 59, 70, 73, 91, 109, 111, 113, 157, 192, 195, 250, 265, 269, 327, 328, 330, 349, 375, 376, 407, 409, 410, 412, 424, 425, 430, 431, 435, 447, 452–459, 462, 464–466, 468–472, 477, 479–482, 485, 538

Irma, 84, 85, 88, 92, 188, 396, 402 Ischemia, 4, 18, 66, 114, 246

Index

Ophthalmology, 329, 445, 446, 459, 482

Ora serrata, 162, 227, 228, 366, 372, 375

Oxygen, 12, 25–27, 57–73, 92, 107, 110, 111, 127, 130, 139–141, 151–155, 157–163, 169–171, 173–176, 189, 221, 222, 227–231, 233, 234, 248, 250, 262, 265, 269, 279–286, 325, 327, 330, 346, 349, 355, 367, 373, 374, 377–381, 407, 412, 453, 528, 530

Oxygen-induced retinopathy, 57–73, 92, 110, 158, 159, 221–235, 269, 280, 327, 330, 373, 453

Parenteral, 409, 421, 422, 425 Pathogenesis, 41, 44–48, 53, 57–59,

61, 63, 67, 68, 73, 82, 84–88, 94, 114, 120, 141, 151, 169, 171, 194, 248, 249, 279, 284, 285, 408, 413, 414, 484

Pathology, 13, 62, 66, 86, 89, 106, 188, 193, 252, 320, 354, 374, 453, 454, 486

Pathophysiology, 112, 139, 151, 163, 244, 363, 364, 367, 372, 486, 487 Perfusion, 23, 107, 154, 155, 171, 302,

348, 354, 356, 373, 374, 411 Pericyte, 2, 4, 6–9, 12, 13, 19–21, 23,

26, 82–86, 88–91, 120, 130–132, 134, 170, 188, 192, 208, 232, 247, 324, 327, 372, 399, 447, 461, 477, 480, 486, 529–532, 537

Peripheral, 11, 58, 62, 64, 89, 91, 113, 123, 124, 127, 131, 134, 135, 154, 157, 169, 187, 195, 227, 228, 280, 285, 286, 340, 341, 347, 350, 355, 367, 368,

370, 371, 374, 380–382, 389–397, 401, 407, 412, 452, 466, 479

Permeability, 4, 8, 13–15, 17, 65, 67, 82, 86, 87, 92, 94, 143, 187–189, 191, 193–196, 246, 263, 291, 328, 348, 368, 407, 408, 432, 447, 450,

555

451, 453, 455, 457, 460, 462, 464, 469, 470, 480, 481, 533

Photoreceptor, 46, 49–52, 82, 88, 91, 109, 124, 130, 155, 157, 227, 250, 311–318, 321, 329, 367, 401, 402, 484, 535

Physiological hypoxia, 130, 131, 140, 160, 169

Pigment epithelium-derived factor, 71, 156, 295, 311–331, 407, 412, 424

Placenta growth factor, 67, 141, 290–298, 301, 344, 345, 453, 459, 460, 535–539

Platelet-derived growth factor, 4, 8, 12, 17, 26, 67, 132, 178, 192, 290, 295, 297–300, 379, 446, 461, 462, 532, 537

Plus disease, 161, 369, 375, 381, 387 Posterior, 47, 58, 104, 105, 121, 161,

162, 169, 233, 368, 375, 380, 392, 398, 419–426, 428, 471, 473, 476, 485–488

Posterior pole, 89, 91, 368, 392 Posterior segment, 42, 104–106, 112,

113, 421–426, 428, 433, 445, 446, 461, 469, 476, 480, 488

Premature, 57–60, 140, 141, 143, 145, 246, 279, 280, 283–285, 363, 370–372, 377, 380, 381

Primate, 41, 43–47, 53, 86, 87, 106, 112–114, 120, 453, 454, 464, 478

Progenitor cell, 10, 339, 340, 343–347, 350, 354–356, 460, 486, 535, 537

Proliferative retinopathy, 63, 90, 140, 142–145, 154, 156, 158, 163, 189, 194, 204, 252, 272, 350, 389, 392, 394, 397

Prostaglandin, 71, 94, 241–243, 247, 248, 347, 476

Prostanoids, 241–246, 248 Proteinase, 14, 259, 260, 262,

265–270, 272, 313, 530 Protein delivery, 311

Protein kinase C, 111, 187, 188, 196, 410, 411, 462

556

Proteolysis, 16, 18, 22, 174, 264, 265,

320, 473, 531

Rat, 6, 8, 9, 17, 23, 24, 26, 45–48, 51, 52, 57, 63–66, 68, 70, 72, 85, 90, 120, 126, 131, 134, 157–160, 162, 190, 191, 194, 214, 223, 250, 251, 269, 279, 280, 285, 293, 295–297, 314–316, 319, 320, 323, 327, 329, 354, 355, 372, 403, 459, 462, 477, 478, 480, 481

Retina, 1, 3, 4, 7, 8, 10, 12, 13, 17, 22–27, 45–49, 51, 52, 58–65, 67, 73, 84, 86, 87, 89–94, 103, 104, 109, 120, 121, 123–132, 134, 139, 140, 143, 144, 151, 152, 155, 157–163, 169–171, 188, 191, 193, 204, 214, 221, 222, 225, 226, 228–235, 249, 262–264, 270, 271, 280, 281, 286, 294–297, 311, 312, 314–321, 323, 325, 328–330, 344, 349–352, 364, 366–368, 370–377, 380, 382, 389, 392–403, 408, 412–414, 419, 421, 430, 431, 433, 447, 452–454, 456, 458, 460, 461, 476, 485, 486, 527, 528, 535

Retinopathy, 1–3, 10, 12, 13, 15, 17, 24, 27, 28, 42, 48, 57, 58, 60, 61–66, 68–70, 81–94, 103, 110, 120, 139, 140, 142–145, 152, 155–159, 161, 163, 170, 177, 187–192, 194–196, 204, 214, 215, 221, 227, 230, 231, 233, 242, 246, 250, 262, 263, 265, 269, 272, 279–284, 290, 294, 297, 311, 312, 319, 326–328, 330, 343, 348–350, 363, 370, 373, 389–394, 397, 403–405, 407–414, 446, 447, 453, 454, 462, 479, 528

Retinopathy of prematurity, 1, 2, 25, 27, 28, 42, 57–70, 73, 120, 139, 152, 153, 203, 214, 221, 230, 233, 242, 246, 279–286, 297, 311, 363–383, 420, 454

Rodent models of retinopathy, 57–73

Index

Sea fans, 389, 390, 397–400 Sequelae, 364

Serine protease, 71, 72, 259, 312, 331, 480, 487, 530, 534

Sickle cell, 153, 155, 290, 372, 389–403

Signaling, 2, 12, 21, 24, 68–70, 91, 175, 178, 188, 189, 205–207, 209, 212–215, 222, 224, 241, 242, 245, 248, 249, 251, 290, 291, 294, 297, 300–302, 321, 323, 346–348, 356, 453, 454, 460–462, 466, 476, 478

Splenomegaly, 390

Stem cell, 11, 345, 347, 349, 460, 485, 486, 538

Strabismus, 369, 434 Stromal-derived growth factor,

290, 486 Subconjunctival, 464, 471, 476

Subretinal, 24, 41–53, 91, 270, 328, 330, 367, 393, 394, 425, 426, 429, 434, 464, 470, 477, 528, 536, 538

Sustained, 14, 190, 196, 300, 355, 368, 398, 421–423, 425, 432, 463, 469, 471, 538

Sympathectomy, 90

Synergy, 289–303

Temporal retina, 85, 86 Tenascin-C, 290, 299

Thrombospondin, 4, 9, 21, 26, 71, 72, 224, 251, 290, 299, 301, 478

Transcleral, 425, 432, 433 Transforming growth factor, 4, 44, 67,

193, 269, 529

Tyrosine, 67, 70, 177, 194, 203–206, 247, 343, 409, 453, 460, 487

Urokinase, 14, 260, 263, 265, 268, 269 Urokinase plasminogen activator, 10,

14–17, 72, 259–262, 265, 268–270, 473

Vascular endothelial growth factor, 4, 5, 10–12, 14, 17, 18, 20–27, 44,

Index

46, 48, 49, 51, 52, 61, 62, 67, 68, 70–72, 89–91, 105, 113, 120, 126, 129–132, 140–145, 156, 160, 169–174, 177, 178, 194, 195, 204, 207, 221, 224, 225, 235, 247–251, 261, 263, 266, 285, 289, 291–302, 316, 319, 322–324, 326, 328, 329, 340–352, 357, 379, 380, 389, 390, 397, 398, 407–414, 429, 433, 435, 447, 448, 451, 453–459, 461–464, 466–470, 473, 478, 480, 482–486, 526–539

Vascular retina, 158, 162, 311, 318, 323

557

Vasculogenesis, 10, 58, 60, 119–135, 151–153, 160, 169, 170, 178, 207, 208, 221–233, 281, 289, 339–357, 453, 461, 529

Vaso-obliteration, 21, 81, 83, 88, 90, 91, 141, 145, 221, 230, 232, 233, 364, 373, 374, 379

Vaso-occlusion, 389–392, 403 Vessel stability, 70, 132, 298 Vitreous humor, 194, 311, 317

Zymography, 262