Ординатура / Офтальмология / Английские материалы / Research Projects in Dry Eye Syndrome_Brewitt_2010

Author Index

Blackie, C.A. 108

Brewitt, H. XI

Bulgen, M. 129

Dunse, M. 12

Frentz, M. 93

Fuchsluger, T.A. 57

Garreis, F. 12, 16

Geerling, G. 49

Gehlsen, U. 40

Giebel, J. 71

Gottschalt, M. 16

Horwath-Winter, J. 83

Hüttmann, G. 40

Jäger, K. 12

Jürgens, C. 71

Kampik, A. 129

Kasper, K. 49

Kirchengast, S. 83

Knop, E. 23, 108

Knop, N. 23, 108

Korb, D.R. 108

Liu, L. 49

Meller, D. 57

Messmer, E.M. 129

Pauklin, M. 57

Paulsen, F.P. 1, 12, 16

Rabensteiner, D.F. 83

Rath, R. 71

Schmut, O. 83

Schrader, S. 49

Schrage, N.F. 93

Schulze, U. 1

Sel, S. 1

Spöler, F. 93

Spreitzhofer, E. 83

Springs, C. 139

Steuhl, K.-P. 57

Steven, P. 40

Tost, F.H.W. 71

Trummer, G. 83

Wachswender, C. 83

Westekemper, H. 57

Witte, T. 123

Amino acid transport, see Cationic amino acid transporters

Amniotic membrane (AM)

lacrimal gland two-dimensional model 50, 51

limbal stem cell deficiency treatment epithelial cell expansion on amniotic

membrane for transplantation 59 transplantation 58

Angiogenin, see Antimicrobial peptides Animal models, see Ex Vivo Eye Irritation Test Antimicrobial peptides (AMPs), see β-Defensin

angiogenin and ocular function 20 mechanism of action 17

ocular expression 17–19 overview 16, 17

psoriasin and ocular function 20 Artificial tears

Ex Vivo Eye Irritation Test studies 101, 102, 104

hydroxypropyl-guar dry eye treatment

efficacy 142, 143 overview 141, 142

properties and characteristics 141 Systane Ultra Lubricant Eye Drops

clinical findings 144, 145 composition 143

mechanism of action 143, 144 tear film physiology 140

Bevacizumab, corneal neovascularization prevention 64, 65

Cartilage, trefoil factor family peptide 3 in articular cartilage

expression 8

osteoarthritis levels 8 Cationic amino acid transporters

CAT2 knockout mice 13 ocular expression 14 types 13

Confocal microscopy conjunctiva-associated lymphoid tissue

intravital microscopy 42 conjunctiva epithelial imaging

diagnostic value 80 goblet cells 76, 78, 79 healthy eye findings 79 image acquisition 73

impression cytology comparison 73–75, 78

non-secretory cells 76, 77 overview 71–73

squamous metaplasia in dry eye 75 summary of findings 81

Conjunctiva-associated lymphoid tissue, see Eye-associated lymphoid tissue; Intravital microscopy

Conjuctival epithelium, see Confocal microscopy

Conjunctivitis, see Seasonal non-allergic conjunctivitis syndrome

Cornea

epithelial stem cell, see Limbal stem cell deficiency

trefoil factor family peptide 3 in healing promotion 4–7

β-Defensin, see also Antimicrobial peptides non-antimicrobial function 20

ocular expression 14, 18–20 overview of defensins 19 psoriasis role 13, 14

Ex Vivo Eye Irritation Test (EVEIT) artificial tear studies 101, 102, 104

dry eye syndrome animal models 94, 95 optical coherence tomography

findings 100–105 principles 95–99

short-term test and dry eye simulation 98, 99 system and scoring 95, 96

Eye-associated lymphoid tissue (EALT) conjunctiva-associated lymphoid tissue

intravital microscopy 42–47 structure and function 24, 25, 40, 41

connectivity 28, 29 dry eye

physiological compensatory mechanisms 36

regulation overview 32, 33

vicious circles and inflammation 34, 35 lymphocyte subtypes

antigen presentation and differentiation 31, 32

types and functions 29–31 lymphoid cells 27, 28 mucosa-associated lymphoid tissue

arrangement and function 26, 27 cell types 25, 26

Eye lid margin, see Lid margin

Fluorescence lifetime, see Two-photon microscopy

α-Fodrin

antibodies as Sjögren’s syndrome marker disease activity correlation 127 prevalence 126

prospects for study 127 specificity 126, 127

function 125

Goblet cell, confocal microscopy of conjunctiva 76, 78, 79

Hydroxypropyl-guar, see Artificial tears

Intravital microscopy, conjunctiva-associated lymphoid tissue

confocal microscopy 42 prospects 46, 47 two-photon microscopy

autofluorescence two-photon microscopy 43–46

principles 43

Keratitis, pathogens 13

Lacrimal gland, artificial gland for dry eye disease treatment

amniotic membrane-based twodimensional model 50, 51

colony-forming capacity of cells 52 prospects 53, 54

rationale 49, 50 three-dimensional model 51, 52 tissue engineering scaffolds 50

Laser scanning confocal microscopy, see Confocal microscopy

LASIK, complications 12 Lid margin

functions

importance in dry eye disease 108–110 ocular surface integrity preservation

110 lid wiper

anatomy 118, 119

epitheliopathy and dry eye 118, 119 preocular tear film distribution 118

meibomian gland

anatomy and function 111, 112 ductal system and keratinization

111, 113 dysfunction

dry eye 114 hyperkeratinization 114

mucocutaneous junction

diagnostic value in dry eye 116–118 line of Marx 115

structure and function 110, 114 Limbal stem cell deficiency (LSCD)

amniotic membrane transplantation 58 epithelial transplantation

bevacizumab injections 64, 65 cell expansion on amniotic

membrane 59 complications 65, 66 outcomes 60–64, 66–68 patient characteristics 59 surgery and postoperative

management 59, 60 treatment overview 58

Line of Marx, see Mucocutaneous junction

Meibomian gland

anatomy and function 111, 112

ductal system and keratinization 111, 113

dysfunction dry eye 114

hyperkeratinization 114 Mucocutaneous junction (MCJ)

diagnostic value in dry eye 116–118 line of Marx 115

structure and function 110, 114 Mucosa-associated lymphoid tissue, see Eye-associated lymphoid tissue

Optical coherence tomography (OCT) Ex Vivo Eye Irritation Test findings

100–105 principles 95–99

Pollen, see Seasonal non-allergic conjunctivitis syndrome

Psoriasin, see Antimicrobial peptides

Seasonal non-allergic conjunctivitis (SNAC) syndrome

overview 83, 84

pollen extract effects on CHANG conjunctival cells

cell count and morphological changes 85, 86, 88–90 microscopic analysis 85, 88

viability assay 86, 87, 89 pollen proteins

polyacrylamide gel electrophoresis 84, 85, 87

zymography 84, 87 treatment prospects 91

Sjögren’s syndrome (SS) diagnosis

α-fodrin antibodies as marker disease activity correlation 127 prevalence 126

prospects for study 127 specificity 126, 127

laboratory findings 124, 125 symptoms 123–125

economic impact 123 epidemiology 123

Systane Ultra Lubricant Eye Drops clinical findings 144, 145 composition 143

mechanism of action 143, 144

Tear film

antimicrobial peptides, see Antimicrobial peptides

hyperosmolarity in dry eye syndrome aging effects 131, 132

diagnostic value 134–136 limitations of study 136, 137 overview 129, 130

patient characteristics in study 130–132 single disease sign correlations 132–134 Tearlab analysis 130, 136

lid wiper and preocular tear film distribution 118

physiology 140

replacement, see Artificial tears Tearlab, tear film osmolarity analysis 130,

136

Trefoil factor family peptide 3 (TFF3) articular cartilage

expression 8 osteoarthritis levels 8

corneal healing promotion 4–7 epithelial healing promotion 3 knockout mice and ocular effects 3, 4 overview of trefoil factor family

functions 2, 3 receptor 2–4

therapeutic prospects in dry eye syndrome 9

Two-photon microscopy, conjunctiva-associated lymphoid tissue intravital microscopy

autofluorescence two-photon microscopy 43–46

principles 43

Wiper, see Lid margin

Zymography, pollen proteases 84, 87