Ординатура / Офтальмология / Английские материалы / Research Projects in Dry Eye Syndrome_Brewitt_2010
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Research Projects in Dry Eye Syndrome
Developments in Ophthalmology
Vol. 45
Series Editors
F. Bandello Milan
W. Behrens-Baumann Magdeburg
Research Projects in
Dry Eye Syndrome
Volume Editor
Horst Brewitt Hannover
54 figures, 1 in color, and 8 tables, 2010
Basel · Freiburg · Paris · London · New York · Bangalore ·
Bangkok · Shanghai · Singapore · Tokyo · Sydney
Horst Brewitt
Ubbenstrasse 11
DE–30159 Hannover
This book was generously supported by
and 
Library of Congress Cataloging-in-Publication Data
Research projects in dry eye syndrome / volume editor, Horst Brewitt.
p. ; cm. -- (Developments in ophthalmology, ISSN 0250-3751 ; v. 45) Includes bibliographical references and index.
ISBN 978-3-8055-9418-9 (hard cover : alk. paper)
1. Dry eye syndromes. I. Brewitt, H. (Horst) II. Series: Developments in ophthalmology, v. 45. 0250-3751 ;
[DNLM: 1. Dry Eye Syndromes. W1 DE998NG v.45 2010 / WW 208 R432 2010] RE216.D78R47 2010
617.7 1--dc22
2010007067
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Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN 0250–3751
ISBN 978–3–8055–9418–9 e-ISBN 978–3–8055–9419–6
Section Title
Contents
VII List of Contributors
XI Preface
Brewitt, H. (Hannover)
1Trefoil Factor Family Peptide 3 at the Ocular Surface. A Promising Therapeutic Candidate for Patients with Dry Eye Syndrome?
Schulze, U.; Sel, S.; Paulsen, F.P. (Halle/Saale)
12Cationic Amino Acid Transporters and β-Defensins in Dry Eye Syndrome
Jäger, K.; Garreis, F.; Dunse, M.; Paulsen, F.P. (Halle/Saale)
16Antimicrobial Peptides as a Major Part of the Innate Immune Defense at the Ocular Surface
Garreis, F.; Gottschalt, M.; Paulsen, F.P. (Halle/Saale)
23Regulation of the Inflammatory Component in Chronic Dry Eye Disease by the Eye-Associated Lymphoid Tissue (EALT)
Knop, N. (Hannover); Knop, E. (Berlin)
40Intravital Multidimensional Real-Time Imaging of the Conjunctival Immune System
Gehlsen, U.; Hüttmann, G.; Steven, P. (Lübeck)
49Generation of Twoand Three-Dimensional Lacrimal Gland Constructs
Schrader, S. (London/Lübeck); Liu, L. (Birmingham); Kasper, K.; Geerling, G. (Würzburg)
57Midterm Results of Cultivated Autologous and Allogeneic Limbal Epithelial Transplantation in Limbal Stem Cell Deficiency
Pauklin, M.; Fuchsluger, T.A.; Westekemper, H.; Steuhl, K.-P.; Meller, D. (Essen)
71Laser Scanning Confocal Microscopy for Conjunctival Epithelium Imaging
Jürgens, C.; Rath, R.; Giebel, J.; Tost, F.H.W. (Greifswald)
83Pollen Enzymes Degrade Human Tear Fluid and Conjunctival Cells: An Approach to Understanding Seasonal Non-Allergic Conjunctivitis
Rabensteiner, D.F.; Spreitzhofer, E.; Trummer, G.; Wachswender, C.; Kirchengast, S.; Horwath-Winter, J.; Schmut, O. (Graz)
93Towards a New in vitro Model of Dry Eye: The ex vivo Eye Irritation Test
Spöler, F.; Frentz, M.; Schrage, N.F. (Aachen)
108The Lid Margin Is an Underestimated Structure for Preservation of Ocular Surface Health and Development of Dry Eye Disease
Knop, E. (Berlin); Korb, D.R.; Blackie, C.A. (Boston, Mass.); Knop, N. (Hannover)
V
123Diagnostic Markers of Sjögren’s Syndrome
Witte, T. (Hannover)
129Hyperosmolarity of the Tear Film in Dry Eye Syndrome
Messmer, E.M.; Bulgen, M.; Kampik, A. (Munich)
139Novel Ocular Lubricant Containing an Intelligent Delivery System: Details of Its Mechanism of Action
Springs, C. (Indianapolis, Ind.)
148Author Index
149Subject Index
VI |
Contents |
List of Contributors
Caroline A. Blackie, Dr. |
Fabian Garreis |
Korb Associates |
Department of Anatomy and Cell Biology |
400 Commonwealth Ave. |
Martin Luther University Halle-Wittenberg |
Unit 2 |
Grosse Steinstrasse 52 |
Boston, MA 02215 (USA) |
DE–06097 Halle/Saale (Germany) |
E-Mail cblackie@tearscience.com |
E-Mail fabian.garreis@medizin.uni-halle.de |
Horst Brewitt, Prof. Dr. |
Gerd Geerling, Prof. Dr. |
Ubbenstrasse 11 |
Klinik für Augenheilkunde |
DE–30159 Hannover (Germany) |
Julius Maximilians Universität Würzburg |
E-Mail HorstBrewitt@T-Online.de |
Josef-Schneider-Str. 11 |
Meral Bulgen |
DE–97080 Würzburg |
E-Mail G.Geerling@augenklinik.uni- |
|
Department of Ophthalmology |
wuerzburg.de |
Ludwig Maximilian University |
U. Gehlsen, Dr. |
Mathildenstrasse 8 |
|
DE–80336 Munich (Germany) |
Department of Ophthalmology |
E-Mail meral.bulgen@yahoo.de |
University Medical Center Schleswig- |
Matthias Dunse |
Holstein |
Campus Lübeck, Ratzeburger Allee 160 |
|
Department of Anatomy and Cell Biology |
DE–23538 Lübeck (Germany) |
Martin Luther University Halle-Wittenberg |
E-Mail gehlsen@anat.uni-luebeck.de |
Grosse Steinstrasse 52 |
Jürgen Giebel, Prof. Dr. |
DE–06097 Halle/Saale (Germany) |
|
E-Mail info@matthiasdunse.de |
Institute of Anatomy and Cell Biology |
Markus Frentz |
Ernst-Moritz-Arndt University |
Friedrich-Loeffler-Str. 23c |
|
Department of Ophthalmology |
DE–17487 Greifswald (Germany) |
RWTH Aachen University |
E-Mail giebel@uni-greifswald.de |
Pauwelsstraße 30 |
Maria Gottschalt, Dr. |
DE–52074 Aachen (Germany) |
|
E-Mail frentz@acto.de |
Department of Anatomy and Cell Biology |
Thomas A. Fuchsluger, Dr. |
Martin Luther University Halle-Wittenberg |
Grosse Steinstrasse 52 |
|
Department of Ophthalmology |
DE–06097 Halle/Saale (Germany) |
University of Duisburg-Essen |
E-Mail maria.gottschalt@web.de |
Hufelandstrasse 55 |
|
DE–45122 Essen (Germany) |
|
E-Mail thomas.fuchsluger@uk-essen.de |
|
VII
Jutta Horwath-Winter, Dr. |
Erich Knop, Dr. |
|
Department of Ophthalmology |
Research Laboratory of the Department of |
|
Medical University of Graz |
Ophthalmology CVK |
|
Auenbruggerplatz 4 |
Charité – Universitätsmedizin Berlin |
|
AT–8036 Graz (Austria) |
Ziegelstrasse 5–9 |
|
E-Mail jutta.horwath@medunigraz.at |
DE–10117 Berlin (Germany) |
|
Gereon Hüttmann, Dr. |
E-Mail erich.knop@charite.de |
|
Nadja Knop, Dr. |
||
Biomedical Optics |
||
University of Lübeck |
Department of Cell Biology in Anatomy |
|
Peter-Monnik-Weg 4 |
Hannover Medical School |
|
DE–23562 Lübeck (Germany) |
Carl-Neuberg-Strasse 1 |
|
E-Mail huettmann@bmo.uni-luebeck.de |
DE–30625 Hannover (Germany) |
|
Kristin Jäger, Dr. |
E-Mail knopnadja@aol.com |
|
Donald R. Korb, Prof. Dr. |
||
Department of Anatomy and Cell Biology |
||
Martin Luther University Halle-Wittenberg |
Korb Associates |
|
Grosse Steinstrasse 52 |
400 Commonwealth Ave. |
|
DE–06097 Halle/Saale (Germany) |
Unit 2 |
|
E-Mail kristin.jaeger@medizin.uni-halle.de |
Boston, MA 02215 (USA) |
|
Clemens Jürgens, Dr. |
E-Mail drkorb@aol.com |
|
L. Liu, Dr. |
||
Klinik für Augenheilkunde |
||
Ernst-Moritz-Arndt-Universität Greifswald |
Academic Unit of Ophthalmology |
|
Ferdinand-Sauerbruch-Strasse |
Institute of Biomedical Research |
|
DE–17475 Greifswald (Germany) |
College of Medical and Dental Sciences |
|
E-Mail juergens@uni-greifswald.de |
University of Birmingham |
|
Anselm Kampik, Prof. Dr. |
GB–B15 2TT Birmingham (UK) |
|
E-Mail leiliudang@googlemail.com |
||
Augenklinik der LMU |
Daniel Meller, Prof. Dr. |
|
Klinikum der Universität München |
||
Campus Innenstadt |
Department of Ophthalmology |
|
Mathildenstrasse 8 |
University of Duisburg-Essen |
|
DE–80336 Munich (Germany) |
Hufelandstrasse 55 |
|
E-Mail akampik@med.uni-muenchen.de |
DE–45122 Essen (Germany) |
|
Karsten Kasper |
E-Mail daniel.meller@uk-essen.de |
|
Elisabeth M. Messmer, Dr. |
||
Department of Ophthalmology |
||
Julius Maximilian University Würzburg |
Department of Ophthalmology |
|
Josef-Schneider-Straße 11 |
Ludwig Maximilian University |
|
DE–97080 Würzburg (Germany) |
Mathildenstrasse 8 |
|
E-Mail k-augen@augenklinik.uni- |
DE–80336 Munich (Germany) |
|
wuerzburg.de |
E-Mail emessmer@med.uni-muenchen.de |
|
Sieglinde Kirchengast |
Mikk Pauklin, Dr. |
|
Department of Ophthalmology |
Department of Ophthalmology |
|
Medical University of Graz |
University of Duisburg-Essen |
|
Auenbruggerplatz 4 |
Hufelandstrasse 55 |
|
AT–8036 Graz (Austria) |
DE–45122 Essen (Germany) |
|
E-Mail sieglinde.kirchengast@ |
E-Mail mikkpauklin@gmail.com |
|
medunigraz.at |
|
VIII |
List of Contributors |
Friedrich P. Paulsen, Prof. Dr.
Department of Anatomy II University of Erlangen-Nürnberg Universitätsstraße 19
DE-91054 Erlangen
E-Mail friedrich.paulsen@anatomie2.med. uni-erlangen.de
Dieter Franz Rabensteiner, Dr.
Department of Ophthalmology Medical University of Graz Auenbruggerplatz 4
AT–8036 Graz (Austria)
E-Mail dieter.rabensteiner@medunigraz.at
Robert Rath, Dr.
Klinik für Augenheilkunde Ernst-Moritz-Arndt-Universität Greifswald Ferdinand-Sauerbruch-Strasse DE–17475 Greifswald (Germany)
E-Mail rath.r@freenet.de
Otto Schmut, Prof. Dr.
Department of Ophthalmology Medical University of Graz Auenbruggerplatz 4
AT–8036 Graz (Austria)
E-Mail otto.schmut@medunigraz.at
Stefan Schrader, Dr.
Cells for Sight Transplantation and Research Programme Department of Ocular Biology and Therapeutics
UCL Institute of Ophthalmology 11–43 Bath Street
GB–EC1V 9EL London (UK) E-Mail mail@stefanschrader.de
Norbert F. Schrage, Prof. Dr.
Department of Ophthalmology
RWTH Aachen University
Pauwelsstraße 30
DE-52074 Aachen (Germany)
E-Mail schrage@acto.de
Ute Schulze
Department of Anatomy and Cell Biology Martin Luther University
Grosse Steinstrasse 52 DE–06097 Halle/Saale (Germany)
E-Mail ute.schulze@medizin.uni-halle.de
Saadettin Sel, Dr.
Department of Ophthalmology Martin Luther University Grosse Steinstrasse 52
DE–06097 Halle/Saale (Germany)
E-Mail saadettin.sel@medizin.uni-halle.de
Felix Spöler, Dr.
Institute of Semiconductor Electronics RWTH Aachen University Sommerfeldstrasse 24
DE–52074 Aachen (Germany) E-Mail spoeler@iht.rwth-aachen.de
Eva Spreitzhofer, Dr.
Department of Ophthalmology Medical University of Graz Auenbruggerplatz 4
AT–8036 Graz (Austria)
E-Mail eva_spreitzhofer@yahoo.de
Clark Springs, Dr.
Department of Ophthalmology Indiana University
200 W. 103rd Street No. 2200 Indianapolis, IN 46290 (USA) E-Mail csprings@iupui.edu
Klaus-Peter Steuhl, Prof. Dr.
Department of Ophthalmology
University of Duisburg-Essen
Hufelandstrasse 55
DE–45122 Essen (Germany)
E-Mail Klaus-Peter.Steuhl@uk-essen.de
Philipp Steven, Dr.
Department of Ophthalmology University Medical Center SchleswigHolstein
Campus Lübeck, Ratzeburger Allee 160 DE–23538 Lübeck (Germany)
E-Mail p.steven@uk-sh.de
Frank Tost, Prof. Dr.
Klinik und Poliklinik für Augenheilkunde Ernst-Moritz-Arndt-Universität Greifswald Ferdinand-Sauerbruch-Strasse DE–17475 Greifswald (Germany)
E-Mail tost@uni-greifswald.de
List of Contributors |
IX |