Ординатура / Офтальмология / Английские материалы / Recent Advances in Retinal Degeneration_LaVail, Hollyfield, Anderson _2008

422

Mesopia-induced degradation of ERG, 196

Mice with rhodopsin, T17M mutation, 30 Microphotodiode Arrays (MPAs), 377 Mouse 21D1 characterization

analysis of, 238–239 molecular cloning, 238

Mouse Eyes Implantation, 380–381 Mouse primary RPE cell and ARPE19 cell

culture, 322–323

pulse-chase experiment for, 324–325 ROSs phagocytosis, 323–324

Müller-photoreceptor interaction, 405 Multiplex ligation-dependent probe

amplification (MLPA), 205 Murine model of age related retinal

degeneration, 165

Nanoceria particles, 54

and intracellular ROIs accumulation, 55 and photoreceptor cells, 57–58 radical-scavenging mechanism and, 58 retina rescue by, 57

Neosporin Ophthalmic Solution, antibiotic solution, 378

Neuroprotectin D1 (NPD1), 39 PEDF-induced NPD1 synthesis, 42 synthesis and bioactivity, 41

Neurotrophin receptor activation, 344–345

expression regulation, 345–346 NF-kB pro-survival transcriptional

pathways, 344

Notch/Delta signalling pathway, 279 Nyctalopi 3D structure, 251

Optic Nerve Head (ONH), 400 Optomotor response in RPE65-/- mice,

92–93

Ornithine amino transferase (OAT) gene, 24

Pax6 expression, 8–9

PD 98059 effect on insulin-stimulated 3H-thydimine incorporation of hRPE cells, 272

PEDF-induced NPD1 synthesis, 42 Peripheral membrane-associated proteins

downregulation, 354–355 Peroxiredoxin 6, 307

Phosphatidyl-inosytol transfer protein (PITP) family, 231

Photoreceptor cells and CNTF, 46 differentiation, 6–7

Index

electroretinography and, 55 synaptogenesis, 12

Photoreceptor outer segment fragments (POS), 369

P23H-3 rats

dark-adapted flash-evoked electroretinogram (ERG), 194–195

light restriction and degeneration, 193–194 Pigment epithelial-derived factor-stimulated

NPD1 synthesis, 39 Pigment epithelium derived factor

(PEDF), 61

P ITPNM3 gene genomic structure, 232 POS phagocytosis study by RPE cells,

370–371

Preparation of detergent-resistant membranes (DRM) from ROS, 336

Progenitors. see Stem cells

Proliferative diabetic retinopathy (PDR), 313 Protein transport model in cones, 357–358

P RPF31 (RP11) gene, 205 PRSS11 serine protease gene, 216

Putative dilysine (KXKXX) endoplasmic reticulum retention

signal, 283

Q626H mutation, 233

rAAV vector persistance, 124

rcd1 dog model (PDE6B mutation), 46 Rds-associated retinal diseases, 135

Rds expression levels in C214S transgenic retinas, 135

Recombinant adeno-associated viral (rAAV) vectors, 187

Refsum disease, 25

Re-growth of ERG, mechanisms of, 198 Regulation of complement activation (RCA)

locus, 216

Remote Analysis Computation for gene Expression data (RACE) online tool, 76

Reproductive cloning, 5 Retina enriched genes, 182

Retinal adhesion, role for αvβ5 integrin, 372–373

Retinal cDNA microarray, 179 Retinal degeneration in chicken (rd

chicken), 353 Retinal gene therapy, 121

Retinal neurons, primary culture, 54 Retinal pigment epithelium (RPE), 39, 261,

369, 393

phagocytosis and degradation by, 321–322 Retinal regeneration

Index

in fish, 365–366

in mammals barriers, 362 Retina structure

in C214S transgenics, 134 in VPP transgenics, 101

Retinitis pigmentosa, 23 clinical trials for

red blood cell docosahexaenoic (RBC DHA) levels and, 27

vitamin A intake for, 26, 28 Retinitis Pigmentosa (RP), 377 Retinopathy of prematurity (ROP), 313 Retinoschisin (RS) in photoreceptor

interactions with Extracellular Matrix (ECM), 294–295

and interaction with membrane phospholipids, 292–293

ions and, 293–294 isoforms of, 292 multiprotein complex, 295

organization and molecular interaction, 291 Rhodopsin (R), 354–357, 365, 371, 378,

403, 405

and arrestin transcriptional expression by uantitative real-time PCR, 403

content in retina, 405

and GCs transport in rods, 354, 356–357 gene (RHO), 24, 107

mutant P23H-3 transgenic rat, 193 Ribozymes, 99–100

design for treatment of P23H associated ADRP, 101–102

and siRNA treatment, 108–109

in vitro catalytic efficiency of, 102–104 Rod and cone electroretinography (ERG), 131 Rod-/Cone-specific Bcl-x Knockout mice

generation, 69–70

Rodents vision and optomotor response (OR), 90

ROD progenitor cells, 361–368 Rod-specific Bcl-x Knockout mice

characterization, 70

Royal College of Surgeons (RCS), 369 RPE cells and A2E accumulation, 40 RPE phagocytosis, role of αvβ5 integrin,

371–372

RPGRIP knock-out/KO mouse and gene replacement therapy, 31

R Transport Carriers (RTCs), 356 Rz397 and siRNA301 expression, 110

SAM algorithm and retina cDNA targets, 181 Scanning-laser Ophthalmoscopy (SLO), 172 Short Mouse Opsin Promoter-controlled cre

(SMOPC1) mice, 69–70

423

Single membrane-spanning region (TM), 352

siRNA301 expression, 110 Stargardt disease, 22

Stargardt like macular dystrophy (STGD3), 283 animal maintenance and tissue collection,

284–285 Stem cells

clonning and, 4–5

as photoreceptors, 5–6 Synuclein alpha (Snca), 384

Teleost retina, neurogenesis in, 363–364 tg6-mouse

retinal function of, 174–175 retinal vasculature, 173

Therapeutic cloning, 4–5 Transcription factor expression and

microenvironmental signals, 9 Transgenic mice generation, 130–131 Trans-golgi Network (TGN), 356 Treated eye

bilateral ERG recordings from, 141 morphometry of fundic regions of, 142

Trizol reagent (Invitrogen), 180

TRK receptor activation in retina, 343–344

USH2A gene, 24

Usher syndrome, 222

VEGFR 1

γ -Secretase-dependent RIP and, 317 regulated intramembrane proteolysis (RIP),

315–316

signalling in vascular endothelium and RPE, 313–314

Viral vectors, 148

with transgene expression for ocular gene therapy, 113

Virus mediated gene delivery and neuronal progenitors, 147

Visual and retinal function loss in light stressed mice, 157

VPP transgenic mouse models of ADRP, 100–101

a-Wave in rhodopsin-mutant degeneration, 197 Whole-cell patch clamp, 329

X-linked recessive RP (XLRP), 221 XOPS-mCFP transgenic zebrafish, 366

ZBED4

molecular cloning, 241

subcellular localization of, 241–242 Zebrafish retina anatomy, 362–363