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1 Diagnosis of Keratoconus

 

 

Fig. 1.22 Elevation-based topographer. It depends on the Scheimpflug image and evaluates both corneal surfaces

Although the elevation-based topographers evaluate both corneal surfaces depending on the principle of Scheimpflug image (Fig. 1.22), Placido-based topographers still can give more accurate data about the anterior corneal surface especially in case of corneal scars.

The new topographers combine both techniques to achieve the best corneal topography.

For full discussion of the curvature and elevation maps, please refer to my book “Corneal Topography in Clinical Practice” published by Jaypee Brothers 2009.

Bibliography

Barr JT et al (2006) Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Cornea 25:16–25 Brancati F et al (2004) A locus for autosomal dominant keratoconus maps to human chromosome 3p14-q13. J Med Genet

41:188–192

Caroline P et al (2006) Etiology, diagnosis, and management of keratoconus: new thoughts and new understandings. Pacific University College of Optometry. Retrieved on 2006-03-26 Chwa M et al (2006) Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus

fibroblasts. Invest Ophthalmol Vis Sci 47(5):1902–1910 Colin J (2006) European clinical evaluation: use of Intacs for

the treatment of keratoconus. J Cataract Refract Surg 32: 747–755

Cullen JF, Butler HG (1963) Mongolism (Down’s syndrome) and keratoconus. Br J Ophthalmol 47:321–330

Dash DP et al (2010) Mutational screening of VSX1 in keratoconus patients from the European population. Eye (Lond) 24:1085–1092

Elder MJ (1994) Leber congenital amaurosis and its association with keratoconus and keratoglobus. J Pediatr Ophthalmol Strabismus 31:38–40

Fink BA et al (2005) Differences in keratoconus as a function of gender. Am J Ophthalmol 140(3):459–468

Galin MA, Berger R (1958) Atopy and keratoconus. Am J Ophthalmol 45:904

Harrison RJ et al (1989) Association between keratoconus and atopy. Br J Ophthalmol 73:816–822

Haugen OH (1992) Keratoconus in the mentally retarded. Acta Ophthalmol (Copenh) 70:111–114

Hestnes A et al (1991) Ocular findings in Down’s syndrome. J Ment Defic Res 35:194–203

Jafri B et al (2004) Asymmetric keratoconus attributed to eye rubbing. Cornea 23:560–564

Kanski JJ (2007) Clinical ophthalmology: a systematic approach. Elsevier, Edinburgh

Krachmer JH et al (1984) Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 28:293 Kuming BS, Joffe L (1977) Ehlers-Danlos syndrome associated

with keratoconus: a case report. S Afr Med J 52:403–405 Li X et al (2007) Longitudinal study of keratoconus progression.

Exp Eye Res 85:502–507

Lichter H et al (2000) Keratoconus and mitral valve prolapse. Am J Ophthalmol 129:667–668

Mazzotta C et al (2008) Confocal microscopy identification of keratoconus associated with posterior polymorphous corneal dystrophy. J Cataract Refract Surg 34:318–321

Bibliography

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Nowak DM, Gajecka M (2011a) The genetics of keratoconus. Middle East Afr J Ophthalmol 18:2–6

Nowak DM, Gajecka M (2011b) The genetics of keratoconus. Ophthalmic Genet 18(1):2–6

Olivares JL et al (1997) Keratoconus: age of onset and natural history. Optom Vis Sci 74:147

Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42: 297–319

Rahi A et al (1977) Keratoconus and coexisting atopic disease. Br J Ophthalmol 61:761

Shapiro MB, France TD (1985) The ocular features of Down’s syndrome. Am J Ophthalmol 99:659–663

Sinjab MM (2009) Corneal topography in clinical practice (pentacam system): basics and clinical interpretation. Jaypee Brothers Medical Publishers, New Delhi

Sinjab MM (2010) Step by step reading pentacam topography (basics and case study series). Jaypee – Highlights Medical Publishers, New Delhi

Wachler BSB (2008) Modern management of keratoconus. Jaypee Brothers Medical Publishers, New Delhi

Weissman BA, Yeung KK (2006) Keratoconus. eMedicine: Keratoconus. Accessed 12 Feb 2006

Yue BY et al (1984) Heterogeneity in keratoconus: possible biochemical basis. Proc Soc Exp Biol Med 175:336