Ординатура / Офтальмология / Английские материалы / Pharmacology and Vitreoretinal Surgery_Gandorfer_2009
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Pharmacology and Vitreoretinal Surgery
Developments in Ophthalmology
Vol. 44
Series Editor
W. Behrens-Baumann Magdeburg
Section Title
Pharmacology and
Vitreoretinal Surgery
Volume Editor
Arnd Gandorfer Munich
30 figures, 13 in color, 2009
Basel · Freiburg · Paris · London · New York · Bangalore ·
Bangkok · Shanghai · Singapore · Tokyo · Sydney
Arnd Gandorfer
Vitreoretinal and Pathology Unit
Augenklinik der Ludwig-Maximilians-Universität
Mathildenstrasse 8
DE–80336 Munich (Germany)
The volume editor thanks ThromboGenics for the financial support to cover the costs of the color illustrations.
Library of Congress Cataloging-in-Publication Data
Pharmacology and vitreoretinal surgery / volume editor, Arnd Gandorfer. p. ; cm. – (Developments in ophthalmology, ISSN 0250-3751 ; v. 44)
Includes bibliographical references and indexes. ISBN 978-3-8055-9029-7 (hard cover : alk. paper)
1. Retina--Surgery. 2. Vitreous humor. 3. Enzymes--Therapeutic use. I. Gandorfer, Arnd.
[DNLM: 1. Vitreous Body--surgery. 2. Combined Modality Therapy. 3. Retina--surgery. 4. Retinal Diseases--surgery. 5. Vitrectomy--methods. 6. Vitreous Body--drug effects. W1 DE998NG v.44 2009 / WW 250 P536 2009] RE551.P43 2009
617.7‘3--dc22
2009009511
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents®.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2009 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN 0250–3751
ISBN 978–3–8055–9029–7 e-ISBN 978–3–8055–9030–3
Section Title
Contents
VII List of Contributors
XI Preface
Gandorfer, A. (Munich)
Pharmacologic Vitreolysis
1Objective of Pharmacologic Vitreolysis
Gandorfer, A. (Munich)
7Vitreous as a Substrate for Vitreolysis
Bishop, P.N. (Manchester)
20Hyaluronidase for Pharmacologic Vitreolysis
Narayanan, R. (Hyderabad); Kuppermann, B.D. (Orange, Calif.)
26Microplasmin-Assisted Vitrectomy
Gandorfer, A. (Munich)
31Pharmacologic Vitreodynamics and Molecular Flux
Goldenberg, D.T. (Royal Oak, Mich.); Trese, M.T. (Royal Oak, Mich./Rochester, Mich.) Proliferative Vitreoretinopathy
37Glial Cell Changes of the Human Retina in Proliferative Vitreoretinopathy
Wickham, L.; Charteris, D.G. (London)
46Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy
Eibl, K.H. (Munich); Fisher, S.K.; Lewis, G.P. (Santa Barbara, Calif.) Diabetic Retinopathy and Diabetic Macular Edema
56Neuroprotection for Diabetic Retinopathy
Imai, H.; Singh, R.S.J.; Fort, P.E.; Gardner, T.W. (Hershey, Pa.)
69VEGF Inhibitors and Vitrectomy for Diabetic Vitreoretinopathy
Cury Jr, C.E.; Rodrigues, E.B. (Sao Paulo); Meyer, C.H. (Bonn); Farah, M.E. (Sao Paulo)
V
Age-related Macular Degeneration
82Tissue Plasminogen Activator-Assisted Vitrectomy: Surgical Drainage of Submacular Hemorrhage
Kamei, M.; Tano, Y. (Suita) Retinopathy of Prematurity
89Anti-Angiogenic Therapy in the Management of Retinopathy of Prematurity
Drenser, K.A. (Royal Oak, Mich./Rochester, Mich.)
98Author Index
99Subject Index
VI |
Contents |
Section Title
List of Contributors
Paul N. Bishop |
Steven K. Fisher |
University of Manchester |
Neuroscience Research Institute |
Manchester Royal Eye Hospital |
University of California |
Oxford Road |
Santa Barbara, CA 93106-5060 (USA) |
Manchester M13 9WH (UK) |
|
David G. Charteris |
Patrice E. Fort |
|
Penn State Hershey Eye Center and |
||
Moorfields Eye Hospital |
Department of Cellular and Molecular |
|
City Road |
Physiology |
|
London EC1V 2PD (UK) |
Penn State College of Medicine |
|
Carlos E. Cury, Jr. |
500 University Drive, HU097 |
|
Hershey, PA 17033 (USA) |
||
Vision Institute, Department of Ophthalmology |
Arnd Gandorfer |
|
Federal University of Sao Paulo |
||
Rua Presidente Coutinho 579 |
Vitreoretinal and Pathology Unit |
|
conj 501 |
Augenklinik der Ludwig-Maximilians- |
|
Florianópolis |
Universität |
|
SC 88015–300 (Brazil) |
Mathildenstrasse 8 |
|
Kimberly A. Drenser |
DE–80336 Munich (Germany) |
|
Thomas W. Gardner |
||
Eye Research Institute, University Oakland |
||
3535 West 13 Mile Road, Suite 344 |
Penn State Hershey Eye Center and |
|
Royal Oak, MI 48073 (USA) |
Department of Cellular and Molecular |
|
Kirsten H. Eibl |
Physiology |
|
Penn State College of Medicine |
||
University Eye Hospital LMU |
500 University Drive, HU097 |
|
Ludwig-Maximilians-University |
Hershey, PA 17033 (USA) |
|
Mathildenstr. 8 |
David T. Goldenberg |
|
DE-80336 Munich (Germany) |
||
Michel E. Farah |
3535 W. 13 Mile Rd., Suite 344 |
|
Royal Oak, MI 48073 (USA) |
||
Vision Institute, Department of Ophthalmology |
|
|
Federal University of Sao Paulo |
|
|
Rua Presidente Coutinho 579 |
|
|
conj 501 |
|
|
Florianópolis |
|
|
SC 88015–300 (Brazil) |
|
VII
Hisanori Imai |
Eduardo B. Rodrigues |
Penn State Hershey Eye Center and |
Vision Institute, Department of Ophthalmology |
Department of Cellular and Molecular |
Federal University of Sao Paulo |
Physiology |
Rua Presidente Coutinho 579 |
Penn State College of Medicine |
conj 501 |
500 University Drive, HU097 |
Florianópolis |
Hershey, PA 17033 (USA) |
SC 88015–300 (Brazil) |
Motohiro Kamei |
Ravi S.J. Singh |
|
Department of Ophthalmology |
Penn State Hershey Eye Center and |
|
Osaka University Medical School |
Department of Cellular and Molecular |
|
2–2 Yamadaoka |
Physiology |
|
Suita, 565-0871 (Japan) |
Penn State College of Medicine |
|
Baruch Kuppermann |
500 University Drive, HU097 |
|
Hershey, PA 17033 (USA) |
||
UC Irvine Medical Center |
Yasuo Tano |
|
Ophthalmology Clinic |
||
101 The City Drive South |
Department of Ophthalmology |
|
Orange, CA 92697 (USA) |
Osaka University Medical School |
|
Geoffrey P. Lewis |
2–2 Yamadaoka |
|
Suita, 565-0871 (Japan) |
||
Neuroscience Research Institute |
Michael T. Trese |
|
University of California |
||
Santa Barbara, CA 93106-5060 (USA) |
3535 W. 13 Mile Rd., Suite 344 |
|
Carsten H. Meyer |
Royal Oak, MI 48073 (USA) |
|
Louisa Wickham |
||
Department of Ophthalmology |
||
University of Bonn |
Moorfields Eye Hospital |
|
Ernst-Abbe-Strasse 2 |
City Road |
|
DE–53127 Bonn (Germany) |
London EC1V 2PD (UK) |
|
Raja Narayanan |
|
|
Smt Kanuri santhamma Vitreoretina center |
|
|
L.V. Prasad Eye Institute |
|
|
L.V. Prasad Marg, Banjara Hills |
|
|
Hyderabad 500034 (India) |
|
VIII |
List of Contributors |
In memoriam of Professor Yasuo Tano, who suddenly passed away on
31 January 2009.
