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Ординатура / Офтальмология / Английские материалы / Pharmacology and Vitreoretinal Surgery_Gandorfer_2009

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Pharmacology and Vitreoretinal Surgery

Developments in Ophthalmology

Vol. 44

Series Editor

W. Behrens-Baumann Magdeburg

Section Title

Pharmacology and

Vitreoretinal Surgery

Volume Editor

Arnd Gandorfer Munich

30 figures, 13 in color, 2009

Basel · Freiburg · Paris · London · New York · Bangalore ·

Bangkok · Shanghai · Singapore · Tokyo · Sydney

Arnd Gandorfer

Vitreoretinal and Pathology Unit

Augenklinik der Ludwig-Maximilians-Universität

Mathildenstrasse 8

DE–80336 Munich (Germany)

The volume editor thanks ThromboGenics for the financial support to cover the costs of the color illustrations.

Library of Congress Cataloging-in-Publication Data

Pharmacology and vitreoretinal surgery / volume editor, Arnd Gandorfer. p. ; cm. – (Developments in ophthalmology, ISSN 0250-3751 ; v. 44)

Includes bibliographical references and indexes. ISBN 978-3-8055-9029-7 (hard cover : alk. paper)

1. Retina--Surgery. 2. Vitreous humor. 3. Enzymes--Therapeutic use. I. Gandorfer, Arnd.

[DNLM: 1. Vitreous Body--surgery. 2. Combined Modality Therapy. 3. Retina--surgery. 4. Retinal Diseases--surgery. 5. Vitrectomy--methods. 6. Vitreous Body--drug effects. W1 DE998NG v.44 2009 / WW 250 P536 2009] RE551.P43 2009

617.7‘3--dc22

2009009511

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents®.

Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.

All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

© Copyright 2009 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com

Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN 0250–3751

ISBN 978–3–8055–9029–7 e-ISBN 978–3–8055–9030–3

Section Title

Contents

VII List of Contributors

XI Preface

Gandorfer, A. (Munich)

Pharmacologic Vitreolysis

1Objective of Pharmacologic Vitreolysis

Gandorfer, A. (Munich)

7Vitreous as a Substrate for Vitreolysis

Bishop, P.N. (Manchester)

20Hyaluronidase for Pharmacologic Vitreolysis

Narayanan, R. (Hyderabad); Kuppermann, B.D. (Orange, Calif.)

26Microplasmin-Assisted Vitrectomy

Gandorfer, A. (Munich)

31Pharmacologic Vitreodynamics and Molecular Flux

Goldenberg, D.T. (Royal Oak, Mich.); Trese, M.T. (Royal Oak, Mich./Rochester, Mich.) Proliferative Vitreoretinopathy

37Glial Cell Changes of the Human Retina in Proliferative Vitreoretinopathy

Wickham, L.; Charteris, D.G. (London)

46Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy

Eibl, K.H. (Munich); Fisher, S.K.; Lewis, G.P. (Santa Barbara, Calif.) Diabetic Retinopathy and Diabetic Macular Edema

56Neuroprotection for Diabetic Retinopathy

Imai, H.; Singh, R.S.J.; Fort, P.E.; Gardner, T.W. (Hershey, Pa.)

69VEGF Inhibitors and Vitrectomy for Diabetic Vitreoretinopathy

Cury Jr, C.E.; Rodrigues, E.B. (Sao Paulo); Meyer, C.H. (Bonn); Farah, M.E. (Sao Paulo)

V

Age-related Macular Degeneration

82Tissue Plasminogen Activator-Assisted Vitrectomy: Surgical Drainage of Submacular Hemorrhage

Kamei, M.; Tano, Y. (Suita) Retinopathy of Prematurity

89Anti-Angiogenic Therapy in the Management of Retinopathy of Prematurity

Drenser, K.A. (Royal Oak, Mich./Rochester, Mich.)

98Author Index

99Subject Index

VI

Contents

Section Title

List of Contributors

Paul N. Bishop

Steven K. Fisher

University of Manchester

Neuroscience Research Institute

Manchester Royal Eye Hospital

University of California

Oxford Road

Santa Barbara, CA 93106-5060 (USA)

Manchester M13 9WH (UK)

 

David G. Charteris

Patrice E. Fort

Penn State Hershey Eye Center and

Moorfields Eye Hospital

Department of Cellular and Molecular

City Road

Physiology

London EC1V 2PD (UK)

Penn State College of Medicine

Carlos E. Cury, Jr.

500 University Drive, HU097

Hershey, PA 17033 (USA)

Vision Institute, Department of Ophthalmology

Arnd Gandorfer

Federal University of Sao Paulo

Rua Presidente Coutinho 579

Vitreoretinal and Pathology Unit

conj 501

Augenklinik der Ludwig-Maximilians-

Florianópolis

Universität

SC 88015–300 (Brazil)

Mathildenstrasse 8

Kimberly A. Drenser

DE–80336 Munich (Germany)

Thomas W. Gardner

Eye Research Institute, University Oakland

3535 West 13 Mile Road, Suite 344

Penn State Hershey Eye Center and

Royal Oak, MI 48073 (USA)

Department of Cellular and Molecular

Kirsten H. Eibl

Physiology

Penn State College of Medicine

University Eye Hospital LMU

500 University Drive, HU097

Ludwig-Maximilians-University

Hershey, PA 17033 (USA)

Mathildenstr. 8

David T. Goldenberg

DE-80336 Munich (Germany)

Michel E. Farah

3535 W. 13 Mile Rd., Suite 344

Royal Oak, MI 48073 (USA)

Vision Institute, Department of Ophthalmology

 

Federal University of Sao Paulo

 

Rua Presidente Coutinho 579

 

conj 501

 

Florianópolis

 

SC 88015–300 (Brazil)

 

VII

Hisanori Imai

Eduardo B. Rodrigues

Penn State Hershey Eye Center and

Vision Institute, Department of Ophthalmology

Department of Cellular and Molecular

Federal University of Sao Paulo

Physiology

Rua Presidente Coutinho 579

Penn State College of Medicine

conj 501

500 University Drive, HU097

Florianópolis

Hershey, PA 17033 (USA)

SC 88015–300 (Brazil)

Motohiro Kamei

Ravi S.J. Singh

Department of Ophthalmology

Penn State Hershey Eye Center and

Osaka University Medical School

Department of Cellular and Molecular

2–2 Yamadaoka

Physiology

Suita, 565-0871 (Japan)

Penn State College of Medicine

Baruch Kuppermann

500 University Drive, HU097

Hershey, PA 17033 (USA)

UC Irvine Medical Center

Yasuo Tano

Ophthalmology Clinic

101 The City Drive South

Department of Ophthalmology

Orange, CA 92697 (USA)

Osaka University Medical School

Geoffrey P. Lewis

2–2 Yamadaoka

Suita, 565-0871 (Japan)

Neuroscience Research Institute

Michael T. Trese

University of California

Santa Barbara, CA 93106-5060 (USA)

3535 W. 13 Mile Rd., Suite 344

Carsten H. Meyer

Royal Oak, MI 48073 (USA)

Louisa Wickham

Department of Ophthalmology

University of Bonn

Moorfields Eye Hospital

Ernst-Abbe-Strasse 2

City Road

DE–53127 Bonn (Germany)

London EC1V 2PD (UK)

Raja Narayanan

 

Smt Kanuri santhamma Vitreoretina center

 

L.V. Prasad Eye Institute

 

L.V. Prasad Marg, Banjara Hills

 

Hyderabad 500034 (India)

 

VIII

List of Contributors

In memoriam of Professor Yasuo Tano, who suddenly passed away on

31 January 2009.