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Ординатура / Офтальмология / Английские материалы / Primary Care Ophthalmology_Palay, Krachmer_2005

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Therapeutic Medications

385

 

 

Table 17–16 Antiglaucoma Medications: Carbonic Anhydrase Inhibitors

Generic Name

Trade Name

Typical Dosage

Comments

 

 

 

 

Topical

 

 

 

Brinzolamide

Azopt (1%)

1 drop 3 times a day

Not as effective as oral preparations

Dorzolamide

Trusopt (2%)

1 drop 3 times a day

Not as effective as oral preparations

hydrochloride

Cosopt

1 drop twice a day

Combined with timolol maleate

 

Oral

 

 

 

Acetazolamide

Diamox

250 mg tablet 4 times a day

Numerous systemic side effects

 

Diamox Sequel

500 mg tablet 2 times a day

Slightly better tolerated

Methazolamide

Neptazane

50 mg tablets 2 times a day

Not as effective as Diamox but

 

 

 

appears to be better tolerated by

 

 

 

some patients

 

 

 

 

Prostaglandins. This newer class of agents is used to treat open-angle glaucoma and ocular hypertension. The mechanism of action is to increase uveoscleral outflow, thus reducing intraocular pressure. The most common side effects are hyperemia, an increase in iris pigmentation, and lash growth. These agents have become heavily prescribed, even as monotherapy, due to lack of autonomic side effects and once-daily dosing.

Table 17–17 Antiglaucoma Medications: Prostaglandins

Generic Name

Trade Name

Typical Dosage

 

Comments

 

 

 

 

 

Bimatoprost

Lumigan (0.03%)

1 drop daily (evening)

}

Note effects on iris color,

Latanoprost

Xalatan (0.005%)

1 drop daily (evening)

lashes

Travoprost

Travatan (0.004%)

1 drop daily (evening)

 

Unoprostone

Rescula (0.15%)

1 drop 2 times a day

 

Not as efficacious

 

 

 

 

 

Hyperosmotic Agents. Given systemically, hyperosmotic agents increase the osmolality of the blood. This creates an osmotic gradient between the intravascular space and vitreous cavity and effectively pulls fluid from the vitreous into the bloodstream. These medications are used to acutely lower the intraocular pressure in an attack of angle-closure glaucoma and to reduce eye pressure for certain ocular procedures.

Table 17–18 Antiglaucoma Medications: Hyperosmotic Agents

Generic Name

Trade Name

Typical Dosage

Comments

 

 

 

 

Glycerin

Osmoglyn (50%)

1-1.5 g/kg

Antiemetic often required to

 

 

 

prevent side effect of vomiting

Mannitol

Osmitrol (5%-20%)

0.5-2 g/kg

Intravenous drug; adult dose ranges

 

 

 

from 20 to 200 g/24 hr

 

 

 

 

386 CHAPTER 17 • Guide to Ophthalmic Medications

Agents for Relief of Allergy Symptoms (Seasonal Allergic Conjunctivitis)

Ocular allergy encompasses a broad spectrum of diseases characterized by a marked type I hypersensitivity response. Exposure to environmental allergens such as animal dander, pollens, and dust can cause symptoms in sensitized individuals. An allergic response is typically characterized by conjunctival injection, chemosis (swelling of the conjunctiva), tearing, eyelid swelling, burning, and ocular and periocular itching. Treatment of allergic ocular disease ideally entails removing the offending agent or modifying the patient’s environment and treating the patient topically to provide symptomatic relief.

Table 17–19 Agents for Relief of Allergy Symptoms

Generic Name

Trade Name

Typical Dosage

Mechanism of Action

 

 

 

 

Azelastine hydrochloride

Optivar

1 drop 2 times a day

Histamine H1 antagonist

Cromolyn

Crolom

1 drop 4 times a day

Mast cell inhibitor

Emedastine difumurate

Emadine

1 drop up to 4 times

H1 antagonist

 

 

a day

 

Epinastine hydrochloride

Elestat

1 drop 2 times a day

Antihistamine and mast cell stabilizer

Ketorolac

Acular

1 drop 4 times a day

NSAID

Ketotifen

Zaditor

1 drop 2 times a day

Antihistamine and mast cell stabilizer

Levocabastin

Livostin

1 drop 4 times a day

H1 antagonist

Lodoxamide

Alomide

1 drop 4 times a day

Mast cell inhibitor

Naphazoline/antazoline

Vasocon-A

1 drop 4 times a day

Antihistamine/decongestant

Naphazoline/pheniramine

Naphcon-A

1 drop 4 times a day

Antihistamine/decongestant

 

Opcon-A

 

 

Nedocromil

Alocril

1 drop 2 times a day

Mast cell stabilizer

Olopatadine hydrochloride

Patanol

1 drop 2 times a day

Antihistamine and mast cell stabilizer

Pemirolast potassium

Alamast

1 drop 4 times a day

Mast cell stabilizer

 

 

 

 

NSAID, nonsteroidal anti-inflammatory drug.

Index

Note: Page numbers followed by f refer to figures (illustrations); page numbers followed by t refer to tables.

A

Aging—cont’d

Anterior chamber of eye—cont’d

 

Abducens nerve (sixth cranial nerve), 7,

and loss of lens elasticity, 128

inflammatory cells in

222

and macular degeneration, 173-176,

as postoperative finding, 181, 182f

Abducens nerve (sixth cranial nerve)

174f, 175f

as sign of corneal ulcer, 111, 112f

palsy, 32, 222-223

and thinning of orbital septum, 67

as sign of uveitis, 141, 142f

signs of, 222, 222f

AIDS (acquired immunodeficiency

shallow, penlight demonstration of,

Abrasion, of cornea, 331-333, 332f

syndrome), 298

194f

due to conjunctival foreign body,

ocular lesions associated with, 177,

slit lamp examination of, 13

331, 339, 339f

298, 299f

Anterior ischemic optic neuropathy,

Abscess. See Cellulitis.

Alkali injury, to eye, 349f, 349-350,

201-205

Abuse (child abuse), ocular signs of,

350f

arteritic, 203-205, 204f

261-262, 262f

Allen figures, in vision testing of

nonarteritic, 201-203, 202f

Acanthamoeba infection, keratitis due to,

children, 236, 236f

Anterior scleritis, 47f, 121, 121f, 122f

44f

Allergic conjunctivitis, 58, 58f, 59f, 96,

Anterior uveitis, 140-145

Accommodation, 127, 129f

97f

ankylosing spondylitis and, 141f,

age-related changes in, 30, 230,

treatment of, 59, 96-97

293-294

230f

medications used in, 386t

Behçet’s disease and, 294

Accommodative esotropia, 268,

vs. other conjunctivitides, 36t

hypopyon accompanying, 141, 142f

269f

Alpha agonists, for glaucoma, 383, 383t

iridal nodules in, 142, 143f

Acid injury, to eye, 350

Amaurosis fugax, 30

keratic precipitates associated with,

Acquired immunodeficiency syndrome

Amblyopia, 269-271

141, 141f

(AIDS), 298

Amiodarone therapy, 317

synechiae as signs of, 141, 143f

ocular lesions associated with, 177,

ocular problems associated with, 317,

Antibiotic ocular medications, 375-378,

298, 299f

317f, 318

376t-378t, 381t

Acquired nystagmus, 226-227

Amsler grid testing, 10-11, 11f

Antifungal ocular medications, 379,

Actinic keratosis, 74

Anesthetics, 373

379t

eyelid involvement in, 74-75, 75f

Angiography, 153

Antiglaucoma medications, 194, 196,

Acuity (visual acuity), 2

Angioid streaks, in retina, 297

382-385, 383t-385t

measurement of, 2-4

Ehlers-Danlos syndrome and, 297,

Anti-inflammatory ocular medications,

Snellen charts in, 3f, 4f

297f, 298

380-381, 380t-382t

refractive power and, 4-6

Angle-closure glaucoma, 28, 39-40,

Antiviral ocular medications, 378,

Acute angle-closure glaucoma. See

195-197

379t

Angle-closure glaucoma.

treatment of, 196

Applanation tonometry, 14f, 14-15

Adenoviral conjunctivitis, 56

laser iridectomy in, 193f, 196

Aqueous humor

in children, 259-260

Anisocoria, 216-218

flow of, 189, 190f

Adie’s syndrome, 216, 217f

Ankylosing spondylitis, 293

blockage of. See Angle-closure

After-cataract, 136, 136f

anterior uveitis associated with, 141f,

glaucoma.

Aging

293-294

leakage of, Seidel test for, 344,

and cataract formation, 128-131,

Anterior chamber of eye, 1

344f

130f, 131f

blood in, 39, 40f, 353f, 353-355

Arcus, of cornea, 299, 299f

and changes in accommodation, 30,

impaired clearance of, in sickle cell

Arteritis, giant cell, 203-205

230, 230f

disease, 354

optic neuropathy in, 204, 204f

387

388

Index

 

 

 

 

Bowel disease, inflammatory, 301

 

Arthritis, rheumatoid, 308

Cellulitis

ocular problems associated with,

ocular lesions associated with, 301,

orbital, 48f, 279f, 279-281, 280f

 

308f, 308-309, 309f

301f

pediatric cases of, 263-264

Artificial tears, 106-107, 375t

Brain

preseptal, 49, 275-276, 278-279

Astigmatism, 5, 5f

infarct in, and visual loss, 27

pediatric cases of, 263-264

Atrophic (“dry”) age-related macular

tumor of, and visual loss, 29

Central retinal artery occlusion, 162,

 

degeneration, 29, 174, 174f,

Branch retinal artery occlusion, 162. See

162f. See also Retinal artery,

 

175

also Retinal artery, occlusion

occlusion of.

 

 

of.

Central retinal vein occlusion, 167,

B

 

Branch retinal vein occlusion, 167, 168,

167f, 168, 169

 

168f, 169

Chalazion, 50, 51f, 82-83

 

 

Bacterial conjunctivitis, 55, 55f, 91f, 92,

Buckling, scleral, in retinal surgery, 186,

in children, 266, 267

 

93f, 94

187f

Chemical injury, to eye, 348-351, 349f,

discharge associated with, 55, 55f,

Bull’s-eye maculopathy

350f

 

92, 92f, 93f

in patients receiving chloroquine,

Chemosis, allergen-induced, 96, 97f

pediatric cases of, 260

319, 319f

Cherry-rod spot, in fovea of retina, as

vs. other conjunctivitides, 36t

in patients receiving

sign of arterial occlusion, 17,

Bacterial corneal ulcer, 111, 112f, 113f

hydroxychloroquine, 325,

163, 163f

in contact lens wearers, 334, 335f

325f

Children. See Pediatric patients.

Basal cell carcinoma, of eyelid, 77f,

Burn(s), ocular, 348-353, 349f, 350f,

Chlamydial conjunctivitis, 56-57,

 

77-78

352f

94-95, 95f

Behçet’s disease, 294

Burning sensation, ocular, 34

laboratory findings in, 95, 96f

ocular lesions in, 294-295

Busacca nodules, 142, 143f

treatment of, 57-58, 95

Benign essential blepharospasm, 86-87,

 

vs. other conjunctivitides, 36t

 

87f

C

Chloroquine therapy, 318-319

Beta blockers, for glaucoma, 382,

ocular problems associated with, 319,

 

 

383t

Calcium accumulation, on cornea, 115,

319f

Binocular diplopia, causes of, 31-33

115f

Cholinergics, for glaucoma, 383, 384t

Blepharitis, 34, 51, 79-81, 98f

Canalicular injury, 361, 362t

Choroid, 2, 139, 140f

conjunctivitis and, 97-98

Canaliculitis, 284f, 284-285

Chronic conjunctivitis, in children, 260

facial sebaceous gland dysfunction

Carbonic anhydrous inhibitors, for

Cialis (tadalafil) therapy, 327

 

(rosacea) and, 98, 98f

glaucoma, 384, 385t

ocular effects of, 328

infection and, 51, 52f, 80, 80f, 84,

Carcinoma, of eyelid, 77f, 77-79, 79f

Ciliary body, 2, 139, 140f

 

85f

Carotid artery–cavernous sinus fistula,

Ciliary muscle paralysis, agents

meibomian gland dysfunction and,

223-224

inducing, 374, 374t

 

51, 52f, 81

red eye associated with, 65, 65f,

Coloboma, 254-255, 255f

pediculosis and, 52, 53f

224f

Color vision, 11-12

seborrheic, 51, 51f, 80, 80f

Cataract(s), 29

Confrontation visual field test, 10, 11f

Blepharospasm, 86-87, 87f

congenital, 245-246

Congenital eye anomalies, 245-259

Blindness. See Visual loss.

and leukocoria, 245, 246f

Conjunctiva(e), 89, 90f. See also

Blood cells, in anterior chamber of eye,

cortical, 130, 130f

Conjunctivitis.

 

39, 40f, 353f, 353-355

dense white, 131, 131f

chemosis of, allergen-induced, 96,

impaired clearance of, in sickle cell

diabetes mellitus and, 296, 296f

97f

 

disease, 354

laser therapy for, 136, 137f

examination of, 7, 13

Blood loss. See Hemorrhage.

nuclear, 130, 130f

foreign body in, 339f, 339-341

Blow-out fracture, orbital, 33, 363-365,

posterior subcapsular, 131, 131f

corneal abrasion due to, 331, 339,

 

364f

senile, 128-131, 130f, 131f

339f

Blue sclera(e)

surgery for, 132-136, 133f-135f

growth(s) on or in, 60-62, 62f,

in Ehlers-Danlos syndrome, 297f

opacification following, 136-137

98-102, 99f-101f

in osteogenesis imperfecta, 306, 306f

traumatic, 359f

extension of, onto cornea, 61, 62f,

Botox therapy, 318

Wilson’s disease and, 316

113, 114f

management of blepharospasm via,

Cavernous sinus, fistula between carotid

HIV infection and, 298, 299f

 

87

artery and, 223-224

hemorrhagic discoloration of, 337f,

ocular problems associated with,

red eye associated with, 65, 65f,

337-339

 

318

224f

laceration and, 341, 341f

 

 

Index

389

 

 

 

 

Conjunctiva(e)—cont’d

Contusion, periorbital/ocular, 329-330,

Cornea—cont’d

 

inflammation of. See Conjunctivitis.

330f

refractive surgery of, 116, 117f

 

injection (congestion) of

Copper deposition, sites and signs of,

ring in

 

as manifestation of infection, 89,

in Wilson’s disease, 316, 316f

as sign of embedded iron foreign

90f, 92f, 95f

Cornea, 1, 103, 104f

body, 63, 64f

 

as sign of uveitis, 141, 141f

abrasion of, 331-333, 332f

as sign of Wilson’s disease, 316,

laceration of, 341f, 341-342

due to conjunctival foreign body,

316f

 

scarring of, in Stevens-Johnson

331, 339, 339f

scarring of

 

syndrome, 312, 312f

arcus of, 299, 299f

from herpes simplex virus

 

slit lamp examination of, 13

calcium accumulation on, 115, 115f

infection, 108f

 

Conjunctivitis, 35, 36t, 54-58, 89-98

chemical injury to, 349f, 350f

from herpes zoster ophthalmicus,

adenoviral, 56

clouding of, mucopolysaccharidosis

109f

 

in children, 259-260

and, 303, 303f

in Stevens-Johnson syndrome,

 

allergic, 58, 58f, 59f, 96, 97f

contact lens injury to, 40, 43f,

312, 312f

 

treatment of, 59, 96-97

333-335, 334f, 335f

slit lamp examination of, 13

 

medications used in, 386t

copper deposition in, 316

thermal injury to, 351, 352, 352f

 

vs. other conjunctivitides, 36t

cysts of, in patients receiving

thickness of, 105f

 

bacterial, 55, 92, 94

cytosine arabinoside, 321,

glaucoma risk in relation to, 191

discharge associated with, 55, 55f,

321f

transplantation of, 116

 

92, 92f, 93f

drying of. See Dry eye.

sutures used in, 116, 116f

 

pediatric cases of, 260

dystrophies of, 273

ulcer of, 28

 

vs. other conjunctivitides, 36t

erosion of, recurrent, 28, 62, 63f,

bacterial infection and, 111, 112f,

blepharitis and, 97-98

114f, 114-115

113f

 

chlamydial, 56-57, 94-95, 95f

examination of, 13

in contact lens wearers, 334,

laboratory findings in, 95, 96f

excess exposure of, 326

335f

 

treatment of, 57-58, 95

myotonic dystrophy and, 304,

fungal infection and, 111, 113f

vs. other conjunctivitides, 36t

304f

herpes simplex virus infection and,

chronic, in children, 260

extension of conjunctival growth

44f

 

drug allergy and, 58, 59f

onto, 61, 62f, 113, 114f

Pseudomonas infection and, in

 

eye-rubbing and, 59

foreign body in or on, 63, 64f,

contact lens wearers, 334,

herpes simplex virus infection and,

342-345

335f

 

36t

movement of, under contact lens,

rheumatoid arthritis and, 308,

 

in children, 260

334f

309f

 

molluscum contagiosum and, 60, 61f

glue injury to, 358f

ultraviolet radiation injury to, 332f,

Neisseria gonorrhoeae infection and, 48,

hyopic injury to, from contact lens,

336

 

49f, 92, 93f

333

vascularization of

 

in infants, 239, 240, 240f

infectious lesions of, 40, 43f, 44f,

blepharoconjunctivitis and, 97, 97f

Neisseria meningitidis infection and, 92

107-112

herpes simplex virus infection and,

pediatric cases of, 56, 238-240, 240f,

in contact lens wearers, 334, 335f

107, 108f

 

259-261

infiltrates in

verticillate lines on, in patients using

vernal, 58, 58f

infectious ulcer and, 111, 112f

amiodarone, 317, 317f

 

in children, 260

subepithelial, secondary to viral

Cortical cataract, 130, 130f

 

viral, 55-56, 89, 90f, 91, 91f

conjunctivitis, 91, 92f

Corticosteroids

 

follicular lesions in, 55, 55f, 91,

inflammation of, 44f, 107-108, 108f

as anti-inflammatory agents, 380,

91f

Wegener’s granulomatosis and,

380t, 381

 

pediatric cases of, 259-260

315, 315f

as source of ocular problems, 320

subepithelial corneal infiltrates

laceration of, 345-347, 346f

Cotton-wool spots, on retina, 152,

 

associated with, 91, 92f

opacity of, white, 255-257

152f, 167f

 

vs. other conjunctivitides, 36t

precipitates on

in AIDS patients, 298

 

vs. nasolacrimal duct obstruction, in

in iritis, 46f

Cranial nerve palsies. See ordinal cranial

infants, 241, 242f

in sarcoidosis, 309, 310f

nerve entries, e.g., Third cranial

Contact dermatitis, 86

in syphilis, 313f

nerve (oculomotor nerve)

 

eyelid involvement in, 85-86, 86f

in uveitis, 141, 142f

palsy.

 

Contact lens injury, 40, 43f, 333-335,

recurrent erosion of, 28, 62, 63f,

Craniopharyngioma, chiasmal

 

334f, 335f

114f, 114-115

compression by, 215f

 

390 Index

Crystalline deposition, retinal, in patients using tamoxifen, 326, 327f

Crystalline lens, 1, 127, 128f accommodation by, 127, 129f

age-related changes in, 30, 230, 230f

copper deposition in, 316 examination of, 13

loss of elasticity of, with aging, 128 opacity of. See Cataract(s). subluxation of

syndrome-associated occurrence of, 302, 302f, 373

traumatic, 330f

Cupping, of optic disc, in glaucoma, 189, 191f

Cycloplegics, 374, 374t Cyst(s)

corneal, in patients receiving cytosine arabinoside, 321, 321f

epithelial inclusion, of eyelid, 76f, 76-77

Cytarabine (cytosine arabinoside) therapy, 320

ocular abnormalities correlated with, 321, 321f

Cytomegalovirus infection, retinitis due to, 177-180, 178f

Cytosine arabinoside (Cytarabine) therapy, 320

ocular abnormalities correlated with, 321, 321f

D

Dacryoadenitis, 282-283, 283f, 291, 291f

Dacryocele, in infants, 243, 243f Dacryocystitis, 49, 49f, 281-282,

282f

Degeneration, macular, 26, 29 age-related, 173-176

drusen in, 174, 174f, 175f retinal hemorrhage in, 175, 175f

Dense white cataract, 131, 131f Dermatitis, eyelid involvement in,

84-86, 85f, 86f Dermatomyositis, 295

ocular problems associated with, 295, 295f

Dermoid

corneal, 256, 256f

eyebrow area as site of, 257f

Descemet’s membrane, 103 copper deposition in, 316

Detachment

posterior vitreous, 183 retinal, 26, 183-185

diabetes mellitus and, 155, 155f surgery for, 186

scleral buckling in, 186, 187f tear leading to, 183, 184f

Diabetes mellitus, 296

cataract as complication of, 296, 296f

macular edema associated with, 157-159, 158f

retinopathy in, 153-157 extra-retinal neovascularization

characterizing, 154, 154f complications associated with,

154, 155, 155f Diagnostic medications, 373-374

Diffuse anterior scleritis, 47f, 121, 121f Digoxin toxicity, ocular symptoms of,

321-322 Diplopia, 31

causes of, 31-33 Dislocation, of lens

syndrome-associated occurrence of, 273, 302, 302f

traumatic, 330f Distance acuity chart, 3f

Distorted vision (metamorphopsia), 30 Double vision, 31

causes of, 31-33

Droopy eyelids. See Eyelid(s), drooping of.

Drug allergy, and conjunctivitis, 58, 59f Drug-induced ocular lesions, 317-328 Drusen, 174, 174f, 175f, 211, 212f “Dry” (atrophic) age-related macular

degeneration, 29, 174, 174f, 175

Dry eye, 54, 54f, 103-107, 105f, 106f

artificial tears for, 106-107, 375t punctal plugs in treatment of, 107,

107f

severe, in patients with Sjögren syndrome, 40, 41f, 42f

tear test for, 18, 106 Dystrophy(ies)

corneal, 273 myotonic, 303, 304

ocular lesions associated with, 303-304, 304f

retinal, 273

E

Ectropion, 52, 53f, 67-68, 69f Edema

macular, diabetes mellitus and, 157-159, 158f

optic disc, 208, 209f, 210, 266f Ehlers-Danlos syndrome

angioid streaking of retina in, 297, 297f, 298

blue sclera(e) in, 297f Embolus (emboli), retinal artery

occlusion by, 162, 163f, 164, 165, 165f

treatment of, 166 Emmetropia, 4, 5f Endophthalmitis, 28, 140

endogenous, 183

foreign body as cause of, 45, 47f, 182, 182f

postoperative, 181 trauma and, 182

Entropion, 52, 53f, 68, 69, 70f Epidemic keratoconjunctivitis, 56, 57f Epiretinal membrane, 185f, 185-186 Episclera, 119

Episcleritis, 42, 46f, 120-124, 121f lupus erythematosus and, 314, 314f

Epithelial cyst(s)

of cornea, in patients receiving cytosine arabinoside, 321, 321f

of eyelid, 76f, 76-77

Erectile dysfunction, drugs for, 327 ocular effects of, 328

Erosion, corneal, recurrent, 28, 62, 63f, 114f, 114-115

Erythema, of eyelid(s), 35

in viral conjunctivitis, 89, 91f Erythema multiforme, 311

ocular lesions associated with, 311-312, 312f

Esodeviation, 8, 10f Esotropia, 234, 235f, 267, 268

accommodative, 268, 269f congenital, 251-252

Essential blepharospasm, 86-87, 87f Ethambutol-induced visual loss, 322 Exodeviation, 8, 10f Exophthalmometry, 19, 20f Exophthalmos (proptosis), 37t

thyroid disease and, 285, 285f, 286f

Exotropia, 234, 235f, 267, 268 congenital, 251-252

 

 

Index

391

Exposure, excessive, of cornea, 326

Eyelid(s)—cont’d

 

 

Fourth cranial nerve (trochlear nerve)

myotonic dystrophy and, 304, 304f

molluscum contagiosum on, 83-84,

palsy, 32, 220-222

 

Extracapsular cataract extraction, 134

84f

signs of, 220, 221f

 

Extraocular muscles, 7, 9f, 277f

port-wine stain on, 250

Fovea of retina, 150. See also Macula.

Exudative (“wet”) age-related macular

seborrheic keratoses on, 73-74,

cherry-rod spot in, as sign of arterial

degeneration, 26, 174, 175,

74f

occlusion, 17, 163, 163f

 

175f, 176

spasm of, 86-87, 87f

Fracture, orbital, 33, 363-365, 364f

 

Eye(s). See Ocular entries and structure-

squamous cell carcinoma of, 78-79,

Funduscopy, 15-17

 

specific citations.

79f

color and structural details on, 16,

Eyedrop-related hazards, 20-21

swelling of, 35

17, 149, 150, 150f, 151f

 

Eyelash(es), rubbing of, against globe,

turning in of, 52, 53f, 68, 69, 70f

Fungal corneal ulcer, 111, 113f

 

52, 54f, 70, 71f

turning out of, 52, 53f, 67-68, 69f

 

 

Eyelid(s), 67, 68f, 69f

twitching of, 35

G

 

actinic keratoses on, 74-75, 75f

xanthomas on, 75-76, 76f

 

 

 

basal cell carcinoma of, 77f, 77-78

 

Giant cell arteritis, 203-205

 

carcinoma of, 77f, 77-79, 79f

F

optic neuropathy in, 204, 204f

 

contact dermatitis involving, 85-86,

Glaucoma, 189-197

 

 

 

86f

Facial nerve (seventh cranial nerve)

angle-closure, 28, 39-40, 195-197

cyst of, 76f, 76-77

palsy, as factor in

treatment of, 196

 

dermatitis involving, 84-86, 85f, 86f

lagophthalmos, 71, 71f

laser iridectomy in, 193f, 196

drooping of, 37t, 67, 72, 72f

and dry eye, 106f

congenital, 248-249

 

congenital, 247f, 247-248

Farsightedness (hyperopia), 5, 5f

medications for, 194, 196, 382-385,

third cranial nerve palsy and, 67,

Fields of vision, 10

383t-385t

 

219, 219f

effects of glaucoma on, 189, 192f

neovascular, 154

 

epithelial inclusion cyst of, 76f,

flashes in, 30

open-angle, 29, 190-195

 

76-77

relation between defects in, and

treatment of, 194-195

 

erythema of, 35

lesions of optic nerve or optic

filtering bleb in, 195, 195f

 

in viral conjunctivitis, 89, 91f

chiasm, 199, 200f, 201

optic disc cupping in, 189, 191f

 

examination of, 7, 8f, 11

testing of, 10-11, 11f, 20, 21f

pupillary dilation in, 41f, 196f

 

eversion and, 7, 8f, 60f

Fistula, carotid artery–cavernous sinus,

retinal vein occlusion and, 168

 

floppy, 72-73, 73f

223-224

risk of, in relation to corneal

 

glue injury to, 357, 358

red eye associated with, 65, 65f,

thickness, 191

 

heliotrope discoloration of, in

224f

visual fields in, 189, 192f

 

patients with

Fixation, assessment of, in pediatric

Glue injury

 

dermatomyositis, 295, 295f

patients, 234, 234f

to cornea, 358f

 

hemangioma of, in infants, 249, 249f

Flashes, in visual fields, 30

to eyelids, 357, 358

 

herpes simplex virus dermatitis

Flashlight test, of pupillary function,

Gonioscopy, 18, 18f

 

involving, 84-85, 85f

6-7

Gonococcal infection, and

 

inflammation of, 35, 51, 79-81, 98f

Floaters, 31

conjunctivitis, 48, 49f, 92,

conjunctivitis and, 97-98

Floppy eyelid syndrome, 72-73, 73f

93f

 

facial sebaceous gland dysfunction

Fluorescein stain, 153, 373

in infants, 239, 240, 240f

 

(rosacea) and, 98, 98f

Foreign body

Granulomatosis, Wegener’s, 315

 

infection and, 51, 52f, 80, 80f, 84,

conjunctival, 339f, 339-341

ocular lesions associated with, 315f,

85f

abrasion of cornea by, 331, 339,

315-316

 

meibomian gland dysfunction and,

339f

Granulomatous uveitis, sarcoidosis and,

51, 52f, 81

corneal, 63, 64f, 342-345

309, 310f

 

pediculosis and, 52, 53f

movement of, under contact lens,

 

 

seborrhea and, 51, 51f, 80, 80f

334f

H

 

keratoses on, 73-75, 74f, 75f

intraocular, 45, 182f, 358-361, 359f,

 

 

 

laceration of, 361-363, 362f

360f

Halos, around lights, perception of,

louse infestation of, 52, 53f

endophthalmitis associated with,

31

 

meibomian glands of, 67, 69f

45, 47f, 182

Headache

 

lesions due to blockage or

Foreign body sensation, 34

migraine, 265

 

dysfunction of, 50, 51, 51f,

Fourth cranial nerve (trochlear nerve),

visual symptoms of, 30

 

52f, 81, 82, 83f

7, 220

pediatric cases of, 264-265

 

392

 

Index

 

 

 

 

 

 

Heliotrope discoloration, of eyelid, in

Hyperlipidemia, ocular lesions

Intraepithelial neoplasia, conjunctival,

 

 

patients with

associated with, 299f,

99-100, 100f

 

 

dermatomyositis, 295, 295f

299-300

Intraocular pressure

Hemangioma, in infants, 249f, 249-250

Hyperopia (farsightedness), 5, 5f

measurement of, 14f, 14-15, 15f,

Hemorrhage. See also Hyphema.

Hyperosmotic medications, for

191-192

retinal, 17, 152-153

glaucoma, 385, 385t

normal to high, in glaucoma. See

 

cytomegalovirus infection and,

Hypertension

Glaucoma.

 

 

178, 178f

intracranial, 208, 210

Intrauterine infections, and ocular

 

macular degeneration and, 175,

and headache, in children, 265

pathology, 245

 

 

175f

and papilledema, 208, 209f, 266f

Involutional ectropion, 68, 69f

 

posterior uveitis and, 146, 146f

systemic, and retinopathy, 159-161,

Involutional entropion, 53f, 68, 70f

 

Roth spot, 176-177, 177f

300

Iridectomy, via laser, for glaucoma,

 

shaken baby syndrome and, 261,

with arteriolar narrowing, 159,

193f, 196

 

 

262f

160, 160f

Iridodonesis, in Marfan syndrome, 302

 

sickle cell disease and, 170, 170f

Hypertropia, 269

Iris (irides), 1, 139, 140f. See also Iritis.

 

venous occlusion and, 167, 167f,

Hyphema, 39, 353, 353f. See also

differences between colors of,

 

 

168f

Hemorrhage.

258-259

retrobulbar, 356-357

impaired clearance of, in sickle cell

examination of, 13

subconjunctival, 60, 61f, 337f,

disease, 354

neovascularization of, in diabetic

 

337-339

traumatic, 39, 40f, 353-355

retinopathy, 154, 154f

 

around conjunctival laceration,

Hypopyon

nodules on

 

 

341, 341f

corneal ulcer and, 111, 112f

in anterior uveitis, 142, 143f

vitreous, 26, 186

postoperative occurrence of, 181,

in neurofibromatosis, 305, 305f

Herpes simplex virus infection

182f

tremulousness of, in Marfan

and blepharitis, 84, 85f

uveitis and, 141, 142f

syndrome, 302

and conjunctivitis, 35t

 

Iritis, 40, 45f, 46f

 

in children, 260

I

pediatric cases of, 260

and dermatitis, 84

traumatic, 355-356

 

 

eyelid involvement in, 84-85,

Idiopathic intracranial hypertension

Ischemic optic neuropathy, 27,

 

 

85f

(pseudotumor cerebri), 208,

201-205

and iritis, 40, 45f

210

anterior, 201-205

and keratitis, 107-108, 108f

papilledema associated with, 208,

arteritic, 203-205, 204f

and ulceration of cornea, 44f

209f

nonarteritic, 201-203, 202f

Herpes zoster ophthalmicus, 108-111,

In situ keratomileusis, via excimer laser,

Isoniazid-induced visual loss, 323

 

 

109f, 110f

116, 117f

Itching, of eyes, 34

HIV infection and, 298

Inclusion cyst, of eyelid, 76f, 76-77

 

Hertel exophthalmometry, 19, 20f

Indocyanine green angiography, 153

K

Heterochromia iridis, 258-259

Infants. See Pediatric patients.

 

HIV (human immunodeficiency virus)

Inflammatory bowel disease, 301

Kaposi’s sarcoma, on conjunctiva, 298,

 

 

infection, 298

ocular lesions associated with, 301,

299f

ocular lesions associated with, 177,

301f

Kayser-Fleischer ring, 316, 316f

 

 

298, 299f

Inflammatory cells

Keratic precipitates

Hordeolum (stye), 50, 50f, 81-82, 82f

in anterior chamber of eye

in iritis, 46f

in children, 266-267

as postoperative finding, 181, 182f

in sarcoidosis, 309, 310f

Horner syndrome, 218, 218f

as sign of corneal ulcer, 111, 112f

in syphilis, 313f

Human immunodeficiency virus (HIV)

in anterior chamber of eye or

in uveitis, 141, 141f, 142f

 

 

infection, 298, 299f

vitreous, as sign of uveitis,

Keratitis

ocular lesions associated with, 177,

141, 142f, 145, 146f

infection and, 44f, 107-108, 108f

 

 

298, 299f

Inherited ocular dystrophies, in

Wegener’s granulomatosis and, 315,

Hutchinson’s sign, 108-109, 109f

pediatric patients, 273

315f

Hydroxychloroquine (Plaquenil)

Inherited pigmentary retinopathy,

Keratoconjunctivitis, epidemic, 56,

 

 

therapy, 324

171-173, 172f

57f

ocular toxicity of, 324-326, 325f

Intracranial hypertension, 208, 210

Keratoconjunctivitis sicca. See Dry eye;

Hyopic injury, to cornea, from contact

and headache, in children, 265

Sjogren syndrome.

 

 

lens, 333

and papilledema, 208, 209f, 266f

Keratomileusis, laser in situ, 116, 117f

 

 

Index

393

 

 

 

 

Keratosis

Lupus erythematosus, systemic, 314

Myasthenia gravis, 33

 

actinic, 74

ocular lesions associated with, 314,

ocular, 33, 225f, 225-226

 

eyelid involvement in, 74-75, 75f

314f

Mydriatics, 374, 374t

 

seborrheic, eyelid involvement in,

Luxation, of lens

Myopia (nearsightedness), 4-5, 5f

 

73-74, 74f

syndrome-associated occurrence of,

severity of, risk of vitreous

 

Koeppe nodules, 142, 143f

273, 302, 302f

detachment correlated with,

 

traumatic, 330f

183

 

L

 

syndrome-associated occurrence of,

M

273

 

 

 

Laceration

Myositis, orbital, 290, 290f

 

 

 

of conjunctiva, 341f, 341-342

Macula, 151

Myotonic dystrophy, 303, 304

 

of cornea, 345-347, 346f

bull’s-eye appearance of

ocular lesions associated with,

 

of eyelid, 361-363, 362f

in patients receiving chloroquine,

303-304, 304f

 

of sclera, 347f, 347-348

319, 319f

 

 

Lacrimal apparatus, 275, 277f, 278f. See

in patients receiving

N

 

also Nasolacrimal duct entries

hydroxychloroquine, 325,

 

 

 

and citations beginning with the

325f

Nasolacrimal duct, 275

 

prefix Dacryo-.

degeneration of, 26, 29

Nasolacrimal duct obstruction, 48-49,

dye test of, 18-19

age-related, 173-176

281

 

Lagophthalmos, 70-71, 71f

drusen in, 174, 174f, 175f

pediatric cases of, 241f, 241-244

 

and dry eye, 106f

retinal hemorrhage in, 175, 175f

treatment of, 242-244, 243f

 

Large pupil, discrepant in size from

edema of, in diabetic patients,

vs. congenital glaucoma, 248

 

other pupil, 36, 216-218

157-159, 158f

vs. conjunctivitis, 241, 242f

 

Laser in situ keratomileusis, 116, 117f

Marfan syndrome, 302

Near acuity chart, 4f

 

Laser therapy

ocular lesions associated with, 302,

Nearsightedness (myopia), 4-5, 5f

 

for cataract, 136, 137f

302f

severity of, risk of vitreous

 

for glaucoma, 193f, 194, 196

Meibomian glands, 67, 69f

detachment correlated with,

for refractive error, 116, 117f

lesions due to blockage or

183

 

Leber’s optic neuropathy, 211

dysfunction of, 50, 51, 51f,

syndrome-associated occurrence of,

Lens (contact lens), injury from, 40,

52f, 81, 82, 83f

273

 

43f, 333-335, 334f, 335f

Melanoma, conjunctival, 101f

Necrotizing scleritis, 122, 122f

 

Lens (crystalline lens), 1, 127, 128f

Melanosis, racial, 102

rheumatoid arthritis and, 308, 308f

accommodation by, 127, 129f

conjunctival lesion associated with,

Wegener’s granulomatosis and,

 

age-related changes in, 30, 230,

101f, 102

315f

 

230f

Mellaril (thioridazine) toxicity, and

Neisseria gonorrhoeae infection, and

 

copper deposition in, 316

pigmentary retinopathy, 323,

conjunctivitis, 48, 49f, 92,

examination of, 13

324f

93f

 

loss of elasticity of, with aging, 128

Metamorphopsia (distorted vision), 30

in infants, 239, 240, 240f

 

opacity of. See Cataract(s).

Migraine, 265

Neisseria meningitidis infection, and

 

subluxation of

visual symptoms of, 30

conjunctivitis, 92

 

syndrome-associated occurrence

Molluscum contagiosum, 83

Neovascular glaucoma, 154

 

of, 302, 302f, 373

conjunctivitis associated with, 60,

Neovascularization, of optic disc and

traumatic, 330f

61f

iris, in diabetic retinopathy,

Leukocoria, congenital cataract and,

eyelid involvement in, 83-84, 84f

154, 154f

 

245, 246f

HIV infection and, 298

complications associated with, 154,

Leukoma, 255-257

Monocular diplopia, causes of, 32

155, 155f

 

Levitra (vardenafil) therapy, 327

Motor system problems, and neuro-

Nerve, optic. See Optic nerve entries and

ocular effects of, 328

ophthlamic disorders,

Optic disc.

 

Lice, infestation of eyelids by, 52, 53f

218-227

Nerve fiber layer, of retina, 152, 152f

Light(s)

Mucopolysaccharidoses, 302-303

Nerve palsies. See ordinal cranial nerve

 

intolerance of, 31

ocular lesions associated with, 303,

entries, e.g., Third cranial nerve

perception of halos around, 31

303f

(oculomotor nerve) palsy.

 

Lisch nodules, 305, 305f

“Mutton-fat” keratic precipitates

Neurofibromatosis, 304

 

Louse infestation, of eyelids, 52, 53f

in sarcoidosis, 309, 310f

ocular lesions associated with, 305,

Lubricant tears, artificial, 106-107, 375t

in uveitis, 141, 142f

305f

 

394

Index

 

 

 

 

 

Peaked (teardrop) pupil, 254, 255f,

Neuro-ophthalmic disorders, 199-227

Oculomotor nerve (third cranial nerve)

disc pathology in, 201. See also Optic

palsy, 32, 219-220

346, 346f

 

nerve disorders.

and ptosis, 67, 219, 219f

Pediatric patients, 229

motor system problems and,

Open-angle glaucoma, 29, 190-195

amblyopia in, 269-271

 

218-227

treatment of, 194-195

cataracts in, 245-246

sensory pathway problems and, 199,

filtering bleb in, 195, 195f

chalazion in, 266-267

 

200f, 201

Ophthalmoscopy. See Funduscopy.

coloboma in, 254-255

Nevus (nevi), conjunctival, 100, 101f

Optic chiasm, lesions of, 213, 215f,

congenital eye anomalies in, 245-259

Night blindness, 30

215-216

conjunctivitis in, 56, 238-240, 240f,

Nodular anterior scleritis, 47f, 121,

visual field defects due to, 201

259-261

 

122f

Optic disc, 201

esotropia in, 251, 252, 267, 268

Nodular episcleritis, 121f

cupping of, in glaucoma, 189, 191f

exotropia in, 251, 252, 267, 268

Nodule(s)

edema of, 208, 209f, 210, 266f

glaucoma in, 248-249

iridal

neovascularization of, in diabetic

headache in, 264-265

 

in anterior uveitis, 142, 143f

retinopathy, 154, 154f, 155f

hemangioma in, 249-250

 

in neurofibromatosis, 305, 305f

pallor of, 211

heterochromia iridis in, 258-259

sarcoid, ocular, 309, 310f

Optic nerve, 2, 149

hordeolum (stye) in, 266-267

Nonarteritic anterior ischemic optic

Optic nerve disorders, 201-213

inherited ocular dystrophies in,

 

neuropathy, 201-203,

correlation between visual field

273

 

202f

defects and, 199, 200f

iritis in, 260

Nonsteroidal anti-inflammatory ocular

disc pathology in, 201. See also specific

leukoma in, 255-257, 256f

 

medications, 381, 381t

abnormalities under Optic disc.

nasolacrimal duct obstruction in,

Nuclear cataract, 130, 130f

infiltrative, 210, 211

241f, 241-244, 248

Nystagmus

inflammmatory, 27, 205-208, 207f

nystagmus in, 252-254

acquired, 226-227

ischemic, 27, 201-205, 202f, 204f

ocular disorders in, 238-273

pediatric cases of, 252-254

neoplastic, 213, 214f

ocular examination in, 230-238

 

 

thyroid disease and, 287, 287f

lid speculum as aid to, 239f

O

 

toxic, 211

timing of, 23, 231, 232

 

traumatic, 211, 365-367

ocular trauma in, 261-263, 262f

 

 

Ocular disorders. See also particular lesion

Orbit, 275, 276f

orbital/preseptal cellulitis in,

 

types and site-specific entries.

effects of disease of, 45, 48f

263-264

drug-induced, 317-328

Orbital blow-out fracture, 33, 363-365,

port-wine stain in, 250

pediatric, 238-273. See also specific

364f

ptosis in, 247f, 247-248

 

conditions under Pediatric

Orbital cellulitis, 48f, 279f, 279-281,

refractive errors in, 273-275

 

patients.

280f

retinoblastoma in, 257-258

signs and symptoms of, 25-38

pediatric cases of, 263-264

retinopathy of prematurity in, 231,

syndrome-associated occurrence of,

Orbital myositis, 290, 290f

244-245

 

273

Orbital pseudotumor, 33, 288-291

strabismus in, 251-252, 267-269

systemic disease–related, 293-317

classification of, 288-291, 288f-291f

stye (hordeolum) in, 266-267

traumatic, 182, 329-367. See also

Orbital septal thinning, age-related, 67

syndrome-associated occurrence of

 

specific types, e.g., Laceration.

Osteogenesis imperfecta, 306

ocular disorders in,

 

in children, 261-263, 262f

blue sclerae in, 306, 306f

273

Ocular examination, 1-23

 

visual development in, 229

pediatric, 230-238

P

visual loss in, 269-271

 

lid speculum as aid to, 239f

Pediculosis, blepharitis due to, 52,

 

 

 

timing of, 23, 231, 232

Pain, ocular, 34

53f

Ocular medications, 369-386,

Pallor, optic disc, 211

Penlight demonstration, of shallow

 

370t-386t

Palsy(ies), cranial nerve. See ordinal

anterior chamber, 194f

problems with patients’ consumption

cranial nerve entries, e.g., Third

Perimetry, 20, 21f

 

of, 20, 21

cranial nerve (oculomotor

Periorbital contusion, 329-330, 330f

Ocular trauma, 182, 329-367. See also

nerve) palsy.

Phacoemulsification, 133f, 133-134,

 

specific types, e.g., Laceration.

Panuveitis, 140

134f, 135f

pediatric cases of, 261-263, 262f

Papilledema, 208, 209f, 210, 266f

Phenothiazine-induced pigment

Oculomotor nerve (third cranial nerve),

Patching, of eye, 20, 22f

deposition, in eye, 323

 

7, 218-219

in pediatric vision testing, 237, 237f

Photophobia, 31