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Association between birth weight deviation and visual function

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ASSOCIATION BETWEEN BIRTH WEIGHT DEVIATION AND VISUAL FUNCTION

L. MARTIN,1 D. LEY,2 K. MARSAL,3 A.L. HÅRD4 and A. HELLSTRÖM4

1Department of Clinical Science, Karolinska Institute, Stockholm; Departments of 2Pediatrics and 3Obstetrics and Gynecology, Lund University Hospital, Lund; 4Department of Clinical Neurosciences, Section of Ophthalmology and International Pediatric Growth Research Center, Sahlgrenska University Hospital/East, Gothenburg; Sweden

Abstract

Introduction

Intrauterine growth restriction (IUGR), resulting in a birth weight small for gestational age, is a recognized risk factor for neurological deficits later in life. In a recent study, it was found that IUGR was associated with reduced axonal area in the optic nerve at young adult age.1

Objective

To evaluate the influence of IUGR on visual function.

Design and methods

The authors studied 25 IUGR subjects and 21 carefully matched normal controls, using Snellen visual acuity (VA), full-threshold frequency-doubling technology (FDT) perimetry,2 and the recently developed Rarebit microdot perimetry.3 With regard to best-corrected VA, 60% correctly identified letters was set as the cut-off.

Results

There was a significant correlation between birth weight deviation and the Rarebit hit rate (p = 0.009), but not with FDT indices. The mean hit rate was significantly lower in the IUGR group compared to the control group (p = 0.01).

Conclusion

These data indicate that IUGR is associated with slightly impaired visual function, which can be detected using Rarebit, but not FDT perimetry.

Address for correspondence: L. Martin, MD, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden

Perimetry Update 2002/2003, pp. 361–362

Proceedings of the XVth International Perimetric Society Meeting, Stratford-upon-Avon, England, June 26–29, 2002

edited by David B. Henson and Michael Wall

© 2004 Kugler Publications, The Hague, The Netherlands

362

L. Martin et al.

References

1.Ley et al: Abnormal neural morphology in young adults following intrauterine growth restriction. (in preparation)

2.Johnson CA, Wall M, Murray F et al: A Primer for Frequency Doubling Technology. Dublin, CA: Humphrey Systems 1998

3.Frisén L: New, sensitive window on abnormal spatial vision: Rarebit probing. Vision Res 2002

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