- •Pediatric Retina
- •Preface
- •1: Development of the Retina
- •1.1 To suppose that the eye . . . could have been formed by natural selection, seems, I freely confess, absurd . . .1
- •1.2 Good order is the foundation of all things2
- •1.3 All that you touch you Change. All that Change Changes you3
- •1.4 Men are born with two eyes, but only one tongue, in order that they should see twice as much as they say4
- •1.7 More than Meets the Optic Vesicle6
- •1.9 Focusing on the Fovea: A Marvel of Development
- •1.10 Nature and Books belong to the eyes that see them7
- •References
- •2: Anatomy and Physiology of the Retina
- •2.1 Introduction
- •2.2 Anatomy of the Retina
- •2.2.2 Cellular Organization of the Retina
- •2.2.2.1 Retinal Pigment Epithelium
- •2.2.2.2 Photoreceptors
- •2.2.2.3 Interneuron Cells
- •2.2.2.4 Ganglion Cells
- •2.2.2.5 Glial Cells
- •2.2.3.1 Bruch’s Membrane
- •2.2.3.2 Retinal Pigment Epithelium
- •2.2.3.3 Photoreceptor Layer
- •2.2.3.4 External Limiting Membrane
- •2.2.3.5 Outer Nuclear Layer
- •2.2.3.6 Outer Plexiform Layer
- •2.2.3.7 Inner Nuclear Layer
- •2.2.3.8 Inner Plexiform Layer
- •2.2.3.9 Ganglion Cell Layer
- •2.2.3.10 Nerve Fiber Layer
- •2.2.5 Blood Supply of the Retina
- •2.2.5.1 Choroidal Circulation
- •2.2.5.2 Hyaloid Circulation
- •2.2.5.3 Retinal Circulation
- •2.2.5.5 Regulation of Blood Flow to the Retina
- •2.2.6 Optic Nerve
- •2.2.6.1 Physiology and Development
- •2.3 Physiology of the Retina
- •2.3.1 The Retinal Pigment Epithelium
- •2.3.3 Image-Forming Visual System
- •2.3.3.1 Detection of Photons by Visual Pigment in the Photoreceptor Cell
- •2.3.3.2 Light Activation of the Photopigment
- •2.3.4 Nonimage-Forming Visual System
- •2.3.5 Targets of Retinal Projections
- •2.4 Retinal Development
- •2.4.2 Foveal Development
- •References
- •3.1 Full-Field ERG
- •3.1.1.1 Rod Response
- •3.1.1.2 Standard Combined Response
- •3.1.1.3 Oscillatory Potentials
- •3.1.1.4 Single-Flash Cone Response
- •3.1.1.5 Light-Adapted Flicker Response
- •3.1.2 Repeat Variability
- •3.1.4 Clinical Uses of the Full-Field ERG
- •3.1.4.2 Stationary Night Blindness
- •3.1.4.3 Enhanced S-Cone Syndrome
- •3.1.4.4 Leber Congenital Amaurosis
- •3.2 Focal and Multifocal ERG
- •References
- •4: Retinopathy of Prematurity (ROP)
- •4.1 Introduction
- •4.2 History
- •4.3 Classification
- •4.4 Incidence
- •4.5 Natural History and Prognosis
- •Disease with Little or No Risk
- •Disease with Moderate Risk
- •Disease with High Risk
- •4.6 Pathogenesis
- •4.7 Screening
- •4.8 Management
- •4.9 Prevention
- •4.10 Interdiction
- •4.11 Corrective Therapy
- •4.12 Mitigation
- •4.13 Medicolegal Considerations
- •4.14 Conclusion
- •References
- •5: Optic Nerve Malformations
- •5.1 Optic Nerve Hypoplasia
- •5.1.1 Overview/Clinical Significance
- •5.1.2 Classification
- •5.1.3 Genetics
- •5.1.4 Pathophysiology
- •5.1.5 Natural History
- •5.1.6 Diagnosis
- •5.1.7 Treatment
- •5.2 Morning Glory Disc Anomaly
- •5.2.1 Overview/Clinical Significance
- •5.2.2 Classification
- •5.2.3 Genetics
- •5.2.4 Pathophysiology
- •5.2.5 Natural History
- •5.2.6 Diagnosis
- •5.2.7 Treatment
- •5.2.8 Associations and Complications
- •5.3 Optic Nerve Head Pits
- •5.3.1 Introduction
- •5.3.2 Overview with Clinical Significance
- •5.3.3 Classification
- •5.3.4 Genetics
- •5.3.5 Pathophysiology
- •5.3.6 Incidence
- •5.3.8 Diagnosis and Diagnostic Aids
- •5.3.9 Treatment
- •5.3.10 Complications and Associations
- •5.4 Optic Disc Coloboma
- •5.4.1 Introduction
- •5.4.2 Genetics
- •5.4.3 Pathophysiology
- •5.4.4 Natural History and Prognosis
- •5.4.5 Diagnosis and Diagnostic Aids
- •5.4.6 Treatment
- •5.5 Optic Nerve Tumor
- •5.5.1 Glioma
- •5.5.1.1 Introduction
- •5.5.2 Overview with Clinical Significance
- •5.5.2.1 Optic Nerve Glioma
- •5.5.2.2 Optic Chiasmal Glioma
- •5.5.3 Pathophysiology
- •5.5.4 Incidence
- •5.5.6 Diagnosis
- •5.5.7 Treatment
- •5.5.8 Social and Family Impact
- •5.6.1 Introduction
- •5.6.3 Pathophysiology
- •5.6.4 Incidence
- •5.6.5 Diagnosis and Diagnostic Aids
- •5.6.6 Treatment
- •5.7 Melanocytoma
- •5.7.1 Introduction
- •5.7.2 Pathophysiology
- •5.7.3 Natural History and Prognosis
- •5.7.4 Diagnosis and Diagnostic Aids
- •5.7.5 Treatment
- •5.8 Metastatic Tumors: Leukemia
- •5.8.1 Introduction
- •5.8.2 Pathophysiology
- •5.8.3 Natural History and Prognosis
- •5.8.4 Treatment
- •5.8.4.1 Other Elevated Disc Anomalies
- •5.9 Drusen
- •5.9.1 Introduction
- •5.9.2 Pathophysiology
- •5.9.3 Natural History and Prognosis
- •5.9.4 Diagnosis and Diagnostic Aids
- •5.10 Hyperopia
- •5.11 Persistence of the Hyaloid System
- •5.12 Tilted Disc
- •5.12.1 Introduction
- •5.12.2 Historical Context
- •5.12.3 Overview with Clinical Significance
- •5.12.4 Genetics
- •5.12.5 Pathophysiology
- •5.12.6 Incidence
- •5.13 Myelinated Nerve Fibers
- •5.13.1 Introduction
- •5.13.2 Genetics
- •5.13.3 Pathophysiology
- •5.13.4 Incidence
- •References
- •6.1.1 Albinism
- •6.1.1.1 Disorders Specific to Melanosomes
- •Hermansky–Pudlak Syndrome
- •Chediak–Higashi Syndrome
- •Diagnosis and Treatment
- •6.1.2 Gyrate Atrophy
- •6.1.3 Cystinosis
- •6.1.3.1 Primary Hyperoxaluria
- •6.2.1 The Gangliosidoses
- •6.2.2 GM1 Gangliosidosis
- •6.2.3 GM2 Gangliosidosis
- •6.2.3.1 Tay–Sachs Disease
- •6.2.4 Sandhoff Disease
- •6.2.5 Niemann–Pick Disease
- •6.2.7 Type C Niemann–Pick Disease
- •6.2.8 Fabry Disease
- •6.2.9 Farber Lipogranulomatosis
- •6.2.10 The Mucopolysaccharidoses
- •6.2.10.1.1 MPS I H: Hurler Syndrome
- •6.2.10.1.2 MPS I S: Scheie Syndrome
- •6.2.10.1.3 MPS I H/S: Hurler–Scheie Syndrome
- •6.2.10.2 MPS II: Hunter Syndrome
- •6.2.10.3 MPS III: Sanfilippo Syndrome
- •6.2.10.4 MPS IV: Morquio Syndrome
- •6.2.10.5 MPS VI: Maroteaux–Lamy Syndrome
- •6.2.10.6 MPS VII: Sly Syndrome
- •6.3 Disorders of Glycoprotein
- •6.3.1 Sialidosis
- •6.4 Disorders of Peroxisomes
- •6.4.1 Refsum Disease
- •References
- •7: Phacomatoses
- •7.1 Introduction
- •7.2 Neurofibromatosis
- •7.2.1 Neurofibromatosis Type 1
- •7.2.1.1 Introduction
- •7.2.1.2 Historical Context
- •7.2.1.3 Overview with Clinical Significance
- •7.2.1.4 Genetics
- •7.2.1.5 Natural History and Prognosis
- •7.2.1.6 Signs and Symptoms
- •7.2.2 Ocular Manifestations
- •7.2.2.1 Lisch Nodules
- •7.2.2.2 Optic Pathway Glioma
- •7.2.2.3 Neurofibroma of the Eyelid and Orbit
- •7.2.3 Systemic Manifestations
- •7.2.3.1 Café-au-lait Spot
- •7.2.3.2 Neurofibroma
- •7.2.3.3 CNS Abnormality
- •Diagnosis and Diagnostic Aids
- •Treatment
- •Social and Family Impact
- •7.2.4 Neurofibromatosis Type 2 (NF2)
- •7.2.4.1 Introduction
- •7.2.4.2 Historical Context
- •7.2.4.3 Overview with Clinical Significance
- •7.2.4.4 Classification
- •7.2.4.5 Genetics
- •7.2.4.6 Incidence
- •7.2.4.7 Natural History and Prognosis
- •7.2.4.8 Signs and Symptoms
- •Ocular Findings
- •Systemic Findings
- •Vestibular Schwannoma
- •Diagnosis and Diagnostic Aids
- •Treatment
- •Complications and Associations
- •Social and Family Impact
- •7.3 Von Hippel–Lindau Disease
- •7.3.1 Introduction
- •7.3.2 Historical Context
- •7.3.3 Overview with Clinical Significance
- •7.3.4 Classification
- •7.3.5 Genetics
- •7.3.6 Pathophysiology
- •7.3.7 Incidence
- •7.3.8 Natural History and Prognosis
- •7.3.9 Signs and Symptoms
- •7.3.9.1 Ocular Manifestations
- •Retinal Capillary Hemangioma
- •7.3.9.2 Systemic Manifestations
- •CNS Hemangioma
- •Renal Cell Carcinoma
- •Pheochromocytoma
- •Pancreatic Cystadenoma and Islet Cell Tumors
- •Epididymis Cystadenoma
- •7.3.10 Diagnosis and Diagnostic Aids
- •7.3.10.1 Coats’ Disease
- •7.3.10.2 Racemose Hemangioma
- •7.3.10.3 Retinal Cavernous Hemangioma
- •7.3.10.4 Retinal Macroaneurysm
- •7.3.10.5 Vasoproliferative Tumor
- •7.3.11 Fluorescein Angiography
- •7.3.12 Indocyanine Green Angiography
- •7.3.13 Ultrasonography
- •7.3.14 Magnetic Resonance Imaging
- •7.3.16 Treatment
- •7.3.17 Observation
- •7.3.18 Laser Photocoagulation
- •7.3.19 Cryotherapy
- •7.3.21 Plaque Radiotherapy
- •7.3.22 Proton Beam Radiotherapy
- •7.3.24 Enucleation
- •7.3.25 Social and Family Impact
- •7.4 Tuberous Sclerosis Complex
- •7.4.1 Introduction
- •7.4.2 Historical Context
- •7.4.3 Overview with Clinical Significance
- •7.4.4 Classification
- •7.4.5 Genetics
- •7.4.6 Incidence
- •7.4.7 Natural History and Prognosis
- •7.4.8 Signs and Symptoms
- •7.4.8.1 Ocular Findings
- •Retinal Astrocytic Hamartoma
- •7.4.8.2 Systemic Findings
- •Dermatologic Manifestations
- •Neurologic Manifestations
- •Visceral Manifestations
- •Diagnosis and Diagnostic Aids
- •Treatment
- •Social and Family Impact
- •7.5 Sturge-Weber Syndrome
- •7.5.1 Introduction
- •7.5.2 Historical Context
- •7.5.3 Overview with Clinical Significance
- •7.5.4 Incidence
- •7.5.5 Genetics
- •7.5.6 Pathophysiology
- •7.5.7 Natural History and Prognosis
- •7.5.8 Signs and Symptoms
- •7.5.8.1 Diffuse Choroidal Hemangioma
- •7.5.8.2 Glaucoma
- •7.5.8.3 Nevus Flammeus
- •7.5.8.4 Leptomeningeal Hemangiomatosis
- •7.5.8.5 Diagnosis and Diagnostic Aids
- •7.5.8.6 Treatment
- •7.5.8.7 Social and Family Impact
- •7.6 Wyburn-Mason Syndrome
- •7.6.1 Introduction
- •7.6.2 Historical Context
- •7.6.3 Overview with Clinical Significance
- •7.6.4 Classification
- •7.6.5 Genetics
- •7.6.6 Pathophysiology
- •7.6.7 Natural History and Prognosis
- •7.6.8 Signs and Symptoms
- •7.6.8.1 Ocular Findings
- •Retinal Arteriovenous Malformation
- •Diagnosis and Diagnostic Aids
- •Treatment
- •7.6.9 Ataxia Telangiectasia
- •7.6.9.1 Introduction
- •7.6.9.2 Historical Context
- •7.6.9.3 Overview with Clinical Significance
- •7.6.9.4 Classification
- •7.6.9.5 Genetics
- •7.6.9.6 Incidence
- •7.6.9.7 Natural History and Prognosis
- •7.6.9.8 Signs and Symptoms
- •7.6.9.9 Diagnosis and Diagnostic Aids
- •7.6.9.10 Treatment
- •7.6.9.11 Social and Family Impact
- •7.7 Retinal Caverous Hemangioma
- •7.7.1 Introduction
- •7.7.2 Historical Context
- •7.7.3 Overview with Clinical Significance
- •7.7.4 Genetics
- •7.7.5 Incidence
- •7.7.6 Natural History and Prognosis
- •7.7.7 Signs and Symptoms
- •7.7.7.1 Ocular Findings
- •7.7.7.2 Systemic Findings
- •Cutaneous Lesions
- •Diagnosis and Diagnostic Aids
- •Treatment
- •References
- •8.1 Introduction
- •8.2 Embryology
- •8.3 Clinical Findings
- •8.3.1 Primary anomalies
- •8.3.2 Secondary findings
- •8.3.3 Differential Diagnosis
- •8.3.3.1 Ancillary Tests
- •8.3.3.2 Prognosis
- •8.3.3.3 Treatment
- •8.4 Practical Surgical Issues
- •8.4.1 The Posterior Surgery
- •References
- •9.1 Introduction
- •9.2 Retinoblastoma Presentation SOP
- •9.2.1 Objective
- •9.2.2 Applicability
- •9.2.3 Scope
- •9.2.4 Clinical Significance
- •9.2.5 Procedures
- •9.2.6 Consequences
- •9.2.7 Related SOPs
- •9.3.1 Objectives
- •9.3.2 Applicability
- •9.3.3 Scope
- •9.3.4 Clinical Significance
- •9.3.5 Procedures
- •9.3.6 Consequences
- •9.3.7 Related SOPs
- •9.4 Genetics of Retinoblastoma SOP
- •9.4.1 Objective
- •9.4.2 Applicability
- •9.4.3 Scope
- •9.4.4 Clinical Significance
- •9.4.5 Procedure
- •9.4.6 Consequences
- •9.4.7 Related SOPs
- •9.5 Screening of Relatives SOP
- •9.5.1 Objective
- •9.5.2 Applicability
- •9.5.3 Scope
- •9.5.4 Clinical Significance
- •9.5.5 Procedure
- •9.5.6 Consequences
- •9.5.7 Related SOPs
- •9.6 Treatment SOP
- •9.7 Enucleation Indications SOP
- •9.7.1 Objective
- •9.7.2 Applicability
- •9.7.3 Scope
- •9.7.4 Clinical Significance
- •9.7.5 Procedure
- •9.7.6 Consequences
- •9.7.7 Related SOPs
- •9.8 Enucleation Technique SOP
- •9.8.1 Objectives
- •9.8.2 Applicability
- •9.8.3 Scope
- •9.8.4 Clinical Significance
- •9.8.5 Procedure
- •9.8.6 Consequences
- •9.8.7 Related SOPs
- •9.9.1 Objectives
- •9.9.2 Applicability
- •9.9.3 Scope
- •9.9.4 Clinical Significance
- •9.9.5 Procedure
- •9.9.6 Consequences
- •9.9.7 Related SOPs
- •9.10 Histopathology Analysis SOP
- •9.10.1 Objectives
- •9.10.2 Applicability
- •9.10.3 Scope
- •9.10.4 Clinical Significance
- •9.10.5 Procedure
- •9.10.6 Consequences
- •9.10.7 Related SOPs
- •9.11 Cryotherapy SOP
- •9.11.1 Objectives
- •9.11.2 Applicability
- •9.11.3 Scope
- •9.11.4 Clinical Significance
- •9.11.5 Procedure
- •9.11.6 Consequences
- •9.11.7 Related SOPs
- •9.12 Laser Therapy SOP
- •9.12.1 Objective
- •9.12.2 Applicability
- •9.12.3 Scope
- •9.12.4 Clinical Significance
- •9.12.5 Procedure
- •9.12.6 Consequences
- •9.12.7 Related SOPs
- •9.13 Local Chemotherapy SOP
- •9.13.1 Objectives
- •9.13.2 Applicability
- •9.13.3 Scope
- •9.13.4 Clinical Significance
- •9.13.5 Procedure
- •9.13.6 Consequences
- •9.13.7 Related SOPs
- •9.14 Systemic Chemotherapy SOP
- •9.14.1 Objectives
- •9.14.2 Applicability
- •9.14.3 Scope
- •9.14.4 Clinical Significance
- •9.14.5 Procedure
- •9.14.6 Consequences
- •9.14.7 Related SOPs
- •9.15 Radiation SOP
- •9.15.1 Objective
- •9.15.2 Applicability
- •9.15.3 Scope
- •9.15.4 Clinical Significance
- •9.15.5 Procedure
- •9.15.6 Consequences
- •9.15.7 Related SOPs
- •9.16.1 Objective
- •9.16.2 Applicability
- •9.16.3 Scope
- •9.16.4 Clinical Significance
- •9.16.5 Procedure
- •9.16.6 Consequences
- •9.16.7 Related SOPs
- •9.17 Follow-Up SOP
- •9.17.1 Objective
- •9.17.2 Applicability
- •9.17.3 Scope
- •9.17.4 Clinical Significance
- •9.17.5 Procedure
- •9.17.6 Consequences
- •9.17.7 Related SOPs
- •References
- •10: Coats’ Disease
- •10.1 Overview
- •10.3 Clinical Aspects
- •10.3.1 Demographics
- •10.3.2 Ocular Findings
- •10.4 Pathology and Pathophysiology
- •10.5 Genetics
- •10.6 Natural History
- •10.8 Management
- •10.9 Systemic Associations
- •10.10 Social and Family Impact
- •10.11 Future Treatment
- •References
- •11.1.1 Stargardt Macular Dystrophy
- •11.1.1.1 Clinical Features: STGD
- •11.1.1.2 Diagnostic Features: STGD
- •11.1.1.3 Differential Diagnosis: STGD
- •11.1.1.4 Inherited Forms: STGD
- •11.1.2 Best Macular Dystrophy
- •11.1.2.1 Clinical Features: BMD
- •11.1.2.2 Diagnostic Features: BMD
- •11.1.2.3 Differential Diagnosis: BMD
- •11.1.2.4 Inherited Forms: BMD
- •11.1.3 Juvenile X-Linked Retinoschisis
- •11.1.3.1 Clinical Features: JXRS
- •11.1.3.2 Diagnostic Features: JXRS
- •11.1.3.3 Differential Diagnosis: JXRS
- •11.1.3.4 Inherited Forms: JXRS
- •11.2.2 Molecular Genetic Testing
- •11.2.3.1 ABCR
- •11.2.3.2 ELOVL4
- •11.2.3.3 PROM1
- •11.2.3.4 BEST-1
- •11.3.1 STGD
- •11.3.3 JXRS
- •11.4.1 STGD Models
- •11.4.2 BMD Models
- •11.4.3 JXRS Models
- •11.5 Phenotypic Diversity
- •11.6 Potential Therapeutics for Juvenile Macular Degenerations
- •References
- •12: Generalized Inherited Retinal Dystrophies
- •12.1 Introduction
- •12.2 Historical Context
- •12.4.1 Retinitis Pigmentosa
- •12.4.1.1 Overview with Clinical Significance
- •12.4.1.2 Genetics
- •12.4.1.3 Pathophysiology
- •12.4.1.4 Prevalence
- •12.4.1.5 Patient History and Evaluation
- •12.4.1.6 Diagnostic Testing
- •12.4.1.7 Treatment
- •12.4.2 Congenital Leber Amaurosis
- •12.4.2.1 Genetics
- •12.4.2.2 Pathophysiology
- •12.4.2.3 Incidence/Prevalence
- •12.4.2.4 Natural History and Prognosis
- •12.4.2.5 Diagnostic Testing
- •12.4.2.6 Treatment
- •12.4.3.1 Genetics
- •12.4.3.2 Pathophysiology
- •12.4.3.3 Incidence
- •12.4.3.4 Natural History and Prognosis
- •12.4.3.5 Diagnostic Testing
- •12.4.3.6 Treatment
- •12.4.3.7 Achromatopsia
- •12.4.4.1 Genetics
- •12.4.4.2 Pathophysiology
- •12.4.4.3 Incidence
- •12.4.4.4 Evaluation and Prognosis
- •12.4.4.5 Diagnostic Testing
- •12.4.4.6 Treatment
- •12.4.4.7 Complications and Disease Associations
- •12.4.4.8 Social Considerations
- •References
- •13: Vitreoretinal Dystrophies
- •13.1 Stickler Syndrome
- •13.1.1 Introduction
- •13.1.2 Historical Context
- •13.1.3 Overview with Clinical Significance
- •13.1.4 Classification
- •13.1.5 Genetics
- •13.1.6 Pathophysiology
- •13.1.7 Incidence
- •13.1.8 Natural History and Prognosis of STK (Signs, Symptoms, Timing, etc.)
- •13.1.9 Diagnosis and Diagnostic Aids
- •13.1.10 Treatment
- •13.1.11 Complications and Associations
- •13.1.12 Social and Family Impact
- •13.2 Wagner Disease
- •13.2.1 Introduction
- •13.2.2 Historical Context
- •13.2.3 Overview with Clinical Significance
- •13.2.4 Classification
- •13.2.5 Genetics
- •13.2.6 Pathophysiology
- •13.2.7 Incidence
- •13.2.9 Diagnosis and Diagnostic Aids
- •13.2.10 Treatment
- •13.2.11 Complications and Associations
- •13.2.12 Social and Family Impact
- •13.3 Juvenile X-Linked Retinoschisis
- •13.3.1 Introduction
- •13.3.2 Historical Context
- •13.3.3 Overview with Clinical Significance
- •13.3.4 Classification
- •13.3.5 Genetics
- •13.3.6 Pathophysiology
- •13.3.7 Incidence
- •13.3.9 Diagnosis and Diagnostic Aids
- •13.3.10 Treatment
- •13.3.11 Complications and Associations
- •13.3.12 Social and Family Impact
- •13.4.1 Introduction
- •13.4.2 Historical Context
- •13.4.3 Overview with Clinical Significance
- •13.4.4 Classification
- •13.4.5 Genetics
- •13.4.6 Pathophysiology
- •13.4.7 Incidence
- •13.4.9 Diagnosis and Diagnostic Aids
- •13.4.10 Treatment
- •13.4.11 Complications and Associations
- •13.4.12 Social and Family Impact
- •13.5 Goldmann-Favre Syndrome
- •13.5.1 Introduction
- •13.5.2 Historical Context
- •13.5.3 Overview with Clinical Significance
- •13.5.4 Classification
- •13.5.5 Genetics
- •13.5.6 Pathophysiology
- •13.5.7 Incidence
- •13.5.9 Diagnosis and Diagnostic Aids
- •13.5.10 Treatment
- •13.5.11 Complications and Associations
- •13.5.12 Social and Family Impact
- •13.6 Incontinentia Pigmenti (IP)
- •13.6.1 Introduction
- •13.6.2 Historical Context
- •13.6.3 Overview with Clinical Significance
- •13.6.4 Classification
- •13.6.5 Genetics
- •13.6.6 Pathophysiology
- •13.6.7 Incidence
- •13.6.9 Diagnosis and Diagnostic Aids
- •13.6.10 Treatment
- •13.6.11 Complications and Associations
- •13.6.12 Social and Family Impact
- •13.7.9 Diagnosis and Diagnostic Aids
- •13.7.10 Treatment
- •13.7.11 Complications and Associations
- •13.7.12 Social and Family Impact
- •References
- •14.1 Introduction
- •14.2 Clinical Course
- •14.3 Differential Diagnosis
- •14.4 Pathology
- •14.5 Selected Conditions
- •14.6 Treatment
- •References
- •15: Proliferative Retinopathies in Children
- •15.1 Introduction
- •15.2 Historical Context
- •15.3 Overview with Clinical Significance
- •15.4 Classification
- •15.5 Genetics (table 15.1)
- •15.5.1 Pathophysiology
- •15.5.2 Natural History and Prognosis
- •15.5.3 Diabetes Mellitus
- •15.5.4 Sickle Cell Disease
- •15.5.5 Incontinentia Pigmenti
- •15.6 Complications and Associations
- •15.7 Social and Family Impact
- •References
- •16: Infectious Diseases of the Pediatric Retina
- •16.1 Introduction
- •16.2 Protozoal Diseases
- •16.2.1 Toxoplasma gondii
- •16.2.1.1 Life Cycle and Transmission
- •16.2.1.2 Epidemiology
- •16.2.1.3 Congenital Infection
- •16.2.1.4 Ocular Disease
- •16.2.1.5 Immunocompromised Patients
- •16.2.1.6 Diagnosis of Ocular Toxoplasmosis
- •16.2.1.7 Treatment
- •16.2.1.8 Treatment in Special Situations
- •16.3 Viral Diseases
- •16.3.1 Cytomegalovirus Retinitis
- •16.3.1.1 Congenital CMV Infection
- •16.3.1.2 Ocular Manifestations
- •16.3.1.3 Acquired CMV Infection
- •16.3.1.4 Ocular Disease
- •16.3.1.5 Pathology
- •16.3.1.6 Diagnosis
- •16.3.1.7 Therapy
- •16.3.2 Varicella Zoster Virus
- •16.3.2.1 Ocular Manifestations
- •16.3.3 Herpes Simplex Virus
- •16.3.3.1 Ocular Disease
- •16.3.4 Acute Retinal Necrosis
- •16.3.4.1 Clinical Presentation
- •16.3.4.2 Diagnosis
- •16.3.4.3 Treatment
- •16.3.5 HIV Infection
- •16.3.5.1 Ocular Manifestations
- •16.3.5.2 Noninfectious HIV Microangiopathy
- •16.3.6 Measles
- •16.3.7 Rubella
- •16.3.7.1 Congenital Rubella Syndrome
- •16.4 Parasitic Infection
- •16.4.1 Toxocariasis
- •16.4.1.1 Ocular Involvement
- •16.4.1.2 Diagnosis
- •16.4.1.3 Differential Diagnosis
- •16.4.1.4 Treatment
- •16.4.2 Onchocerciasis
- •16.4.2.1 Ocular Manifestations
- •16.4.2.2 Diagnosis and Treatment
- •16.5 Bacterial Diseases
- •16.5.1 Syphilis
- •16.5.1.1 Clinical Manifestations
- •16.5.1.2 Congenital Syphilis
- •16.5.1.3 Acquired Syphilis
- •16.5.1.4 Diagnosis
- •16.5.1.5 Syphilis and AIDS
- •16.5.1.6 Treatment
- •16.5.2 Tuberculosis
- •16.5.2.1 Ocular Manifestation
- •16.5.2.2 Diagnosis
- •16.5.2.3 Tuberculosis and AIDS
- •16.5.2.4 Treatment
- •16.6 Rare Childhood Bacterial Diseases
- •16.6.1 Brucellosis
- •16.6.2 Leptospirosis
- •16.6.3 Lyme Disease
- •16.6.4 Cat Scratch Disease
- •16.7 Fungal Disease
- •16.7.1 Histoplasmosis
- •16.7.1.1 Ocular Histoplasmosis Syndrome (OHS)
- •16.7.1.2 Diagnosis and Treatment
- •16.7.2 Fungal Endophthalmitis
- •16.7.2.1 Endogenous Fungal Endophthalmitis
- •Candidiasis
- •Ocular Features
- •Diagnosis and Treatment
- •Rare Causes of Endogenous Endophthalmitis
- •Aspergillosis
- •Cryptococcosis
- •Histoplasmosis
- •Pneumocystis carinii
- •North American Blastomycosis
- •Coccidiomycosis
- •Other Fungal Infections
- •16.7.2.2 Exogenous Fungal Endophthalmitis
- •16.8 Rickettsial Disease
- •References
- •17.1 Introduction
- •17.2 Age of Victims
- •17.4 Perpetrators
- •17.5 Brain Injury
- •17.6 Skeletal Injuries
- •17.7 Acute Ophthalmic Findings
- •17.8 Dating of Retinal Hemorrhages
- •17.9 Treatment of Retinal Hemorrhages
- •17.10 Late Ophthalmic Findings
- •17.13 The Role of the Ophthalmologist
- •References
- •18: Pediatric Retinal Trauma
- •18.1 Introduction
- •18.2 Epidemiology
- •18.3 Etiology of Trauma
- •18.3.1 Sports
- •18.3.2 Assault
- •18.3.3 Birth Trauma
- •18.3.4 Projectile Injury
- •18.3.5 Miscellaneous Causes
- •18.3.6 Sympathetic Ophthalmia
- •18.4 Closed Globe Injuries
- •18.4.1 Traumatic Macular Hole
- •18.4.2 Commotio Retinae
- •References
- •19: Pediatric Uveitis
- •19.1 General Introduction
- •19.2 Classification
- •19.3 Social and Family Impact
- •19.4 Noninfectious
- •19.4.1 Juvenile Rheumatoid Arthritis
- •19.4.1.1 Historical Context
- •19.4.1.2 Clinical Findings/Natural History
- •Subtypes of JRA (Table 19.2) .
- •Screening Guidelines
- •Pathophysiology
- •Diagnosis/Treatment
- •Genetics
- •Complications
- •19.4.2 HLA-B27-Associated Uveitis
- •19.4.2.1 Historical Context
- •19.4.2.2 Clinical Findings/Natural History
- •Pathophysiology/Genetics
- •Diagnosis/Treatment/Complications
- •19.4.3 Tub ulointerstitial Nephritis and Uveitis (TINU)
- •19.4.3.1 Historical Context
- •19.4.3.2 Clinical Findings/Natural History
- •Pathophysiology/Genetics
- •Diagnosis/Treatment/Complications
- •19.4.4 Sarcoidosis
- •19.4.4.1 Historical Context
- •19.4.4.2 Clinical Findings/Natural History
- •Pathophysiology
- •Genetics
- •Diagnosis/Treatment/Complications
- •19.4.5 Pars Planitis
- •19.4.5.1 Historical Context
- •19.4.5.2 Clinical Findings/Natural History
- •Pathophysiology/Genetics
- •Diagnosis
- •Treatment
- •Step 1
- •Step 2
- •Step 3
- •Step 4
- •Complications
- •19.5 Infectious
- •19.5.1 Toxoplasmosis
- •19.5.1.1 Historical Context/Pathophysiology
- •19.5.1.2 Clinical Findings/Natural History
- •Genetics
- •Diagnosis/Treatment/Complications
- •19.5.2 Toxocariasis
- •19.5.2.1 Historical Context/Pathophysiology
- •19.5.2.2 Clinical Findings/Natural History
- •Genetics
- •Diagnosis/Treatment/Complications
- •19.5.3 Bartonella henselae
- •19.5.3.1 Historical Context/Pathophysiology
- •19.5.3.2 Clinical Findings/Natural History
- •Genetics
- •Diagnosis/Treatment/Complications
- •19.5.4.1 Historical Context/Pathophysiology
- •19.5.4.2 Clinical Findings/Natural History
- •Genetics
- •Diagnosis/Treatment/Complications
- •19.5.5 Congenital Ocular Syphilis
- •19.5.5.1 Historical Context/Pathophysiology
- •19.5.5.2 Clinical Findings/Natural History
- •Genetics
- •Diagnosis/Treatment/Complications
- •References
- •Index
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References
1.Cunningham Jr., E.T.: Uveitis in children. Ocul. Immunol. Inflamm. 8(4), 251–261 (2000)
2.Jabs, D.A., Nussenblatt, R.B., Rosenbaum, J.T.: Standard ization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am. J. Ophthalmol. 140(3), 509–516 (2005)
3.Tugal-Tutkun, I., Havrlikova, K., Power, W.J., Foster, C.S.: Changing patterns in uveitis of childhood. Ophthalmology 103(3), 375–383 (1996)
4.Paivonsalo-Hietanen, T., Tuominen, J., Saari, K.M.: Uveitis in children: population-based study in Finland. Acta Oph thalmol. Scand. 78(1), 84–88 (2000)
5.Miyake, K.: Indomethacin in the treatment of postoperative cystoid macular edema. Surv. Ophthalmol. 28(suppl), 554–568 (1984)
6.Yannuzzi, L.A.: A perspective on the treatment of aphakic cystoid macular edema. Surv. Ophthalmol. 28(suppl), 540–553 (1984)
7.Jampol, L.M.: Pharmacologic therapy of aphakic cystoid macular edema. A review. Ophthalmology 89(8), 891–897 (1982)
8.Tso, M.O.M.: Cystoid macular edema. In: Tso, M.O.M. (ed.) Retinal diseases: biomedical foundations and clinical management. JB Lippincott, Philadelphia, PA (1988)
9.Henderly, D.E., Genstler, A.J., Rao, N.A., Smith, R.E.: Pars planitis. Trans. Ophthalmol. Soc. U. K. 105(pt 2), 227–232 (1986)
10.Smith, J.R.: Management of uveitis in pediatric patients: special considerations. Paediatr. Drugs 4(3), 183–189 (2002)
11.Vesterdal, E., Sury, B.: Iridocyclitis and bandshaped corneal opacity in juvenile rheumatoid arthritis. Acta Ophthalmol. (Copenh) 28(3), 321–335 (1950)
12.Sullivan, D.B., Cassidy, J.T., Petty, R.E.: Pathogenic implications of age of onset in juvenile rheumatoid arthritis. Arthritis Rheum. 18(3), 251–255 (1975)
13.Towner, S.R., Michet Jr., C.J., O’Fallon, W.M., Nelson, A.M.: The epidemiology of juvenile arthritis in Rochester, Minnesota 1960-1979. Arthritis Rheum. 26(10), 1208–1213 (1983)
14.Basic and Clinical Science Course. In: Moorthy, R.S. (ed) Intraocular Inflammation and Uveitis: Noninfectious (Auto immune) Uveitis, vol. 9. American Academy of Ophthal mology, San Francisco, CA (2007)
15.Kanski, J.J.: Juvenile arthritis and uveitis. Surv. Ophthalmol. 34(4), 253–267 (1990)
16.Basic and Clinical Science Course. In: Simon, J.W. (ed) Pediatric Ophthalmology and Strabismus: Uveitis in the Pediatric Age Group, vol. 6. American Academy of Ophthalmology, San Francisco, CA (2007)
17.Kanski, J.J.: Anterior uveitis in juvenile rheumatoid arthritis. Arch. Ophthalmol. 95(10), 1794–1797 (1977)
18.Anonymous: American Academy of Pediatrics Section on Rheumatology and Section on Ophthalmology: Guidelines for ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics 92(2), 295–296 (1993)
19.Ohno, S., Char, D.H., Kimura, S.J., O’Connor, G.R.: HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis. Br. J. Ophthalmol. 61(1), 59–61 (1977)
20.Monestier, M., Losman, J.A., Fasy, T.M., et al.: Antihistone antibodies in antinuclear antibody-positive juvenile arthritis. Arthritis Rheum. 33(12), 1836–1841 (1990)
21.Bloom, J.N., Ni, M., Moore, T.L., et al.: Serum antiocular antibodies in patients with juvenile rheumatoid arthritis.
J.Pediatr. Ophthalmol. Strabismus 30(4), 243–248 (1993)
22.Hunt, D.W., Petty, R.E., Millar, F.: Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis. Int. Arch. Allergy Immunol. 100(4), 314–318 (1993)
23.Sabates, R., Smith, T., Apple, D.: Ocular histopathology in juvenile rheumatoid arthritis. Ann. Ophthalmol. 11(5), 733–737 (1979)
24.Merriam, J.C., Chylack Jr., L.T., Albert, D.M.: Early-onset pauciarticular juvenile rheumatoid arthritis. A histopathologic study. Arch. Ophthalmol. 101(7), 1085–1092 (1983)
25.Weiss, A.H., Wallace, C.A., Sherry, D.D.: Methotrexate for resistant chronic uveitis in children with juvenile rheumatoid arthritis [see comment]. J. Pediatr. 133(2), 266–268 (1998)
26.Malagon, C., Van Kerckhove, C., Giannini, E.H., et al.: The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients. J. Rheumatol. 19(1), 160–163 (1992)
27.Dana, M.R., Merayo-Lloves, J., Schaumberg, D.A., Foster, C.S.: Visual outcomes prognosticators in juvenile rheumatoid arthritis-associated uveitis. Ophthalmology 104(2), 236–244 (1997)
28.Sachs, J.A., Brewerton, D.A.: HLA, ankylosing spondylitis and rheumatoid arthritis. Br. Med. Bull. 34(3), 275–278 (1978)
29.Petty, R.E., Malleson, P.: Spondyloarthropathies of childhood. Pediatr. Clin. North Am. 33(5), 1079–1096 (1986)
30.Power, W.J., Rodriguez, A., Pedroza-Seres, M., Foster, C.S.: Outcomes in anterior uveitis associated with the HLA-B27 haplotype. Ophthalmology 105(9), 1646–1651 (1998)
31.Hofley, P., Roarty, J., McGinnity, G., et al.: Asymptomatic uveitis in children with chronic inflammatory bowel diseases. J. Pediatr. Gastroenterol. Nutr. 17(4), 397–400 (1993)
32.Petty, R.E., Smith, J.R., Rosenbaum, J.T.: Arthritis and uveitis in children. A pediatric rheumatology perspective. Am. J. Ophthalmol. 135(6), 879–884 (2003)
33.Rodriguez, A., Akova, Y.A., Pedroza-Seres, M., Foster, C.S.: Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 101(7), 1267–1274 (1994)
34.Taurog, J.D., el-Zaatari, F.A.: In vitro mutagenesis of HLAB27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes.
J.Clin. Invest. 82(3), 987–992 (1988)
35.Ebringer, A.: The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis. Br. J. Rheumatol. 22(4 Suppl 2), 53–66 (1983)
36.Ringrose, J.H.: HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27? Ann. Rheum. Dis. 58(10), 598–610 (1999)
37.Reveille, J.D.: HLA-B27 and the seronegative spondyloarthropathies. Am. J. Med. Sci. 316(4), 239–249 (1998)
38.Dodds, E.M., Lowder, C.Y., Meisler, D.M.: Posterior segment inflammation in HLA-B27+ acute anterior uveitis:
19 Pediatric Uveitis |
455 |
|
|
clinical characteristics [see comment]. Ocul. Immunol. Inflamm. 7(2), 85–92 (1999)
39.Dobrin, R.S., Vernier, R.L., Fish, A.L.: Acute eosinophilic interstitial nephritis and renal failure with bone marrowlymph node granulomas and anterior uveitis. A new syndrome. Am. J. Med. 59(3), 325–333 (1975)
40.Mandeville, J.T., Levinson, R.D., Holland, G.N.: The tubulointerstitial nephritis and uveitis syndrome [see comment]. Surv. Ophthalmol. 46(3), 195–208 (2001)
41.Goda, C., Kotake, S., Ichiishi, A., et al.: Clinical features in tubulointerstitial nephritis and uveitis (TINU) syndrome. Am. J. Ophthalmol. 140(4), 637–641 (2005)
42.Gafter, U., Kalechman, Y., Zevin, D., et al.: Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. Nephrol. Dial. Transplant. 8(9), 821–826 (1993)
43.Iitsuka, T., Yamaguchi, N., Kobayashi, M., et al.: HLA tissue types in patients with acute tubulointerstitial nephritis accompanying uveitis. Nippon Jinzo Gakkai Shi. Jpn. J. Nephrol. 35(6), 723–731 (1993)
44.Sanchez Roman, J., Gonzalez Reina, I., Castillo Palma, M.J., Rocha Castilla, J.L.: Uveitis posterior asociada a nefritis tubulointersticial aguda con respuesta favorable a ciclosporina. Implicaciones patogenicas. Med. Clin. (Barc) 104(3), 118 (1995)
45.Gorrono-Echebarria,M.B.,Calvo-Arrabal,M.A.,Albarran,F., Alvarez-Mon, M.: The tuberculointerstitial nephritis and uveitis (TINU) syndrome is associated with HLA-DR14 in Spanish patients. Br. J. Ophthalmol. 85(8), 1010–1011 (2001)
46.Hirano, K., Tomino, Y., Mikami, H., et al.: A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy. Am. J. Nephrol. 9(6), 499–503 (1989)
47.Radig, H., Bialasiewicz, A.A., Gerding, H., Helmchen, U.: Tubulointerstitielle Nephritis und Uveitis (TINU-Syndrom). Ophthalmologe 89(5), 441–443 (1992)
48.Ellis, D., Fried, W.A., Yunis, E.J., Blau, E.B.: Acute interstitial nephritis in children: a report of 13 cases and review of the literature. Pediatrics 67(6), 862–870 (1981)
49.Sharma, O.P.: Sarcoidosis. Dis. Mon. 36(9), 469–535 (1990)
50.Siltzbach, L.E., James, D.G., Neville, E., et al.: Course and prognosis of sarcoidosis around the world. Am. J. Med. 57(6), 847–852 (1974)
51.Bresnitz, E.A., Strom, B.L.: Epidemiology of sarcoidosis. Epidemiol. Rev. 5, 124–156 (1983)
52.Rosenberg, A.M., Yee, E.H., MacKenzie, J.W.: Arthritis in childhood sarcoidosis. J. Rheumatol. 10(6), 987–990 (1983)
53.Shetty, A.K., Gedalia, A.: Sarcoidosis: a pediatric perspective. Clin. Pediatr. 37(12), 707–717 (1998)
54.Sahn, E.E., Hampton, M.T., Garen, P.D., et al.: Preschool sarcoidosis masquerading as juvenile rheumatoid arthritis: two case reports and a review of the literature. Pediatr. Dermatol. 7(3), 208–213 (1990)
55.Obenauf, C.D., Shaw, H.E., Sydnor, C.F., Klintworth, G.K.: Sarcoidosis and its ophthalmic manifestations. Am. J. Ophthalmol. 86(5), 648–655 (1978)
56.Hunter, D.G., Foster, C.S.: Ocular manifestations of sarcoidosis. In: Albert, D.M., Jakobiec, F.A. (eds.) Principles and Practice of Ophthalmology. Saunders, Philadelphia, PA (1994)
57.Johns, C.J., Scott, P.P., Schonfeld, S.A.: Sarcoidosis. Annu. Rev. Med. 40, 353–371 (1989)
58.Chan, C.C., Wetzig, R.P., Palestine, A.G., et al.: Immunohistopathology of ocular sarcoidosis.Report of a case and discussion of immunopathogenesis. Arch. Ophthalmol. 105(10), 1398–1402 (1987)
59.Rossman, M.D., Thompson, B., Frederick, M., et al.: HLADRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Am. J. Hum. Genet. 73(4), 720–735 (2003)
60.Smith, M.J., Turton, C.W., Mitchell, D.N., et al.: Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax 36(4), 296–298 (1981)
61.Welch, R.B., Maumenee, A.E., Wahlen, H.E.: Peripheral posterior segment inflammation, vitreous opacities, and edema of the posterior pole. Arch. Ophthalmol. 64, 540–549 (1960)
62.Bonfioli, A.A., Damico, F.M., Curi, A.L., Orefice, F.: Intermediate uveitis. Semin. Ophthalmol. 20(3), 147–154 (2005)
63.Guest, S., Funkhouser, E., Lightman, S.: Pars planitis: a comparison of childhood onset and adult onset disease. Clin. Experiment. Ophthalmol. 29(2), 81–84 (2001)
64.Malinowski, S.M., Pulido, J.S., Folk, J.C.: Long-term visual outcome and complications associated with pars planitis. Ophthalmology 100(6), 818–824 (1993). discussion 25
65.Pederson, J.E., Kenyon, K.R., Green, W.R., Maumenee, A.E.: Pathology of pars planitis. Am. J. Ophthalmol. 86(6), 762–774 (1978)
66.Oruc, S., Duffy, B.F., Mohanakumar, T., Kaplan, H.J.: The association of HLA class II with pars planitis. Am. J. Ophthalmol. 131(5), 657–659 (2001)
67.Raja, S.C., Jabs, D.A., Dunn, J.P., et al.: Pars planitis: clinical features and class II HLA associations. Ophthalmology 106(3), 594–599 (1999)
68.Davis, J.L., Mittal, K.K., Nussenblatt, R.B.: HLA in intermediate uveitis. Dev. Ophthalmol. 23, 35–37 (1992)
69.Malinowski, S.M., Pulido, J.S., Goeken, N.E., et al.: The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. Ophthalmology 100(8), 1199–1205 (1993)
70.Eichenbaum, J.W., Friedman, A.H., Mamelok, A.E.: A clinical and histopathological review of intermediate uveitis (“pars planitis”). Bull. N. Y. Acad. Med. 64(2), 164–174 (1988)
71.Green, W.R., Kincaid, M.C., Michels, R.G., et al.: Pars planitis. Trans. Ophthalmol. Soc. U. K. 101(pt 3)(3), 361–367 (1981)
72.Yoser, S.L., Forster, D.J., Rao, N.A.: Pathology of intermediate uveitis. Dev. Ophthalmol. 23, 60–70 (1992)
73.Kaplan, H.J.: Intermediate Uveitis (pars planitis, chronic cyclitis) – a four step approach to treatment. In: Saari, K.M. (ed.) Uveitis update. Excerpta medica, Amsterdam (1984)
74.Lynfield, R., Guerina, N.G.: Toxoplasmosis. Pediatr. Rev. 18(3), 75–83 (1997)
75.Frenkel, J.F.: Toxoplamosis: parasite life cycle, pathology, and immunology. In: Hammond, D.M., Long, P.L. (eds.) The Coccidia: eimeria, isospora, toxoplasma, and related genera. University Park Press, Baltimore, MD (1973)
76.Desmonts, G., Couvreur, J.: Congenital toxoplasmosis. A prospective study of 378 pregnancies. N. Engl. J. Med. 290(20), 1110–1116 (1974)
77.Desmonts, G., Couvreur, J.: Toxoplasmosis in pregnancy and its transmission to the fetus. Bull. N. Y. Acad. Med. 50(2), 146–159 (1974)
78.McMenamin, P.G., Dutton, G.N., Hay, J., Cameron, S.: The ultrastructural pathology of congenital murine toxoplasmic retinochoroiditis. Part I: The localization and morphology
456 |
C. Hood and C.Y. Lowder |
|
|
of Toxoplasma cysts in the retina. Exp. Eye Res. 43(4), 529–543 (1986)
79.Rao, N.A., Font, R.L.: Toxoplasmic retinochoroiditis: elec- tron-microscopic and immunofluorescence studies of form- alin-fixed tissue. Arch. Ophthalmol. 95(2), 273–277 (1977)
80.Bosch-Driessen, L.E., Berendschot, T.T., Ongkosuwito, J.V., Rothova, A.: Ocular toxoplasmosis: clinical features and prognosis of 154 patients. Ophthalmology 109(5), 869–878 (2002)
81.Mets, M.B., Holfels, E., Boyer, K.M., et al.: Eye manifestations of congenital toxoplasmosis. Am. J. Ophthalmol. 122(3), 309–324 (1996)
82.Holland, G.N.: Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease. Am. J. Ophthalmol. 136(6), 973–988 (2003)
83.Dodds, E.M.: Module 10: Ocular toxoplasmosis: clinical presentations, diagnosis, and therapy. Focal points: clinical modules for ophthalmologists. American Academy of Ophthalmology, San Francisco, CA (1999)
84.Rothova, A.: Ocular manifestations of toxoplasmosis. Curr. Opin. Ophthalmol. 14(6), 384–388 (2003)
85.Pinon, J.M., Dumon, H., Chemla, C., et al.: Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. J. Clin. Microbiol. 39(6), 2267–2271 (2001)
86.Stepick-Biek, P., Thulliez, P., Araujo, F.G., Remington, J.S.: IgA antibodies for diagnosis of acute congenital and acquired toxoplasmosis. J. Infect. Dis. 162(1), 270–273 (1990)
87.Aouizerate, F., Cazenave, J., Poirier, L., et al.: Detection of Toxoplasma gondii in aqueous humour by the polymerase chain reaction. Br. J. Ophthalmol. 77(2), 107–109 (1993)
88.Bou, G., Figueroa, M.S., Marti-Belda, P., et al.: Value of PCR for detection of Toxoplasma gondii in aqueous humor and blood samples from immunocompetent patients with ocular toxoplasmosis. J. Clin. Microbiol. 37(11), 3465–3468 (1999)
89.Engstrom Jr., R.E., Holland, G.N., Nussenblatt, R.B., Jabs, D.A.: Current practices in the management of ocular toxoplasmosis. Am. J. Ophthalmol. 111(5), 601–610(1991)
90.Holland, G.N., Lewis, K.G.: An update on current practices in the management of ocular toxoplasmosis [erratum appears in Am J Ophthalmol 2002 Dec;134(6):944]. Am. J. Ophthalmol. 134(1), 102–114 (2002)
91.Stanford, M.R., See, S.E., Jones, L.V., Gilbert, R.E.: Antibiotics for toxoplasmic retinochoroiditis: an evidencebased systematic review [see comment]. Ophthalmology 110(5), 926–931 (2003). quiz 31–2
92.Pearson, P.A., Piracha, A.R., Sen, H.A., Jaffe, G.J.: Atovaquone for the treatment of toxoplasma retinochoroiditis in immunocompetent patients. Ophthalmology 106(1), 148–153 (1999)
93.McAuley, J., Boyer, K.M., Patel, D., et al.: Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial [erratum appears in Clin Infect Dis 1994 Oct;19(4):820]. Clin. Infect. Dis. 18(1), 38–72 (1994)
94.Loewer-Sieger, D.H., Rothova, A., Koppe, J.G., Kylstra, A.: Congenital toxoplasmosis, a prospective study based on 1821 pregnant women. In: Saari, K.M. (ed.) Uveitis update. Elsevier Science Publishers, Amsterdam (1984)
95.Wilder, H.C.: Nematode endophthalmitis. Trans. Am. Acad. Ophthalmol. Otolaryngol. 55, 99–109 (1950)
96.Shields, J.A.: Ocular toxocariasis. A review. Surv. Ophthalmol. 28(5), 361–381 (1984)
97.Glickman, L.T., Schantz, P.M.: Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol. Rev. 3, 230–250 (1981)
98.Despommier, D.: Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin. Microbiol. Rev. 16(2), 265–272 (2003)
99.Molk, R.: Ocular toxocariasis: a review of the literature. Ann. Ophthalmol. 15(3), 216–219 (1983)
100.Stewart, J.M., Cubillan, L.D., Cunningham Jr., E.T.: Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina 25(8), 1005–1013 (2005)
101.Pollard, Z.F., Jarrett, W.H., Hagler, W.S., et al.: ELISA for diagnosis of ocular toxocariasis. Ophthalmology 86(5), 743–752 (1979)
102.Gillespie, S.H.: Human toxocariasis. J. Appl. Bacteriol. 63(6), 473–479 (1987)
103.Siam, A.L.: Toxocaral chorio-retinitis. Treatment of early cases with photocoagulation. Br. J. Ophthalmol. 57(9), 700–703 (1973)
104.Grand, M.G., Roper-Hall, G.: Pars plana vitrectomy for ocular toxocariasis. Retina 1(3), 258–261 (1981)
105.Hagler, W.S., Pollard, Z.F., Jarrett, W.H., Donnelly, E.H.: Resultsofsurgery forocularToxocaracanis.Ophthalmology 88(10), 1081–1086 (1981)
106.Maguire, A.M., Green, W.R., Michels, R.G., Erozan, Y.S.: Recovery of intraocular Toxocara canis by pars plana vitrectomy. Ophthalmology 97(5), 675–680 (1990)
107.Small, K.W., McCuen 2nd, B.W., de Juan Jr., E., Machemer, R.: Surgical management of retinal traction caused by toxocariasis. Am. J. Ophthalmol. 108(1), 10–14 (1989)
108.Adal, K.A., Cockerell, C.J., Petri Jr., W.A.: Cat scratch disease, bacillary angiomatosis, and other infections due to Rochalimaea. N. Engl. J. Med. 330(21), 1509–1515 (1994)
109.Jones, D.B.: Cat-scratch disease. In: Pepose, J.S., Holland, G.N., Wilhelmus, K.R. (eds.) Ocular infection and immunity. Mosby, St. Louis, MO (1996)
110.Margileth, A.M.: Antibiotic therapy for cat-scratch disease: clinical study of therapeutic outcome in 268 patients and a review of the literature. Pediatr. Infect. Dis. J. 11(6), 474–478 (1992)
111.Sweeney, V.P., Drance, S.M.: Optic neuritis and compressive neuropathy associated with cat scratch disease. Can. Med. Assoc. J. 103(13), 1380–1381 (1970)
112.Regnery, R.L., Anderson, B.E., Clarridge 3rd, J.E., et al.: Characterization of a novel Rochalimaea species, R. henselae sp. nov., isolated from blood of a febrile, human immunodeficiency virus-positive patient. J. Clin. Microbiol. 30(2), 265–274 (1992)
113.Cunningham, E.T., Koehler, J.E.: Ocular bartonellosis. Am. J. Ophthalmol. 130(3), 340–349 (2000)
114.Jackson, L.A., Perkins, B.A., Wenger, J.D.: Cat scratch disease in the United States: an analysis of three national databases. Am. J. Public Health 83(12), 1707–1711 (1993)
115.Koehler, J.E., Glaser, C.A., Tappero, J.W.: Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir [see comment]. JAMA 271(7), 531–535 (1994)
19 Pediatric Uveitis |
457 |
|
|
116.Zangwill, K.M., Hamilton, D.H., Perkins, B.A., et al.: Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test [see comment].
N.Engl. J. Med. 329(1), 8–13 (1993)
117.Margileth, A.W., Wear, D.J., Hadfield, T.L., et al.: Catscratch disease. Bacteria in skin at the primary inoculation site. JAMA 252(7), 928–931 (1984)
118.Dreyer, R.F., Hopen, G., Gass, J.D., Smith, J.L.: Leber’s idiopathic stellate neuroretinitis. Arch. Ophthalmol. 102(8), 1140–1145 (1984)
119.Ormerod, L.D., Skolnick, K.A., Menosky, M.M., et al.: Retinal and choroidal manifestations of cat-scratch disease [see comment]. Ophthalmology 105(6), 1024–1031 (1998)
120.Reed, J.B., Scales, D.K., Wong, M.T., et al.: Bartonella henselae neuroretinitis in cat scratch disease. Diagnosis, management, and sequelae [see comment]. Ophthalmology 105(3), 459–466 (1998)
121.Wade, N.K., Levi, L., Jones, M.R., et al.: Optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic Bartonella henselae infection. Am.
J.Ophthalmol. 130(3), 327–334 (2000)
122.Solley, W.A., Martin, D.F., Newman, N.J., et al.: Cat scratch disease: posterior segment manifestations [see comment]. Ophthalmology 106(8), 1546–1553 (1999)
123.Suhler, E.B., Lauer, A.K., Rosenbaum, J.T.: Prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis. Ophthalmology 107(5), 871–876 (2000)
124.Margileth, A.M.: Cat scratch disease. Adv. Pediatr. Infect. Dis. 8, 1–21 (1993)
125.Sander, A., Posselt, M., Bohm, N., et al.: Detection of Bartonella henselae DNA by two different PCR assays and determination of the genotypes of strains involved in histologically defined cat scratch disease. J. Clin. Microbiol. 37(4), 993–997 (1999)
126.Gass, J.D., Scelfo, R.: Diffuse unilateral subacute neuroretinitis. J. R. Soc. Med. 71(2), 95–111 (1978)
127.Gass, J.D., Braunstein, R.A.: Further observations concerning the diffuse unilateral subacute neuroretinitis syndrome. Arch. Ophthalmol. 101(11), 1689–1697 (1983)
128.Gass, J.D., Gilbert Jr., W.R., Guerry, R.K., Scelfo, R.: Diffuse unilateral subacute neuroretinitis. Ophthalmology 85(5), 521–545 (1978)
129.Cortez, R., Denny, J.P., Muci-Mendoza, R., et al.: Diffuse unilateral subacute neuroretinitis in Venezuela. Ophthalmology 112(12), 2110–2114 (2005)
130.Carney, M.D., Combs, J.L.: Diffuse unilateral subacute neuroretinitis. Br. J. Ophthalmol. 75(10), 633–635 (1991)
131.Gass, J.D., Callanan, D.G., Bowman, C.B.: Successful oral therapy for diffuse unilateral subacute neuroretinitis. Trans. Am. Ophthalmol. Soc. 89, 97–112 (1991). discussion 3–6
132.Wilhelmus, K.R.: The history of ocular syphilis. In: Bialasiwicz, A.A., Schall, K.P. (eds.) Infectious diseases of the eye. Eolus Press, Buren, The Netherlands (1994)
133.Wilhelmus, K.R., Lukehart, S.A.: Syphilis. In: Pepose, J.S., Holland, G.N., Wilhelmus, K.R. (eds.) Ocular infection and immunity. Mosby, St. Louis, MO (1996)
134.Deschenes, J., Seamone, C., Baines, M.: The ocular manifestations of sexually transmitted diseases. Can. J. Ophthalmol. 25(4), 177–185 (1990)
135.Sexually Transmitted Diseases Surveillance 2003. Centers for Disease Control and Prevention. Atlanta, GA: U.S. Department of Health and Human Services, September 2004.
136.Ingall, D , Sanchez, P., Baker, C J.: Syphilis. In: Remington, J.S., Llein, J.O. (eds.) Infectious diseases of the fetus and newborn infant, 6th edn. Elsevier Saunders, Philadelphia, PA (2006)
137. Aldave, A.J., King, J.A., Cunningham Jr., E.T.: Ocular syphilis. Curr. Opin. Ophthalmol. 12(6), 433–441 (2001)
138. Browning, D.J.: Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response [see comment]. Ophthalmology 107(11), 2015–2023 (2000)
139. Tamesis, R.R., Foster, C.S.: Ocular syphilis. Ophthalmology
97(10), 1281–1287 (1990)
140. Contreras, F., Pereda, J.: Congenital syphilis of the eye with lens involvement. Arch. Ophthalmol. 96(6), 1052–1053
(1978)
