Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Офтальмология / Английские материалы / Pearls of Glaucoma Management_Giaconi, Law, Caprioli_2009.pdf
Скачиваний:
0
Добавлен:
28.03.2026
Размер:
17.75 Mб
Скачать

20

M. T. Nicolela

 

 

on the follow-up of these “normal” individuals with disc hemorrhages. In repeated glaucoma surveys performed in the population of Dalby, disc hemorrhages were found in 28 out of 3,819 individuals without glaucoma (prevalence of 0.7%). Five out of ten of these individuals who were followed developed glaucoma with a visual field defect 2–7 years after the disc hemorrhage was noted [25].

A more common situation is the occurrence of a disc hemorrhage on a healthy appearing area of the neuroretinal rim in a glaucomatous disc. Disc hemorrhages ­usually occur at the infero-temporal or supero-temporal areas of the rim. Often they recur in the same area until a notch is formed, and then will start occurring at the opposite side of the same disc where the rim is still normal (Fig. 2.2) [6, 26–28]. Studies have shown that optic disc progression occurs in 50–80% of patients with glaucoma following an optic disc hemorrhage, with median follow-up of 2–3 years [1, 29, 30]. In patients with ocular hypertension the rate of progression seems to be lower, with only 14% of patients from the OHTS with disc hemorrhage showing progressive disc changes, which occurred after a median follow-up of 13 months [1]. Therefore, it is important for the clinician to follow patients with glaucoma after optic disc hemorrhages carefully for the first few years after the episode.

Summary for the Clinician

››Disc hemorrhages occur in nonglaucomatous eyes.

››In initially nonglaucomatous eyes, it is unclear what percent of nerves and over what period of time glaucomatous change of the optic nerve occurs after disc hemorrhage. One study found a visual field defect to occur after 2–7 years in 5 of 10 eyes that were followed.

››In optic nerves with established glaucoma, disc hemorrhages are more common.

››Disc hemorrhages are typically found in the infero-temporal or supero-temporal regions of the optic nerve.

››50–80% of patients with glaucoma and disc hemorrhages have been found to progress after 2–3 years of follow-up.

››14% of patients in the OHTS study with disc hemorrhages showed progressive neuroretinal rim loss after median follow-up of 13 months.

References

1. Budenz, D.L., et al. Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study. Ophthalmology 2006, 113(12): 2137–43.

2. Jonas, J.B., G.C. Gusek, and G.O. Naumann. Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intrapapillary characteristics. Graefes Arch Clin Exp Ophthalmol 1988, 226(6): 522–30.

3. Jonas, J.B., G.C. Gusek, and G.O. Naumann. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci 1988, 29(7): 1151–8 [published errata appear in Invest Ophthalmol Vis Sci 1991, 32(6): 1893 and 1992, 32(2): 474–5].

4. Airaksinen, P.J. and A. Heijl. Visual field and retinal nerve fibre layer in early glaucoma after optic disc haemorrhage. Acta Ophthalmol 1983, 61(2): 186–94.

5. Airaksinen, P.J., A. Tuulonen, and E.B. Werner. Clinical evaluation of the optic disc and retinal nerve fiber layer. In The glaucomas, R. Ritch, M.B. Shields, and T. Krupin (eds.). Mosby-Year Book: St. Louis, 1996, pp. 617–57.

6. Drance, S.M. Disc hemorrhages in the glaucomas. Surv Ophthalmol 1989, 33(5): 331–7.

7. Jonas, J.B. and G.O. Naumann. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci 1989, 30(5): 919–26.

8. Jonas, J.B. and D. Schiro. Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma. Br J Ophthalmol 1994, 78(4): 285–90.

9. Sommer, A., et al. Clinically detectable nerve fiber atrophy

precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991, 109(1): 77–83.

10.Nicolela, M.T. and S.M. Drance. Various glaucomatous opticnerveappearances:clinicalcorrelations.Ophthalmology 1996, 103(4): 640–9.

11.Abrams, L.S., et al. Agreement among optometrists, ophthalmologists, and residents in evaluating the optic disc for glaucoma. Ophthalmology 1994, 101(10): 1662–7.

12.Varma, R. W.C. Steinmann, and I.U. Scott. Expert agreement in evaluating the optic disc for glaucoma. Ophthalmology 1992, 99(2): 215–21.

13.Azuara-Blanco, A., et al. Clinical agreement among glaucoma experts in the detection of glaucomatous changes of the optic disk using simultaneous stereoscopic photographs. Am J Ophthalmol 2003, 136(5): 949–50.

14.Coleman, A.L., et al. Interobserver and intraobserver variability in the detection of glaucomatous progression of the optic disc. J Glaucoma 1996, 5(6): 384–9.

15.Ervin, J.C., et al. Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomography in the LSU Experimental Glaucoma (LEG) Study. Ophthalmology 2002, 109(3): 467–81.

16.Zeyen, T., et al. Reproducibility of evaluation of optic disc change for glaucoma with stereo optic disc photographs. Ophthalmology 2003, 110(2): 340–4.

17.Dielemans, I., et al. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study. Ophthalmology 1994, 101(11): 1851–5.

18.Ong, L.S., et al. Asymmetry in optic disc parameters: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci 1999, 40(5): 849–57.

2  Optic Nerve: Clinical Examination

21

 

 

19.Gross, P.G. and S.M. Drance. Comparison of a simple ophthalmoscopic and planimetric measurements of glaucomatous neuroretinal rim areas. J Glaucoma 1995, 4: 314.

20.Jonas, J.B. and K. Papastathopoulos. Ophthalmoscopic measurement of the optic disc. Ophthalmology 1995, 102(7): 1102–6.

21.Ruben, S. Estimation of optic disc size using indirect biomicroscopy. Br J Ophthalmol 1994, 78(5): 363–4.

22.Artes, P.H. and B.C. Chauhan. Longitudinal changes in the visual field and optic disc in glaucoma. Prog Retin Eye Res 2005, 24(3): 333–54.

23.Miglior, S., et al. Results of the European Glaucoma Prevention Study. Ophthalmology 2005, 112(3): 366–75.

24.Healey, P.R., et al. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology 1998, 105(2): 216–23.

25.Bengtsson, B. Optic disc haemorrhages preceding manifest glaucoma. Acta Ophthalmol 1990, 68(4): 450–4.

26.Airaksinen, P.J., E. Mustonen, and H.I. Alanko. Optic disc haemorrhages precede retinal nerve fibre layer defects in ocular hypertension. Acta Ophthalmol 1981, 59(5): 627–41.

27.Airaksinen, P.J. and A. Tuulonen. Early glaucoma changes in patients with and without an optic disc haemorrhage. Acta Ophthalmol 1984, 62(2): 197–202.

28.Soares, A.S., et al. Factors associated with optic disc hemorrhages in glaucoma. Ophthalmology 2004, 11(9): 1653–7.

29.Siegner, S.W. and P.A. Netland. Optic disc hemorrhages and progression of glaucoma. Ophthalmology 1996, 103(7): 1014–24.

30.Tuulonen, A., et al. Optic disk cupping and pallor measurements of patients with a disk hemorrhage. Am J Ophthalmol 1987, 103(4): 505–11.