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115

List of Fillers

Bradley T. Kovach

345

Table 115.1. List of fillers

Category

Trade name

Composition

Year of

FDA–approved

 

(company)

 

FDA

indications (year of

 

 

 

approval

approval)

Superficial dermal fillers

 

 

 

 

Cosmoderm I

Human collagen 35 mg/ml

2003

Injection into the

 

(Allergan)

in 0.3% lidocaine

 

superficial papillary

 

 

 

 

dermis for correction of

 

 

 

 

soft tissue contour

 

 

 

 

deficiencies such as

 

 

 

 

wrinkles and acne scars

 

Cosmoderm II

Human collagen 65 mg/ml

2005

Same as Cosmoderm I

 

(Allergan)

in 0.3% lidocaine

 

 

 

Zyderm I

Bovine collagen 35 mg/ml

1981

Same as Cosmoderm I

 

(Allergan)

in 0.3% lidocaine

 

 

 

Zyderm II

Bovine collagen 65 mg/ml

1983

Same as Cosmoderm I

 

(Allergan)

in 0.3% lidocaine

 

 

Midand deep dermal fillers

 

 

 

 

Cosmoplast

Human collagen 35 mg/ml

2003

Injection in the midto

 

(Allergan)

crosslinked with

 

deep dermis for

 

 

glutaraldehye in 0.3%

 

correction of soft tissue

 

 

lidocaine

 

contour deficiencies

 

 

 

 

such as wrinkles and

 

 

 

 

acne scars

 

Captique

Hyaluronic acid 5.5 mg/ml

2004

Injection in the midand

 

(Allergan)

 

 

deep dermis for

 

 

 

 

correction of moderate

 

 

 

 

to severe facial

 

 

 

 

wrinkles and folds

 

 

 

 

(such as the nasolabial

 

 

 

 

folds)

Additional clinical uses

Overlay of deeper

fillers

Same as

Cosmoderm I

Same as

Cosmoderm I

Same as

Cosmoderm I

Lip augmentation, folds (such as nasolabial folds and marionette lines), angles of the mouth

Lip augmentation, marionette lines, tear troughs, angles of the mouth, prejowl sulcus, atrophic scars, others

Duration of

effect

2–4 months

2–4 months 2–4 months 2–4 months

3–5 months

3–5 months

continued

Fillers of List 115 Chapter

347

Table 115.1. Continued

Category

Trade name

Composition

Year of

FDA–approved

 

(company)

 

FDA

indications (year of

 

 

 

approval

approval)

 

Elevess

Hyaluronic acid 28 mg/ml

2006

Same as Captique

 

(Galderma

with 0.3% lidocaine

 

 

 

Phama. S.a.,

 

 

 

 

and Anika

 

 

 

 

Therapeutics)

 

 

 

 

Augmentation

 

 

 

 

Product

 

 

 

 

(Anika

 

 

 

 

Therapeutics,

 

 

 

 

Inc.)

 

 

 

 

Fascian (Fascia

Freeze-dried cadaveric

FDA

FDA approval not

 

Biosystems,

fascia lata reconstituted

approval

required

 

LLC)

with saline or lidocaine

not

 

 

 

 

required

 

 

Hylaform

Hyaluronic acid 5.5 mg/ml

2004

Same as Captique

 

(Allergan)

 

 

 

 

Juvederm Ultra

Hyaluronic acid 24 mg/ml

2006

Same as Captique

 

(Allergan)

 

 

 

 

Restylane

Hyaluronic acid 20 mg/ml

2003

Same as Captique

 

(Medicis)

 

 

 

 

Zyplast

Bovine collagen 35 mg/ml

1985

Same as Cosmoplast

 

(Allergan)

crosslinked with

 

 

 

 

glutaraldehye in 0.3%

 

 

 

 

lidocaine

 

 

Deep dermal fillers

 

 

 

 

Hylaform Plus

Hyaluronic acid 5.5 mg/ml

2004

Same as Captique

 

(Allergan)

 

 

 

Additional clinical

Duration of

uses

effect

Not commercially

Approximately

available

6 months

Lip augmentation,

Not well

rhytids and folds,

known (at

atrophic scars

least 3–4

 

months)

Same as Captique

3–5 months

Same as Captique

6–12 months

Same as Captique

5–7 months

Same as Cosmoplast

3–5 months

Marionette lines,

3–5 months

angles of the

 

mouth atrophic

 

scars, prejowl

 

sulcus

 

hovacK .T.B 348

Juvederm Ultra

Hyaluronic acid 24 mg/ml

2006

Same as Captique

Plus

 

 

 

(Allergan)

Calcium hydroxyapatite

 

 

Radiesse

2006 (for

Subdermal implantation

(Bioform

microspheres

cosmetic

for correction of

Medical, Inc.)

 

use)

moderate to severe

 

 

 

facial wrinkles and

 

 

 

folds, such as the

 

 

 

nasolabial folds;

 

 

 

subdermal implantation

 

 

 

for correction of

 

 

 

HIV-associated

 

 

 

lipoatrophy; oral/

 

 

 

maxillofacial defects;

 

 

 

vocal cord insufficiency;

 

 

 

radiographic tissue

 

 

 

marking

Subcutaneous fillers

 

 

 

AdatoSil-5000

Liquid injectable silicone

1994

Prolonged retinal

(Bausch and

 

 

tamponade in

Lomb)

 

 

complicated retinal

 

Polymethylmethacrylate

 

detachments

Artefill (Artes

2006

Correction of the

Medical, Inc)

microspheres in vehicle

 

nasolabial folds

 

of 3.5% bovine collagen

 

 

 

with 0.3% lidocaine

 

 

Autologous fat

Autologous fat

FDA

FDA approval not

 

 

approval

required

 

 

not

 

 

 

required

 

Same as Hylaform

6–12 months

Plus

 

Cutaneous lip

9–18 months

augmentation (not

 

vermillion lip),

 

age-related

 

lipoatrophy, facial

 

contouring,

 

atrophic scars

 

Moderate to severe

Permanent

rhytids and folds,

 

atrophic scars

 

Moderate to severe

Permanent

rhytids and folds,

 

atrophic scars

 

Lip augmentation,

1 year–

facial folds, facial

permanent

contouring,

 

lipoatrophy, dorsal

 

hand

 

augmentation,

 

correction of

 

liposuction

 

contour defects

continued

 

Fillers of List 115 Chapter

349

Table 115.1. Continued

Category

Trade name

Composition

Year of

FDA–approved

 

(company)

 

FDA

indications (year of

 

 

 

approval

approval)

 

Cymetra (Life

Human cadaveric proteins,

FDA

FDA approval not

 

Cell

primarily collagen,

approval

required (classified as

 

Corporation)

elastin, and

not

banked human tissue)

 

 

glycosaminoglycans

required

 

 

 

 

(classified

 

 

 

 

as banked

 

 

 

 

human

 

 

Sculptra (Dermik Poly-L-lactic acid particles

tissue)

 

 

2004

HIV-associated facial

 

Laboratories)

2–50 m in diameter

 

lipoatrophy

 

 

reconstituted with 2–

 

 

 

 

10 ml saline or lidocaine

 

 

 

Silikon-1000

Liquid injectable silicone

1997

Same as AdatoSil-5000

 

(Alcon)

 

 

 

Subdermal implants

 

 

 

 

Advanta

Expanded

2000

Facial plastic and

 

(Oceanbreeze

polytetrafluoroethylene

 

reconstructive surgery

 

Surgical

 

 

 

 

Supply)

 

 

FDA approval not

 

Alloderm (Life

Human cadaveric proteins,

FDA

 

Cell

primarily collagen,

approval

required (classified as

 

Corporation)

elastin, and

not

banked human tissue)

 

 

glycosaminoglycans

required

 

 

 

 

(classified

 

 

 

 

as banked

 

human tissue)

hovacK .T.B 053

Additional clinical

Duration of

uses

effect

Lip augmentation,

3–6 months

deep rhytids and

 

folds, atrophic

 

scars

 

Age-related

Up to 2 years

lipoatrophy, facial

 

contouring

 

Moderate to severe

Permanent

rhytids and folds,

 

atrophic scars

 

Lip augmentation,

Permanent

deep rhytids and

 

folds

 

Same as Advanta

6–12 months

Softform (Tissue

Expanded

1998

Plastic and reconstructive

Same as Advanta

Permanent

Technologies,

polytetrafluoroethylene

 

surgery

 

 

Inc.)

 

 

 

 

 

Ultrasoft (Tissue Expanded

2001

Plastic and reconstructive

Same as Advanta

Permanent

Technologies,

polytetrafluoroethylene

 

surgery

 

 

Inc.)

 

 

 

 

 

Fillers of List 115 Chapter

351

116

Dermal Filler Pearls:

the Hyaluronic Acids

John R. Burroughs and Richard L. Anderson

Our preferred hyaluronic acid dermal fillers are Restylane, Perlane, and

Juvederm. Each of these has a very high safety profile and are easier to inject than Radiesse. They are outstanding for lip enhancement, including the vermillion border, perioral rhytids, and for less severe glabellar and nasolabial folds or as a superficial fine tuning to deeper filling with Radiesse. The newer, higher viscosity hyaluronic acids, however, are excellent for deep lip augmentation, nasolabial folds, and deep rhytid

lling.We have found excellent success treating nasojugal (“tear trough”) deformities with hyaluronic acids, which offers a nonsurgical option to cosmetic lower eyelid blepharoplasty (Figure 116.1). Patients require variable amounts depending on the desired outcome and severity of the folds. Injections deep (periosteally) or just below the orbicularis tend to cause less swelling and bruising below the eyes. The effects are potentiated by the concomitant application of Botox. We generally use the provided needle and find that direct injection with withdrawal of the needle as well as the described “feathering” technique both work well.

We routinely perform the infraorbital and mental nerve blocks as previously prescribed, as lip injections are quite painful. Premark the perioral rhytids prior to the nerve blocks to ensure optimal filling.

We have found that the hyaluronic acids last longer when Botox is also injected. We recommend that patients not aggressively massage any perceived irregularities, as this can worsen bruising and swelling and the patient may inadvertently overmassage the filler out of position. We advise patients to ice the areas a few hours following injections to reduce swelling. Injection to areas of high dynamicity (the perioral rhytids) will last less time that relatively adynamic areas, such as horizontal forehead rhytids or lower eyelid tear trough defects. Perlane and Juvederm Ultra Plus contain higher concentrations and reportedly last longer than the other hyaluronic formulations. Deep rhytids may further benefit by first performing subcision with a needle (e.g., 27-gauge) followed by placement of hyaluronic filler.

352

Chapter 116 Dermal Filler Pearls: the Hyaluronic Acids 353

A

B

Figure 116.1. (A) Preinjection of Restylane in a patient with pronounced lower eyelid hollowness “tear trough deformities.” (B) Immediately following the injections, showing the marked improvement.

117

Radiesse Pearls

John R. Burroughs and Richard L. Anderson

For deep glabellar and nasolabial folds, our preferred filler is Radiesse® Radiesse is calcium hydroxyapatite gel. Radiesse is an excellent dermal ller for severe folds, wrinkles that require large volumes and respond well to deep placement, which is critical with Radiesse. It is recommended to inject Radiesse below the dermis to avoid visibly noticeable lumps and irregularities. For the nasolabial folds, inject slightly medial to each nasolabial fold as the natural muscular action of the facial muscles will tend to lateralize the effect and can worsen the appearance of the

folds if not placed medially (Figure 117.1).

We inject with a 1.25-inch 27-gauge needle as the material is quite thick. A linear threading or fanning technique can be used to achieve linear filling or volumization. Mark the nasolabial folds prior to injection of a nerve block, which is preferred by most patients for nasolabial and lip augmentation. The nerve block is performed by injecting the upper and lower gingival sulcus with a 1.25-inch 27-gauge needle in line with the patient’s pupils, which will anesthetize the infraorbital and mental nerves. Use 1–2% lidocaine with epinephrine with 1–2 ml at each injection site. It is critical to premark the nasolabial folds prior to local anesthetic injection due to distortion of the tissues and to ensure slight medialization of the fi ller placement. A single syringe (1.3 cc) of Radiesse is adequate for most nasolabial folds. Some patients desire or require a second syringe at a later time to achieve an optimal result. In the glabellar areas a quarter to half a syringe is all that is required. Patients should be cautioned, and placement must be precise in the glabellar region as necrosis and or visual loss has been reported with intravascular injection of llers. In general, glabellar fold injections are not uncomfortable, and we do not inject local anesthetic, which distorts the target area. However, a small amoung (0.5 cc) of local may be injected for supratrochlear and suproorbital nerve blocks.Radiesse is not optimal for lip augmentation, as the patients often complain of lumps and irregularities. Caution must be exercised to avoid injecting Radiesse too superficially, which can cause skin necrosis. We have found Radiesse to give improvement for the reported 2 years in most of our patients.

354

Chapter 117 Radiesse Pearls 355

Figure 117.1. Injection of Radiesse into the left nasolabial fold. Note the slight medial placement to the premarked nasolabial fold.

118

Juvederm Pearls: Fine and

Superficial Lines

John R. Burroughs and Richard L. Anderson

Juvederm is a newer nonanimal-based hyaluronic acid that has the advantage of lower viscosity allowing for easier injection. Juvederm is technically for filling minimal rhytids, particularly for perioral lines and for defining the vermillion border. It works very well to enhance the vermillion border as an adjunct to deeper lip augmentation with Restylane, Perlane, and Juvederm Ultra Plus. Superficial, fine lines may also be treated by fi rst performingsubcision with an injection needle (e. g., 27-gauge), followed by an injection of hyaluronic acid through a 32guage needle. The 32-gauge needle seems to thin the filler viscosity, enabling fine, super cial rhytid filling while avoiding lumps. Caution is needed with superficial filling to avoid skin color discoloration, and it is imperative to ensure that the needle is securely fastened to the luer-lock syringe to avoid accidental needle expulsion and potential ocular injury.1

Reference

1.Lin DJ, Sami MS, Burroughs JR, Soparkar CN, Patrinely JR. Ocular injury from local anesthetic injections: needle expulsion—the luer-lock allure. Arch Facial Plast Surg 2006;8:436.

356