Introduction
The Vancouver Orbital Symposium represented an unusual opportunity to bring together many disciplines to review knowledge, interact, and assess challenges for the future. It also culminated and rewarded my tenure as chair of ophthalmology at the University of British Columbia and marks my return to full-time practice, teaching, and research.
The 47 faculty presentations, open submissions, and posters brought together experts from many disciplines including basic science, neuroimaging, radiotherapy, oncology, infectious disease, endocrinology, pathology, molecular biology, and surgery. We tackled major topics in orbital inflammatory disease, lymphoproliferative disorders, optic nerve, and meningeal lesions, problems in oncology, vascular disorders, and of course an extended look at the current status of thyroid orbitopathy.
This conference was anteceded by a two-day meeting of the Orbital Society, whose members became the core faculty of the symposium. I am grateful for the honor of their commitment to this endeavor and the plan to repeat this symposium under the auspices of the society every four to five years. The
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Introduction |
meeting was well attended throughout, and the discussions lively, intelligent, and enthusiastic. In short, this event was the highlight of my career and especially noteworthy by the participation of 27 of my fellows, to whom I am most grateful. Ultimately, it is the joy of lifelong learning and the challenge of patient care that set the tone of the symposium.
I look forward to the continued active endeavor.
Jack Rootman
Contributors
Hind M. Al-Katan Department of Ophthalmology, Security Forces Hospital, Riyadh, Saudi Arabia
Jugpal Arneja The Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Stephen Baker Department of Ophthalmology and Visual Sciences, Eye Care Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Luigi Bartalena Cattedra di Endocrinologia, Universita dell’Insubria, Varese, Italy
George B. Bartley Mayo Clinic, Jacksonville, Florida, U.S.A.
Kenneth W. Berean Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Guilio Bonavolonta Department of Ophthalmology, University
of Naples, Naples, Italy
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Contributors |
Frank Buffam Department of Ophthalmology, University of British Columbia and the Vancouver General Hospital, Vancouver, British Columbia, Canada
Anthony W. Chow Division of Infectious Diseases, Department of Medicine, University of British Columbia and Vancouver Hospital Health Sciences Centre, Vancouver, British Columbia, Canada
Jonathan C. Choy Department of Pathology and Laboratory Medicine, St. Paul’s Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
Kimberly P. Cockerham Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania, U.S.A.
Joseph M. Connors Division of Medical Oncology, University of British Columbia and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Peter J. Dolman Department of Ophthalmology and Visual Sciences, and Department of Pathology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
Jonathan J. Dutton University of North Carolina, Chapel Hill, North Carolina, U.S.A.
Ian Epstein Thyroid Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada
Kenneth A. Feldman Department of Ophthalmology, Kaiser Permanente Medical Center, Harbor City, California, U.S.A.
Randy D. Gascoyne Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Robert Alan Goldberg Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, California, U.S.A.
James H. Goldie University of British Columbia, Vancouver, British Columbia, Canada
Contributors |
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Colum A. Gorman Mayo Clinic, Rochester, Minnesota, U.S.A.
Douglas A. Graeb Diagnostic and Therapeutic Neuroradiology,
St. Michael’s Hospital, University of Toronto, Toronto, Ontario,
Canada
Gerald J. Harris Section of Orbital and Oculoplastic Surgery, Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
Thomas J. Joly Department of Ophthalmology, Vancouver
General Hospital, University of British Columbia, Vancouver,
Canada
Steven E. Katz William H. Havener Eye Center, The Ohio State University, Columbus, Ohio, U.S.A.
Michael Kazim Columbia University, New York, New York,
U.S.A.
John S. Kennerdell Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania, U.S.A.
Dino D. Klisovic William H. Havener Eye Center, The Ohio State University, Columbus, Ohio, U.S.A.
Marko I. Klisovic William H. Havener Eye Center, The Ohio State University, Columbus, Ohio, U.S.A.
Jocelyne S. Lapointe Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Kate Lazier Thyroid Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada
Martin Lubow William H. Havener Eye Center, The Ohio State University, Columbus, Ohio, U.S.A.
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Contributors |
Roy Ma Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Claudio Marcocci Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Varese, Italy
Michele Marino` Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Varese, Italy
Joseph C. Maroon Presbyterian University Hospital,
Pittsburgh, Pennsylvania, U.S.A.
Thomas R. Marotta Diagnostic and Therapeutic Neuroradiology, St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada
Barbara Mazzi Dipartimento di Endocrinologia e Metabolismo, Universita` di Pisa, Varese, Italy
Bruce M. McManus Department of Pathology and Laboratory Medicine, St. Paul’s Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
Alan A. McNab Orbit, Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, Victoria, Melbourne, Australia
Francesca Menconi Dipartimento di Endocrinologia e Metabolismo, Universita` di Pisa, Varese, Italy
Eugenia Morabito Dipartimento di Endocrinologia e Metabolismo, Universita` di Pisa, Varese, Italy
Wieslaw L. Nowinski Biomedical Imaging Laboratory, Agency for Science, Technology and Research (ASTAR), Singapore
Sylvia Pasternak Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
Aldo Pinchera Dipartimento di Endocrinologia e Metabolismo, Universita` di Pisa, Varese, Italy
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Roberto Rocchi Dipartimento di Endocrinologia e Metabolismo, Universita` di Pisa, Varese, Italy
Jack Rootman Department of Ophthalmology and Visual Sciences, and Department of Pathology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
Peerooz Saeed Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
Mario Salvi Cattedra di Endocrinologia, Universita di Panna, Panna, Italy
Kam Shojania Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Donald Smallman Thyroid Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada
Terry J. Smith Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, and School of Medicine, University of California, Los Angeles, California, U.S.A.
Diego Strianese Department of Ophthalmology, University of
Naples, Naples, Italy
Roger E. Turbin Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania, U.S.A.
Sumalee Vangveeravong Department of Ophthalmology,
Siriraj Hospital, Bangkok, Thailand
Jack R. Wall Thyroid Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada
Valerie A. White Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Wilmar M. Wiersinga Department of Medicine, Academic
Medical Center, University of Amsterdam, Amsterdam,
The Netherlands
Orbital Inflammatory Disease
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Orbital Inflammatory Disease:
Classification and New Insights
JACK ROOTMAN
Department of Ophthalmology and Visual
Sciences, and Department of Pathology,
University of British Columbia,
Vancouver General Hospital,
Vancouver, British Columbia, Canada
Over the last 20 years, our experience at the University of British Columbia Orbital Clinic in managing over 6000 orbital cases has led to a paradigm shift in terms of understanding orbital inflammatory disease. This is characterized by broad clinical definitions of inflammations shifting to diagnoses that are based on pathologic, anatomic, and systemic associations of disease. In recent years, we have seen increasing diagnostic specificity brought about by immunopathologic and molecular techniques, which in turn will link to specific treatment based on disease pathogenesis (1).
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