- •Preface
- •Basic physics
- •Acoustic Wave
- •Laws of Acoustic Energy
- •Frequency and Resolution
- •Instrumentation
- •A-scan
- •Biometric A-scan
- •Standardized A-scan
- •B-scan
- •Special techniques
- •Ultrasound Biomicroscopy
- •Immersion B-scan
- •Color Doppler Ultrasonography
- •Three-Dimensional Ultrasonography
- •References
- •Resolution
- •Transducers
- •Clinical use of ultrasound biomicroscopy
- •Technique
- •Measuring Ocular Structures
- •Normal Ocular Structures
- •Anterior chamber
- •The cornea
- •Anterior chamber angle region
- •The iris
- •The ciliary body
- •The zonule
- •Glaucoma
- •Corneal and Scleral Disease
- •Intraocular Lens Complications
- •Trauma
- •Conjunctival and Adnexal Disease
- •Anterior Segment Tumors
- •Iris tumors
- •Ciliary body tumors
- •Extrascleral extension of intraocular tumors
- •Corneal involvement
- •Cysts
- •Peripheral choroidal tumors
- •Future directions
- •References
- •Ophthalmic Biometry
- •Axial eye length measurements
- •Instruments and Methods
- •A-scan Biometry
- •Contact method
- •Immersion technique
- •Velocity Settings
- •Special Clinical Situations
- •Silicone oil
- •Posterior staphyloma
- •Pseudophakic eyes
- •Intraocular lens power calculations
- •Formulas
- •First generation
- •Second generation
- •Third generation
- •Fourth generation
- •Selection of the Best Formula
- •Special Clinical Situations
- •Post refractive surgery
- •Clinical history method
- •Contact lens method
- •K value obtained by topography
- •Double K formulas
- •Post radial keratotomy and cataract surgery
- •References
- •Evaluation of the cornea
- •Congenital Corneal Opacification
- •Corneal Lesions
- •Corneal Dystrophies
- •Refractive Surgery
- •Evaluation of intraocular lenses
- •Posterior Chamber Intraocular Lenses
- •Anterior Chamber Intraocular Lenses
- •Phakic Intraocular Lenses
- •Evaluation of anterior segment trauma
- •Iridocorneal Angle Trauma
- •Foreign Body
- •Surgical Planning
- •Descemet’s Membrane Detachment
- •Summary
- •References
- •Glaucoma
- •Anterior angle evaluation
- •Plateau Iris Configuration
- •Ciliary Body Cysts
- •Pigmentary Glaucoma
- •Synechiae
- •Iridocorneal Endothelial Syndromes
- •Scleritis
- •Evaluation after glaucoma surgery
- •Filtering Bleb
- •Hypotony
- •Choroidal Effusion/Hemorrhage
- •Vitreous Hemorrhage
- •Aqueous Misdirection
- •Glaucoma Drainage Device
- •Congenital glaucoma
- •The future
- •References
- •Vitreoretinal Disorders
- •Vitreous hemorrhage
- •Posterior vitreous detachment
- •Retinal detachment
- •Rhegmatogenous Retinal Detachment
- •Tractional Retinal Detachment
- •Exudative Retinal Detachment
- •Total Retinal Detachment
- •Differential Diagnosis
- •Associated Retinal Detachment
- •Giant Retinal Tear
- •Differential Diagnosis
- •Retinal pigment epithelium detachment
- •Retinoschisis
- •Disciform lesions
- •Postsurgical changes
- •Scleral Buckle
- •MIRAgel Implant
- •Gas/Air Bubbles
- •Silicone oil
- •Retained Perfluorocarbon Liquids
- •References
- •Intraocular Tumors
- •Retinoblastoma
- •Differential diagnosis of retinoblastoma
- •Persistent Hyperplastic Primary Vitreous
- •Coats’ Disease
- •Toxocariasis
- •Medulloepithelioma
- •Benign uveal tumors
- •Iris and Ciliary Body Nevus
- •Choroidal Nevus
- •Uveal Melanocytoma
- •Malignant uveal tumors
- •Iris and Ciliary Body Melanoma
- •Choroidal Melanoma
- •A-scan
- •B-scan
- •Tumor biometry
- •Intraoperative confirmation of plaque placement
- •Response to radiation therapy
- •Differential Diagnosis of Choroidal Melanoma
- •Circumscribed choroidal hemangioma
- •Choroidal metastasis
- •Leiomyoma
- •Age-related macular and extramacular degeneration
- •Posterior scleritis
- •Intraocular calcification
- •Astrocytic Hamartoma
- •Choroidal Osteoma
- •Sclerochoroidal Calcification
- •Others
- •References
- •Uveitis
- •Anterior Uveitis
- •Intermediate Uveitis
- •Pars Planitis
- •Hypotony and Uveitis
- •Posterior Uveitis
- •Panuveitis
- •Sympathetic ophthalmia and Vogt-Koyanagi-Harada syndrome
- •Scleral inflammatory disease
- •Episcleritis
- •Scleritis
- •Anterior scleritis
- •Posterior scleritis
- •Inflammatory leukocoria (toxocariasis)
- •Infectious endophthalmitis
- •Inflammatory orbital diseases
- •References
- •Optic Nerve Disorders
- •Technique
- •30deg Test
- •Papilledema
- •Adults
- •Intracranial pathology
- •Children
- •Optic disc drusen
- •Adults
- •Young Adults
- •Congenital disc anomalies
- •Optic Disc Coloboma
- •Morning Glory Disc Anomaly
- •Tilted Optic Disc
- •Pseudodoubling of the Optic Disc
- •Retrobulbar optic nerve lesions
- •Gaze-evoked amaurosis
- •Giant cell arteritis
- •References
- •Rhegmatogenous retinal detachment
- •Hemorrhagic choroidal detachment
- •Lens dislocation
- •Intraocular foreign body
- •Endophthalmitis
- •References
Ophthalmic Biometry
Karolinne Maia Rocha, MD, PhD, Ronald R. Krueger, MD, MSE*
KEYWORDS
Biometry IOL calculation Refractive surgery
Cataract surgery and intraocular lens (IOL) implantation are currently evolving into a refractive procedure. The precision of biometry is crucial for meeting expectations of patients undergoing cataract surgery. Moreover, the optimal results for new IOLs being developed, such as toric, multifocal, accommodative, and aspheric, all depend on the accuracy of biometry measurements. For all of these reasons, biometry is an important and currently relevant topic to be discussed.
The fundamental points for accurate biometry include the axial length measurements, corneal power calculation, and IOL position (effective lens position [ELP]), the selection of the most appropriate formula, and its clinical application.
AXIAL EYE LENGTH MEASUREMENTS
Instruments and Methods
The measurement of axial eye length is one of the most important steps for IOL lens power calculation. An error in axial length measurement of 1 mm can cause an error in IOL power of 2.5 D (approximately). The continual refinements of ultrasound use in ophthalmology are important in minimizing this error.
Although laser interferometry (IOL Master, Zeiss, Germany) was developed to increase the accuracy of biometry measurements, in some eyes that are unable to fixate, it is not possible to perform accurate examinations with this method.1 Optical coherence biometry is a noncontact and operator-independent method that emits an infrared beam which is reflected back from the retinal pigment epithelium. The reflected light beam is captured by the instrument, and the axial length is calculated by the interferometer. The patient needs to fixate on the device’s internal light to allow for axiality with the fovea. Patients with dense nuclear or subcapsular cataracts, patients
with retinal detachment, and patients for whom cooperation is poor need to be evaluated by the ultrasonic methods.
A-scan Biometry
An A-scan is currently used for biometric calculations, but in some cases the precision of the measurements can be optimized by a B-scan. Clinical decisions can be made during dynamic examinations. In eyes with staphyloma or nanophthalmos, the A-scan can be guided by the B-scan. A-scan biometry includes two main techniques: the contact method and the immersion technique.
Contact method
In the contact (applanation) method, the ultrasound probe directly touches the cornea. In the echogram for the axial eye length measurement, the first spike represents the probe tip placed on the cornea, followed by the anterior lens capsule, posterior lens capsule, vitreous cavity, retina, sclera, and orbital tissue echoes (Fig. 1). The contact technique is completely examiner dependent because it requires direct contact and anterior compression of the cornea. Previous studies have demonstrated a mean shortening of axial length by 0.1 to 0.33 mm using the contact technique compared with immersion technique.2–5
Immersion technique
Because the immersion method eliminates compression of the globe, this technique has been shown to be more precise than contact biometry (Fig. 2). In the immersion technique, a scleral shell filled with fluid is placed over the cornea while the patient lies supine. The probe is immersed in the fluid overlying the cornea. Clinically, this method is important in eyes with a small axial length (high hyperopia, microphthalmos, nanophthalmos).
Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Mail code i-32, Cleveland, OH 44195, USA * Corresponding author.
E-mail address: krueger@ccf.org (R.R. Krueger).
Ultrasound Clin 3 (2008) 195–200 doi:10.1016/j.cult.2008.04.005
1556-858X/08/$ – see front matter ª 2008 Published by Elsevier Inc.
ultrasound.theclinics.com
196 |
Rocha & Krueger |
Table 1
Sound velocities for axial length measurements
Medium |
Velocity (m/s) |
Soft tissue |
1550 |
Cornea |
1641 |
Aqueous/vitreous |
1532 |
Crystalline lens |
1641 |
Silicone oil |
980 |
Fig. 1. Contact A-scan of a normal phakic eye. The spikes correspond to corneal surface (C), anterior (AL) and posterior lens capsule (PL), and retina (R).
Velocity Settings
Sound waves travel at different speeds according to the physical properties of the medium. The ultrasound velocity varies in relation to the medium within the eye, IOL materials, and even axial length (Tables 1 and 2).6,7 In a normal phakic eye, the average ultrasound velocity is 1555 m/s. In eyes with a short axial length (w20 mm), it is 1560 m/s, whereas in longer eyes it is 1550 m/s. This difference is due to an inverse proportional shift in the axial ratio of solid to liquid as the eye increases in length.
Special Clinical Situations
Special cases include eyes containing silicone oil, posterior pole staphyloma, and pseudophakic eyes.
Silicone oil
The higher refractive index and slower sound velocity (980 m/s) of silicone oil in comparison
Fig. 2. Immersion A-scan of a normal phakic eye. The spikes correspond to water bath (W), anterior and posterior corneal surface (C), anterior (AL) and posterior lens capsule (PL), and retina (R).
with the normal vitreous impairs the biometry accuracy. A-scan echograms usually seem longer than the real axial length in eyes filled with silicone oil. Careful evaluation of individual eyes should be taken to avoid a hyperopic error in these eyes. During the A-scan measurements, the patient should be positioned as upright as possible to keep the silicone oil in contact with the retina and to avoid it shifting into the anterior chamber. Overall, the baseline axial length should be measured, if possible, before silicone oil injection. The IOL Master, using optical coherence tomography laser interferometry, has shown satisfactory results when calculating IOL power in silicone oil–filled eyes.8
Posterior staphyloma
The possibility of a posterior staphyloma should be considered in all eyes with high axial myopia, particularly when axial length is difficult to measure and is greater than 26 mm (Fig. 3). In these cases, the retinal peak is difficult to capture during the A-scan measurement. B-scan ultrasonography is a complimentary method that should be considered in these cases.9 An axial immersion B-scan is a variant method that is able to obtain an echogram that highlights the central echoes of the cornea, the anterior and posterior lens, and macula
Table 2
Average sound velocities according to lens status
Eye Types |
Velocity (m/s) |
Phakic |
1555 |
Aphakic |
1532 |
Pseudophakic (PMMA) |
1556 |
Pseudophakic (acrylic) |
1549 |
Pseudophakic (silicone) |
1476 |
Phakic (gas) |
534 |
Phakic (silicone oil) |
1139 |
Aphakic (silicone oil) |
1052 |
Abbreviation: PMMA, polymethyl methacrylate.
