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Ophthalmic Biometry

Karolinne Maia Rocha, MD, PhD, Ronald R. Krueger, MD, MSE*

KEYWORDS

Biometry IOL calculation Refractive surgery

Cataract surgery and intraocular lens (IOL) implantation are currently evolving into a refractive procedure. The precision of biometry is crucial for meeting expectations of patients undergoing cataract surgery. Moreover, the optimal results for new IOLs being developed, such as toric, multifocal, accommodative, and aspheric, all depend on the accuracy of biometry measurements. For all of these reasons, biometry is an important and currently relevant topic to be discussed.

The fundamental points for accurate biometry include the axial length measurements, corneal power calculation, and IOL position (effective lens position [ELP]), the selection of the most appropriate formula, and its clinical application.

AXIAL EYE LENGTH MEASUREMENTS

Instruments and Methods

The measurement of axial eye length is one of the most important steps for IOL lens power calculation. An error in axial length measurement of 1 mm can cause an error in IOL power of 2.5 D (approximately). The continual refinements of ultrasound use in ophthalmology are important in minimizing this error.

Although laser interferometry (IOL Master, Zeiss, Germany) was developed to increase the accuracy of biometry measurements, in some eyes that are unable to fixate, it is not possible to perform accurate examinations with this method.1 Optical coherence biometry is a noncontact and operator-independent method that emits an infrared beam which is reflected back from the retinal pigment epithelium. The reflected light beam is captured by the instrument, and the axial length is calculated by the interferometer. The patient needs to fixate on the device’s internal light to allow for axiality with the fovea. Patients with dense nuclear or subcapsular cataracts, patients

with retinal detachment, and patients for whom cooperation is poor need to be evaluated by the ultrasonic methods.

A-scan Biometry

An A-scan is currently used for biometric calculations, but in some cases the precision of the measurements can be optimized by a B-scan. Clinical decisions can be made during dynamic examinations. In eyes with staphyloma or nanophthalmos, the A-scan can be guided by the B-scan. A-scan biometry includes two main techniques: the contact method and the immersion technique.

Contact method

In the contact (applanation) method, the ultrasound probe directly touches the cornea. In the echogram for the axial eye length measurement, the first spike represents the probe tip placed on the cornea, followed by the anterior lens capsule, posterior lens capsule, vitreous cavity, retina, sclera, and orbital tissue echoes (Fig. 1). The contact technique is completely examiner dependent because it requires direct contact and anterior compression of the cornea. Previous studies have demonstrated a mean shortening of axial length by 0.1 to 0.33 mm using the contact technique compared with immersion technique.2–5

Immersion technique

Because the immersion method eliminates compression of the globe, this technique has been shown to be more precise than contact biometry (Fig. 2). In the immersion technique, a scleral shell filled with fluid is placed over the cornea while the patient lies supine. The probe is immersed in the fluid overlying the cornea. Clinically, this method is important in eyes with a small axial length (high hyperopia, microphthalmos, nanophthalmos).

Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Mail code i-32, Cleveland, OH 44195, USA * Corresponding author.

E-mail address: krueger@ccf.org (R.R. Krueger).

Ultrasound Clin 3 (2008) 195–200 doi:10.1016/j.cult.2008.04.005

1556-858X/08/$ – see front matter ª 2008 Published by Elsevier Inc.

ultrasound.theclinics.com

196

Rocha & Krueger

Table 1

Sound velocities for axial length measurements

Medium

Velocity (m/s)

Soft tissue

1550

Cornea

1641

Aqueous/vitreous

1532

Crystalline lens

1641

Silicone oil

980

Fig. 1. Contact A-scan of a normal phakic eye. The spikes correspond to corneal surface (C), anterior (AL) and posterior lens capsule (PL), and retina (R).

Velocity Settings

Sound waves travel at different speeds according to the physical properties of the medium. The ultrasound velocity varies in relation to the medium within the eye, IOL materials, and even axial length (Tables 1 and 2).6,7 In a normal phakic eye, the average ultrasound velocity is 1555 m/s. In eyes with a short axial length (w20 mm), it is 1560 m/s, whereas in longer eyes it is 1550 m/s. This difference is due to an inverse proportional shift in the axial ratio of solid to liquid as the eye increases in length.

Special Clinical Situations

Special cases include eyes containing silicone oil, posterior pole staphyloma, and pseudophakic eyes.

Silicone oil

The higher refractive index and slower sound velocity (980 m/s) of silicone oil in comparison

Fig. 2. Immersion A-scan of a normal phakic eye. The spikes correspond to water bath (W), anterior and posterior corneal surface (C), anterior (AL) and posterior lens capsule (PL), and retina (R).

with the normal vitreous impairs the biometry accuracy. A-scan echograms usually seem longer than the real axial length in eyes filled with silicone oil. Careful evaluation of individual eyes should be taken to avoid a hyperopic error in these eyes. During the A-scan measurements, the patient should be positioned as upright as possible to keep the silicone oil in contact with the retina and to avoid it shifting into the anterior chamber. Overall, the baseline axial length should be measured, if possible, before silicone oil injection. The IOL Master, using optical coherence tomography laser interferometry, has shown satisfactory results when calculating IOL power in silicone oil–filled eyes.8

Posterior staphyloma

The possibility of a posterior staphyloma should be considered in all eyes with high axial myopia, particularly when axial length is difficult to measure and is greater than 26 mm (Fig. 3). In these cases, the retinal peak is difficult to capture during the A-scan measurement. B-scan ultrasonography is a complimentary method that should be considered in these cases.9 An axial immersion B-scan is a variant method that is able to obtain an echogram that highlights the central echoes of the cornea, the anterior and posterior lens, and macula

Table 2

Average sound velocities according to lens status

Eye Types

Velocity (m/s)

Phakic

1555

Aphakic

1532

Pseudophakic (PMMA)

1556

Pseudophakic (acrylic)

1549

Pseudophakic (silicone)

1476

Phakic (gas)

534

Phakic (silicone oil)

1139

Aphakic (silicone oil)

1052

Abbreviation: PMMA, polymethyl methacrylate.