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Ординатура / Офтальмология / Английские материалы / Ocular Differential Diagnosis 7th edition_Roy_2002

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Kirkali P, Kansu T. Lid lag in hyperkalemic periodic paralysis. Ann Ophthal 1991;23:422â??423.

Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.

Tan E, et al. Lid lag and the Guillain-Barré syndrome. J Clin Neuro-Ophthal 1990;10:121â??123.

Blepharospasm (Spasmodic Eyelid Closure)

Most common and important: Psychogenic onset commonly in children and young adults

1. Addison disease (adrenal cortical insufficiency)

2. Associated with syphilis, tetanus, and tetany

3. Basal ganglion dysfunctionâ??onset usually after middle age; including Parkinson disease (shaking palsy)

4. Cerebral palsy

5. Cogan syndrome (nonsyphilitic interstitial keratitis) with vestibuloauditory symptoms 6. Drugs, including the following:

acetophenazine

dimethindene

methdilazine

amitriptyline

diphenhydramine

methotrimeprazine

amodiaquine

diphenylpyraline

nortriptyline

amoxapine(?)

doxepin

pentylenetetrazol

amphetamine

doxylamine

perazine

antazoline

dronabinol

pericyazine

brompheniramine

droperidol

perphenazine

butaperazine

emetine

pheniramine

carbinoxamine

ethopropazine

phenmetrazine

carphenazine

fluphenazine

phenylephrine

 

 

chloroquine

haloperidol

piperacetazine

 

 

chlorpheniramine

hashish

prochlorperazine

 

 

chlorpromazine

hydroxychloroquine

promazine

 

 

clemastine

imipramine

promethazine

 

 

clomipramine

levodopa

propiomazine

 

 

desipramine

levothyroxine

protriptyline

 

 

dexbrompheniramine

liothyronine

pyrilamine

 

 

dexchlorpheniramine

liotrix

selegiline

 

 

dextroamphetamine

lorazepam

tetrahydrocannabinol

 

 

dextrothyroxine

marihuana

thiethylperazine

 

 

diethazine

mesoridazine

thiopropazate

 

 

dimercaprol

methamphetamine

thioproperazine

 

 

thioridazine

trifluperidol

tripelennamine

 

 

thyroglobulin

triflupromazine

triprolidine

 

 

thyroid

trimeprazine

vidarabine

 

 

trifluoperazine

trimipramine

vinblastine

 

 

 

 

 

 

 

P.66

 

 

7.

Electrical injury

 

 

8.

Encephalitis

 

 

9.

Epidemic keratoconjunctivitis

 

 

10.

Hallervordenâ??Spatz

 

 

11.

Hereditary reflex blepharospasm

 

12.

Idiopathic (essential)

 

 

13.

Leprosy (Hansen disease)

 

 

14.

Meige syndrome

 

 

15.

Obsessiveâ??compulsive disorder

 

16. *Pain or light sensitivity following injury or inflammation or foreign bodies of lids, conjunctiva, cornea, or iris

17. Photosensitivity and sunburn

18. Poison ivy dermatitis

19. Postencephalitic blepharospasm

20. Psychogenic obsessiveâ??compulsive disorderâ??onset commonly in children and young adults

21. Psychologic reflex blepharospasmâ??seen in premature infants with tactile stimulation of lids

22. Sparganosis

23. Systemic scleroderma (progressive systemic sclerosis)

24. Thomsen syndrome (congenital myotonia syndrome)

25. Tourette syndrome (coprolalia, generalized tic)

Defazio G, et al. Genetic contribution to idiopathic adult-onset blepharospasm and cranial-cervical dystonia. Eur Neurol 1993;33:345â??350.Bibliographic Links

Fraunfelder FT, Fraunfelder FW. Drug-induced ocular side effects. Woburn, MA: Butterworth-Heinemann, 2001.

Larumbe R, et al. Reflex blepharospasm associated with bilateral basal ganglia lesion. Movement Disorders 1993;8:198â??200.Bibliographic Links

Patel BC, Anderson RL. Blepharospasm. Ophthalmic Practice 1993;11:293â??302.

Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.

Facial Palsy

Facial palsy is defined as paralysis of facial muscles supplied by the seventh nerve; orbicularis oculi paralysis may result in epiphora and ectropion.

1. Congenital

2. Birth injury with nerve crushed at exit of stylomastoid foramen 3. Myogenic paralysis

A.Myotonic atrophia

B.Facioscapulohumeral type of muscular dystrophy

C.Myasthenia gravis (Erbâ??Goldflam syndrome)

D.Hypokalemia, periodic

E.Curare poisoning

F.Botulism

G.Congenital facial diplegia (Möbius syndrome)

P.67

H.Infants, from maternal ingestion of thalidomide

I.Kugelbergâ??Welander syndrome

4. Neurologic paralysis

A.Supranuclear paralysisâ??upper face, including orbicularis relatively unaffected with affected lower face

1. Voluntary movementâ??pyramidal fibers involved, such as in Weber syndrome, with contralateral hemiplegia of face and limbs and ipsilateral oculomotor paralysis

2. Weakness or abolition of the emotional movements of the face with retention of full voluntary activity, such as with lesion of anterior part of frontal lobe or near optic thalamus

B.Peripheral paralysisâ??involvement of upper and lower face

1. Pontine lesionâ??associated structures involved include sixth nerve, conjugate ocular deviation to the same side, ipsilateral paralysis of jaw muscles, and pyramidal tract in paralysis of limb of opposite side

a.Acute nuclear lesions, such as with anterior poliomyelitis, Landry paralysis, or degenerative conditions

b.Foville syndromeâ??ipsilateral sixth nerve with loss of conjugate deviation to same side and hemiplegia of the opposite limbs

c.Millardâ??Gubler syndromeâ??ipsilateral sixth nerve paralysis and hemiplegia of the opposite limbs

d.Parotid gland surgery

e.Progressive muscular atrophy

f.Syringobulbia

g.Tumors

h.Vascular lesions

2. Posterior fossaâ??associated with nerve deafness, loss of taste on anterior two thirds of tongue, and occasionally diminution of tears

a.Acoustic neuroma

b.CHARGE (coloboma, heart disease, atresia choanae, retarded growth and retarded development or central nervous system anomalies, genital hypoplasia, and ear anomalies or deafness) syndrome association

c.Facial neuritis due to polyneuritis cranialis, beriberi, encephalitis, diabetes, or intrathecal anesthesia

d.Fracture of the skull

e.Meningitis, including syphilitic and tuberculous

f. Preauricular cyst associated with congenital cholesteatoma g. Tumors of facial nerve

3. Petrous temporal boneâ??associated with decreased lacrimation and salivary secretion, loss of taste on anterior two thirds of tongue, and intensified sensation of loud noises

a.Arteriosclerosis

b.*Bell palsyâ??inflammation of facial nerve of unknown cause

c.Cephalic tetanus

d.Diabetes mellitus (Willis disease)

e.Fractures

f.Herpes zoster, spread from geniculate ganglion

g.Hypertension P.68

h.Nerve leprosy (Hansen disease)

i.Otitis media

j.Secondary syphilis

4. Facial lesions at or beyond the stylomastoid foramen

a.Fracture of the ramus of the mandible

b.Melkerssonâ??Rosenthal syndrome (Melkersson idiopathic fibroedema)

c.Neoplasia or inflammatory swelling of parotid, such as in uveoparotid fever (Heerfordt disease) and Mikulicz disease

d.Supporting lymph nodes behind the angle of the jaw

Eggenberger ER. Facial palsy in Lyme disease. N Engl J Med 1993;328:1571.Bibliographic Links

Lacombe D. Facial palsy and cranial nerve abnormalities in CHARGE association. Am J Med Genet 1993;15:351â??353.

Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.

Infrequent Blinking

1. *Contact lens use

2. Encephalitis, acute

3. Encephalitis or mild postencephalitic states

4. *Ethanol intake

5. Infants in first few months of life

6. Parkinson syndrome, including mycostatic paresis of parkinsonism

7. Psychotic states

8. Progressive supranuclear palsy

9. Thyrotoxicosis including exophthalmic ophthalmoplegia (Stellwag sign)

Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.

Walsh FB, Hoyt WF. Clinical neuro-ophthalmology, 4th ed. Baltimore: Williams & Wilkins, 1985.

Frequent Blinking

1. *Reflexâ??strong lights, sudden approach of objects toward eyes, loud noises, and touching the cornea; reflex blinking common in albinos and light intolerance

2. Spontaneousâ??mental state and environment

A.Children with habit spasm and facial tic

B.Blepharospasm

C.*Older persons with inadequate lacrimation and local irritation of the eyes

3. Disorders of central nervous system disease, such as parkinsonism or various forms of pseudobulbar palsy

4. Drugs, including the following:

acetylcholine

carbachol

etidocaine

allobarbital

carbamazepine

heptabarbital

ambenonium

chloroprocaine

hexethal

amobarbital

chloroquine

hexobarbital

amodiaquine

clofibrate

hydroxychloroquine

aprobarbital

cyclobarbital

isoflurophate

barbital bupivacaine

cyclopentobarbital

levodopa

butabarbital

demecarium

lidocaine

butalbital

dibucaine

mephobarbital

butallylonal

echothiophate

mepivacaine

butethal

edrophonium

methacholine

metharbital

pilocarpine

secobarbital

methitural

piperocaine

talbutal

methohexital

prilocaine

tetracaine

methylphenidate

primidone

thiamylal

neostigmine

probarbital

thiopental

pentobarbital

procaine

vinbarbital

phenobarbital

propoxycaine

 

physostigmine

pyridostigmine

 

P.69

Fraunfelder FT, Fraunfelder FW. Drug-induced ocular side effects. Woburn, MA: Butterworth-Heinemann, 2001.

Moses RA. Adler's physiology of the eye, 8th ed. St. Louis: CV Mosby, 1986.

Walsh FB, Hoyt WF. Clinical neuro-ophthalmology, 4th ed. Baltimore: Williams & Wilkins, 1985.

Lid Edema (Puffiness or Bagginess of Lids)

1. *Noninflammatory or minimally inflammatory swelling

A.Acosta syndrome (Mountain climbers syndrome)

B.Allergic gastroenteropathy with protein loss

C.Arteriovenous fistula

D.Cardiac and renal disease

1. Nephrosis and acute glomerulonephritisâ??early morning edema

2. Starvation and cachexia

E.Dermatochalasis

F.Elephantiasis

1. Chronic eczema or infection (erysipelas)

2. Hemolymphangioma

3. Leprosy (Hansen disease)

4. Lues (syphilis)

5. Melkerssonâ??Rosenthal syndrome (Melkersson idiopathic fibroedema)

6. Nonneâ??Milroyâ??Meige disease (idiopathic hereditary lymphedema)

7. von Recklinghausen disease (neurofibromatosis)

8. Traumatic disruption of the lymph drainage system

9. Tuberculosis

G.Endocrine exophthalmos (hyperthyroidism)

H.Foix syndrome (cavernous sinus syndrome)

I.Granulomatous ileocolitis

J.Hutchinson syndrome (adrenal cortex neuroblastoma with orbital metastasis)

K.Infectious generalized diseases 1. Diphtheria

2. Infectious mononucleosis

3. Malaria

4. Meningococcal meningitis

5. Pertussis (whooping cough)

6. Rheumatic fever

7. Scarlet fever

8. Trypanosomiasis

9. Tuberculosis

10. Yellow fever

L. Melkersson-Rosenthal syndrome

M.Nasal nerve syndrome (Charlin syndrome) P.70

N.Parasitic infestations 1. Anthrax

2. Ascariasis

3. Chlamydia

4. Dermatophytosis

5. Myiasis

6. Onchocerciasis syndrome (river blindness)

7. Tapeworms

8. Toxocariasis

9. Trichinosis

O.Protrusion of fat through orbital fascia

P.Retinoblastoma

Q.Stasis, including premenstrual edema

R.Superior vena cava syndrome

S.Systemic scleroderma (progressive systemic scleroderma)

T.*Tumors and pseudotumors

1. Benign and malignant ectodermal and mesodermal tumors

2. Brillâ??Symmers disease (lymphosarcoma)

3. Hemangiomas

4. Hodgkin disease

5. Leukemic deposit

6. Liposarcoma

7. Meningiomas of sphenoid ridge with impediment of venous circulation of ophthalmic veins or cavernous sinus

8. Neurofibromatosis

9. Pseudotumors

a.Amyloid degeneration

b.Eosinophilic or basophilic granulomas

U.Trauma

1. Basilar skull fractures

2. Injury

3. *Surgery

V.Angioneurotic edema caused by drugs, including the following:

amitriptyline

acenocoumarol

auranofin

acetaminophen

amobarbital

aurothioglucose

acetanilid

amoxapine

aurothioglycanide

acetophenazine

amoxicillin

azatadine

acetyldigitoxin

ampicillin

bacitracin

acyclovir

anisindione

barbital

adrenal cortex

antazoline

belladonna

injection

 

 

albuterol

antimony lithium

bendroflumethiazide

 

thiomalate

 

alcohol

antimony potassium

benzalkonium

 

tartrate

 

aldosterone

antimony sodium

benzathine penicillin G

 

tartrate

 

allobarbital

antimony sodium

benzphetamine

 

thioglycolate

 

alprazolam

 

benzthiazide

aluminum nicotinate

antipyrine

betamethasone

aminosalicylate(?)

aprobarbital

betaxolol

aminosalicylic

aspirin

bleomycin

acid(?)

 

 

amiodarone

atropine

botulinum A toxin

brimonidine tartrate

chlorprothixene

dicloxacillin

brompheniramine

chlortetracycline

dicumarol

bupivacaine

chlorthalidone

diethazine

busulfan

chrysarobin

diethylcarbamazine

butabarbital

ciprofloxacin

diethylpropion

butalbital

cisplatin

digitalis

butallylonal

clindamycin

digitoxin

butaperazine

clofibrate

digoxin

butethal

clomipramine

diltiazem

cactinomycin

clonazepam

dimethindene

capreomycin

clonidine

dimethyl sulfoxide

captopril

clorazepate

diphenadione

carbamazepine

cloxacillin

diphenhydramine

carbenicillin

cobalt

diphenylpyraline

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