Ординатура / Офтальмология / Английские материалы / Ocular Differential Diagnosis 7th edition_Roy_2002
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Isenberg SJ. The eye in infancy. Chicago: Year Book Medical, 1989.
Staphyloma of Cornea (Corneal Stretching with Incarceration of Uveal Tissue)
1. Advanced keratoconus (see p. 288)
2. Avitaminosis A with keratomalacia
3. Congenital
4. *Following corneal ulcer (see p. 281, 283), neuroparalytic keratitis, corneal leprosy, and severe corneal injury
5. Mucoviscidosis (cystic fibrosis of the pancreas)
Arffa RC. Grayson's diseases of the cornea, 3rd ed. St. Louis: Mosbyâ??Year Book, 1991.
Whorl-Like Corneal Lesions
1. *Amiodarone toxicity
2. Amodiaquine hydrochloride administration
3. Atabrine administration
4. *Chloroquine and hydroxychloroquine toxicity
5. Chlorpromazine administration
6. *Fabry disease (diffuse angiokeratosis)
7. Incontinentia pigmenti
8. Indomethacin administration
9. Meperidine hydrochloride
10. Quinacrine administration
11. Urethan administration
Arffa RC. Grayson's diseases of the cornea, 3rd ed. St. Louis: Mosbyâ??Year Book, 1991.
Fraunfelder FT, Fraunfelder FW. Drug-induced ocular side effects. Woburn, MA: Butterworth-Heinemann, 2001.
Kaplan LJ, Cappaert WE. Amiodarone keratopathy. Arch Ophthalmol 1982;100:601.Bibliographic Links
Ferreira RC, et al. Corneal abnormalities associated with incontinentia pigmenti. Am J Opthalmol 1997;123:549â??551.Bibliographic Links
P.291
Corneal Dermoids
These congenital corneal limbal lesions grow slowly. Tumors are yellowish, elevated, and variable in size; they consist of fibrofatty tissue covered by epidermal rather than by conjunctival epithelium and may contain ectodermal derivatives such as hair follicles, sebaceous glands, and sweat glands. Trauma, irritation, and puberty hasten their growth.
1. Blochâ??Sulzberger syndrome (incontinentia pigmenti) 2. Cri-du-chat syndrome (cat-cry syndrome)
3. Duane retraction syndrome
4. Multiple dermoids of the cornea associated with miliary aneurysms of the retina 5. Neurocutaneous syndrome (ectomesodermal dysgenesis)
6. Nevus sebaceous of Jadassohn (linear nevus sebaceous of Jadassohn) 7. *Oculoauriculovertebral dysplasia (Goldenhar syndrome)
8. Organoid nevus syndrome
9. Ring dermoid syndromeâ??autosomal dominant
10. Sporadic
11. Thalidomide teratogenicities
Diagnostic Table
Corneal dermoids
View Table
Arffa RC. Grayson's diseases of the cornea, 3rd ed. St. Louis: Mosbyâ??Year Book, 1991.
Benjamin SN, Allen HF. Classification for limbal dermoid choristomas and brachial arch
anomalies. Arch Ophthalmol 1972;87:305â??314.Bibliographic Links
Brodsky MC, et al. Oculocerebral dysgenesis in the linear nevus sebaceous syndrome. Ophthalmology 1997;104:497â??503.Bibliographic Links
Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
P.292
P.293
Corneal Problems Associated with Keratotic Skin Lesions
1. Ectodermal dysplasia (anhidrotic)
2. *Ichthyosis
3. Keratosis follicularis
4. Keratosis follicularis spinulosa decalvans
5. Keratosis plantaris and palmaris
6. Pityriasis rubra pilaris
Arffa RC. Grayson's diseases of the cornea, 3rd ed. St. Louis: Mosbyâ??Year Book, 1991.
Wilson LA. External diseases of the eye. New York: Harper & Row, 1979.
Corneal Problems Associated with Lid Excrescences
1. Keratosis folliculosis
2. Lipid proteinosis
3. *Molluscum contagiosum
4. Verruca vulgaris
Arffa RC. Grayson's diseases of the cornea, 3rd ed. St. Louis: Mosbyâ??Year Book, 1991.
Wilson LA. External diseases of the eye. New York: Harper & Row, 1979.
Corneal Disease Associated with Lenticular Problems
1. Aberfeld syndrome (ocular and facial abnormalities syndrome)â??cataracts, microcornea 2. Acrodermatitis chronica atrophicansâ??keratomalacia, corneal opacification, cataracts
3. Addison syndrome (idiopathic hypoparathyroidism)â??keratoconjunctivitis, corneal ulcers, keratitic moniliasis, cataracts
4. Amiodaroneâ??corneal deposits, anterior subcapsular cataracts
5. Amyloidosisâ??amyloid deposits of cornea, corneal dystrophy, pseudopodia lentis
6. Andersonâ??Warburg syndrome (oligophreniaâ??microphthalmos syndrome)â??corneal opacification and lenticular destruction with a mass visible behind the lens
7. Andosky syndrome (atopic cataract syndrome)â??atopic keratoconjunctivitis, keratoconus, uveitis, subcapsular cataract
8. Aniridiaâ??microcornea and subluxated lenses
9. Anterior chamber cleavage syndrome (Reeseâ??Ellsworth syndrome)â??corneal opacities, anterior pole cataract
10. Anterior segment ischemia syndromeâ??corneal edema, corneal ulceration, cataract
11. Apert syndrome (absent digits cranial defects syndrome)â??exposure keratitis, cataracts, ectopia lentis
12. Arteriovenous fistula (arteriovenous aneurysm)â??bullous keratopathy, cataract
13. Aspergillosisâ??corneal ulcer, keratitis, cataract
14. *Atopic disease (atopic eczema, Besnier prurigo)â??keratoconjunctivitis, keratoconus, cataract
15. Autosomal dominantâ??cataracts and microcornea
16. Avitaminosis C (scurvy)â??keratitis, corneal ulcer, cataract
17. Chickenpox (varicella)â??corneal ulcer, corneal opacity, keratitis, cataract
18. Chlorpromazineâ??corneal and lens opacities
19. Choleraâ??keratomalacia, cataract
20. Chromosome partial deletion (short-arm) syndromeâ??cataracts, corneal opacities P.294
21. Cockayne syndrome (Mickey Mouse syndrome)â??cataracts, band keratopathy, corneal dystrophy
22. Congenital spherocytic anemia (congenital hemolytic jaundice)â??congenital cataract, ring-shaped pigmentary corneal deposits
23. Crouzon syndrome (Parrot-head syndrome)â??exposure keratitis, cataract, corneal dystrophy
24. Cryptophthalmia syndrome (cryptophthalmosâ??syndactyly syndrome)â??cornea differentiated from sclera, lens absence to hypoplasia, dislocation, and calcification
25. Cytomegalic inclusion disease (cytomegalovirus)â??cataract, corneal opacities
26. Darierâ??White syndrome (keratosis follicularis)â??keratosis, corneal subepithelial infiltrations, corneal ulceration, cataract
27. Dermatitis herpetiformis (Duhringâ??Broca disease)â??corneal vascularization, cataract
28. Diphtheriaâ??keratitis, corneal ulcer, cataract
29. Ehlersâ??Danlos syndrome (fibrodysplasia elastica generalisata)â??microcornea, keratoconus, lens subluxation
30. Electrical injuryâ??corneal perforation, necrosis of cornea, anterior or posterior subcapsular cataracts
31. Exfoliation syndrome (capsular exfoliation syndrome)â??cataract, dislocated lens, corneal dystrophy, lens capsule exfoliation
32. Folling syndrome (phenylketonuria)â??corneal opacities, cataracts
33. *Fuchs syndrome (I) (heterochromic cyclitis syndrome)â??secondary cataract, edematous corneal epithelium
34. Goldscheider syndrome (epidermolysis bullosa)â??bullous keratitis, corneal subepithelial blisters to corneal perforation, cataract
35. Gorlinâ??Goltz syndrome (multiple basal cell nevi syndrome)â??cataract, corneal leukoma 36. Grönbladâ??Strandberg syndrome (elastorrhexis)â??keratoconus, cataract, subluxation
of lens
37. Hallermannâ??Streiff syndrome (oculomandibulofacial dyscephaly)â??cataracts, microcornea
38. Hanhart syndrome (recessive keratosis palmoplantaris)â??dendritic corneal lesions, keratitis, corneal haze, corneal neovascularization, cataract
39. Heerfordt syndrome (uveoparotid fever)â??band keratopathy, keratoconjunctivitis, cataract
40. Hereditary ectodermal dysplasia syndrome (Siemens syndrome)â??keratosis, corneal erosions, corneal dystrophy, cataract, lens luxation
41. *Herpes simplexâ??keratitis, corneal ulcer, cataract
42. *Herpes zosterâ??keratitis, corneal ulcer, cataract
43. Histiocytosis X (Handâ??Schüllerâ??Christian syndrome)â??pannus, bullous keratopathy, corneal ulcer, cataract
44. Hodgkin diseaseâ??keratitis, cataract
45. Homocystinuria syndromeâ??dislocated lens, cataract, keratitis
46. Hutchinsonâ??Gilford syndrome (progeria)â??cataract, microcornea
47. Hydatid cyst (echinococcosis)â??keratitis, corneal abscess, cataract
48. Hypervitaminosis Dâ??band keratopathy, cataract
49. Hypoparathyroidismâ??keratitis, cataract
50. Hypophosphatasia (phosphoethanolaminuria)â??cataract, corneal subepithelial calcifications
51. Influenzaâ??keratitis, cataract P.295
52. Jadassohn-type anetodermalâ??keratoconus, cataract
53. Jadassohnâ??Lewandowsky syndrome (pachyonychia congenita)â??corneal dyskeratosis, cataract
54. *Juvenile rheumatoid arthritis (Still disease)â??band keratopathy, cataract 55. Kussmaul disease (periarteritis nodosa)â??corneal ulcer, cataract
56. Kyrle disease (hyperkeratosis penetrans)â??subcapsular cataracts, subepithelial corneal opacities
57. Leri syndrome (carpal tunnel syndrome)â??corneal clouding, cataract
58. Listerellosis (listeriosis)â??keratitis, corneal abscess and ulcer, cataract
59. Little syndrome (nailâ??patella syndrome)â??microcornea, keratoconus, cataract
60. Lowe syndrome (oculocerebrorenal syndrome)â??cloudy cornea, cataracts, megalocornea, corneal dystrophy
61. Malariaâ??keratitis, cataract
62. Marchesani syndrome (brachymorphia with spherophakia)â??lentic ulnar myopia, ectopia lentis, megalocornea, corneal opacity
63. Marfan syndrome (arachnodactylyâ??dystrophiaâ??mesodermalis congenita)â??lens dislocation, cataract, megalocornea, lenticular myopia
64. Matsoukas syndrome (oculocerebroarticuloskeletal syndromes)â??cataract, corneal sclerosis
65. Meckel syndrome (dysencephalia splanchnocystica syndrome)â??sclerocornea, microcornea, cataract
66. Morbilli (rubeola, measles)â??corneal ulcer, cataract
67. Mucolipidosis IV (ML IV)â??corneal clouding, cataract
68. Nematode ophthalmia syndrome (toxocariasis)â??cataract, larvae present in the cornea 69. Neurodermatitis (lichen simplex chronicus)â??keratoconjunctivitis, atopic cataracts,
keratoconus
70. Ocular toxoplasmosis (toxoplasmosis)â??keratitis, cataract
71. Oculodental syndrome (Peter syndrome)â??macrocornea, opacities of the corneal margin, ectopic lentis, corneoscleral staphyloma
72. O'Donnellâ??Pappas syndromeâ??presenile cataract, peripheral corneal pannus
73. Paget syndrome (osteitis deformans)â??corneal ring opacities, cataract
74. Passow syndrome (status dysraphicus syndrome)â??neuroparalytic keratitis, zonular cataract
75. Pemphigus foliaceus (Cazenave disease)â??pannus, corneal infiltration, cataract
76. Pigmentary ocular dispersion syndrome (pigmentary glaucoma)â??Krukenberg spindle, equatorial pigmentation of lens capsule
77. Pseudohypoparathyroidism (Seabrightâ??Bantan syndrome)â??punctate cataracts, keratitis
78. Radiationâ??corneal ulcer, punctate keratitis, cataracts, exfoliation of lens capsule 79. Refsum syndrome (phytanic acid oxidase deficiency)â??corneal opacities, cataracts
80. Relapsing polychondritisâ??corneal ulcer, cataracts, keratoconjunctivitis sicca
81. Retinal disinsertion syndromeâ??lens subluxation, keratoconus
82. Retinopathy of prematurityâ??cataracts, corneal opacification
83. Rieger syndrome (dysgenesis mesodermalis corneae et irides)â??microcornea, corneal opacities in Descemet membrane, dislocated lens
84. Romberg syndrome (facial hemiatrophy)â??neuroparalytic keratitis, cataracts
85. Rubella syndrome (German measles)â??corneal haziness, cataracts, microcornea
86. Sabinâ??Feldman syndromeâ??posterior lenticonus, microcornea
87. Sanfilippoâ??Good syndrome (MPS III)â??deposits in cornea and lens P.296
88. Schafer syndrome (keratosis palmoplantaris syndrome)â??lesions in the lower portion of the cornea, cataract
89. Schaumann syndrome (sarcoidosis syndrome)â??keratitis sicca, band-shaped keratitis, complicated cataract
90. Scheie syndrome (MPS IS)â??diffuse haze to marked corneal clouding, cataracts 91. Stannus cerebellar syndromeâ??corneal vascularization, corneal opacities, cataracts
92. Stevensâ??Johnson syndrome (erythema multiforme exudativum)â??keratitis, corneal ulcers, cataracts, pannus
93. Stickler syndrome (hereditary progressive arthroophthalmopathy)â??keratopathy, cataracts
94. Thioridazineâ??corneal and lens opacities
95. Toxic lens syndromeâ??pigment precipitation on the surface of an intraocular lens, chronic uveitis
96. Trisomy syndromeâ??corneal and lens opacities
97. Turner syndrome (gonadal dysgenesis)â??corneal nebulae, cataracts
98. Ultraviolet radiationâ??band keratopathy, keratitis, discoloring of lens
99. van Bogaertâ??Schererâ??Epstein syndrome (familial hypercholesterolemia syndrome)â??lipid keratopathy, cataract, juvenile corneal arcus
100. von Recklinghausen syndrome (neurofibromatosis)â??nodular swelling of corneal nerves, cataracts
101. Waardenburg syndrome (interoculoiridodermatoauditive dysplasia)â??microcornea, cornea plana, lenticonus
102. Wagner syndrome (hereditary hyaloideoretinal degeneration and palatoschisis)â??corneal degeneration, including band-shaped keratopathy, cataracts
103. Ward syndrome (nevus jaw cyst syndrome)â??congenital cataracts, congenital corneal opacities
104. Wegener syndrome (Wegener granulomatosis)â??corneal ulcer, corneal abscess, cataract 105. Weil disease (leptospirosis)â??keratitis, cataract
106. Werner syndrome (progeria of adults)â??juvenile cataracts, bullous keratitis, trophic
corneal defects
107. Yersiniosisâ??corneal ulcer, cataract
108. Zellweger syndrome (cerebrohepatorenal syndrome of Zellweger)â??corneal opacities, cataract
Bilgami NL, et al. Marfan syndrome with microcornea, aphakia, and ventricular systolic defect. Indian Heart J 1981;33:78â??80.Bibliographic Links
Gualtieri CT, et al. Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine. Am J Psychiatry 1982;139:1178â??1180.Bibliographic Links
Polomeno RC, Cummings C. Autosomal dominant cataracts and microcornea. Can J Ophthalmol 1979;14:227â??229.Bibliographic Links
Roy FH. Ocular syndromes and systemic diseases, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
Corneal Disease Associated with Retinal Problems
1. Abdominal typhus (enteric fever)â??corneal ulcer, retinal detachment, central retinal artery emboli
2. Acanthamoebaâ??keratitis, pannus, corneal ring abscess, retinal perivasculitis
3. African eyeworm diseaseâ??keratitis, central retinal artery occlusion, macular hemorrhages 4. Amyloidosisâ??amyloid corneal deposits, corneal dystrophy, retinal hemorrhages
5. Andersonâ??Warburg syndrome (oligophreniaâ??microphthalmos syndrome)â??corneal opacification, malformed retina with retina pseudotumors
P.297
6. Angioedema (hives)â??central serous retinopathy, corneal edema
7. Anterior segment ischemia syndromeâ??corneal edema midperiphery retinal hemorrhages 8. Apert syndrome (acrodysplasia)â??exposure keratitis, retinal detachment
9. Arteriovenous fistulaâ??bullous keratopathy, retinal hemorrhages
10. Aspergillosisâ??corneal ulcer, keratitis, retinal hemorrhages, retinal detachment
11. Atopic dermatitisâ??keratoconus and retinal detachment
12. Avitaminosis Câ??retinal hemorrhages, keratitis, corneal ulcer 13. Bacillus cereusâ??ring abscess of cornea, necrosis of retina
14. Bang disease (brucellosis)â??keratitis, chorioretinitis, macular edema
15. Behçet syndrome (dermatostomataâ??ophthalmic syndrome)â??keratitis, posterior corneal abscess, retinal vascular changes
16. Bietti disease (Bietti marginal crystalline dystrophy)â??marginal corneal dystrophy, retinitis punctate albescens
17. Candidiasisâ??keratitis, corneal ulcer, retinal atrophy, retinal detachment
18. Carotid artery syndromeâ??corneal ulcer, loss of corneal sensation, retinal edema, engorgement of retinal veins
19. Chickenpox (varicella)â??corneal ulcer, corneal opacity, retinitis, hemorrhagic retinopathy 20. *Chloroquineâ??corneal epithelial pigmentation, macular lesions
21. Chronic granulomatous disease of childhoodâ??keratitis, destructive chorioretinal lesions 22. Cockayne syndrome (dwarfism with retinal atrophy and deafness)â??pigmentary
degeneration, band keratopathy, corneal dystrophy
23. Crohn disease (granulomatous ileocolitis)â??marginal corneal ulcers, keratitis, macular edema, macular hemorrhages
24. Cryoglobulinemiaâ??deep corneal opacities, venous stasis
25. Cystinosis (aminoaciduria)â??crystals in cornea and pigment in retina 26. Dengue feverâ??keratitis, corneal ulcer, retinal hemorrhages
27. Diffuse keratoses syndromeâ??corneal nodular thickening in the stroma worse in fall, retinal phlebitis
28. Diphtheriaâ??keratitis, corneal ulcer, central artery occlusion
29. Disseminated lupus erythematosus (Kaposiâ??Libmanâ??Sacks syndrome)â??keratitis, keratoconjunctivitis sicca, corneal ulcer, central retinal vein occlusion, retinal detachment
30. Ehlersâ??Danlos syndrome (cutis hyperelastica)â??keratoconus and retinitis pigmentosa 31. Electrical injuryâ??corneal perforation, retinal edema, retinal hemorrhages, pigmentary
degeneration, retinal holes, dilatation of retinal veins
32. Fabry disease (diffuse angiokeratosis)â??whorl-like changes in cornea, central retinal artery occlusion, tortuosity of retinal vessels
33. Goldscheider syndrome (epidermolysis bullosa)â??bullous keratitis with opacities, retinal detachment
34. Gronbladâ??Strandberg syndrome (systemic elastodystrophy)â??angioid streaks of the retina, macular hemorrhages, retinal detachment, keratoconus
35. Hammanâ??Rich syndrome (alveolar capillary block syndrome)â??keratomalacia ischemic retinopathy, cystic macular changes
36. Heerfordt syndrome (uveoparotid fever)â??band keratopathy, retinal vasculitis
37. Hennebert syndrome (luetic otitic nystagmus syndrome)â??interstitial keratitis, disseminated syphilitic chorioretinitis
38. Histiocytosis X (Handâ??Schüllerâ??Christian syndrome)â??retinal hemorrhage, retinal detachment, bullous keratopathy, corneal ulcer, pannus
P.298
39. Hodgkin diseaseâ??keratitis, retinal hemorrhages
40. Hollenhorst syndrome (chorioretinal infarction syndrome)â??hazy cornea, serous retinal detachment, pigmentary retinopathy
41. Hunter syndrome (MPS II)â??splitting or absence of peripheral Bowman membrane, stromal haze, pigmentary retinal degeneration, narrowed retinal vessels
42. Hurlerâ??Scheie syndrome (MPS IH-S)â??corneal clouding, pigmentary retinopathy 43. Hurler syndrome (gargoylism)â??diffuse corneal haziness, retinal pigmentary changes,
megalocornea, retinal detachment
44. Hydatid cyst (echinococcosis)â??keratitis, abscess of cornea, retinal detachment, retinal hemorrhages
45. Hyperlipoproteinemiaâ??arcus juvenilis, lipemia retinalis, xanthomata of retina
46. Hyperparathyroidismâ??band keratopathy, vascular engorgement of retina
47. Hypovitaminosis Aâ??keratomalacia with perforation, corneal opacity, retinal degeneration 48. Idiopathic hypercalcemia (blue-diaper syndrome)â??band keratopathy, optic atrophy,
papilledema
49. Indomethacinâ??corneal deposits, reduced retinal sensitivity
50. Influenzaâ??keratitis, retinal hemorrhage
51. Japanese River fever (typhus)â??keratitis, retinal hemorrhages
52. Juvenile rheumatoid arthritis (Still disease)â??band keratopathy, macular edema
53. Kahler disease (multiple myeloma)â??crystalline deposits of cornea, central retinal artery occlusion, retinal microaneurysms
54. Kussmaul disease (periarteritis nodosa)â??retinal detachment, pseudoretinitis pigmentosa, corneal ulcer
55. Leber tapetoretinal dystrophy syndrome (retinal aplasia)â??keratoconus, salt-and-pepper or â??bone corpuscleâ? pigmentation, yellowish-brown or gray macular lesions
56. Lubarschâ??Pick syndrome (primary amyloidosis)â??amyloid corneal deposits, retinal hemorrhages
57. Lymphogranuloma venereum disease (Nicolasâ??Favre disease)â??keratitis, pannus, corneal ulcer, keratoconus, tortuosity of retinal vessels, retinal hemorrhages
58. Marfan syndrome (arachnodactyly dystrophia mesodermalis congenita)â??keratoconus, retinitis pigmentosa
59. Meckel syndrome (dysencephalia splanchnocystica syndrome)â??sclerocornea, microcornea, retinal dysplasia
60. Meningococcemiaâ??keratitis, retinal endophlebitis
61. Mikuliczâ??Radeski syndrome (dacryosialoadenopathy)â??keratoconjunctivitis, retinal candlewax spots
62. ML IV (mucolipidosis IV)â??corneal clouding, corneal opacities, retinal atrophy
63. Morbilli (measles-rubeola)â??keratitis, corneal ulcer, pigmentary retinopathy, central retinal