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Ocular Blood Flow

Leopold Schmetterer • Jeffrey W. Kiel

Editors

Ocular Blood Flow

Editors

 

Leopold Schmetterer, Ph.D.

Jeffrey W. Kiel, Ph.D., FARVO

Department of Clinical Pharmacology

Deptartment of Ophthalmology

Center of Medical Physics and

University of Texas Health Science Center

Biomedical Engineering

San Antonio, TX

Medical University of Vienna

USA

Vienna

 

Austria

 

ISBN 978-3-540-69468-7 ISBN 978-3-540-69469-4 (eBook)

DOI 10.1007/978-3-540-69469-4

Springer Heidelberg New York Dordrecht London

Library of Congress Control Number: 2012934553

© Springer-Verlag Berlin Heidelberg 2012

This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law.

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

Printed on acid-free paper

Springer is part of Springer Science+Business Media (www.springer.com)

Contents

Part I

Anatomy

 

1

Anatomy of the Ocular Vasculatures. . . . . . . . . . . . . . . . . . . . . .

3

 

Gerard A. Lutty, Imran Bhutto, and Donald Scott McLeod

 

Part II Measurement of Ocular Blood Flow

 

2

Determination of Ocular Blood Flows

 

 

with the Microsphere Method . . . . . . . . . . . . . . . . . . . . . . . . . . .

25

 

Siv F.E. Nilsson and Albert Alm

 

3

Laser Doppler Flowmetry in Animals . . . . . . . . . . . . . . . . . . . . .

49

 

Jeffrey W. Kiel and Herbert A. Reitsamer

 

4

Oxygen Measurements in Animals . . . . . . . . . . . . . . . . . . . . . . .

65

 

Robert A. Linsenmeier

 

5

Measurement of Ocular Blood Flow: Angiography . . . . . . . . . .

95

 

Sebastian Wolf

 

6

Measurement of Retinal Vessel Diameters . . . . . . . . . . . . . . . . .

101

 

Gerhard Garhöfer and Walthard Vilser

 

7

Laser Doppler Techniques for Ocular

 

 

Blood Velocity and Flow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

123

 

Charles E. Riva

 

8

Color Doppler Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

147

 

Ingeborg Stalmans, Selim Orgül, and Leopold Schmetterer

 

9

Other Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

159

 

Gerhard Garhöfer and Leopold Schmetterer

 

Part III

Physiology

 

10

Systemic Determinants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

173

 

John V. Lovasik and Hélène Kergoat

 

11

Local Determinants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

211

 

Jeffrey W. Kiel

 

v

vi

Contents

 

 

12 Neural Control of Ocular Blood Flow . . . . . . . . . . . . . . . . . . . . . 243 Anton Reiner, Malinda E.C. Fitzgerald, and Chunyan Li

13 Endothelial and Adrenergic Control . . . . . . . . . . . . . . . . . . . . . . 311 Gerhard Garhöfer and Leopold Schmetterer

14 Retinal Ischemia in Relation to Glaucoma

and Neuroprotection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347 Neville N. Osborne

Part IV Disease

15 Ocular Blood Flow in Diabetes: Contribution

to the Microvascular Lesions of Diabetic Retinopathy . . . . . . . 365 Tim M. Curtis and Tom A. Gardiner

16 Age-Related Macular Degeneration:

Hemodynamic Changes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389

Constantin J. Pournaras, Efstratios Mendrinos, and Jean-Antoine

C. Pournaras

17 The Role of Ocular Blood Flow Abnormalities

in the Pathogenesis of Glaucoma . . . . . . . . . . . . . . . . . . . . . . . . . 411 Balwantray C. Chauhan

18 Ocular Blood Flow in Disease: Other Diseases. . . . . . . . . . . . . . 429 Makoto Araie and Junko Kami

19 Systemic Diseases: Cardiovascular Disease

and Ocular Manifestation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 433

Ghazaleh Gouya and Michael Wolzt

Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 451

Part I

Anatomy

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