- •Dedication
- •Foreword
- •Preface
- •Ocular Allergy Overview
- •The ocular surface
- •Clinical examination
- •Immunopathophysiology of ocular allergy
- •Acute allergic conjunctivitis
- •Vernal keratoconjunctivitis
- •Atopic keratoconjunctivitis
- •Giant papillary conjunctivitis
- •Contact dermatitis of the eyelids
- •Blepharoconjunctivitis
- •Bacterial conjunctivitis
- •Viral conjunctivitis
- •Vasomotor conjunctivitis
- •Ocular examination
- •Ophthalmic procedures and testing
- •Summary
- •References
- •Ocular Mast Cells and Mediators
- •Mast cell mediators
- •Preformed granule-associated mediators
- •Biogenic amines
- •Proteoglycans
- •Neutral proteases
- •Newly generated mediators
- •Lipid mediators
- •Cytokines
- •Mast cell heterogeneity
- •Phenotypic heterogeneity
- •Functional heterogeneity
- •Pharmacologic heterogeneity
- •Ocular mast cells
- •The normal eye
- •Mast cells in diseases of the eye
- •Allergic conjunctivitis
- •Vernal conjunctivitis
- •Giant papillary conjunctivitis
- •Experimental autoimmune uveitis
- •Summary
- •References
- •Allergic Conjunctivitis
- •History
- •Examination
- •Seasonal and perennial allergic conjunctivitis
- •Seasonal allergic conjunctivitis
- •Perennial allergic conjunctivitis
- •Procedures
- •Late-phase reaction
- •Treatment
- •Antihistamines
- •Mast cell stabilizers
- •Lodoxamide tromethamine 0.1% (Alomide)
- •Ketorolac tromethamine (Acular)
- •Olopatadine (Patanol, Pataday)
- •Ketotifen (Zaditor)
- •Nedocromil (Alocril)
- •Pemirolast (Alamast)
- •Azelastine (Optivar)
- •Epinastine (Elestat)
- •Corticosteroids (Vexol, Lotemax)
- •Summary
- •References
- •Vernal Conjunctivitis
- •History
- •Epidemiology
- •Clinical manifestation
- •Conjunctival signs
- •Limbal signs
- •Corneal signs
- •Pathogenesis
- •Laboratory evaluation
- •Allergy testing
- •Conjunctival examination
- •Tear evaluation
- •Ocular challenge test
- •Treatment
- •Mast cell stabilizers
- •Antihistamines
- •Corticosteroids
- •Immunosuppressive agents
- •Other medical therapies
- •Surgical therapy
- •Treatment of secondary infections
- •Hyposensitization and immunotherapy
- •Prognosis
- •References
- •Giant Papillary Conjunctivitis
- •Signs and symptoms
- •Stages of giant papillary conjunctivitis
- •Stage 1: preclinical giant papillary conjunctivitis
- •Stage 2: mild giant papillary conjunctivitis
- •Stage 3: moderate giant papillary conjunctivitis
- •Stage 4: severe giant papillary conjunctivitis
- •Epidemiology
- •Histopathology
- •Coated contact lenses
- •Pathophysiology
- •Treatment
- •Treatment for stage 1: preclinical giant papillary conjunctivitis
- •Treatment for stage 2: mild giant papillary conjunctivitis
- •Treatment for stage 3: moderate giant papillary conjunctivitis
- •Treatment for stage 4: severe giant papillary conjunctivitis
- •Summary
- •References
- •Recognizing marginal dry eye disease
- •Contact lens wear in patients with dry eye
- •The use of therapeutic contact lenses in dry eye
- •The use of contact lenses in a patient with ocular allergy
- •Contact lenses and allergic reactions
- •Managing contact lens wear in the patient with ocular allergy
- •Summary of contact lens use in patient with ocular allergy
- •References
- •Mucous membrane pemphigoid
- •Clinical features
- •Diagnostic studies
- •Disease course and treatment
- •Linear immunoglobulin A disease
- •Clinical features
- •Diagnostic studies
- •Disease course and treatment
- •Epidermolysis bullosa acquisita
- •Clinical features
- •Diagnostic studies
- •Disease course and treatment
- •Ocular pemphigus vulgaris
- •Clinical features
- •Diagnostic studies
- •Disease course and treatment
- •Summary
- •References
- •Seborrheic dermatitis
- •Treatment
- •Vitiligo
- •Heliotrope rash
- •Port-wine stains
- •Xanthelasmas and plane xanthomas
- •Seborrheic keratosis
- •Skin tags
- •Warts
- •Comedones
- •Syringoma
- •Rosacea
- •Lipoid proteinosis
- •Angioedema
- •Contact urticaria
- •Erysipelas
- •Trichinosis
- •Chalazion
- •Hordeolum
- •Nevi
- •Sarcoid
- •Hemangioma
- •Basal cell carcinoma
- •Squamous cell carcinoma
- •Sebaceous carcinoma
- •Malignant melanoma
- •Eyelid dermatitis
- •Atopic dermatitis
- •Contact dermatitis
- •Acute, subacute, and chronic
- •Epidemiology
- •Irritant versus allergic
- •Etiologies
- •Irritation due to mascara and eye cosmetic preservatives
- •Fragrance
- •Irritation due to conjunctival deposition
- •Nail polish
- •Metals
- •Aeroallergens
- •Medications/eyedrops/contact lens solution
- •Paper
- •Plants
- •Histology
- •Diagnosis
- •Herpes simplex
- •Herpes zoster
- •Treatment considerations for the eyelids
- •Eyelid dermatitis
- •Infections
- •Urticaria and angiodema
- •Benign tumors and growths
- •Malignant tumors
- •‘‘Cosmetic’’ lesions of the eyelids
- •Vascular lesions
- •Vitiligo
- •Others
- •References
- •Bacterial conjunctivitis
- •Viral conjunctivitis/herpes simplex virus infections
- •Treatment of infectious conjunctivitis
- •Nasolacrimal duct obstruction
- •Allergic conjunctivitis
- •Neonatal conjunctivitis
- •Congenital glaucoma
- •Uveitis
- •References
- •Ocular Allergy Treatment
- •Ocular allergy treatment algorithm
- •Advisory nonprescription interventions
- •Environmental control
- •Cold compresses
- •Lubrication
- •Contact lenses
- •Decongestants
- •Antihistamines
- •Oral antihistamines
- •Topical antihistamines
- •Topical antihistamines
- •Levocabastine
- •Emedastine
- •Cromoglycate
- •Lodoxamide
- •Pemirolast
- •Ketorolac
- •Multiple action agents
- •Olopatadine
- •Ketotifen
- •Nedocromil
- •Azelastine
- •Epinastine
- •Mizolastine
- •Picumast
- •Amlexanox
- •Topical antihistamines and dry eye
- •Steroids
- •Ophthalmic steroids
- •Intranasal steroids
- •Immunomodulatory agents
- •Cyclosporine
- •Immunotherapy
- •Summary
- •References
DERMATOLOGIC AND ALLERGIC CONDITIONS OF THE EYELID |
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electrodessication and curettage. Larger lesions can be surgically excised or treated with cryosurgery, chemical surgery, radiotherapy. For areas that need more aggressive management such as large areas, those found in di - cult locations such as around the medial and lateral canthi, or recurrent lesions, referral to a skilled Mohs’ surgeon is recommended.
Despite rare metastasis of BCC, the tendency for local invasion warrants early intervention and removal. The overall cure rate is approximately 95%; however, despite excision, lesions seen arising from the medial canthus have been found to have a high recurrence rate (w60%) [137].
SCC has a higher rate of metastasis (up to 10%) such that a more aggressive approach is optimal. Immediate histologic monitoring of surgical margins with frozen sections or Mohs’ micrographic surgery also allows for smaller margins of excision in an area where tissue conservation is important [138]. Mohs’ surgery is the treatment of choice to ensure complete removal, especially in di cult-to-manage areas.
As with other cancers of the eyelid, wide local excision or Mohs’ surgery is necessary for sebaceous carcinomas [139]. Prognosis is poor, with mortality second only to malignant melanoma. A clinicopathologic study of sebaceous carcinoma revealed the occurrence of death in 9% and mutilating exenteration in 23% of the patients studied [140].
Malignant melanomas metastasize, so early detection, excision, and evaluation for metastatic disease are of vital importance. Tumor thickness is an important predictor of prognosis. Margin control by mapped serial excision or by modified Mohs’ micrographic surgery is a useful technique to ensure complete excision and minimization of local recurrence [49].
‘‘Cosmetic’’ lesions of the eyelids
Vascular lesions
Due to the natural course of hemangiomas, they are usually left alone. Treatment is available when the lesions present cosmetic problems, a ect surrounding organs, or interfere with normal functions. When sought, treatment for hemangiomas includes oral steroids, intralesional steroids [141], ultrapotent topical steroids [142], and laser [45,143].
Port-wine stains are cosmetic problems. Treatment is with the use of lasers. Alternatively, camouflage techniques (DermaBlend, CoverMark) may be used to cover the defect.
Vitiligo
Vitiligo involving the eyelids is best treated with cover-up measures. Cosmetic camouflaging agents such as DermaBlend and Covermark are available and can be chosen to match the patient’s natural skin color. For localized vitiligo, topical corticosteroids are the preferred drugs. Extensive lesions over the body may be treated with topical or oral psoralens with UV-A light exposure (PUVA). In a recent double-blind randomized control
