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Acknowledgments

Alan Tomlinson, Department of Optometry, Glasgow Caledonian University, Glasgow, U.K. for advice on pathophysiology of contact lens wear over many years (Chapter 6 and Appendix D) and Acanthamoeba.

Consuelo Ferrer ,Vissum, Alicante, Spain for assistance with molecular biology (Chapter 3) and advice with Appendix D and for photomicrographs of Fusarium. Jorge Alio, Chief Ophthalmologist, Vissum, Alicante, Spain for supplying photos of fungal keratitis and for much useful discussion on causes and prevention of postoperative endopthalmitis.

David Lloyd, Renaissance Healthcare, Epsom, U.K. and Klaus Geldsetzer, Santen gmbh Munich, Germany for pharmaceutical advice and for assistance with Chapter 4 and Appendices C and D.

Gholam Peyman, Department of Ophthalmology, University of Tucson, Arizona, U.S.A.; Kirk Wilhelmus, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, U.S.A.; Steven Barrett, Charing Cross Hospital, London U.K.; Crawford Revie and George Gettinby, Department of Modelling Science, University of Strathclyde, Glasgow U.K.; Peter Barry, Department of Ophthalmology, St. Vincent’s Hospital, Dublin, Eire; Per Montan, Department of Ophthalmology, St. Erik’s Hospital, Gothenburg, Sweden; Gunther Grabner, Department of Ophthalmology, University Hospital, Salzburg, Austria; Luis Cordoves, Department of Ophthalmology, University Hospital, Tenerife, Canary Islands, Spain; Christopher Lowman and Udo Reischl, Departments of Ophthalmology and Molecular Biology, University of Regensburg, Regensburg, Germany; Marie-Jose Tassignon, Department of Ophthalmology, University Hospital, Antwerp, Belgium; Hugo Verbraeken, Department of Ophthalmology, University Hospital, Ghent, Belgium; Suleyman Kaynak, Department of Ophthalmology, University Hospital, Izmir, Turkey and colleagues in the ESCRS (European Society of Cataract & Refractive Surgeons) for their help, discussions, and advice with prophylaxis and management of post-operative endophthalmitis (Chapter 8).

John Hay, Glasgow, U.K. for his original construction of Table 1 in Appendix B and for drug information.

Magnus Peterson, Department of Modelling Science, University of Strathclyde, Glasgow U.K. for Tables 1–5 in Chapter 10 and good advice.

Philip Thomas, Joseph Eye Hospital, Tiruchirrapalli, India for assistance with mycological methods (Chapter 2) and drugs (Appendix A) and Fusarium (Appendix D).

vii

viii Acknowledgments

Tara Beattie, Department of Civil Engineering (Public Health), University of Strathclyde, Glasgow U.K.; Andrew Rogerson, Marshall University, Huntington, West Virginia, U.S.A.; Megan Shoff, Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, Ohio U.S.A. and Scott Schatz, Department of Optometry, Nova SE University, Ft. Lauderdale, U.S.A. for many useful discussions on Acanthamoeba pathogenicity (Chapter 6).

We are also grateful for assistance by Jill Bloom, Senior Drug Information Pharmacist, Moorfields Eye Hospital, London, U.K. and by members of Bausch & Lomb, Kingston, London U.K. for helpful discussions with Appendix C.

Finally, we are most grateful to Alan Burgess, Informa U.K. and for the general assistance of publishing staff of Informa U.S.A.

Contents

Preface to the Second Edition

iii

Preface to the First Edition

v

Acknowledgements vii

 

Contributors xi

 

n

Pathogenesis of Infection and the Ocular Immune Response

1

1

n

Microbiology

23

 

 

 

 

2

 

 

 

 

n

Molecular Biology

61

 

 

 

3

 

 

 

n

Pharmacology and Pharmacokinetics 105

 

4

 

n

Cellulitis, Blepharitis, and Dacrocystitis 127

 

5

 

n

Conjunctiva, Cornea, and Anterior Chamber 139

 

6

 

n

Uvea and Retina

191

 

 

 

7

 

 

 

n

Endophthalmitis Including Prevention and Trauma 239

 

8

 

n

Tropical Ophthalmomycoses

271

 

9

 

n

Epidemiology

307

 

 

 

10

 

 

 

 

 

APPENDIX A

Modes of Delivery and Formulations of Antibiotics and

 

 

 

Antifungal Drugs

323

 

 

Protozoa, Helminths, and Arachnids: Ocular Disease and

APPENDIX B

 

 

 

Chemotherapy

333

 

 

 

345

APPENDIX C

Prevention of Hospital-Acquired Ocular Infection

 

APPENDIX D

Contact Lens-Associated Keratitis, Fusarium, Disinfecting Solutions,

 

 

 

and Hygiene

353

 

 

Index 367

ix

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