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Commissioning Editor: Russell Gabbedy

Development Editor: Ben Davie

Editorial Assistant: Kirsten Lowson

Project Manager: Srikumar Narayanan

Design: Charles Gray

Illustration Manager: Bruce Hogarth

Marketing Managers (UK/USA): Richard Jones / Radha Mawrie

Ocular Disease: Mechanisms

and Management

Leonard A. Levin, md, phd

Daniel M. Albert, md, ms

Canada Research Chair of Ophthalmology and Visual Sciences

RRF Emmett A. Humble Distinguished Director of

University of Montreal

the UW Eye Research Institute

Montreal, Quebec, Canada

F.A. Davis Professor, Department of Ophthalmology

Professor of Ophthalmology and Visual Sciences

and Visual Sciences

University of Wisconsin

School of Medicine and Public Health

Madison, WI, USA

University of Wisconsin-Madison

 

 

University of Wisconsin

 

 

Madison, WI, USA

 

 

 

 

 

 

 

 

 

SAUNDERS an imprint of Elsevier Inc

© 2010, Elsevier Inc All rights reserved.

The chapter entitled 44. Optic Atrophy is in the public domain.

First published 2010

The right of Leonard A. Levin and Daniel M. Albert to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333; e-mail: healthpermissions@elsevier.com. You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions.

13 digit ISBN: 978-0-7020-2983-7

British Library Cataloguing in Publication Data

A catalogue record for this book is available from the British Library

Library of Congress Cataloging in Publication Data

A catalog record for this book is available from the Library of Congress

Notice

Medical knowledge is constantly changing. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the Publisher nor the author assume any liability for any injury and/or damage to persons or property arising from this publication.

The Publisher

 

 

The

 

 

Working together to grow

publisher’s

libraries in developing countries

policy is to use

paper manufactured

www.elsevier.com | www.bookaid.org | www.sabre.org

from sustainable forests

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Printed in China

 

 

Last digit is the print number:  9  8  7  6  5  4  3  2  1

 

 

List of Contributors

Anthony P Adamis MD

Sally S Atherton PhD

Audrey M Bernstein PhD

Adjunct Professor

Regents Professor and Chair

Assistant Professor of Ophthalmology

Division of Ophthalmology and

Department of Cellular Biology

Department of Ophthalmology

Visual Sciences

and Anatomy

Mount Sinai School of Medicine

University of Illinois College of Medicine

Medical College of Georgia

New York, NY, USA

Bronxville, NY, USA

Augusta, GA, USA

 

 

 

Pooja Bhat MD

Grazyna Adamus PhD

Tin Aung MBBS MMed(Ophth)

Fellow

Professor of Ophthalmology and

FRCS(Ed) FRCOphth

Massachusetts Eye Research &

Graduate Neuroscience

Senior Consultant and Head

Surgery Institute

Ocular Immunology Laboratory

Glaucoma Service

Cambridge, MA, USA

Casey Eye Institute

Singapore National Eye Centre,

 

Department of Ophthalmology

Deputy Director, Singapore Eye

Douglas Borchman PhD

Oregon Health and Science University

Research Institute,

Professor

Portland, OR, USA

Associate Professor

Department of Ophthalmology and

 

National University of Singapore

Visual Sciences

Daniel M Albert MD MS

Singapore

Kentucky Lions Eye Center

Emmett A Humble Distinguished Director

 

University of Louisville

Eye Research Institute,

Rebecca S Bahn MD

Louisville, KY, USA

Professor and Chair Emeritus,

Professor of Medicine

 

F A Davis Professor,

Division of Endocrinology

Stephen Brocchini

Lorenz E Zimmerman Professor

Mayo Clinic

Professor of Chemical Pharmaceutics

Ophthalmology & Visual Sciences

Rochester, MN, USA

Department of Pharmaceutics

School of Medicine and Public Health

 

The School of Pharmacy

Clinical Sciences Center

David Sander Bardenstein MD

University of London

University of Wisconsin

Professor

London, UK

Madison, WI, USA

Departments of Ophthamology and Visual

 

 

Sciences, and Pathology

Claude Burgoyne MD

Ann-Christin Albertsmeyer Can Med

Case Western Reserve University School

Research Director

Research Assistant (Predoctoral)

of Medicine

Optic Nerve Head Research Laboratory

Department of Ophthalmology

Cleveland, OH, USA

Devers Eye Institute

Schepens Eye Research Institute

 

Portland, OR, USA

Boston, MA, USA

Neal P Barney MD

 

 

Associate Professor of Ophthalmology

Michelle Trager Cabrera MD

Nishani Amerasinghe BSc MBBS MRCOphth

Department of Ophthalmology and

Clinical Associate

Specialist Registrar

Visual Sciences

Department of Opthalmology

Southampton Eye Unit

University of Wisconsin School of Medicine

Duke University

Southampton University Hospitals

Madison, WI, USA

Durham, NC, USA

NHS Trust

 

 

Southampton, UK

David C Beebe PhD FARVO

Richard J Cenedella

 

The Janet and Bernard Becker Professor of

Professor

Michael G Anderson PhD

Ophthalmology and Visual Sciences,

Department of Biochemistry

Assistant Professor of Molecular Physiology

Professor of Cell Biology and Physiology

A T Still University of Health Sciences,

and Biophysics

Department of Ophthalmology and

Kirksville College of Osteopathic Medicine

Department of Molecular Physiology

Visual Sciences

Kirksville, MO, USA

and Biophysics

Washington University

 

University of Iowa

St Louis, MO, USA

Jin-Hong Chang PhD

Iowa City, IA, USA

 

Assistant Professor of Ophthalmology

 

Adrienne Berman MD

Department of Opthalmology and

 

Clinical Assistant Professor

Visual Sciences

 

Department of Ophthalmology and

University of Illinois at Chicago

 

Visual Sciences

Chicago, IL, USA

 

University of Illinois Eye and Ear Infirmary

 

 

Chicago, IL, USA

 

List of Contributors

 

Aimee Chappelow MD

Annegret Hella Dahlmann-Noor

Joseph L Demer MD PhD

 

Cole Eye Institute

Dr med PhD FRCOphth FRCS(Ed) DipMedEd

The Leonard Apt Professor of

 

The Cleveland Clinic Foundation

Senior Clinical Research Associate

Ophthalmology,

 

Cleveland, OH, USA

Ocular Biology and Therapeutics

Professor of Neurology

 

 

UCL Institute of Ophthalmology

Jules Stein Eye Institute

 

Anuj Chauhan PhD

London, UK

David Geffen School of Medicine

 

Associate Professor and Director of

 

University of California, Los Angeles

 

the Graduate Programs

Reza Dana MD MPH MSc

Los Angeles, CA, USA

 

Department of Chemical Engineering

Professor and Director of Cornea Service

 

 

University of Florida

Massachusetts Eye & Ear Infirmary

Suzanne M Dintzis MD PhD

 

Gainesville, FL, USA

Harvard Medical School

Assistant Professor

 

 

Boston, MA, USA

Department of Pathology

 

Abbot F Clark PhD

 

University of Washington School of

 

Professor of Cell Biology and Anatomy

Helen Danesh-Meyer MBChB FRANZCO

Medicine

 

and Director

Sir William & Lady Stevenson Associate

Seattle, WA, USA

 

North Texas Eye Research Institute

Professor of Ophthalmology

 

 

University of North Texas Health

Department of Ophthalmology

J Crawford Downs PhD

 

Science Center

University of Auckland

Associate Scientist and Research Director

 

Fort Worth, TX, USA

Auckland, New Zealand

Ocular Biomechanics Laboratory

 

 

 

Devers Eye Institute

 

Ellen B Cook PhD

Julie T Daniels BSc(Hons) PhD

Portland, OR, USA

 

Associate Scientist

Reader in Stem Cell Biology and

 

 

Department of Medicine

Transplantation

Henry Edelhauser PhD

 

University of Wisconsin School of Medicine

UCL Institute of Ophthalmology

Ferst Professor and Director of

 

and Public Health

London, UK

Ophthalmology Research

 

Madison, WI, USA

 

Department of Ophthalmology

 

 

Darlene A Dartt PhD

Emory University Eye Center

 

Zélia M Corrêa MD PhD

Senior Scientist, Harold F. Johnson

Atlanta, GA, USA

 

Assistant Professor of Ophthalmology

Research Scholar

 

 

Department of Ophthalmology

Schepens Eye Research Institute,

David Ellenberg MD

 

University of Cincinnati College

Associate Professor

Research Fellow

 

of Medicine

Harvard Medical School

Department of Ophthalmology and

 

Cincinnati, OH, USA

Schepens Eye Research Institute

Visual Sciences

 

 

Boston, MA, USA

University of Illinois at Chicago

 

Scott Cousins MD

 

Chicago, IL, USA

 

The Robert Machemer Professor of

Mohammad H Dastjerdi MD

 

 

Ophthalmology and Immunology,

Postdoctoral Fellow

Victor Elner MD PhD

 

Vice Chair for Research

Schepens Eye Research Institute

The Ravitz Foundation Professor of

 

Department of Ophthalmology

Boston, MA, USA

Ophthlamology and Visual Sciences

 

Duke University School of Medicine

 

Professor, Department of Pathology

 

Durham, NC, USA

Nigel W Daw PhD

Kellogg Eye Center

 

 

Professor Emeritus of Ophthalmology and

University of Michigan

 

Gerald Cox MD PhD FACMG

Visual Science

Ann Arbor, MI, USA

 

Staff Physician in Genetics, Children’s

Departments of Ophthalmology and

 

 

Hospital Boston

Visual Science

Steven K Fisher PhD

 

Instructor of Pediatrics, Harvard

University of Yale

Professor, Molecular Cellular and

 

Medical School

New Haven, CT, USA

Developmental Biology

 

Vice President of Clinical Research

 

Neuroscience Research Institute

 

Genzyme Corporation

Daniel G Dawson MD

University of California, Santa Barbara

 

Cambridge, MA, USA

Visiting Assistant Professor of

Santa Barbara, CA, USA

 

 

Ophthalmology

 

 

Scott Adam Croes MS PhD

Emory University Eye Center

Robert Folberg MD

 

Professor of Human Anatomy

Atlanta, GA, USA

Dean, Oakland University William

 

and Physiology

 

Beaumont School of Medicine,

 

Department of Biology

Alejandra de Alba Campomanes

Professor of Biomedical Sciences, Pathology,

 

Shasta College

MD MPH

and Ophthalmology

 

Redding, CA, USA

Director of Pediatric Ophthalmology

Oakland University William Beaumont

 

 

San Francisco General Hospital

School of Medicine

 

Karl G Csaky MD PhD

San Francisco, CA, USA

Rochester, MI, USA

 

Associate Professor

 

 

 

Department of Ophthalmology

 

 

 

Duke University

 

 

 

Durham, NC, USA

 

 

 

 

 

 

x

 

 

 

 

 

 

 

List of Contributors

 

 

C Stephen Foster MD FACS FACR

Lynn K Gordon MD PhD

Vinay Gutti MD

 

 

Founder and President, Ocular Immunology

Associate Professor Ophthalmology

Private Practice

 

and Uveitis Foundation,

Jules Stein Eye Institute

Cornea, External Disease and

 

Clinical Professor of Ophthalmology

UCLA School of Medicine

Refractive Surgery

 

Harvard Medical School,

Los Angeles, CA, USA

La Mirada Eye and Laser Center

 

Founder and President

 

La Mirada, CA, USA

 

Massachusetts Eye Research and

Irene Gottlob MD

 

 

 

Surgery Institution

Professor of Ophthalmology

John R Guy MD

 

Cambridge, MA, USA

Department of Cardiovascular Sciences

Bascom Palmer Eye Institute

 

 

Ophthalmology Group

Miami, FL, USA

 

Gary N Foulks MD FACS

University of Leicester

 

 

 

The Arthur and Virginia Keeney Professor

Leicester Royal Infirmary

J William Harbour MD

 

of Ophthalmology and Vision Science

Leicester, UK

The Paul A Cibis Distinguished Professor

 

Division of Ophthalmology

 

of Ophthalmology

 

University of Louisville School of Medicine

John D Gottsch MD

Department of Ophthalmology and

 

Louisville, KY, USA

The Margaret C Mosher Professor of

Visual Sciences

 

 

Ophthalmology

Washington University School of Medicine

 

Frederick T Fraunfelder MD

Johns Hopkins School of Medicine

St Louis, MO, USA

 

Professor of Ophthalmology

Wilmer Eye Institute

 

 

 

Casey Eye Institute

Baltimore, MD, USA

Mary Elizabeth Hartnett MD

 

Portland, OR, USA

 

Professor of Ophthalmology

 

 

Frank M Graziano MD PhD

Department of Ophthalmology

 

Frederick W Fraunfelder MD

Professor of Medicine

University of North Carolina

 

Associate Professor of Ophthalmology

Department of Medicine

Chapel Hill, NC, USA

 

Casey Eye Institute

University of Wisconsin School of Medicine

 

 

 

Portland, OR, USA

and Public Health

Sohan S Hayreh MD MS PhD DSc FRCS(Edin)

 

 

Madison, WI, USA

FRCS(Eng) FRCOphth(Hon)

 

Anne Fulton MD

 

Professor Emeritus of Ophthalmology

 

Senior Associate in Ophthalmology

Hans E Grossniklaus MD MBA

Department of Ophthalmology & Director

 

Department of Ophthalmology

Professor of Medicine

Ocular Vascular Clinic

 

Children’s Hospital Boston

Emory Eye Center

University of Iowa Hospitals and Clinics

 

Boston, MA, USA

Emory University School of Medicine

Iowa City, IA, USA

 

 

Atlanta, GA, USA

 

 

 

Ronald Gaster MD

 

Susan Heimer PhD

 

Professor of Ophthalmology

Deborah Grzybowski PhD

Postdoctoral Research Fellow

 

Department of Opthalmology

Professor of Ophthalmology and

Schepens Eye Research Institute and

 

University of California

Biomedical Engineering

Department of Ophthalmology

 

Irvine, CA, USA

The Ohio State University

Harvard Medical School

 

 

College of Medicine

Boston, MA, USA

 

Stylianos Georgoulas MD

Columbus, OH, USA

 

 

 

Ocular Repair and Regeneration

 

Robert Hess DSc

 

Biology Unit

Clyde Guidry PhD

Professor and Director of Research

 

UCL Institute of Ophthalmology

Associate Professor of Ophthalmology

Department of Ophthalmology

 

London, UK

Department of Ophthalmology

McGill University

 

 

University of Alabama School of Medicine

Montreal, QC, Canada

 

Michael S Gilmore PhD

Birmingham, AB, USA

 

 

 

The C L Schepens Professor of

 

Nancy M Holekamp MD

 

Ophthalmology

Neeru Gupta MD PhD FRCSC DABO

Partner, Barnes Retina Institute,

 

Harvard Medical School,

Professor of Ophthalmology and Vision

Professor of Clinical Ophthalmology

 

Senior Scientist

Sciences, Laboratory Medicine and

Department of Ophthalmology and

 

Schepens Eye Research Institute

Pathobiology, University of Toronto,

Visual Sciences

 

Boston, MA, USA

Director

Washington University School of Medicine

 

 

Glaucoma & Nerve Protection Unit

St Louis, MO, USA

 

Ilene K Gipson PhD

Keenan Research Centre at the Li Ka Shing

 

 

 

Senior Scientist and Professor of

Knowledge Institute

Suber S Huang MD MBA

 

Ophthalmology

St Michael’s Hospital

The Philip F. and Elizabeth G. Searle

 

Department of Ophthalmology

Toronto, ON, Canada

Professor of Ophthalmology,

 

Schepens Eye Research Institute

 

Vice-Chair, Department of Ophthalmology

 

Boston, MA, USA

David H Gutmann MD PhD

& Visual Sciences

 

 

The Donald O Schnuck Family Professor

Case Western Reserve University School

 

Michaël J A Girard PhD

Department of Neurology,

of Medicine,

 

Ocular Biomechanics Laboratory

Director, Neurofibromatosis Center

Director, Center for Retina and

 

Devers Eye Institute, Legacy Health System

Washington University School of Medicine

Macular Disease

 

Portland, OR, USA

St Louis, MO, USA

University Hospitals Eye Institute

 

 

 

Cleveland, OH, USA

 

 

 

 

 

 

xi

List of Contributors

 

Sudha K Iyengar PhD

Peng Tee Khaw PhD FRCP FRCS FRCOphth

Leonard A Levin MD PhD

 

Professor

FIBiol FRCPath FMedSci

Canada Research Chair of Ophthalmology

 

Departments of Epidemiology & Biostatistics

Professor of Ocular Healing and Glaucoma

and Visual Sciences

 

and Department of Ophthalmology

and Consultant Ophthalmic Surgeon,

Department of Ophthalmology

 

Case Western Reserve University

Director of Research and Development,

University of Montreal,

 

Cleveland, OH, USA

Moorfields Eye Hospital NHS

Professor, Department of Ophthalmology

 

 

Foundation Trust,

and Visual Sciences

 

Allen T Jackson

Director, National Institute for Health

University of Wisconsin

 

Massachusetts Eye Research and

Biomedical Research Centre,

Madison, WI, USA

 

Surgery Institute

Programme Director, Eyes & Vision, UCL

 

 

Harvard Medical School

Partners Academic Health Science Centre

Geoffrey P Lewis PhD

 

Cambridge, MA, USA

London, UK

Research Biologist, Neurobiology

 

 

 

Neuroscience Research Institute

 

L Alan Johnson MD

Alice S Kim MD

University of California, Santa Barbara

 

Private Practice

Division of Ophthalmology

Santa Barbara, CA, USA

 

Sierra Eye Associates

Maimonides Medical Center

 

 

Reno, NV, USA

Brooklyn, NY, USA

Zhuqing Li MD PhD

 

 

 

Staff Scientist

 

Peter F Kador PhD

Henry Klassen MD PhD

Laboratory of Immunology

 

Professor

Assistant Professor

National Eye Institute

 

Departments of Ophthalmology and

Department of Ophthalmology

National Institutes of Health

 

Pharmaceutical Sciences

University of California, Irvine,

Bethesda, MD, USA

 

University of Nebraska Medical Center

School of Medicine

 

 

Omaha, NE, USA

Orange, CA, USA

Amy Lin MD

 

 

 

Assistant Professor of Ophthalmology

 

Alon Kahana MD PhD

Paul Knepper MD PhD

Department of Ophthalmology

 

Full Member, University of Michigan

Research Scientist

Loyola University

 

Comprehensive Cancer Center,

University of Illinois at Chicago

Maywood, IL, USA

 

Attending Surgeon, C S Mott

Department of Opthalmology &

 

 

Children’s Hospital,

Visual Science

Robert A Linsenmeier PhD

 

Assistant Professor

Chicago, IL, USA

Professor of Biomedical Engineering,

 

Department of Ophthalmology and

 

Neurobiology & Physiology, and

 

Visual Sciences

Jane F Koretz PhD

Ophthalmology

 

Kellogg Eye Center

Professor of Biophysics

Biomedical Engineering Department

 

University of Michigan

Biochemistry and Biophysics Program

Northwestern University

 

Ann Arbor, MI, USA

Rensselaer Polytechnic Institute,

Evanston, IL, USA

 

 

Science Center

 

 

Randy Kardon MD PhD

Troy, NY, USA

Robert Listernick MD

 

Professor and Director of

 

Professor of Pediatrics, Feinberg School of

 

Neuro-ophthalmology,

Mirunalini Kumaradas MD Opth(SL)

Medicine, Northwestern University,

 

Pomerantz Family Chair in Ophthalmology,

FRCS (UK)

Attending Physician

 

Director for Iowa City VA Center for

Lecturer

Division of General Academic Pediatrics

 

Prevention and Treatment of Vision Loss

Faculty of Medicine

Children’s Memorial Hospital

 

Department of Ophthalmology and

University of Colombo

Chicago, IL, USA

 

Visual Sciences

Colombo, Sri Lanka

 

 

University of Iowa and Department of

 

Martin Lubow MD

 

Veterans Affairs

Jonathan H Lass MD

Associate Professor of Ophthalmology

 

Iowa City, IA, USA

The Charles I Thomas Professor and

Department of Ophthalmology

 

 

Chairman

The Ohio State University Eye and

 

Maria Cristina Kenney MD PhD

Department of Ophthalmology and

Ear Institute

 

Professor of Ophthalmology

Visual Sciences

Columbus, OH, USA

 

The Gavin Herbert Eye Institute

Case Western Reserve University,

 

 

Orange, CA, USA

Director, University Hospitals Eye Institute

Andrew Maniotis PhD

 

 

Cleveland, OH, USA

Visiting Associate Professor of

 

Timothy Scott Kern PhD

 

Bioengineering

 

Professor of Medicine

David Lederer MD

Division of Science and Engineering

 

Department of Medicine

Fellow

University of Illinois at Chicago

 

Division of Clinical and Molecular

Department of Ophthalmology

Chicago, IL, USA

 

Endocrinology

Duke University

 

 

Center for Diabetes Research

Durham, NC, USA

Pascale Massin MD PhD

 

Case Western Reserve University

 

Professor of Ophthalmology

 

Cleveland, OH, USA

Mark Lesk MSc MD FRCS(C) CM DABO

Ophthalmology Department

 

 

Director of Vision Health Research

Lariboisiere Hospital

 

 

University of Montreal

Paris, France

 

 

Montreal, QC, Canada

 

 

 

 

 

xii

 

 

 

 

 

 

 

List of Contributors

 

 

Katie Matatall BS

Robert Nickells BSc PhD

Jonathan T Pribila MD, PhD

 

 

Department of Ophthalmology &

Professor of Ophthalmology and

Pediatric Ophthalmology and Adult

 

Visual Sciences

Visual Sciences

Strabismus Fellow

 

Washington University School of Medicine

Department of Ophthalmology and

Department of Ophthalmology

 

St Louis, MO, USA

Visual Sciences

University of Minnesota

 

 

University of Wisconsin

Minneapolis, MN, USA

 

Russell L McCally PhD

Madison, WI, USA

 

 

 

Associate Professor of Ophthalmology,

 

Frank A Proudlock PhD

 

The Wilmer Eye Institute, Johns Hopkins

Robert B Nussenblatt MD MPH

Lecturer in Ophthalmology

 

Medical Institutions

Department of Pathology and

Ophthalmology Group

 

Principal Professional Staff

Cancer Center

University of Leicester

 

Applied Physics Laboratory

University of Illinois

Robert Kilpatrick Clinical Sciences Building

 

Johns Hopkins University

Chicago, IL, USA

Leicester Royal Infirmary

 

Laurel, MD, USA

 

Leicester, UK

 

 

Joan M O’Brien MD

 

 

 

Stephen D McLeod MD

Professor of Ophthalmology and Pediatrics

Xiaoping Qi MD

 

Professor of Ophthalmology

Comprehensive Cancer Center

Associate Scientist of Ophthalmology

 

Department of Ophthalmology

University of California San Francisco

College of Medicine

 

University of California San Francisco

San Francisco, CA, USA

University of Florida

 

San Francisco, CA, USA

 

Gainesville, FL, USA

 

 

Daniel T Organisciak PhD

 

 

 

Muhammad Memon MD

Professor of Biochemistry and

Narsing A Rao MD

 

Visiting Academic

Molecular Biology,

Professor of Ophthalmology and Pathology,

 

Department of Neuroscience

Director, Petticrew Research Laboratory

Keck School of Medicine, University of

 

Imperial College London

Department of Biochemistry and

Southern California,

 

London, UK

Molecular Biology

Director of Experimental Ophthalmic

 

 

Boonshoft School of Medicine

Pathology and Ocular Inflammations

 

Joan W Miller MD

Wright State University

Doheny Eye Institute

 

The Henry Willard Williams Professor of

Dayton, OH, USA

Los Angeles, CA, USA

 

Ophthalmology and Chair, Harvard

 

 

 

 

Medical School,

Michel Paques MD PhD

Robert Ritch MD

 

Chief, Department of Ophthalmology

Professor of Ophthalmology

Professor of Ophthalmology, New York

 

Massachusetts Eye and Ear Infirmary

Clinical Investigation Center

Medical College, Valhalla, NY,

 

Boston, MA, USA

XV-XX Hospital and University of Paris VI

The Shelley and Steven Einhorn

 

 

Paris, France

Distinguished Chair in Ophthalmology,

 

Austin K Mircheff PhD

 

Chief, Glaucoma Services

 

Professor of Physiology & Biophysics and

Heather R Pelzel BSc

Surgeon Director

 

Professor of Ophthalmology

Research Assistant

New York Eye and Ear Infirmary

 

Department of Physiology & Biophysics

Department of Ophthalmology and

New York, NY, USA

 

Keck School of Medicine

Visual Sciences

 

 

 

University of Southern California

University of Wisconsin

Joseph F Rizzo III

 

Los Angeles, CA, USA

Madison, WI, USA

Associate Professor of Ophthalmology

 

 

 

Massachusetts Eye and Ear Infirmary

 

Jay Neitz PhD

Shamira Perera MBBS BSc FRCOphth

Harvard Medical School

 

The Bishop Professor

Research Fellow, Singapore Eye

Boston, MA, USA

 

Department of Ophthalmology

Research Institute,

 

 

 

University of Washington

Consultant

Michael D Roberts PhD

 

Seattle, WA, USA

Glaucoma Service

Post Doctoral Research Fellow

 

 

Singapore National Eye Centre

Ocular Biomechanics Laboratory

 

Maureen Neitz PhD

Singapore

Devers Eye Institute

 

The Ray H Hill Professor

 

Portland, OR, USA

 

Department of Ophthalmology

Eric A Pierce MD PhD

 

 

 

University of Washington

Associate Professor of Ophthalmology

James T Rosenbaum MD

 

Seattle, WA, USA

F M Kirby Center for Molecular

Professor of Ophthalmology, Medicine and

 

 

Ophthalmology

Cell Biology

 

Christine C Nelson MD FACS

University of Pennsylvania School of

The Edward E Rosenbaum Professor of

 

Professor of Ophthalmology and Surgery

Medicine

Inflammation Research

 

Kellog Eye Center

Philadelphia, PA, USA

Oregon Health & Science University

 

University of Michigan

 

Portland, OR, USA

 

Ann Arbor, MI, USA

Jean Pournaras MD

 

 

 

 

Research Fellow

Barry Rouse PhD DSc

 

 

Service d’ophtalmologie

Distinguished Professor

 

 

Hôpital Lariboisière

Department of Pathobiology

 

 

Paris, France

University of Tennessee

 

 

 

Knoxville, TN, USA

 

 

 

 

 

 

xiii

List of Contributors

 

Daniel R Saban PhD

Genevieve Aleta Secker PhD BSc

Arun N E Sundaram MBBS FRCPC

 

Postdoctoral Fellow in Ophthalmology

Post-Doctoral Fellow

Fellow, Division of Neurology and Vision

 

Division of Ophthalmology

SA Pathology

Sciences Research Program, University of

 

Schepens Eye Research Institute

Centre for Cancer Biology

Toronto,

 

Boston, MA, USA

Department of Haematology

Consultant

 

 

Adelaide, SA, Australia

Neuro-ophthalmology Center

 

Alfredo A Sadun MD PhD

 

University Health Network

 

Thornton Professor of Ophthalmology

Srilakshmi M Sharma MRCP MRCOphth

Toronto, ON, Canada

 

and Neurosurgery

Uveitis Fellow

 

 

Department of Ophthalmology

Bristol Eye Hospital

Janet S Sunness MD

 

USC Keck School of Medicine

University of Bristol NHS Trust

Medical Director

 

Los Angeles, CA, USA

Bristol, UK

Richard E Hoover Rehabilitation Services

 

 

 

for Low Vision and Blindness

 

Abbas K Samadi PhD

James A Sharpe MD FRCPC

Greater Baltimore Medical Center

 

Assistant Professor of Surgery and

Professor of Neurology, Medicine,

Baltimore, MD, USA

 

Biochemistry

Ophthalmology and Visual Sciences, and

 

 

Department of Biochemistry

Otolaryngology, University of Toronto,

Nathan T Tagg MD

 

University of Kansas Medical Center

Director

Neurologist and Neuro-ophthalmologist

 

Kansas City, KS, USA

Neuro-ophthalmology Center

Walter Reed Army Medical Center

 

 

University Health Network

National Naval Medical Center

 

Pranita Sarangi BVSc&AH PhD

Toronto, ON, Canada

Bethesda, MD, USA

 

Postdoctoral Research Associate

 

 

 

David H Smith Center for Vaccine Biology

Heather Sheardown BEng PhD

Daniela Toffoli MD

 

and Immunology

Professor

Ophthalmology Resident, PGY-5

 

University of Rochester Medical Center

Department of Chemical Engineering and

Department of Ophthalmology

 

Rochester, NY, USA

School of Biomedical Engineering

Université de Montréal

 

 

McMaster University

Montréal, QC, Canada

 

Andrew P Schachat MD

Hamilton, ON, Canada

 

 

Professor of Ophthalmology, Lerner College

 

Cynthia A Toth MD

 

of Medicine

Alex Shortt MD PhD MRCOphth

Professor of Ophthalmology and

 

Vice Chairman

Clinical Lecturer in Ophthalmic

Biomedical Engineering

 

Cole Eye Institute

Translational Research

Department of Biomedical Engineering

 

Cleveland Clinic Foundation

Biomedical Research Centre for

Duke University

 

Cleveland, OH, USA

Ophthalmology

Durham, NC, USA

 

 

Moorfields Eye Hospital

 

 

Joel E Schechter PhD

London, UK

Elias I Traboulsi MD

 

Professor of Cell and Neurobiology

 

Professor of Ophthalmology

 

Keck School of Medicine

Ying-Bo Shui MD PhD

Cleveland Clinic Lerner College of Medicine

 

University of Southern California

Senior Scientist

Case University

 

Los Angeles, CA, USA

Department of Ophthalmology and

The Cole Eye Institute

 

 

Visual Sciences

Cleveland, OH, USA

 

A Reagan Schiefer MD

Washington University in St Louis

 

 

Trainee in Endocrinology

St Louis, MO, USA

James C Tsai MD

 

Division of Endocrinology

 

The Robert R Young Professor and

 

Mayo Clinic

Ian Sigal PhD

Chairman

 

Rochester, MN, USA

Research Associate

Department of Ophthalmology and

 

 

Devers Eye Institute

Visual Science

 

Ursula Schlötzer-Schrehardt ProfDr

Ocular Biomechanics Laboratory

Yale University School of Medicine,

 

Professor

Portland, OR, USA

Chief of Ophthalmology, Yale-New

 

Department of Ophthalmology

 

Haven Hospital

 

University of Erlangen-Nürnberg

James L Stahl PhD

Yale Eye Center

 

Erlangen, Germany

Associate Scientist

New Haven, CT, USA

 

 

Department of Medicine

 

 

Ingo Schmack MD

University of Wisconsin School of Medicine

Budd Tucker PhD

 

Attending Physician

and Public Health

Investigator

 

University of Bochum

Madison, WI, USA

Department of Ophthalmology

 

Department of Ophthalmology

 

Schepens Eye Research Institute, Harvard

 

Bochum, Germany

Roger F Steinert MD

Medical School

 

 

Professor and Chair of Ophthalmology,

Boston, MA, USA

 

Leopold Schmetterer PhD

Professor of Biomedical Engineering,

 

 

Professor

Director, Gavin Herbert Eye Institute

 

 

Departments of Clinical Pharmacology and

University of California Irvine

 

 

Biomedical Engineering and Physics

Irvine, CA, USA

 

 

Medical University of Vienna

 

 

 

Vienna, Austria

 

 

 

 

 

 

xiv

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